Condition
Critical Illness Clinical Trials
Studies of critical illness, matched by condition name and medical subject headings. Start with those open to enrolment.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 390Critical Illness, Shock
Individualised Blood Pressure Targets Versus Standard Care Among Critically Ill Patients With Shock
Aim The aim of the proposed RCT is to determine effectiveness of a strategy, where MAP (mean arterial blood pressure) targets during vasopressor therapy for shock in ICU are individualized based on patients' own pre-illness MAP…
- Trial name
- REACT-SHOCK (NCT05850962)
- Testing
- Individualised MAP target
- Where
- Australia
- Volunteers
- 1,260 people
- Sponsor
- Rakshit Panwar
Sepsis, Myopathy Critical Illness
Characterization and Longitudinal Monitoring of Muscular Phenotype in Patients Admitted to Intensive Care for Sepsis
Approximately 40% of patients develop muscle dysfunction during their stay in intensive care, particularly in the context of sepsis.
- Trial name
- REAMUS (NCT07074028)
- Testing
- Medical Research Council sum score (MRC-SS) test, Handgrip test combined with surface electromyography (sEMG), Electrical activity during maximal voluntary contraction of the rectus femoris
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Centre Hospitalier de Saint-Brieuc
Critical Illness, Geriatric Patient
Dynamic Inflammatory Changes and Nutritional Risk Scores in ICU Patients Aged 65 Years and Older
"This prospective observational study aims to evaluate the prognostic value of dynamic changes in the serum uric acid-to-albumin ratio (UAR) measured on admission (Day 0) and on Day 3, along with mNUTRIC and PNI scores, regarding…
- Conditions
- Critical Illness, Geriatric Patient, Mortality, Inflamation
- Trial name
- NCT07888010
- Testing
- Uric Acid to Albumin Ratio (UAR) and Nutritional Risk Scores
- Where
- Turkey (Türkiye)
- Volunteers
- 224 people
- Sponsor
- Ankara Etlik City Hospital
Critical Illness
Cycling Within an Interactive and Immersive Virtual Environment During Critical Illness: a Patient-centred Approach for Lower Limb Rehabilitation
This study aims to investigate whether combining cycling exercise with an immersive and interactive virtual reality (VR) environment improves motivation compared with cycling without visual support or cycling while watching a…
- Trial name
- VRCycling-ICU (NCT07894146)
- Testing
- Basic-Cycle, TV-Cycle, VR-Cycle
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- KU Leuven
Critical Illness, Neuropathy
Establishing Normative Data for Pupillometer Assessments in Neuro-Intensive Care
The purpose of this study is to collect a large amount of data that may assist in addressing the gap in knowledge of understanding pupillometer readings using a pupillometer device.
- Trial name
- ENDPANIC (NCT02804438)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Texas Southwestern Medical Center
Implementation Science, Delirium
Behavioral Economic & Staffing Strategies in the ICU
The overarching goal of this study is to support the "real world" assessment of strategies used to foster adoption of several highly efficacious evidence-based practices in healthcare systems that provide care to critically ill…
- Conditions
- Implementation Science, Delirium, Critical Illness, Mechanical Ventilation Complication
- Trial name
- BEST-ICU (NCT06184945)
- Testing
- Realtime audit and feedback, RN Implementation Facilitator
- Where
- 3 sites in United States
- Volunteers
- 16,500 people
- Sponsor
- University of Nebraska
Critical Illness, ICU-acquired Weakness
Beyond Voluntary Effort: Reliability and Validity of Magnetic Femoral Nerve Stimulation for Assessing Quadriceps Strength in Critically Ill Patient
Intensive care unit-acquired weakness (ICU-AW) is a common complication of critical illness and can negatively affect recovery and long-term physical functioning.
- Trial name
- TWITCH FORCE (NCT07891273)
- Testing
- Magnetic Femoral Nerve Stimulation
- Volunteers
- 33 people
- Sponsor
- Daniel Langer
Critical Illness, Hyperglycemia
Stress Hyperglycemia Ratio and Glucose Variability in Critically Ill Patients
This prospective cohort study aims to evaluate the stress hyperglycemia ratio and glucose variability among critically ill patients admitted to the intensive care unit.
- Trial name
- NCT07892222
- Volunteers
- 75 people
- Sponsor
- Assiut University
Mechanical Ventilation, Critically Ill Intensive Care Unit Patients
Ketamine Sedation in the ICU (KANINE) RCT
Sedation is given to intensive care unit (ICU) patients to treat discomfort, anxiety, agitation, and to help facilitate care, particularly when they require a breathing tube.
- Trial name
- KANINE (NCT06767358)
- Testing
- ketamine hydrochloride
- Where
- 3 sites in Canada
- Volunteers
- 54 people
- Sponsor
- McMaster University
Critical Illness, Mechanical Ventilation Complication
Enteral Feeding in Mechanically Ventilated Children
This prospective cohort study aims to assess enteral feeding practices and the adequacy of energy and protein delivery among mechanically ventilated children admitted to the pediatric intensive care unit.
- Trial name
- NCT07884838
- Volunteers
- 60 people
- Sponsor
- Assiut University
Completed, with results posted
All –Critical Illness
Alpha 2 Agonists for Sedation to Produce Better Outcomes From Critical Illness (A2B Trial)
Many patients in intensive care (ICU) need help to breathe on a breathing machine and need pain killers and sedatives to keep them comfortable and pain free.
- Trial name
- A2B (NCT03653832)
- Testing
- Dexmedetomidine, Clonidine, Propofol
- Where
- 38 sites in United Kingdom
- Volunteers
- 1,404 people
- Sponsor
- University of Edinburgh
Critical Illness, Wounds and Injury
Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention
This study is a multicenter randomized controlled trial to determine the effectiveness of a closed loop/autonomous oxygen titration system (O2matic PRO100) to maintain normoxemia (goal range SpO2 90-96%, target 93%) during the…
- Conditions
- Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
- Trial name
- SAVE-O2 AI (NCT06374225)
- Testing
- Automated Titration (O2matic)
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Child, Intensive Care Unit Acquired Weakness
Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children
While mortality in U.S. pediatric intensive care units (PICUs) is improving, surviving children frequently develop persistent physical, cognitive, and psychological impairments.
- Conditions
- Child, Intensive Care Unit Acquired Weakness, Critical Illness, Hospital Acquired Pressure Ulcer
- Trial name
- PICU Up! (NCT04989790)
- Testing
- PICU Up!
- Where
- 11 sites in United States
- Volunteers
- 1,470 people
- Sponsor
- Johns Hopkins University
Critical Illness
Psychological Support Based on Positive Suggestions (PSBPS) on Mental Health Morbidity and Cognitive Function
The Researchers are trying to evaluate efficacy of a psychotherapeutic approach that can be applied to those who are critically ill.
- Trial name
- NCT04045210
- Testing
- Psychological Support Based on Positive Suggestions
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Mayo Clinic
Critical Illness
Gastric Ultrasound in Tube Fed Intubated Patients
This study will use point of care (POC) gastric ultrasound to confirm that nasojejunal tube (NJ) feeds result in minimal to no gastric content and therefore are low risk for aspiration and should be allowed at the very least to…
- Trial name
- NCT04612348
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Joseph D. Tobias