Drug or intervention
Buprenorphine Clinical Trials
Studies that test Buprenorphine, alone, with other treatments or as the comparison.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 107Opioid Use Disorder
Examining Analgesic Synergy and Efficacy in Trauma Care
Traumatic injury is responsible for over 25 million (16%) Emergency Department visits and over 225,000 deaths each year per 2021 Center for Disease Control data. This is the 3rd leading cause of death in the US.
- Trial name
- EASE (NCT07435077)
- Testing
- Buprenorphine, Oxycodone
- Where
- United States
- Volunteers
- 282 people
- Sponsor
- Wake Forest University Health Sciences
Opioid-Related Disorders, Drug Addiction
Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder
Background: People with addictions often find it hard to choose the long-term benefits of abstinence over the short-term effects of using drugs.
- Trial name
- NCT03745339
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Chronic Pain, Opioid Use Disorder
Cannabidiol in Opioid Use Disorder and Chronic Pain With Buprenorphine
This is a randomized, placebo-controlled, crossover human laboratory study investigating the dose-dependent safety and acute effects of Cannabidiol (CBD) on measures of pain and opioid craving in outpatients with opioid use…
- Trial name
- NCT07886606
- Testing
- 400 mg Cannabidiol, 800 mg Cannabidiol, 1200 mg Cannabidiol
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Yale University
Cesarean Delivery
BUprenorphine Versus Morphine for Postcesarean Analgesia (BUMP)
In this study the researchers are randomizing pregnant patients coming for elective cesarean delivery to receive either intrathecal buprenorphine or morphine for their analgesia.
- Trial name
- NCT07786012
- Testing
- buprenorphine, morphine
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Opioid Use Disorder
Semaglutide for Helping Opioid Recovery
The is a pilot, 12-week, double-blind, placebo-controlled, randomized trial of individuals with opioid use disorder (OUD) newly initiating buprenorphine to receive either weekly injections of semaglutide (n=23) or matching…
- Trial name
- SHORE (NCT06639464)
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Brigham and Women's Hospital
Opioid Use Disorder
Integrating MOUD in Nonmedical Community Settings (Better Together)
A multisite effectiveness-implementation study will be conducted in four sites to evaluate interventions to improve engagement and retention in MOUD with buprenorphine treatment persons with Opioid Use Disorder (OUD) in urban…
- Trial name
- NCT06416020
- Testing
- HC-MOUD Only, BT-MOUD with Buprenorphine
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- Howard University
Opioid Use Disorder
Acceptability and Feasibility of Extended-Release Subcutaneous Buprenorphine on a Mobile Pharmacy Clinic
This exploratory project will assess the acceptability and feasibility of monthly extended-release subcutaneous buprenorphine (BRIXADI; XR-B) to treat opioid use disorder (OUD) among persons in the community receiving care on a…
- Trial name
- NCT07176351
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Postsurgical Pain Management, Postsurgical Pain, Chronic
An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service
The goal of this clinical trial is to learn whether a pain-management program called a Transitional Pain Service can help prevent long-term pain and reduce opioid needs after surgery in adult surgical patients who may be at…
- Conditions
- Postsurgical Pain Management, Postsurgical Pain, Chronic, Opioid Use After Surgery
- Trial name
- TPS-Select (NCT07296770)
- Testing
- TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures
- Where
- United States
- Volunteers
- 474 people
- Sponsor
- University of California, San Francisco
Opiod Use Disorder
Chicago Data-driven Opioid Use Disorder Screening, Engagement, Treatment and Planning System
This study, called the Chicago Data-driven Opioid use disorder Screening, Engagement, Treatment and Planning (C-DOSETaP) System, tests a new system of clinical care for patients with opioid use disorder (OUD) across a large…
- Trial name
- C-DOSETaP (NCT07498322)
- Testing
- OUD screening, MOUD, Continuity of care
- Where
- United States
- Volunteers
- 271,031 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Substance Use, Substance-Related Disorders
Clinician Practice Companion to Address Youth Substance Use
Substance use, including the use of opioids, cannabis, and other drugs, is common among adolescents and young adults, and overdose has become a leading cause of death among youth in Canada and the United States.
- Conditions
- Substance Use, Substance-Related Disorders, Adolescent Substance Use, Cannabis Use
- Trial name
- NCT07725289
- Testing
- Practice Companion
- Where
- 5 sites in United States, Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Completed, with results posted
All 199Opioid Use Disorder, Opioid Overdose
A Bundled Intervention
Opioid overdose deaths have reached historically high records in the United States and are particularly concentrated among patients after emergency department (ED) discharge.
- Trial name
- B-CARE (NCT06593093)
- Testing
- a bundled intervention, including peer support specialist, buprenorphine, physician care, and telehealth
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Opioid-Related Disorders, NAS
MOms in REcovery (MORE) Study: Defining Optimal Care
Northern New England has among the highest rates of opioid dependence in the U.S. This region also has among the highest rates of opioid-related deaths in the U.S., with a disproportionate high rate among pregnant women with…
- Conditions
- Opioid-Related Disorders, NAS, Substance Use Disorders, Mental Health
- Trial name
- MORE (NCT04251208)
- Testing
- Observational Study
- Where
- 10 sites in United States
- Volunteers
- 2,510 people
- Sponsor
- Trustees of Dartmouth College
Telehealth at the Library, Control Group
"Bupe by the Book": Testing Library Telehealth With Unstably Housed Persons With Opioid Use Disorder
Public libraries nationwide are facing an on-premise opioid overdose crisis. Many persons with opioid use disorder (OUD) remained unhoused and profoundly hard to reach.
- Trial name
- BBB (NCT05872386)
- Testing
- Library Telehealth with Buprenorphine Provider, Treatment-as-Usual Control group
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Opioid Use Disorder
STAMPS: South Carolina Buprenorphine Treatment Initiation, Adherence, and Retention Utilizing Mobile Health Units and Peer Support Specialists
The study is a 1-arm prospective interventional cohort quasi-experimental with retrospective control group. Enrolled participants will be compared to previously established mobile health patients, who did not work with a peer…
- Trial name
- NCT06384781
- Testing
- Peer Support Checklist
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Prisma Health-Upstate
Opioid Use Disorder, Medication Adherence
MHealth Incentivized Adherence Plus Patient Navigation
Polysubstance use involving opioids and methamphetamine is emerging as a new public health crisis. Patients with opioids and methamphetamine use often experience serious medical complications requiring hospitalization, which…
- Conditions
- Opioid Use Disorder, Medication Adherence, Polysubstance Drug Use (Indiscriminate Drug Use), Methamphetamine-dependence
- Trial name
- MIAPP (NCT06027814)
- Testing
- Patient Navigation and mHealth (PN+mHealth)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Washington