Drug or intervention
Treatment as usual Clinical Trials
Studies that test Treatment as usual, alone, with other treatments or as the comparison.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 2,019Lymphoplasmacytic Lymphoma, Waldenstrom Macroglobulinemia
Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma
This phase II trial studies the effects of venetoclax and rituximab in comparison to ibrutinib and rituximab or zanubrutinib in treating patients with previously untreated Waldenstrom's macroglobulinemia/lymphoplasmacytic…
- Trial name
- NCT04840602
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy
- Where
- 146 sites in United States
- Volunteers
- 92 people
- Sponsor
- National Cancer Institute (NCI)
Traumatic Brain Injuries, TBI (Traumatic Brain Injury)
Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI)
The primary goal of this study is to evaluate the effectiveness of an integrated therapeutic model - combining VR and standard psychotherapy in improving executive function and hyperarousal adults impacted with mTBI.
- Conditions
- Traumatic Brain Injuries, TBI (Traumatic Brain Injury), MTBI - Mild Traumatic Brain Injury, mTBI
- Trial name
- ReVIVE (NCT07890337)
- Testing
- Virtual Reality, Standard Psychotherapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
HER2-positive Breast Cancer, Breast Cancer
A Study of Skipping Radiation Therapy in People With Breast Cancer
The purpose of this study is to find out whether it is safe to skip (omit) radiation therapy to the breast after lumpectomy in people with low-risk HER2-positive breast cancer who are receiving HER2-targeted therapy.
- Trial name
- SuperHERO (NCT07895511)
- Testing
- HER2-targeted therapy, Tamoxifen, No Radiation Therapy
- Where
- 7 sites in United States
- Volunteers
- 136 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Lung Non-Small Cell Carcinoma, Lung Non-Small Cell Squamous Carcinoma
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
This phase III ALCHEMIST treatment trial tests the addition of pembrolizumab to usual chemotherapy for the treatment of stage IIA, IIB, IIIA or IIIB non-small cell lung cancer that has been removed by surgery.
- Conditions
- Lung Non-Small Cell Carcinoma, Lung Non-Small Cell Squamous Carcinoma, Lung Non-Squamous Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8
- Trial name
- NCT04267848
- Testing
- Biospecimen Collection, Carboplatin, Cisplatin
- Where
- 1,151 sites in United States, Guam
- Volunteers
- 1,210 people
- Sponsor
- National Cancer Institute (NCI)
Suicide, Secure Firearm Storage
Reducing Firearm Suicide Among Veterans: Evaluating the Effectiveness of Peer-Delivered Lethal Means Counseling
Suicide prevention is a top priority for the Department of Veterans Affairs (VA), with a major emphasis on developing innovative and effective ways to prevent firearm suicide.
- Trial name
- NCT07033884
- Testing
- Peer Engagement and Exploration of Responsibility and Safety, Active Control
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Pneumonia; Pulmonary Infection
A Multicenter Randomized Trial of CT-Based AI Decision Support for Early Pneumonia Care
Adults hospitalized with pneumonia who need new or increased oxygen support or have defined immunocompromise will be assigned to usual care with or without access to a CT-based AI report.
- Trial name
- NCT07895290
- Testing
- CT-Based AI Decision Support for Pneumonia
- Where
- China
- Volunteers
- 4,800 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Diabetes (DM)
RIGHTEST iFree 2 CGM System for Glycemic Control in Adults With Diabetes Mellitus
The goal of this clinical trial is to find out whether using a real-time continuous glucose monitoring (CGM) system can improve daily blood sugar control compared with usual self-monitoring of blood glucose (SMBG; finger-stick…
- Trial name
- NCT07889375
- Testing
- Continuous Glucose Monitoring (CGM), Self-monitoring of blood glucose (SMBG)
- Where
- Taiwan
- Volunteers
- 324 people
- Sponsor
- Bionime Corporation
Core Binding Factor Acute Myeloid Leukemia
Testing the Addition of Venetoclax or Gemtuzumab Ozogamicin (GO) to Usual Treatment Regimen (Cytarabine and Daunorubicin, "7+3") for Core Binding Factor Acute Myeloid Leukemia (CBF-AML) to Improve Response (A MYELOMATCH Treatment Trial)
This phase II MYELOMATCH treatment trial compares the effect of venetoclax to gemtuzumab ozogamicin, when given with cytarabine and daunorubicin ("7+3" regimen), for the treatment of patients with core binding factor acute…
- Trial name
- NCT06917911
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Cytarabine
- Where
- 74 sites in United States, Puerto Rico
- Volunteers
- 162 people
- Sponsor
- National Cancer Institute (NCI)
Cerebral Palsy (CP)
Ayres Sensory Integration Intervention for Children With Cerebral Palsy
This study will examine whether a 12-week Ayres Sensory Integration (ASI)-based physiotherapy program can improve motor skills and daily functioning in young children with cerebral palsy.
- Trial name
- ASI-CP-PT (NCT07895485)
- Testing
- Ayres Sensory Integration-Based Physiotherapy, Usual Physiotherapy and Rehabilitation
- Volunteers
- 30 people
- Sponsor
- Izgi Miray Demirbag
Metastatic Nasopharyngeal Carcinoma, Recurrent Nasopharyngeal Carcinoma
Testing the Addition of BMS-986016 (Relatlimab) to the Usual Immunotherapy After Initial Treatment for Recurrent or Metastatic Nasopharyngeal Cancer
This phase II trial tests the addition of BMS-986016 (relatlimab) to the usual immunotherapy after initial treatment for nasopharyngeal cancer that has come back after a period of improvement (recurrent) or that has spread from…
- Conditions
- Metastatic Nasopharyngeal Carcinoma, Recurrent Nasopharyngeal Carcinoma, Stage IV Nasopharyngeal Carcinoma AJCC v8
- Trial name
- NCT06029270
- Testing
- Biospecimen Collection, Bone Scan, Carboplatin
- Where
- 95 sites in United States, Australia and 3 more
- Volunteers
- 156 people
- Sponsor
- National Cancer Institute (NCI)
Completed, with results posted
All 1,009Telehealth at the Library, Control Group
"Bupe by the Book": Testing Library Telehealth With Unstably Housed Persons With Opioid Use Disorder
Public libraries nationwide are facing an on-premise opioid overdose crisis. Many persons with opioid use disorder (OUD) remained unhoused and profoundly hard to reach.
- Trial name
- BBB (NCT05872386)
- Testing
- Library Telehealth with Buprenorphine Provider, Treatment-as-Usual Control group
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Smoking Cessation
Improving Adherence to Web-Based Cessation Programs: A Social Network Approach
This study will compare the efficacy of an interactive, evidence-based smoking cessation website (WEB) alone and in conjunction with 1) a theory-driven, empirically-informed social network (SN) protocol designed to integrate…
- Trial name
- NCT01544153
- Testing
- WEB, Social Network, Nicotine Replacement Therapy (NRT)
- Where
- United States
- Volunteers
- 5,292 people
- Sponsor
- Truth Initiative
Avoidant/Restrictive Food Intake Disorder
Confirming the Efficacy/Mechanism of Family Therapy for Children With Low Weight ARFID
This study is examining the efficacy and mechanism of family therapy compared to usual care for children between the ages of 6 and 12 who are diagnosed with Avoidant/Restrictive Food Intake Disorder.
- Trial name
- NCT04450771
- Testing
- Family-based Treatment for ARFID, Manualized Non-Specific Usual Care for ARFID
- Where
- United States
- Volunteers
- 285 people
- Sponsor
- Stanford University
Type 2 Diabetes Mellitus With Hypoglycemia, Aging
Prepare for Your Diabetes Care
As adults with type 2 diabetes age, they are increasingly vulnerable to treatment-related hypoglycemia and its related complications (including hospitalization and death).
- Conditions
- Type 2 Diabetes Mellitus With Hypoglycemia, Aging, Patient Activation
- Trial name
- NCT05263310
- Testing
- Prepare for Your Diabetes Care, Usual Care
- Where
- United States
- Volunteers
- 672 people
- Sponsor
- Kaiser Permanente
Primary Progressive Aphasia
Treating Primary Progressive Aphasia (PPA) Using High-definition tDCS
This is a double-blind, sham-controlled, crossover study in which subjects with the non-fluent/agrammatic and logopenic variants of primary progressive aphasia (naPPA and lvPPA, respectively) will undergo language testing and…
- Trial name
- NCT04046991
- Testing
- high-definition transcranial direct current stimulation, modified constraint-induced language therapy
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Pennsylvania