Research institution
Boston Children's Hospital Clinical Trials
Studies where Boston Children's Hospital is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 142Attention-Deficit/Hyperactivity Disorder (ADHD)
Phase 1: Thrive Together
During this first phase of the study, the investigators are conducting focus group to conduct a needs assessment. Specifically, the investigators will be holding focus groups with adolescents with ADHD as well as separate focus…
- Trial name
- THRIVE Phase 1 (NCT07894094)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Children's Hospital
Drug Effect
Pharmacokinetics of Sedatives and Analgesics During Extracorporeal Membrane Oxygenation (ECMO) Support
This study will measure plasma concentrations of dexmedetomidine, fentanyl, morphine and midazolam in pediatric patients supported with extracorporeal membrane oxygenation (ECMO) aiming to understand the pharmacokinetics of these…
- Trial name
- NCT03593408
- Testing
- Dexmedetomidine, Fentanyl, Midazolam
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Boston Children's Hospital
Proximal Tibia Fracture, Tibial Shaft Fracture
MY01 Pressure Monitoring in Adolescent Tibia Fractures
The goal of this clinical trial is to learn more about anterior leg compartment pressures in adolescents who have sustained tibia fractures.
- Conditions
- Proximal Tibia Fracture, Tibial Shaft Fracture, Acute Compartment Syndrome
- Trial name
- NCT07674043
- Testing
- Continuous Compartmental Pressure Monitor
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Vestibular Migraine
Validation of the Vestibular Migraine Patient Assessment Tool and Handicap Inventory (VM-PATHI) for Adolescents
Vestibular migraine (VM) is the most common cause of episodic dizziness in children and adults. Dizziness, especially in conjunction with other migraine symptoms (headache, photophobia, phonophobia, etc.) can profoundly decrease…
- Trial name
- NCT07532109
- Testing
- Vestibular Migraine Patient Assessment Tool and Handicap Inventory (VM-PATHI)
- Where
- 3 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Chronic Pain, Child
Exercise as Medicine for Pediatric Chronic Pain
Youth with chronic pain struggle to go to school, play sports, or spend time with friends and family due to pain. Medications are often ineffective, and aerobic exercise may improve both pain sensitivity and participation in…
- Conditions
- Chronic Pain, Child, Adolescent
- Trial name
- NCT07182006
- Testing
- Aerobic Exercise
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Brief Resolved Unexplained Event, Apparent Life Threatening Event
Effect of Thickened Feeds on Clinical Outcomes in Children With Brief Resolved Unexplained Event
This observational study will examine the effects of thickened feeds on clinical outcomes and healthcare utilization in infants with brief resolved unexplained event (BRUE).
- Conditions
- Brief Resolved Unexplained Event, Apparent Life Threatening Event, Oropharyngeal Dysphagia
- Trial name
- BRUE (NCT04477460)
- Testing
- Thickened feeds, Non-thickened feeds
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Boston Children's Hospital
Pregnant Woman With Single Pregnancy, Ultrasound Fetal Medicine
Continuous Wireless Ultrasound to Monitor Fetal Health
This study is a single-center, prospective, and non-randomized feasibility study designed to evaluate the practicality, tolerability, and data quality of short-duration continuous fetal monitoring using a wireless bioadhesive…
- Trial name
- NCT07676474
- Testing
- Wireless Ultrasound Device
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Enteral Feeding Intolerance
Effect of Blenderized Enteral Tube Feeds on Pediatric Upper Gastrointestinal Tract Physiology
Blenderized diets consist of a wide range of table foods such as fruits, vegetables, meat and legumes, pureed in a blender and administered via gastrostomy tube.
- Trial name
- NCT04900597
- Testing
- Elecare Jr, Nourish, Real Foods Blends
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Boston Children's Hospital
Cannabis Use, Cannabis Intoxication
Study of an Oral Fluid Testing Approach
The purpose of this study is to identify and evaluate oral fluid testing as a biologic measure of cannabis use days that can be assessed remotely.
- Conditions
- Cannabis Use, Cannabis Intoxication, Cannabis Use Disorder
- Trial name
- SOFTA (NCT06891235)
- Testing
- Biologic testing for THC
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Boston Children's Hospital
Persistent Postural Perceptual Dizziness, Vestibular Migraine
Virtual Reality and Biofeedback for Adolescents With Chronic Dizziness
Both persistent postural-perceptual dizziness (PPPD) and vestibular migraine (VM) are common diagnoses in patients presenting to physicians for evaluation of vestibular symptoms such as dizziness and vertigo.
- Conditions
- Persistent Postural Perceptual Dizziness, Vestibular Migraine, Chronic Dizziness
- Trial name
- NCT07374640
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Boston Children's Hospital
Completed, with results posted
All 78Pulmonary Artery Stenosis
Cutting Balloon Study
The primary objective of this study is to evaluate the safety and efficacy of transcatheter Cutting Balloon therapy for branch pulmonary artery stenosis resistant to low pressure dilation.
- Trial name
- CB (NCT01205568)
- Testing
- Transcatheter Cutting Balloon therapy, High Pressure Balloon Angioplasty
- Where
- 6 sites in United States
- Volunteers
- 73 people
- Sponsor
- Boston Children's Hospital
Autism, Autism Spectrum Disorder
First CRUSH: Piloting the Preliminary Feasibility and Acceptability of the Competence in Romance and Understanding Sexual Health (CRUSH) Curriculum
The goal of this clinical trial is to learn about the feasibility and acceptability of a behavioral intervention in designed to provide sexual education and improve the behavioral skills of autistic adults for intimate…
- Trial name
- NCT05910658
- Testing
- Competence in Romance and Understanding Sexual Health (CRUSH)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Boston Children's Hospital
Pain, Postoperative, Numbness
Lidocaine Versus Bupivacaine in Orthognathic Surgery
In this research study, we want to learn more about the impact of two different local anesthetics (bupivacaine and lidocaine) on patient experience following orthognathic (jaw) surgery.
- Conditions
- Pain, Postoperative, Numbness, Temperature Sensation, Perception of Touch
- Trial name
- NCT06450028
- Testing
- 10 cc of 0.25% bupivacaine hydrochloride with 1:200,000 epinephrine, 6.8 cc of 2% lidocaine hydrochloride with 1:100,000 epinephrine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Pediatric Heart Transplantation, Immunosuppression
Tacrolimus/Everolimus vs. Tacrolimus/MMF in Pediatric Heart Transplant Recipients Using the MATE Score
The TEAMMATE Trial will enroll 210 pediatric heart transplant patients from 25 centers at 6 months post-transplant and follow each patient for 2.5 years.
- Conditions
- Pediatric Heart Transplantation, Immunosuppression, Chronic Kidney Diseases, Cardiac Allograft Vasculopathy
- Trial name
- TEAMMATE (NCT03386539)
- Testing
- Everolimus, Tacrolimus, Mycophenolate Mofetil
- Where
- 25 sites in United States
- Volunteers
- 211 people
- Sponsor
- Boston Children's Hospital
Blood Pressure
Validation of a Novel Non-invasive Continuous Blood Pressure Monitor in Children Ages 2- 17 Years-old
This is a prospective observational study to investigate if a non-invasive blood pressure monitoring device, the CareTaker Pulse Decomposition Analysis (PDA), can accurately measure blood pressure in children when compared to an…
- Trial name
- NCT04817137
- Testing
- CareTaker PDA Device
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Boston Children's Hospital