Research institution
Brigham and Women's Hospital Clinical Trials
Studies where Brigham and Women's Hospital is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 205Spinal Surgery for Lumbar Spinal Stenosis (LSS)
Activity Post Spinal Surgery Engagement Trial
Back pain can be disabling, limiting the ability to walk and to engage in physical activity. For patients with degenerative lumbar spinal stenosis, decompressive surgery often provides substantial pain relief and improved…
- Trial name
- ASSET (NCT07825480)
- Testing
- Wrist based activity tracker wear, Basic Study Activities, Telephonic Active Coaching (Motivational Interviewing) + Financial Incentives
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Brigham and Women's Hospital
Pancreatic Ductal Adenocarcinoma (PDAC), Family History of Pancreas Cancer
Reach and Engagement of GENetic Education, Risk Assessment, and TEsting Feasibility Trial
This study will test a remote approach to help people who may be at higher risk for pancreatic cancer learn about and decide whether to get genetic testing and a blood test that looks for signs of several cancers (MCED testing).
- Conditions
- Pancreatic Ductal Adenocarcinoma (PDAC), Family History of Pancreas Cancer, Genetic Testing, Multi-cancer Early Detection
- Trial name
- REGENERATE (NCT07787156)
- Testing
- Telephone education session, Online educational materials
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Brigham and Women's Hospital
Infant Development, Language Development
The Impact of Music Medicine on Preterm Brain Development and Behavior
The investigators are conducting a two-site randomized control trial with the aim of defining the impact of music (M) without or with parent voice (MPV) on very preterm infants' acute and cumulative stress, intranetwork…
- Conditions
- Infant Development, Language Development, Prematurity, Stress
- Trial name
- NCT06536296
- Testing
- Music, Music and parent voice, Standard Care
- Where
- 2 sites in United States
- Volunteers
- 243 people
- Sponsor
- Brigham and Women's Hospital
Inflammatory Bowel Disease (IBD)
Biophysical Assessments of Acupuncture Points in Inflammatory Bowel Disease
Acupuncture points or acupoints are fundamental to the practice of acupuncture, yet their scientific basis remains unclear. According to traditional explanations of acupuncture, acupoints can become tender or more sensitive to…
- Trial name
- NCT07681895
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Epilepsy, Functional Neurological Disorder
EXercise-induced PhysioLogical Adaptations In Neurological Disorders
The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers.
- Conditions
- Epilepsy, Functional Neurological Disorder, Mild Cognitive Impairment, Dementia
- Trial name
- EXPLAIN (NCT07883720)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Dietary Intervention
Eating to Adjust the Timing System
The goal of this clinical trial is to test the effects of dietary composition on the rhythms of food intake, appetite regulation, and rhythms of energy expenditure.
- Trial name
- EATS (NCT05800990)
- Testing
- dietary intervention
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Dietary Habits
Can Food Timing Reduce Your Diabetes Risk?
The goal of this clinical trial is to test whether food timing impacts metabolic health in healthy participants. Participants will: complete 2 inpatient stays be provided with test meals have frequent blood draws
- Trial name
- NCT05862818
- Testing
- Day shift protocol - Diet order A-B, Day shift protocol - Diet order B-A, Night shift protocol - Diet order A-B
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Emergency Department Visit, Home Care Services
Acute Hospital Care at Home for People Living With Dementia
The investigators will perform a parallel-group multicenter randomized controlled trial of a 1-year pre-enrolled acute hospital care at home intervention vs usual care for people living with dementia.
- Conditions
- Emergency Department Visit, Home Care Services, Dementia
- Trial name
- NCT06819852
- Testing
- Acute hospital care at home, Standard medical treatment
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Brigham and Women's Hospital
Osteoarthritis, Knee, Post-traumatic Osteoarthritis
Preventing Injured Knees From osteoArthritis: Severity Outcomes
This study is being done to find out if metformin is effective at reducing pain by delaying the onset of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL) reconstruction.
- Conditions
- Osteoarthritis, Knee, Post-traumatic Osteoarthritis, ACL Tear
- Trial name
- PIKASO (NCT06096259)
- Testing
- Metformin
- Where
- 9 sites in United States
- Volunteers
- 512 people
- Sponsor
- Brigham and Women's Hospital
ME/CFS, Long COVID
LIFT: Life Improvement Trial
The LIFT will be conducted at Brigham and Women's Hospital (BWH) of Harvard Medical School, focusing on the effect of Pyridostigmine (Mestinon) and Low-Dose Naltrexone (LDN) in subjects aged 18-70 meeting the Canadian consensus…
- Conditions
- ME/CFS, Long COVID, PASC
- Trial name
- LIFT (NCT06366724)
- Testing
- Pyridostigmine, Low-Dose Naltrexone
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Brigham and Women's Hospital
Completed, with results posted
All 266Multiple Sclerosis
Role of Microglial Activation and Norepinephrine Transporter Abnormalities in Pathogenesis of MS-related Fatigue
The overarching aim is to assess the role of microglial activation and norepinephrine transporter binding in pathogenesis of MS-related fatigue, using novel Positron Emission Tomography (PET) radiotracers, [F-18]PBR06 and…
- Trial name
- NCT04144257
- Testing
- [F-18]PBR06, [C-11]Methylreboxetine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Brigham and Women's Hospital
Acute Kidney Injury
Deferoxamine for the Prevention of Cardiac Surgery-Associated Acute Kidney Injury
Multiple lines of evidence support a central role of iron in causing acute kidney injury (AKI), including the finding that prophylactic administration of iron chelators attenuates AKI in animal models.
- Trial name
- DEFEAT-AKI (NCT04633889)
- Testing
- Deferoxamine, Normal saline
- Where
- 3 sites in United States
- Volunteers
- 320 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Design and Usability Testing of a Tailored Intervention About Sleep and Sleep Disorders Among Transportation Workers
The objective of this protocol is to conduct a focus group to identify OSA beliefs, attitudes, and knowledge among employees in the transportation industry on shift schedules.
- Trial name
- NCT05039528
- Testing
- Personalized OSA messages, Control
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Metabolic Syndrome, Hypertension
Aldosterone, the Mineralocorticoid Receptor, and Cardiovascular Disease in Obesity
This study will evaluate whether the mineralocorticoid receptor antagonist eplerenone, when compared to chlorthalidone plus potassium chloride, can improve cardiac MRI-derived myocardial perfusion reserve and fibrosis…
- Conditions
- Metabolic Syndrome, Hypertension, Overweight and Obesity
- Trial name
- NCT04519164
- Testing
- Eplerenone, Chlorthalidone with potassium chloride
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Brigham and Women's Hospital
Depressive Disorder, Major, Depression
Individualized Functional Connectivity Targeting in aiTBS for Depression
The goal of this clinical trial is to estimate the importance of neuroimaging in accelerated intermittent theta burst stimulation (aiTBS) for depression.
- Conditions
- Depressive Disorder, Major, Depression, Mood Disorders, Mental Disorder
- Trial name
- AINT (NCT05680727)
- Testing
- transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital