Research institution
Centre Leon Berard Clinical Trials
Studies where Centre Leon Berard is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 50Head & Neck Cancer
Radiotherapy In a Sitting Position for Enhanced Reproducibility
Qualitative, longitudinal and single-center study To explore the reproductibility and the acceptability of the sitting position for head and neck cancer patients through their experience of sitting and supine positions in the…
- Trial name
- RISE R (NCT07887048)
- Testing
- Simulation of radiotherapy session in sitting position
- Volunteers
- 16 people
- Sponsor
- Centre Leon Berard
Gastro Oesophageal Cancer
Biomarker Investigation for Early Gastric Cancer Detection
GASTROTRACK is a prospective, single-center clinico-biological cohort study evaluating non-invasive biomarkers for gastric and gastroesophageal junction adenocarcinomas (GEC).
- Trial name
- GASTROTRACK (NCT07884669)
- Testing
- Saliva sampling, Gastric juice sampling, Blood sampling
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre Leon Berard
Breast Cancer, Medico-economic Impact
Preoperative Magnetic Tracking in Breast Surgery in France: French Medical-economic Study.
MAGNETO is a French medico-economic study on preoperative localization in breast cancer surgery. The main objective is to conduct a cost-consequence analysis comparing magnetic clip localization with the use of metallic wires for…
- Conditions
- Breast Cancer, Medico-economic Impact, Breast Cancer Surgery
- Trial name
- MAGNETO (NCT06906601)
- Testing
- magnetic clip localization, metallic wire localization., Breast cancer surgery
- Where
- 7 sites in France
- Volunteers
- 772 people
- Sponsor
- Centre Leon Berard
Vulvar Squamous Cell Carcinoma
Safety and Efficacy of Nivolumab and Imiquimod Combination in Vulvar Squamous Cell Carcinoma Patients
COLOMBE is a multicenter, single arm, phase 1/2 trial designed to evaluate the safety and efficacy of imiquimod cream with IV low dose nivolumab in primary resectable vulvar squamous cell carcinoma patients prior to surgery…
- Trial name
- COLOMBE (NCT07679841)
- Testing
- Imiquimod 5% cream, Nivolumab
- Where
- 11 sites in France
- Volunteers
- 50 people
- Sponsor
- Centre Leon Berard
Metastatic Clear Cell Renal Cell Carcinoma
Phase I Study Evaluating 161Tb-PSMA Therapy in Adult Patients With Metastatic Clear Cell Renal Cell Carcinoma
This study is an open label, Phase I study investigating the safety and clinical activity of 4 IV injections of 161Tb-PSMA-1 in patients with mccRCC.
- Trial name
- PRadR2 (NCT07828249)
- Testing
- 161Tb-PSMA-1 (radiopharmaceutical)
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Centre Leon Berard
Re-irradiation, Radiotherapy
Contribution of Multicenter Expertise and Deformable Fusion Software for Re-irradiations With Curative Intent
We propose to evaluate the contribution of a standardized process combining, a validation of re-irradiation indications by a group of multi-professional experts (radiotherapists and physicists) and, a collective validation of the…
- Trial name
- ADERE (NCT06668038)
- Testing
- Multidisciplinary and multicenter validation of re-irradiation with curative intent
- Where
- 10 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Leon Berard
Seminoma, Stage II
De-escalation Study for Stage IIa/IIb < 3 cm Seminoma
Phase II, multicenter, prospective, randomized, non-comparative, de-escalation study. Patients with stage IIa/IIb < 3 cm seminoma histologically proved after orchiectomy will be included in the study and will receive 1 cycle of…
- Trial name
- EDEN (NCT05529251)
- Testing
- Radiotherapy boost, Carboplatin AUC7, 3 cycles of EP
- Where
- 15 sites in France
- Volunteers
- 90 people
- Sponsor
- Centre Leon Berard
Glioma, CNS Tumor, Adult
Combination of Tarlatamab and Temozolomide in Patients With Central Nervous System Tumors
This clinical trial is a 2-phase trial designed to evaluate the safety of tarlatamab in combination with a fixed dose of metronomic temozolomide in adolescents and adults with CNS tumors (stratified into two age-based cohorts)…
- Conditions
- Glioma, CNS Tumor, Adult, CNS Tumor, Childhood
- Trial name
- TARLATEM (NCT07243470)
- Testing
- Tarlatamab, Temozolomide (TMZ)
- Where
- 12 sites in France
- Volunteers
- 70 people
- Sponsor
- Centre Leon Berard
Gastric Cancers
R-GASTIM- Study of Gastric Cancer Operable
Clinicobiological cohort of gastric cancers operated in our institution.
- Trial name
- R-GASTIM (NCT07787052)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Leon Berard
Lung Neoplasms, Non Small Cell Lung Cancer
ERICA-02 Study : Impact of Physical Exercise on the Tumor Immune Microenvironment in Patients Treated With Neoadjuvant Chemoimmunotherapy for Non-small Cell Lung Cancer
Recent advances combining chemotherapy and immunotherapy before surgery have significantly improved outcomes for patients with resectable non-small cell lung cancer (NSCLC).
- Trial name
- ERICA-02 (NCT07786909)
- Testing
- Physical activity recommendations, Physical Activity (PA) Intervention
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Centre Leon Berard