Research institution
Children's Hospital Medical Center, Cincinnati Clinical Trials
Studies where Children's Hospital Medical Center, Cincinnati is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 127Congenital Heart Disease (CHD)
Autologous Thymus Transplant in Children With Congenital Heart Disease: A Pilot Study
This pilot study will look at whether putting back a child's own thymus tissue during heart surgery is safe and may help support the immune system in children with congenital heart disease (CHD).
- Trial name
- ATTT (NCT07799259)
- Testing
- Autologous Thymus Transplant
- Volunteers
- 10 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Asthma in Children, Asthma Chronic
Asthma Ctrl SMART Trial
The primary objective is to examine the efficacy of an mHealth adherence intervention (Asthma Ctrl) on adherence to daily inhaled corticosteroids as measured by electronically monitored adherence in adolescents with asthma.
- Trial name
- NCT07512622
- Testing
- Asthma Ctrl, Asthma Ctrl+, Control
- Where
- 2 sites in United States
- Volunteers
- 389 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hematologic Malignancy, Leukemia
Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution
The use of venetoclax-based therapies for pediatric patients with relapsed or refractory malignancies is increasingly common outside of the clinical trial setting.
- Conditions
- Hematologic Malignancy, Leukemia, Lymphoma, Acute Lymphocytic Leukemia
- Trial name
- NCT06131801
- Testing
- 1. Drug: The Venetoclax PK study is collecting bodily fluid samples (ie., whole blood and optional cerebrospinal fluid) of patients prescribed venetoclax as crushed tablets per standard of care.
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant
International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository
Doctors and other medical scientists want learn about the biology of DIPG/DMG and to develop better ways to diagnose and treat patients with DIPG/DMG.
- Conditions
- Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant, Diffuse Midline Glioma
- Trial name
- NCT03101813
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
HIV Infections
Screen Smart: Using Digital Health to Improve HIV Screening and Prevention
The goal of this interrupted time series quasi-experimental design study is to implement universal opt- out HIV testing and linkage to HIV preventive care in 15-21 year old adolescents visiting the pediatric emergency department…
- Trial name
- Screen Smart (NCT06003192)
- Testing
- Universal Opt-out HIV Screening
- Where
- 4 sites in United States
- Volunteers
- 63,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pediatric Medical Complexity Based on PMCA Score of 3
Comprehensive Assessment of Reactions to Pharmacogenetics in Complex Care Patients
The goal of this clinical trial is to determine the feasibility and acceptability of Pharmacogenetic Testing, and the attitudes towards the same in caregivers of complex care patients in Cincinnati, OH.
- Trial name
- CAREPICC (NCT07060300)
- Testing
- Agree to Pharmacogenetic Testing
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hereditary Pulmonary Alveolar Proteinosis
Safety and Efficacy of PMT Therapy of hPAP
The major goal of this study is to evaluate a new type of cell transplantation therapy for individuals with hereditary PAP, study a new treatment that may be useful for treatment of other diseases, and research mechanisms that…
- Trial name
- NCT05761899
- Testing
- Gene-Corrected Macrophages administered by bronchoscopic instillation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Acute Kidney Injury
Amino Acid Therapy Evaluating the Incidence of New-Onset AKI
The goal of this clinical trial is to learn whether giving amino acids through an IV during and after heart surgery can protect the kidneys of children with congenital heart disease.
- Trial name
- PROTEIN (NCT07880951)
- Testing
- Amino Acid infusion, Lactated Ringer Solution
- Volunteers
- 270 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Dystonia, Pediatric
Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia
The goal of this study is to understand the development and progression of childhood dystonia, a movement disorder, in children.
- Conditions
- Dystonia, Pediatric, Deep Brain Stimulation, Motor Development
- Trial name
- NCT07325175
- Testing
- DBS
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Migraine, Musculoskeletal Pain
Overlapping Pain Trajectory Study
The goal of this observational study is to learn about spatial and temporal nociceptive filtering in adolescents with chronic overlapping pain conditions (COPCs). The main questions it aims to answer are: 1.
- Conditions
- Migraine, Musculoskeletal Pain, Functional Abdominal Pain Disorders, Chronic Pain
- Trial name
- COPC (NCT05752396)
- Testing
- Conditioned Pain Modulation, Offset Analgesia, Spatial Summation
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Completed, with results posted
All 126Virtual Reality, Medical Education
An Automated Virtual Reality Intervention to Enhance Firearm Safety Counseling in Pediatrics
Clinicians will complete a screen-based automated virtual reality training intervention to learn how to counsel caregivers of pediatric patients on secure firearm storage.
- Conditions
- Virtual Reality, Medical Education, Motivational Interviewing, Gun Violence Prevention
- Trial name
- NCT07265141
- Testing
- An Automated Virtual Reality Intervention to Support Firearm Safety Counseling in Clinicians
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Magnetic Resonance Imaging
Clinical Use of a New Neonatal MRI System
The purpose of the present study is to make medically indicated state of the art/high end magnetic resonance imaging (MRI) exams available to all infants in the Cincinnati Children's Hospital Medical Center (CCHMC) Neonatal…
- Trial name
- NCT01801865
- Testing
- GE OPTIMA MR430s with HDX/GE Electronics
- Where
- United States
- Volunteers
- 657 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Sleep, Circadian Rhythm Disorders
Sleep Timing, Eating and Activity Measurement Study
There is strong reason to believe that sleep promotion during adolescence could yield long-term health rewards; the investigators' data show that, when they get more sleep, Morning Larks have impressively reduced intake of…
- Conditions
- Sleep, Circadian Rhythm Disorders, Dietary Habits
- Trial name
- STEAM (NCT04992611)
- Testing
- Sleep Extension (Early), Sleep Extension (Late)
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Bronchiolitis Obliterans
Hp129 Xenon Imaging and BOS in Lung Transplantation
The research is being conducted to develop new imaging methods that are sufficiently sensitive to allow for early diagnosis of BOS, a chronic allograft rejection affecting 50-60% of lung transplanted recipients who survive 5…
- Trial name
- NCT03603899
- Testing
- Hp 129Xenon
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hematopoietic Stem Cell Transplant
Oral Supplementation of 2'-Fucosyllactose in Allogeneic Bone Marrow Transplant Recipients
High dose chemotherapy and radiation used as preparative regimens in patients undergoing an allogeneic hematopoietic stem cell transplant (HSCT) disrupts intestinal homeostasis by damaging the intestinal epithelium and altering…
- Trial name
- NCT04263597
- Testing
- 2'-fucosyllactose
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati