Research institution
Helsinki University Central Hospital Clinical Trials
Studies where Helsinki University Central Hospital is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 50Type 1 Diabetes
The Impact of Early Automated Insulin Delivery (AID) Therapy on Diabetes Control and Comorbidities, and Cost-effectiveness of AID Treatment
The purpose of this study is to investigate the effect of early initiated automated insulin de-livery (AID) treatment in type diabetes in children aged 7-16 years to glycemic control, diabe-tes distress of patients and…
- Trial name
- NCT07423637
- Testing
- Omnipod 5, Multiple daily injections of insulin
- Where
- 2 sites in Finland
- Volunteers
- 100 people
- Sponsor
- Helsinki University Central Hospital
Cholelithiasis, Cholecystitis
STALL vs Sole Local Wound Infiltration in Laparoscopic Cholecystectomy
This trial is a prospective randomized superiority trial comparing sole ropivacaine based local trocar site infiltration to local infiltration combined with laparoscopic ropivacaine TAP block (STALL) in LCC.
- Conditions
- Cholelithiasis, Cholecystitis, Gallbladder Cancer
- Trial name
- STALL (NCT06123117)
- Testing
- single transversus abdominis laparoscopy-guided plane block, local trocar site ropivacaine infiltration
- Where
- Finland
- Volunteers
- 850 people
- Sponsor
- Helsinki University Central Hospital
Carpal Tunnel Syndrome
Finnish Carpal Tunnel Surgery Study
Carpal tunnel syndrome (CTS) is a common condition caused by pressure from a ligament on a nerve in the wrist, leading to pain, numbness, and weakness in the hand.
- Trial name
- FINCATS (NCT07614425)
- Testing
- Carpal tunnel release
- Where
- 2 sites in Finland
- Volunteers
- 180 people
- Sponsor
- Helsinki University Central Hospital
Cardiometabolic Diseases, Obesity
Prenatal Programming of Childhood Obesity and Cardio Metabolic Disorders
This is a prospective 11-17 -years follow-up of two existing pregnancy cohort (PREDO) and prevention (RADIEL) studies. The main objective is to investigate the associations between maternal overweight, obesity, hypertensive…
- Trial name
- NCT05223530
- Where
- Finland
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Infection Post Op, Hysterectomy
Does Additional Use of Preoperative Azithromycin Decrease Posthysterectomy Infections
During hysterectomy bacteria may enter into the peritoneal cavity through vaginal opening and contaminate the healing tissues. The risk for deep infection after hysterectomy is about 5%.
- Conditions
- Infection Post Op, Hysterectomy, Antibiotics, Prophylactic
- Trial name
- NCT05337566
- Testing
- Azithromycin Pill + Cefuroxime
- Where
- 6 sites in Finland
- Volunteers
- 2,278 people
- Sponsor
- Helsinki University Central Hospital
Appendicitis
Protocol Based Selective Imaging Versus Routine Computed Tomography or Ultrasound in Suspected Appendicitis
The goal of this clinical trial is to compare protocol based selective imaging to routine imaging in adult patients with suspected appendicitis.
- Trial name
- PROSECCO (NCT06083064)
- Testing
- Abdominal imaging, Score based selective abdominal imaging, Score based selective observation combined with selective abdominal imaging
- Where
- 3 sites in Finland
- Volunteers
- 900 people
- Sponsor
- Helsinki University Central Hospital
Cholecystectomy, Laparoscopic, Choledocholithiasis
ChOlecystectomy aFter successFul Endoscopic Common Bile Duct Stone Extraction in Elderly
The goal of this study is to compare safety and efficacy of laparoscopic cholecystectomy versus wait-and-see policy after endoscopic removal of common bile duct stones in elderly.
- Conditions
- Cholecystectomy, Laparoscopic, Choledocholithiasis, Cholelithiasis
- Trial name
- COFFEE (NCT07001423)
- Testing
- Laparoscopic cholecystectomy
- Where
- 12 sites in Finland
- Volunteers
- 400 people
- Sponsor
- Helsinki University Central Hospital
Kidney Failure, Paraproteinemias
The Effect of Daratumumab in Patients With Monoclonal Gammopathy of Renal Significance (MGRS) in Finland
The goal of this clinical trial is to learn if drug daratumumab works to treat kidney diseases other than AL-amyloidosis that fall under the category of monoclonal gammopathy of renal significance (MGRS).
- Conditions
- Kidney Failure, Paraproteinemias, Glomerulonephritis
- Trial name
- DAMOCLES (NCT06889948)
- Testing
- Daratumumab
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Helsinki University Central Hospital
Paresis, Lumbar Disc Herniation
Validation of a Methodology Using Isometric Dynamometer for Ankle STrength Assessment to Quantify LDH-induced Paresis
Lumbar disc herniation (LDH) is a common condition that may cause lower limb motor weakness (paresis), particularly affecting ankle dorsiflexion and plantarflexion.
- Trial name
- VAST-LDH (NCT07763522)
- Testing
- Strength test validity and reliability
- Where
- Finland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Severe Asthma, Asthma
Execise Intervention in Adult Severe Asthma
Physical activity has been shown to improve asthma control in individuals with asthma. Patients with severe asthma frequently experience exacerbations, which often result in a physically inactive lifestyle.
- Trial name
- NCT07655037
- Testing
- Exercise intervention
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Helsinki University Central Hospital
Completed, with results posted
All 16Asthma, Aspirin-Induced, Chronic Rhinosinusitis With Nasal Polyps
Aggravated Airway Inflammation: Research on Biological Treatment (Mepolizumab)
Primary objective: to investigate the efficacy of Mepolizumab 100 milligram (mg) every month compared to placebo in reducing validated Sinonasal Outcome Test -22 score and on reducing endoscopic Nasal Polyp Score.
- Trial name
- AirGOs-biol (NCT04823585)
- Testing
- Mepolizumab
- Where
- Finland
- Volunteers
- 95 people
- Sponsor
- Helsinki University Central Hospital
Food Allergy
The Effect of Per Oral Immunotherapy in Severe Milk, Peanut and Egg Allergy in Adults
The aim is to analyse the results of per oral immunotherapy treatment in severe milk, peanut or egg allergy in adults. This is the second part of the oral immunotherapy study in adults at Skin and Allergy Hospital.
- Trial name
- NCT03361072
- Testing
- Oral immunotherapy
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Helsinki University Central Hospital
Functional Gastrointestinal Disorders
Behavioral Therapy in Patients With Rumination
The study aim is to diagnose patients with the rumination syndrome defined by the Rome IV criteria and to treat them with behavioral therapy consisting of diaphragmatic breathing exercises and physiotherapy to relax tensed…
- Trial name
- NCT05232097
- Testing
- Behavioral therapy, Physiotherapy
- Where
- 2 sites in Finland
- Volunteers
- 11 people
- Sponsor
- Helsinki University Central Hospital
Asthma
Comparison of Biologicals in Treatment of Severe Asthma
This is a retrospective clinical study on adult patients (18 years or more) with biological therapy for severe asthma at the Helsinki University Central Hospital (HUCH).
- Trial name
- BiSA (NCT04158050)
- Testing
- IL5 Antagonist or anti-IL5R-antibody or Omalizumab
- Where
- Finland
- Volunteers
- 64 people
- Sponsor
- Helsinki University Central Hospital
Contraception
Synthetic vs Natural Estrogen in Combined Oral Contraception
The main objective of the study is to compare the metabolic effects of natural estradiol and synthetic ethinylestradiol used in combined oral contraception in healthy women.
- Trial name
- SYLVI (NCT02352090)
- Testing
- Ethinyl estradiol / dienogest, Estradiol valerate / dienogest, Dienogest
- Where
- 2 sites in Finland
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital