Research institution
Indiana University Clinical Trials
Studies where Indiana University is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 196Pregnancy Preterm, Premature Birth
The Periviable GOALS Decision Support Tool
The Periviable GOALS (Getting Optimal Alignment around Life Support) decision support tool (DST) is meant to facilitate informed shared decision-making regarding neonatal resuscitation for families facing the threat of a…
- Conditions
- Pregnancy Preterm, Premature Birth, Pregnancy Complications, Obstetric Labor, Premature
- Trial name
- NCT05264779
- Testing
- Periviable GOALS DST
- Where
- 12 sites in United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
Testicular Cancer, Survivorship
Late Subclinical Cardiovascular Disease in Testicular Cancer Survivors
Late subclinical cardiovascular disease in testicular cancer survivors exposed to cisplatin-based chemotherapy and bone marrow transplant
- Conditions
- Testicular Cancer, Survivorship, ASCVD, Coronary Artery Disease
- Trial name
- NCT05611307
- Testing
- Lipid profile, Coronary artery assessment, Hormone levels for hypogonadism
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Binge Eating, Overweight and Obesity
Cognitive and Behavioral Approaches to Reduce Binge Eating and Excess Weight in Adolescents (Online)
This study will compare a psychological treatment (cognitive-behavioral therapy; CBT-BED) and a lifestyle beahvioral obesity intervention (LBOI) for adolescents who experience binge eating and have overweight or obesity.
- Conditions
- Binge Eating, Overweight and Obesity, Eating Disorders in Adolescence
- Trial name
- CARE2 (NCT07856784)
- Testing
- Cognitive-Behavioral Therapy for Adolescent Binge Eating, Lifestyle Behavioral Obesity Intervention, Active Control
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Indiana University
Plasma Cell Dyscrasias
The Indiana Myeloma Registry
This is a prospective, non-interventional, observational study. The purpose of this study is to collect data and bio-specimens that will support future research
- Trial name
- NCT03616483
- Testing
- This is a non-interventional trial
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- Indiana University
Alcohol Use, Adolescent
Evaluating Caregiver Involvement in Primary Care-Based Brief Interventions for Adolescent Alcohol Use Problems
Intervention for mild severity alcohol use among U.S. teens is crucial, as alcohol is the most commonly used substance in this age group, yet few receive the necessary interventions.
- Conditions
- Alcohol Use, Adolescent, Mild Alcohol Use Disorder, Mild Substance Use Disorder
- Trial name
- NCT06593652
- Testing
- Teen Intervene - Adolescent Only, Teen Intervene with Caregiver Session, Family Check Up
- Where
- United States
- Volunteers
- 615 people
- Sponsor
- Indiana University
Depression, Treatment Resistant
rTMS to Target Neural Connectivity and Rumination in Treatment-Resistant Depression
The goal of this clinical trial is to learn if Transcranial Magnetic Stimulation (TMS) to part of the brain called the ventromedial prefrontal cortex (VMPFC) can treat a symptom called rumination in adults with major depression…
- Trial name
- NCT06511544
- Testing
- Transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Indiana University
Heart Failure With Preserved Ejection Fraction
Leg Heat Therapy in Heart Failure With Preserved Ejection Fraction
The objective of this pilot study is to establish evidence to support the validity of HT in improving skeletal muscle function and physical capacity of patients with HFpEF.
- Trial name
- NCT06388226
- Testing
- Leg heat therapy
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Indiana University
Acute Kidney Injury, Fluid Overload
Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0
There is a growing focus on short- and long-term kidney health in neonates, including those with acute kidney injury (AKI). AKI occurs commonly in the Neonatal Intensive Care Unit (NICU) and is associated with adverse outcomes.
- Conditions
- Acute Kidney Injury, Fluid Overload, Prematurity Complications, Risk Factors
- Trial name
- AWAKEN 2 (NCT06823115)
- Where
- 125 sites in United States, Argentina and 31 more
- Volunteers
- 8,000 people
- Sponsor
- Indiana University
Pregnancy
Impact of Standardization on Outcomes Following Cervical Ripening
The primary purpose of this study is to determine if vaginal delivery rate is impacted by the use of standardized methods of cervical ripening. Additional outcomes will be evaluated including maternal and fetal outcomes of labor.
- Trial name
- NCT07576881
- Testing
- Cervical Ripening with a double balloon catheter only, Cervical ripening with a double balloon catheter plus misoprostol, Usual-care control group
- Where
- United States
- Volunteers
- 1,158 people, healthy volunteers welcome
- Sponsor
- Indiana University
Alzheimer Dementia (AD), Caregiver Burden of People With Dementia
VICA: A Virtual Care Assistant for Dementia Caregivers
This pilot randomized controlled trial evaluates the feasibility and preliminary efficacy of VICA, an AI-powered virtual care assistant that delivers evidence-based education, symptom monitoring, and coaching to informal…
- Trial name
- VICA (NCT07779785)
- Testing
- VICA - Virtual Informal Care Assistant, Education only BPSD mobile app
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Indiana University
Completed, with results posted
All 264Acute Lymphoblastic Leukemia, Pediatric, Pediatric Cancer
Biology and Benefits of Music Play and Stories for Kids/Parents During ALL Treatment
Music therapy has become a standard palliative care service in many pediatric and adult hospitals; however, a majority of music therapy research has focused on the use of music to improve psychosocial dimensions of health…
- Trial name
- NCT04400071
- Testing
- Active Music Engagement, Audio Storybooks
- Where
- 4 sites in United States
- Volunteers
- 192 people
- Sponsor
- Indiana University
Healthy Volunteers
Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.2
In its totality, this grant aims to develop a line of research using temporal interference (TI) electrical neurostimulation technology to understand the causal role of deep brain structures in cognition.
- Trial name
- NCT07339072
- Testing
- Temporal Interference (TI) Electrical Stimulation - NAcc 5 Hz TI Active, Temporal Interference (TI) Electrical Stimulation - NAcc 10 Hz TI Active
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Vagus Nerve Stimulation
Recording Cutaneous Vagal Nerve Activity With Multi-Electrode Array (MEA) in Patients Undergoing VNS Therapy
The overall purpose of the ABVN Phase 2 grant is to expand on previous work evaluating vagal nerve function. This will be accomplished through several independent, but related, studies.
- Trial name
- NCT06827548
- Testing
- Multi-Electrode Array (MEA) Recording
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Indiana University
CBD, Transplant Complication
Drug-gene-nutraceutical Interactions of Cannabidiol and Tacrolimus
The information learned in these studies will help to inform doctors as to how to appropriately adjust doses of cannabidiol and tacrolimus in order to improve health outcomes and long-term treatment success for transplant…
- Conditions
- CBD, Transplant Complication, Kidney Disease, Chronic
- Trial name
- NCT05490511
- Testing
- Tacrolimus single dose, Epidiolex single dose, Epidiolex steady-state and tacrolimus single dose
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Indiana University
Dementia, Alzheimer Disease
Aging Brain Care Virtual Program
The program involves a virtual intervention to be delivered by RN or SW care coordinators over one year. Every care partner will receive monthly virtual visits during the first 3 months and then quarterly or more depending on…
- Trial name
- ABCV (NCT06245499)
- Testing
- Aging Brain Care Virtual Program
- Where
- United States
- Volunteers
- 987 people
- Sponsor
- Indiana University