Research institution
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Clinical Trials
Studies where London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 98Limited Stage Small-Cell Lung Cancer
A Randomized Trial of Standard vs. Hypofractionated Accelerated Radiotherapy for Progression in Limited-Stage Small Cell Lung Cancer
This study aims to determine whether an abbreviated course of thoracic radiotherapy, delivered in five fractions over one week between chemotherapy cycles, improves progression-free survival compared with standard radiotherapy…
- Trial name
- SHARP SCLC (NCT07920549)
- Testing
- Radiation Therapy, Hypofractionated Radiation Therapy, Chemotherapy
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Idiopathic Subglottic Stenosis, Subglottic Stenosis (SGS)
Pirfenidone for Idiopathic Subglottic Stenosis: A Pilot Trial of Tolerability and Feasibility
Idiopathic subglottic stenosis (iSGS) is a rare condition where scar tissue forms just below the vocal cords and in the upper windpipe, making the airway narrow.
- Trial name
- NCT07654517
- Testing
- Pirfenidone
- Where
- 2 sites in Canada
- Volunteers
- 44 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
PTSD, Post-traumatic Stress Disorder
Deep Brain Reorienting in Post-traumatic Stress Disorder
This study will evaluate the efficacy of a therapeutic treatment, Deep Brain Reorienting (DBR), for PTSD (Post-traumatic Stress Disorder). Participants will be randomized to either the DBR treatment, or wait-list condition.
- Trial name
- NCT04317820
- Testing
- Deep Brain Reorienting (DBR)
- Where
- Canada
- Volunteers
- 234 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Alzheimer's Disease (AD), Cognitive Impairment
BioMIND Biospecimen Repository
The purpose of the BBR is to facilitate scientific research by serving as a local and external resource for the distribution of human blood and CSF biospecimens, together with their corresponding clinical data, to internal and…
- Trial name
- BBR (NCT07912736)
- Testing
- blood sample and optional csf collection
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Depression - Major Depressive Disorder, Generalized Anxiety Disorder (GAD)
Microbiota Modulation for Psychiatry Patients
The investigators aim to confirm pilot study findings (REB 119638) on the effects of delayed release apple cider vinegar (drACV).
- Conditions
- Depression - Major Depressive Disorder, Generalized Anxiety Disorder (GAD), Anxiety
- Trial name
- ACV-MTPIES-002 (NCT07899424)
- Testing
- Dietary Supplement: Acetate (Apple Cider Vinegar)
- Volunteers
- 62 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Dementia, Agitation
Virtual Reality to Advance Dementia Care and Quality of Life
The goal of this feasibility clinical trial is to learn whether supervised virtual reality (VR) sessions can be safely and practically provided to adults aged 55 years and older with moderate-to-severe dementia who experience…
- Conditions
- Dementia, Agitation, Behavioural and Psychological Symptoms of Dementia, Major Neurocognitive Disorder
- Trial name
- VR-Care (NCT07893678)
- Testing
- Supervised Virtual Reality Sessions
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Symptom Tracking, Cardiology
AI-CLINIC: A Prospective Multisite Feasibility and Safety Study of AI-Assisted Pre-Consultation History-Taking in Outpatient Cardiology
An accurate medical diagnosis depends on the doctor getting a complete picture of the patient's health story, but clinic visits are short.
- Conditions
- Symptom Tracking, Cardiology, Medical History Taking
- Trial name
- AI-CLINIC (NCT07883304)
- Testing
- AI Interview
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Juvenile Idiopathic Arthritis, Children
M3-JIA: Making Mindfulness Matter for Children With JIA
The investigator will evaluate the efficacy of M3©, an intervention for patients with JIA and their caregivers. Children with Juvenile arthritis and their parents will attend an 8 week online program called Making Mindfulness…
- Conditions
- Juvenile Idiopathic Arthritis, Children, Mental Health, Mental Well-being
- Trial name
- M3-JIA (NCT06376149)
- Testing
- M3 Intervention group, M3 Waitlist Group
- Where
- 3 sites in Canada
- Volunteers
- 74 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Total Hip Arthroplasty, Computer-Assisted Surgery
Pre-Op THA Modelling
Replacing diseased hip joints with prosthetic implants in a procedure called total hip arthroplasty (THA) is associated with high rates of patient satisfaction, pain relief, and functional improvement when the implant is…
- Trial name
- NCT05221554
- Testing
- Imageless computer-navigated THA surgery, Standard of care THA surgery, CT-based Computer-navigated THA surgery
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Delirium - Postoperative
Effects of PNB Timing on Postoperative Delirium for Hip Fracture
Hip fracture is a common cause of hospitalization in older adults and is associated with substantial pain and a high risk of delirium.
- Trial name
- NCT07856108
- Testing
- Peripheral Nerve Block for Hip Fracture
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Completed, with results posted
All 11Diabetic Ketoacidosis
Intravenous Fluids in Adults With Diabetic Ketoacidosis in the Emergency Department
Diabetes mellitus is a common chronic disease. It is estimated that up to 40% of adults may develop diabetes in their lifetime. Patients with poorly controlled blood sugars often visit the emergency department for treatment of…
- Trial name
- BRISK-ED (NCT04926740)
- Testing
- Ringer's lactate
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
BPH, Depression
5 Alpha Reductase Inhibitors And The Risk Of Suicide And Depression
In December 2015, Health Canada issued a warning about a potential relationship between suicide and finasteride use and called for further research.
- Conditions
- BPH, Depression, Suicide
- Trial name
- NCT02876757
- Testing
- 5ARI
- Volunteers
- 186,394 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Major Depressive Disorder
Automatic Self Transcending Meditation Versus Treatment as Usual
Depression is a leading contributor to global burden of disease. Antidepressants do not provide adequate response for many patients.
- Trial name
- NCT02149810
- Testing
- Automatic Self Transcending Meditation
- Where
- Canada
- Volunteers
- 95 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Urinary Tract Infection, Recurrent Urinary Tract Infection
Effects of Antibiotic Prophylaxis on Recurrent UTI in Children
Approximately, 3% of males and 8% of females will develop a urinary tract infection (UTI) during childhood, and most of these will be effectively treated by short-term antibiotic therapy.
- Trial name
- NCT02357758
- Testing
- Antibiotic Prophylaxis
- Where
- Canada
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Rhinosinusitis, Aspirin Exacerbated Respiratory Disease
Effect of Dietary Salicylate in Aspirin Exacerbated Respiratory Disease
Aspirin-Exacerbated Respiratory Disease, or AERD, consists of aspirin sensitivity, asthma and nasal polyps. It is currently managed by chronic steroid use, multiple endoscopic sinus surgeries and/or aspirin desensitization.
- Conditions
- Chronic Rhinosinusitis, Aspirin Exacerbated Respiratory Disease, Asthma, Aspirin Sensitivity
- Trial name
- NCT01778465
- Testing
- Low salicylate diet, Normal Diet
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's