Research institution
Ottawa Heart Institute Research Corporation Clinical Trials
Studies where Ottawa Heart Institute Research Corporation is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 42Mitral Regurgitation, Mitral Valve Disease
LEFT ATRIAL MONITORING IN PATIENTS BEFORE AND AFTER MITRAL SURGERY - LAMBDA STUDY
Mitral valve leakage, or mitral regurgitation (MR), is associated with heart failure symptoms including shortness of breath, fatigue, irregular heart rate. When left untreated, it may cause death.
- Conditions
- Mitral Regurgitation, Mitral Valve Disease, Heart Failure
- Trial name
- LAMBDA (NCT06547788)
- Testing
- Mitral valve repair with creation of an 8 mm inter-atrial shunt
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Cardiac Sarcoidosis
Cardiac Sarcoidosis Multi-Center Prospective Cohort
Recent data has shown that sarcoidosis, presenting initially with cardiac manifestations (CS) of either conduction system disease or cardiomyopathy and sustained VT, is not uncommon.
- Trial name
- CHASM-CS (NCT01477359)
- Where
- 14 sites in Canada, Japan
- Volunteers
- 1,500 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Nicotine Dependence, Cigarettes, Nicotine Withdrawal
The INITIATE Study: Initiating Nicotine Dependence Treatment for Smokers Admitted to Emergency Departments
The INITIATE Study is a randomized controlled trial that is testing an intervention designed to increase long-term abstinence among tobacco smokers seen in emergency departments (ED) and other high-volume hospital and community…
- Trial name
- INITIATE (NCT04163081)
- Testing
- Quit Card Intervention (QCI)
- Where
- 4 sites in Canada
- Volunteers
- 1,208 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Menopause, Sleep Disruption
Endocrine Disruption, Menopause, and Poor Sleep in wOmen With Type 2 Diabetes: Effects on Cardiovascular Health
EMPOWER aims to determine the overall effect of menopause and sleep disruption on cardiac remodeling in women with type 2 diabetes.
- Conditions
- Menopause, Sleep Disruption, T2DM
- Trial name
- EMPOWER (NCT07486986)
- Testing
- 4 years of clinical evaluations.
- Volunteers
- 381 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Ablation Techniques, Atrial Fibrillation (Paroxysmal)
Paroxysmal Atrial Fibrillation Repeat Ablation Strategies With Durably Isolated Pulmonary Veins
This study looks at participants who have undergone an ablation procedure for atrial fibrillation previously, and atrial fibrillation has occurred and a second ablation procedure is needed.
- Conditions
- Ablation Techniques, Atrial Fibrillation (Paroxysmal), Quality of Life
- Trial name
- PARADISO (NCT07910825)
- Testing
- Tailored Strategy, Control Strategy
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Pericarditis
Pericardial Imaging Study
The pericardium is a thin, double-layered sac around the heart that helps reduce friction as the heart moves. When this sac gets inflamed, it is called pericarditis, which can cause serious health problems and even be…
- Trial name
- NCT07245849
- Testing
- 18F-FDG PET/CT
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- Ottawa Heart Institute Research Corporation
High Risk Bleeding
Investigating a Personalized Approach to Anti-Platelet Therapy
RAPID PREVENT aims to identify if a personalized (targeted) anti-platelet strategy will reduce bleeding events when compared to the current standard anti-platelet therapy.
- Trial name
- RAPID PREVENT (NCT07602257)
- Testing
- Genotyping guided therapy for anti-platelet management
- Where
- Canada
- Volunteers
- 1,760 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Ascending Aortic Aneurysm Enlargement, Ascending Aorta Aneurysm
Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance
The ascending aorta conducts blood from the heart to the rest of the body. The ascending aorta can become enlarged, and the risk of tearing and rupturing becomes higher with larger aorta.
- Trial name
- TITAN:SvS (NCT03536312)
- Testing
- Thoracic Aortic Surgery
- Where
- 31 sites in United States, Canada and 1 more
- Volunteers
- 610 people
- Sponsor
- Ottawa Heart Institute Research Corporation
COVID - 19, Long COVID Syndrome
Dapagliflozin for Long COVID Syndrome
This is a randomized, placebo-controlled study. Patients with long COVID will be randomized to receive dapagliflozin or placebo for 12 months.
- Conditions
- COVID - 19, Long COVID Syndrome, SARS CoV-2
- Trial name
- DALCO (NCT06907251)
- Testing
- Dapagliflozin (DAPA)
- Where
- Canada
- Volunteers
- 192 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Hypervolemia, Cardiogenic Shock
Capital Offload-Shock
CAPITAL OFFLOAD-SHOCK will aim to answer if early use of renal replacement therapy, like dialysis, in patients with reduced body fluids causing the heart to be unable to pump enough blood through the body reduces in-hospital…
- Conditions
- Hypervolemia, Cardiogenic Shock, Renal Replacement Therapies
- Trial name
- OFFLOAD-SHOCK (NCT07756801)
- Testing
- Immediate renal replacement therapy
- Where
- Canada
- Volunteers
- 456 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Completed, with results posted
All 19Smoking Cessation
Self-directed Titrated Transdermal Nicotine Patch Versus Standard Treatment for Smoking Cessation
The primary aim of this research study is to determine whether titrated, patient-directed transdermal patch NRT, based on smoking history and symptoms of nicotine withdrawal, improves long-term rates of smoking cessation in…
- Trial name
- STEP (NCT01622998)
- Testing
- NicoDerm Patch, Nicorette Inhaler
- Where
- Canada
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Coronary Artery Disease
The Efficacy and Economics of Exercise Maintenance Post-Cardiac Rehabilitation
The purpose of this study is to develop a new intervention to improve the transition of patients from structured, supervised exercise to self-managed home- or approved community-based exercise programs in an effort to increase…
- Trial name
- ECOPCR (NCT01658683)
- Testing
- Exercise Facilitator Intervention
- Where
- 2 sites in Canada
- Volunteers
- 449 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Heart Failure
Randomized Trial of Nordic Walking vs. Standard Cardiac Rehabilitation in Patients With Heart Failure
The main purpose of our project is to see if a 12-week program of Nordic walking is better than standard exercise therapy for increasing exercise capacity (measured by how far people can walk in 6 minutes) and increasing quality…
- Trial name
- NCT02061319
- Testing
- Nordic Walking
- Where
- Canada
- Volunteers
- 77 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Cerebrovascular Disorders, Smoking Cessation
Efficacy and Cost-Effectiveness of Cost-free Pharmacotherapy for Smoking Cessation for High-risk Smokers With Cerebrovascular Disease
Research Aims The aims of this research study are to determine whether cost-free smoking cessation pharmacotherapy: 1. Helps smokers with Transient Ischemic Attack (TIA) or stroke to quit smoking over the long-term, compared to…
- Trial name
- NCT00962988
- Testing
- Cost-Free Pharmacotherapy Group, Prescription Only Group
- Where
- 2 sites in Canada
- Volunteers
- 194 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Coronary Heart Disease
Family Heart Health Program: Randomized, Controlled Trial
Background: Family members (spouses, siblings, offspring) of patients with coronary heart disease (CHD) may themselves be at increased risk for developing CHD for genetic, biochemical and/or behavioural reasons.
- Trial name
- FHHP-RCT (NCT00552591)
- Testing
- 12-week risk reduction program, managed by a Heart Health Educator
- Where
- Canada
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation