Research institution
Pontificia Universidad Catolica de Chile Clinical Trials
Studies where Pontificia Universidad Catolica de Chile is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 45Mechanically Ventilated Patients, Acute Respiratory Failure (ARF)
Impact of Inspiratory Effort and Patient-Ventilator Interaction During the Transition Phase
The goal of this observational study is to learn whether breathing effort and patient-ventilator asynchrony (PVA) during the transition phase are associated with clinical outcomes in mechanically ventilated adults.The main…
- Trial name
- PV-INTERACT (NCT07896967)
- Testing
- PVA classification software
- Where
- Chile
- Volunteers
- 250 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Hospitalisation
Evaluation of a DRG-Based Clinical Management Model in a High-Complexity Chilean Hospital
This study aims to evaluate the effectiveness and scalability of a clinical management model based on the use of Diagnosis-Related Groups (DRGs) in a high-complexity hospital in Chile.
- Trial name
- NCT07896161
- Testing
- Support medical decision making, Standard Care (in control arm)
- Where
- Chile
- Volunteers
- 1,167 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Colorectal Cancer, Liver Metastasis
Liver Transplantation for Colorectal Cancer
This is an observational study that will follow adults with stage IV colorectal cancer whose disease has spread only to the liver (not to other organs) and who are undergoing a liver transplant as part of their cancer treatment.
- Trial name
- NCT07884110
- Testing
- Liver transplantation
- Where
- Chile
- Volunteers
- 10 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Energy Metabolism
Acute Effects of Caffeine on Mitochondrial Function in Peripheral Blood Mononuclear Cells
This randomized, double-blind, placebo-controlled crossover study will evaluate the acute effects of caffeine consumption on substrate utilization, resting energy metabolism, and mitochondrial function in peripheral blood…
- Trial name
- MITOCAFFEINE (NCT07873047)
- Testing
- Caffeine (5 mg/kg)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Gradient Between Radial and Central Aortic Pressure After Cardiopulmonary Bypass
Evaluation of Aortic-Radial Blood Pressure Gradient in Pediatric Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass
Invasive blood pressure monitoring is essential during heart surgery. Usually, doctors measure blood pressure using a small tube (a catheter) placed in an artery, typically in the wrist or arm.
- Trial name
- GARP (NCT07857811)
- Testing
- Placement of a pressure transducer at the accessory port of the CPB arterial cannula
- Where
- 2 sites in Chile
- Volunteers
- 100 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Post-Intensive Care Syndrome (PICS)
Post-ICU Syndrome and Social Determinants of Healths
Medical intensive care has improved dramatically, and today, 70% to 80% of critically ill patients survive. However, several survivors face long-term psychological, cognitive, and/or physical sequelae after discharge and…
- Trial name
- NCT07828301
- Where
- 5 sites in Chile
- Volunteers
- 400 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Atopic Dermatitis
Retention of Vernix Caseosa in Newborns for Primary Prevention of Atopic Dermatitis
Atopic dermatitis (AD), also known as eczema, is a common chronic inflammatory skin disease that usually begins in infancy and causes significant itching, discomfort, and sleep disturbance.
- Trial name
- PROTEGO (NCT07333378)
- Testing
- Retention of Vernix Caseosa After Birth, Removal of Vernix Caseosa After Birth
- Where
- 2 sites in Chile
- Volunteers
- 1,383 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Postoperative Chronic Pain, Hallux Valgus Surgery
Incidence and Risk Factors of Postoperative Chronic Pain in Patients Who Have Undergone Hallux Valgus Surgery
The goal of this observational study is to learn about the incidence and risk factors of postoperative chronic pain in adult patients who have undergone Hallux Valgus surgery (between january 2021 and december 2024).
- Trial name
- NCT07330947
- Where
- Chile
- Volunteers
- 350 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Fibromyalgia, Disabilities
Fibromyalgia and Functional Impact: the Complementary Role of Neural Mobilization.
This study aims to compare the change in overall impact and functional variables of fibromyalgia between a group receiving conventional treatment plus neural mobilization and a group receiving only conventional treatment over 12…
- Conditions
- Fibromyalgia, Disabilities, Pain, Women
- Trial name
- NCT07825506
- Testing
- Conventional Treatment (CT), Conventional Treatment plus Neural Mobilization (CTNM)
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Tracheostomy, Prolonged Mechanical Ventilation
Incremental Dead Space Versus Capping Trial Before Tracheostomy Decannulation
Some critically ill patients need a breathing tube placed directly into the windpipe (tracheostomy) because they require long-term help from a breathing machine.
- Conditions
- Tracheostomy, Prolonged Mechanical Ventilation, Tracheostomy Decannulation
- Trial name
- NCT07810166
- Testing
- Incremental Instrumental Dead Space, Capping Trial
- Where
- Chile
- Volunteers
- 22 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Completed, with results posted
All 3Respiratory Syncytial Virus Infections
A Study to Assess Safety, Tolerability and Immunogenicity of the Live Attenuated hRSV Vaccine rBCG-N-hRSV
Human respiratory syncytial virus (hRSV) is the main cause of lower respiratory tract infection in children under one year of age.
- Trial name
- EVA-VRS01 (NCT03213405)
- Testing
- rBCG-N-hRSV 1/100, rBCG-N-hRSV 1/10, rBCG-N-hRSV full dose
- Where
- Chile
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Bariatric Surgery Candidate, Glucose Intolerance
Effect of Dexmedetomidine on Postoperative Glucose and Insulin Levels.
This study investigated the effect of dexmedetomidine in obese patients undergoing bariatric surgery.
- Conditions
- Bariatric Surgery Candidate, Glucose Intolerance, Insulin Resistance
- Trial name
- NCT03809182
- Testing
- Dexmedetomidine, 0.9% Sodium-chloride, Fentanyl
- Volunteers
- 40 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Prediabetic State, Glucose Intolerance
Multicomponent Telecare Model for Supporting Prediabetes Patients
The purpose of this study is to determine whether a multi-component remote care model (telephone-based) is effective to achieve the modification of unhealthy eating practices and increase physical activity in adults who have…
- Trial name
- MTELECAREP (NCT01671293)
- Testing
- Multicomponent remote care model, Usual care
- Where
- 5 sites in Chile
- Volunteers
- 70 people
- Sponsor
- Pontificia Universidad Catolica de Chile