Research institution
University of California, San Diego Clinical Trials
Studies where University of California, San Diego is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 184Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation
Personalized Ventilator Settings for Patients on ECMO
While mechanical ventilation can be used to sustain life in those with lung injury, it, can further worsen lung injury or prevent lung healing resulting in high morbidity and mortality as seen in Acute Respiratory Distress…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation, Respiratory Failure Patients Treated With ECMO, Respiratory Failure, ICU
- Trial name
- PEEPECMO (NCT07673250)
- Testing
- Personalized Positive End-Expiratory Pressure (PEEP)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of California, San Diego
Systemic Lupus Erthematosus (SLE)
Effect of Anti-inflammatory Diet in Systemic Lupus Erythematous
To study the effect of anti-inflammatory diet on clinical and biological outcomes in lupus
- Trial name
- NCT07713940
- Testing
- anti-inflammatory diet
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of California, San Diego
Sleep-Disordered Breathing, Chronic Opioid Use
Comprehensive Opioid Management and Breathing During Sleep
The REDUCE study will evaluate whether referral to a comprehensive opioid management program improves breathing stability during sleep in adults with chronic opioid use and sleep-disordered breathing.
- Trial name
- REDUCE (NCT07923721)
- Testing
- Comprehensive Opioid Management, Usual Care
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of California, San Diego
Osteoarthritis, Knee
Effect of Anti-inflammatory Diet in Osteoarthritis
In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites.
- Trial name
- NCT06080347
- Testing
- Anti-inflammatory Diet, Healthy Diet
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of California, San Diego
Inflammatory Bowel Disease
Effect of Mediterranean Diet in Inflammatory Bowel Disease
The effects of diet on inflammatory bowel disease is an under-studied area of research. The investigators are interested in further investigating the role that diet contributes to inflammatory bowel disease severity.
- Trial name
- NCT05973500
- Testing
- Mediterranean Diet
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of California, San Diego
Sleep-disordered Breathing, Chronic Opioid Use
Supplemental Oxygen for Sleep-Disordered Breathing in Adults With Chronic Opioid Use.
This study will evaluate whether supplemental oxygen given during sleep improves breathing stability and sleep-disordered breathing in adults who use prescription opioids long term.
- Trial name
- OPIO2 (NCT07923760)
- Testing
- Supplemental Oxygen
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of California, San Diego
Osteoarthritis, Knee
Effect of Anti-inflammatory (ITIS) Diet in Knee Osteoarthritis
To study the effect of anti-inflammatory diet on clinical and biological outcomes in patients with knee osteoarthritis
- Trial name
- NCT05559463
- Testing
- ITIS diet
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Rheumatoid Arthritis
Effect of Anti-inflammatory Diet in Rheumatoid Arthritis
In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites.
- Trial name
- NCT04748809
- Testing
- Diet 1, Diet 2
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- University of California, San Diego
Opioid Use Disorder
Targeting Treatment-Resistant OUD With Ketamine-Assisted Mindfulness Oriented Recovery Enhancement
The goal of this clinical trial is to examine the usefulness of Mindfulness-Oriented Recovery Enhancement combined with Ketamine-Assisted Psychotherapy (KetaMORE) for individuals with opioid use disorder who are receiving…
- Trial name
- NCT07369089
- Testing
- Ketamine, Mindfulness-Oriented Recovery Enhancement (MORE), Support Group
- Where
- 2 sites in United States
- Volunteers
- 88 people
- Sponsor
- University of California, San Diego
Knee Osteoarthristis
Study NRPT Feasibility in Knee Osteoarthritis
To Evaluate Feasibility and Exploratory Clinical and Biomarker Signals of NRPT in Adults with Knee Osteoarthritis
- Trial name
- NRPT (NCT07917403)
- Testing
- NRPT
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Completed, with results posted
All 236Cancer, Fertility Issues
Intervening on Women's Health for Rural Young Cancer Survivors
The purpose of this pilot study is to evaluate the feasibility of a multi-component intervention to improve young female cancer survivors' engagement in goal-concordant reproductive health care.
- Conditions
- Cancer, Fertility Issues, Contraception
- Trial name
- NCT06664034
- Testing
- Multi-component reproductive health care intervention
- Where
- 4 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of California, San Diego
Telehealth at the Library, Control Group
"Bupe by the Book": Testing Library Telehealth With Unstably Housed Persons With Opioid Use Disorder
Public libraries nationwide are facing an on-premise opioid overdose crisis. Many persons with opioid use disorder (OUD) remained unhoused and profoundly hard to reach.
- Trial name
- BBB (NCT05872386)
- Testing
- Library Telehealth with Buprenorphine Provider, Treatment-as-Usual Control group
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Pain, Acute Postoperative, Renal Stone
Continuous Erector Spinae Plane Blocks to Treat Pain Following Percutaneous Nephrolithotomy
This is a randomized, triple-masked, placebo-controlled parallel-arm human subjects clinical trial investigating the addition of a continuous erector spinae plane nerve block to a single-injection erector spinae plane block to…
- Trial name
- NCT05121168
- Testing
- Active bupivacaine 0.25% via an erector spinae plane perineural catheter
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego
HNSCC, Lip SCC
Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma
This is a prospective, multi-center, open-label, non-randomized, multi-arm phase II trial to evaluate the efficacy of combination therapy with pembrolizumab and cetuximab for patients with recurrent/metastatic HNSCC.
- Conditions
- HNSCC, Lip SCC, Oral Cavity Cancer, Oropharynx Cancer
- Trial name
- NCT03082534
- Testing
- Pembrolizumab, Cetuximab
- Where
- 4 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of California, San Diego
Rotator Cuff Repair, Ankle Arthroplasty or Arthrodesis
Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Department of Defense Funded Pragmatic Clinical Trial
Postoperative pain is usually treated with opioids that have undesirable and sometimes dangerous side effects (e.g., vomiting and respiratory depression)-and yet over 80% of patients still experience inadequate pain relief.
- Conditions
- Rotator Cuff Repair, Ankle Arthroplasty or Arthrodesis, Hallux Valgus (Bunion) Resection
- Trial name
- NCT04713098
- Testing
- Peripheral Nerve Stimulation
- Where
- 6 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of California, San Diego