Research institution
University of Florida Clinical Trials
Studies where University of Florida is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 198Endometrioid Endometrial Adenocarcinoma
A Study to Estimate Early Clinical Efficacy Signals of GLP-1 Agonist Administration in Conjunction With Levonorgestrel Intrauterine Device in Obese Patients With Endometrioid Intraepithelial Neoplasia
This study will explore the use of glucagon-like peptide 1 receptor agonist (GLP-1RA) used concurrently with levonorgestrel intrauterine device in patients with poor surgical candidacy for a hysterectomy or patients who are…
- Trial name
- NCT07107334
- Testing
- Glucagon-like peptide 1 receptor agonist
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Emotional Regulation, Alcohol Drinking in College
Momentary Coping Prompts and Hair Steroids in College Students
This study looks at the moments when college students feel a strong emotional swing, and how those moments relate to reacting online when upset, drinking alcohol, and eating in response to emotions.
- Conditions
- Emotional Regulation, Alcohol Drinking in College, Emotional Eating, Aggression
- Trial name
- REACT-Bio (NCT07782398)
- Testing
- Momentary coping prompt, Active control message
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Florida
Emotional Regulation, Alcohol Drinking in College
Just-in-Time Coping Prompts for Reactive Digital Behavior in College Students
This study looks at the moments when college students feel a strong emotional swing, and how those moments relate to reacting online when upset, drinking alcohol, and eating in response to emotions.
- Conditions
- Emotional Regulation, Alcohol Drinking in College, Emotional Eating, Aggression
- Trial name
- REACT (NCT07789314)
- Testing
- Momentary coping prompt, Active control message
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Florida
Brain Metastases
IL-8 Receptor Modified Patient-Derived Activated CD70 CAR T Cell Therapy in Adults With Brain Metastases
This is a Phase I Study evaluating the safety and feasibility of IL-8 receptor-modified patient-derived activated CD70 CAR T cells in adult patients with brain metastases from primary cancer, with either newly diagnosed lesions…
- Trial name
- IMPACT MET (NCT07569263)
- Testing
- Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells, CD70 IHC assay
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Florida
Pancreatic Ductal Adenocarcinoma
Repurposing Mefloquine for Pancreatic Cancer Treatment
Pancreatic cancer (specifically pancreatic ductal adenocarcinoma, PDAC) is a very aggressive disease that is often diagnosed too late for surgery, and the medicines currently available, mainly two chemotherapy combinations called…
- Trial name
- NCT07875907
- Testing
- Mefloquine, Modified FOLFIRINOX, gemcitabine and nab paclitaxel
- Volunteers
- 36 people
- Sponsor
- University of Florida
Hypertension, Resistant to Conventional Therapy
Antihypertensive Mechanisms of Minocycline in Resistant Hypertension
The goal of this clinical trial is to learn about the mechanisms by which minocycline effect blood pressure in individuals with treatment-resistant hypertension.
- Trial name
- NCT06246396
- Testing
- Minocycline Hydrochloride
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Florida
Solid Tumor, Adult
Ivermectin Combined With Immune Checkpoint Inhibition in Cancer (ICONIC)
Public awareness of ivermectin's purported anticancer properties has led to widespread off-label use. In a 2023 cross-sectional study in Loja, Ecuador, 19% of respondents reported using ivermectin as an adjunct to cancer…
- Trial name
- ICONIC (NCT07487805)
- Testing
- Intermediate-dose ivermectin, High-dose ivermectin
- Volunteers
- 80 people
- Sponsor
- University of Florida
Vulvodynia
A Pilot Study on the Efficacy of Oral Low Dose Naltrexone for Vulvodynia
The goal of this observational pilot study is to assess the safety, efficacy, and tolerability of oral low dose naltrexone (LDN) in the treatment of vulvodynia.
- Trial name
- NCT07862400
- Testing
- Low Dose Naltrexone
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Papillomavirus Vaccines
ReMARK: Addressing Disparities in Rural HPV-related Cancer Prevention
There are three main objectives of the protocol. First, we will evaluate the added clinical- and cost- effectiveness of parent-targeted motivational aids (reminder/recall and phone-based MI) alone and when combined with…
- Trial name
- NCT06535139
- Testing
- Brief training, Parent-targeted motivational aids, Healthcare access
- Where
- United States
- Volunteers
- 4,630 people
- Sponsor
- University of Florida
Duchenne Muscular Dystrophy, Duchenne Disease
Evaluating VM100 Nutritional Supplement for Improving Quality of Life in Duchenne Muscular Dystrophy Patients
This pilot study will investigate the potential efficacy of VM100, a nutritional supplement specifically formulated for patients with DMD, on quality of life and physical symptoms.
- Conditions
- Duchenne Muscular Dystrophy, Duchenne Disease, Muscular Dystrophy in Children, DMD
- Trial name
- NCT07766980
- Testing
- VM100 Nutritional Supplement
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Completed, with results posted
All –Cognitive Aging, Alzheimer Disease, Protection Against
The Revitalize Study in Older Adults at Risk for Alzheimer's Disease
The goal of this multi-site double blinded randomized sham-controlled Phase II clinical trial is to test a novel, relatively low cost, low risk, and potentially high impact therapeutic intervention in older adults who are at…
- Trial name
- NCT04018092
- Testing
- Active NIR-PBM
- Where
- 2 sites in United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Florida
Insufficient Lactation
Improving Lactation Success in Black Mothers of Critically Ill Infants
Racial disparities result in Black infants in the neonatal intensive care unit (NICU) receiving less breast milk (BM) than White and Hispanic infants.1 BM improves infant health yet mothers of critically ill infants produce…
- Trial name
- NCT05147987
- Testing
- Hands free wearable breast pump
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Florida
Essential Tremor, Parkinson Disease
Physiology, Imaging and Modeling of Essential Tremor
This project aims to investigate novel ways to deliver brain stimulation to Essential Tremor (ET) patients by introducing software changes to their existing devices.
- Conditions
- Essential Tremor, Parkinson Disease, Dystonia
- Trial name
- NCT03811405
- Testing
- Active biphasic pulse stimulation---Home Settings, Active biphasic pulse stimulation---VIN Biphasic, Active biphasic pulse stimulation---Stimulator Off
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Florida
Medulloblastoma, Neuroectodermal Tumor
Vaccine Immunotherapy for Recurrent Medulloblastoma and Primitive Neuroectodermal Tumor
Immunotherapy is a specific approach to treating cancer that has shown promise in adult patients for the treatment of melanoma, malignant brain tumors, and other cancers.
- Trial name
- Re-MATCH (NCT01326104)
- Testing
- TTRNA-xALT, TTRNA-DCs
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- University of Florida
HPV
Text and Talk: A Multi-level Intervention to Increase Provider HPV Vaccine Recommendation Effectiveness
This study will test the effectiveness of two interventions (parent-targeted text messages and a brief clinician-targeted training) at increasing HPV vaccination among 11- to 12-year-olds living in Florida.
- Trial name
- Text&Talk (NCT05006833)
- Testing
- Brief Provider Training - Bundled Approach, Brief Provider Training - Benefits Approach, Parent Interactive Text Message - Bundled Approach
- Where
- United States
- Volunteers
- 8,043 people, healthy volunteers welcome
- Sponsor
- University of Florida