Research institution
University of Louisville Clinical Trials
Studies where University of Louisville is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 41Eating Disorders
Be Body Brave: Digital Written Exposure Therapy for Eating Disorders
Current eating disorder (ED) treatment options are both inaccessible (80% of people with EDs do not access treatment) and not entirely successful (most people with an ED do not reach full remission).
- Trial name
- BBB (NCT07914712)
- Testing
- Imaginal exposure, Eating disorder journaling
- Volunteers
- 900 people
- Sponsor
- University of Louisville
Financial Toxicity, Cancer
Implementing Stepped Financial and Legal Navigation to Mitigate Financial Toxicity in Adolescent and Young Adult Cancer Patients Oncology Financial and Legal Navigation (OFLN)
The overall objective of this study is to test the effectiveness and implementability of stepped Oncology Financial and Legal Navigation (OFLN) in a noninferiority randomized controlled trial (RCT) using a hybrid type 1…
- Conditions
- Financial Toxicity, Cancer, Adolescent, Young Adult Cancer Survivors
- Trial name
- OFLN (NCT07849699)
- Testing
- Oncology Financial and Legal Navigation (OFLN) Stepped: Low Intensity, Oncology Financial and Legal Navigation (OFLN) Standard, Oncology Financial and Legal Navigation (OFLN) Stepped: High-Intensity
- Where
- United States
- Volunteers
- 294 people
- Sponsor
- University of Louisville
Spinal Cord Injuries
Neuromodulation of Spinal Locomotor Circuitry to Elicit Stepping After Pediatric Spinal Cord Injury
Spinal cord injury (SCI) results in damage to the descending neural pathways and leads to the immediate dysfunction of multiple physiological systems below the level of injury.
- Trial name
- NCT04077346
- Testing
- Biostim-5 transcutaneous spinal stimulator, Transcutaneous Spinal Stimulator + Activity Based Locomotor Training
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Louisville
Spinal Cord Injuries
Transcutaneous Spinal Stimulation: Safety and Feasibility for Upper Limb Function in Children With Spinal Cord Injury
Children who suffer a spinal cord injury in the neck region have difficulty using their hands due to paralysis and/or weakness of their arms and hand muscles.
- Trial name
- NCT04032990
- Testing
- Biostim-5 transcutaneous spinal stimulator
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Louisville
Perinatal Spinal Cord Injury
Understanding Perinatal Spinal Cord Injury
The purpose of this study is to deepen our understanding of children who have a cervical spinal cord injury obtained in utero or at birth and examine the effects of tailored activity-based recovery training (ABRT) in combination…
- Trial name
- NCT06808035
- Testing
- Activity-Based Recovery Training, Transcutaneous Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Louisville
Traumatic Brain Injury (TBI) Patients
Saline Versus Balanced Crystalloid in Traumatic Brain Injury
The goal of this clinical trial is to determine which crystalloid (saline or balanced) should be used in the critical management of Traumatic Brain Injury (TBI) in moderate or severe TBI patients.
- Trial name
- FLUID-TBI (NCT06953674)
- Testing
- Normal Saline (0.9% NaCl), balanced crystalloid
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- University of Louisville
Alcohol Use Disorder, Alcohol-associated Liver Disease
Pomegranate Dietary Supplements in AUD and ALD
The goal of this project is to determine an individual's ability to generate active gut microbial metabolites called urolithins upon consumption of pomegranate dietary supplements.
- Conditions
- Alcohol Use Disorder, Alcohol-associated Liver Disease, Alcoholic Cirrhosis, Healthy
- Trial name
- NCT07678567
- Testing
- Pomegranate Dietary Ssupplement
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Brain Metastases
MeDex: No Perioperative Dexamethasone in Brain Metastases
Perioperative treatment of newly diagnosed cancer patients with brain metastasis without dexamethasone (Dex).
- Trial name
- NCT07044557
- Testing
- Withholding perioperative Dexamethasone
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Louisville
Aneurysmal Subarachnoid Hemorrhage
Dome-Only Aneurysm Coiling in Severe Aneurysmal Subarachnoid Hemorrhage
The DOME study is a clinical trial exploring a new treatment approach for patients who suffered a severe brain bleed due to an aneurysm.
- Trial name
- DOME (NCT07250958)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Louisville
Vision
Intermediate Visual Space Perception
The ability to judge the locations of various objects from oneself during self-motion in the intermediate distance range (~2-25m) is crucial for successful performance of activities of daily living, such as walking and driving.
- Trial name
- NCT05419713
- Testing
- Visual Stimuli for Space Perception
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Completed, with results posted
All 34Urinary Bladder, Neurogenic, Blood Pressure
Recovery of Bladder and Sexual Function After Human Spinal Cord Injury
This study will incorporate critical cross viscero-visceral intersystem interactions to investigate in a controlled laboratory setting the extent, severity, and frequency of occurrence of autonomic dysreflexia with respect to…
- Conditions
- Urinary Bladder, Neurogenic, Blood Pressure, Autonomic Dysreflexia, Bowel Incontinence
- Trial name
- NCT04193709
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Louisville
Air Pollution Toxicity
Nucleophilic Defense Against PM Toxicity (NEAT Trial)
Carnosine is a naturally occurring peptide found in high levels in skeletal muscle and the brain and is also available commercially as a dietary supplement.
- Trial name
- NEAT (NCT03314987)
- Testing
- L-carnosine
- Where
- United States
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Overactive Bladder, Urge Incontinence
Lidocaine Patches Prior to Percutaneous Nerve Evaluation
The study will be a double-blind randomized control trial comparing 4% lidocaine patch placed over the sacrum 3 minutes prior to a percutaneous nerve evaluation (PNE) procedure to a placebo patch in patients already scheduled to…
- Conditions
- Overactive Bladder, Urge Incontinence, Fecal Incontinence
- Trial name
- NCT05783219
- Testing
- Lidocaine patch
- Where
- 2 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Neurogenic Bladder, Spinal Cord Injuries
Gentamicin Bladder Instillation in Individuals With Spinal Cord Injury Having Chronic Urinary Tract Infections
Participants will undergo daily gentamicin bladder instillations to determine if its use will reduce the rate of symptomatic urinary tract infections (UTIs) as well as the use of oral and intravenous antibiotics in adults with…
- Trial name
- NCT03931408
- Testing
- Gentamicin Sulfate, No instillation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Louisville
Spinal Cord Injuries
Recovery of Bladder and Sexual Function After Spinal Cord Injury
Bladder and sexual dysfunction consistently ranks as one of the top disorders affecting quality of life after spinal cord injury.
- Trial name
- NCT03036527
- Testing
- Activity-based locomotor training, Activity-based stand training, Activity-based upper arm ergometry
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Louisville