Research institution
University of Maryland, Baltimore Clinical Trials
Studies where University of Maryland, Baltimore is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 130Pancreatic Cancer, Advanced or Metastatic
Signature Development and Validation Protocol for an Epigenetic Assay in Diagnosing Pancreatic Cancer
The purpose of this research study is to test a new process for diagnosing pancreatic cancer by examining changes to your DNA that can be detected from a blood test.
- Trial name
- NCT07528430
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- University of Maryland, Baltimore
Head and Neck Cancer, Head and Neck Squamous Cell Cancer
A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minimal Risk and Primary Site Disease (SAVED)
Patients with human papillomavirus (HPV)-related oropharyngeal cancer generally have very good outcomes. Patients' treatment responses depend more on their individual cancer characteristics and personal risk factors than on the…
- Conditions
- Head and Neck Cancer, Head and Neck Squamous Cell Cancer, Head and Neck Squamous Cell Carcinoma, Oropharyngeal Carcinoma
- Trial name
- SAVED (NCT07418034)
- Testing
- Dose de-escalation to contralateral neck., Dose de-escalation to gross disease to contralateral neck, Dose de-escalation to gross disease
- Where
- 4 sites in United States
- Volunteers
- 132 people
- Sponsor
- University of Maryland, Baltimore
Renal Injury, Acute Kidney Injury
Early Biomarker Kidney Injury Assessment After Acumen Directed Fluid Management in Cardiac Surgery
This study is to assess the benefits of goal-directed fluid management with ACUMEN in cardiac surgical patients and its impact on cardiac surgery-induced kidney injury.
- Trial name
- BE-KIND (NCT06109714)
- Testing
- Goal Directed Fluid Therapy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Central Line-Associated Bloodstream Infection (CLABSI), Bacteremia
Evaluation of an AI-Assisted Tool for CLABSI Surveillance at VA Medical Centers
Infection prevention and control programs at US hospitals perform surveillance to detect and publicly report hospital-onset central line-associated bloodstream infections (CLABSI) using standards set by CDC's National Healthcare…
- Conditions
- Central Line-Associated Bloodstream Infection (CLABSI), Bacteremia, Bloodstream Infections
- Trial name
- VA-AI-CLABSI (NCT07918352)
- Testing
- Generative AI tool for CLABSI surveillance
- Volunteers
- 30 people
- Sponsor
- University of Maryland, Baltimore
Community Acquired Pneumonia (CAP)
Ceftriaxone Dosage for Non-Critical Community-Acquired Pneumonia
Aim: Demonstrate the equivalent efficacy and superior safety of Ceftriaxone 1 gram daily compared with Ceftriaxone 2 grams daily among hospitalized patients with community-acquired pneumonia who are not admitted to the intensive…
- Trial name
- DC-CAP (NCT07537413)
- Testing
- Ceftriaxone 1 gram daily, Ceftriaxone 2 grams daily
- Where
- 4 sites in United States
- Volunteers
- 900 people
- Sponsor
- University of Maryland, Baltimore
Nsclc, NSCLC Stage II
Adaptive Chemotherapy for Pd-l1 High REsEctablE NSCLC: A Chemo-PHREE Trial
This research study is being done to find out if a drug called cemiplimab is safe in adult patients who have non-small cell lung cancer (NSCLC) that can be surgically removed (resectable Stage II, IIIA, or select IIIB NSCLC).
- Conditions
- Nsclc, NSCLC Stage II, NSCLC, Stage III, NSCLC Stage IIIB
- Trial name
- NCT07746388
- Testing
- Cemiplimab
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Maryland, Baltimore
Fatigue in Cancer Survivors
Targeting HealthY Eating to Maintain Energy While Living With Cancer
Treatments for advanced and metastatic cancer can cause fatigue and accelerate the progression to frailty. There are few effective mitigation strategies for fatigue or frailty in chronic cancer in part because the underlying…
- Trial name
- THYME (NCT07826871)
- Testing
- Nutrition counseling, Time-restricted eating
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- University of Maryland, Baltimore
Missing Tooth/Teeth
S-TiUltra Implant Study
This prospective clinical study will compare early healing and implant stability between two Nobel Biocare dental implant systems, NobelReplace S-TiUltra and NobelReplace CC TiUnite.
- Trial name
- NCT07911319
- Testing
- NobelReplace S-TiUltra, NobelReplace TiUnite
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Maryland, Baltimore
Plasma Cell Disorder
Subcutaneous Daratumumab Administration in the Thigh Vs Abdomen in Plasma Cell Disorders
The purpose of this study is to look at the safety, tolerability, and serum concentration of daratumumab administered subcutaneously in the thigh versus the abdomen in patients with plasma cell disorders.
- Trial name
- NCT07075510
- Testing
- Daratumumab Injection
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Maryland, Baltimore
Open tíbia Fracture
Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy
The Beads vs Vac trial is a multi-centre randomized controlled trial of 312 participants with a severe open tibia fracture requiring multiple irrigation and debridement surgeries.
- Trial name
- BeadsvsVac (NCT05615844)
- Testing
- Antibiotic Cement Bead Pouch, Negative Pressure Wound Therapy
- Where
- 35 sites in United States, Canada
- Volunteers
- 312 people
- Sponsor
- University of Maryland, Baltimore
Completed, with results posted
All 167Knee Osteoarthritis, Depression
Exercise Plus Duloxetine for Knee Osteoarthritis
This study evaluates the addition of duloxetine to aerobic exercise in the treatment of symptomatic knee osteoarthritis and depressive symptoms in adults.
- Trial name
- NCT04111627
- Testing
- Aerobic exercise, Duloxetine
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Maryland, Baltimore
Acute Kidney Injury
Preop Digifab in CABG to Reduce Ouabain Levels and Prevent AKI
Acute kidney injury (AKI) occurs in up to 30% of patients undergoing coronary artery bypass graft (CABG) surgery, and often requires patients to go on dialysis.
- Trial name
- NCT03810417
- Testing
- Digoxin Antibodies Fab Fragments, Baseline EO > 360 pM, EO < 360 pM
- Where
- 2 sites in United States
- Volunteers
- 267 people
- Sponsor
- University of Maryland, Baltimore
Heart Diseases, Coronary Disease
CES1 Carriers in the PAPI Study
This study builds, in part, upon preliminary results generated as part of the Pharmacogenomics Anti-Platelet Intervention (PAPI) Study (NCT00799396).
- Conditions
- Heart Diseases, Coronary Disease, Coronary Artery Disease, Cardiovascular Diseases
- Trial name
- NCT03188705
- Testing
- Clopidogrel, Aspirin
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Myocardial Infarction, Thrombosis
CES1 Crossover Trial of Clopidogrel and Ticagrelor
The purpose of this investigation is to evaluate when genetic variation in the carboxylesterase 1 (CES1) gene influences antiplatelet therapy response, as assessed by ex vivo platelet aggregometry, in healthy participants treated…
- Conditions
- Myocardial Infarction, Thrombosis, Platelet Dysfunction
- Trial name
- NCT03161678
- Testing
- Clopidogrel, Ticagrelor
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Neoplasms, Therapy
Time-Restricted Eating to Address Persistent Cancer-Related Fatigue
This study will assess the feasibility of delivering a 12-week time-restricted eating intervention as well as the intervention's preliminary efficacy on persistent cancer-related fatigue among cancer survivors compared to a…
- Conditions
- Neoplasms, Therapy, Fatigue, Diet Therapy
- Trial name
- NCT05256888
- Testing
- Time-restricted eating, Healthy lifestyle education
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Maryland, Baltimore