Research institution
University of Massachusetts, Worcester Clinical Trials
Studies where University of Massachusetts, Worcester is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 52Cardiac Arrest, Out-Of-Hospital, Hypotension
Cardiac Arrest - Ultrasound Detection of Occult Perfusion
The goal of this study is to describe the population of patients presenting after out of hospital cardiac arrest with occult perfusion, defined as a patient without a palpable pulse but with some evidence of pulsatile arterial…
- Trial name
- NCT07897370
- Where
- 8 sites in United States
- Volunteers
- 1,400 people
- Sponsor
- University of Massachusetts, Worcester
Proximal Humerus Fracture
Study on Outcomes of Proximal Humerus Fractures
Patients undergoing either operative or non-operative treatment of proximal humerus fractures will be studied with the goal of understanding which treatment modality provides optimal post-injury outcomes.
- Trial name
- NCT07060664
- Testing
- open reduction internal fixation, intramedullary nail, reverse total shoulder arthroplasty
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Massachusetts, Worcester
Opioid Abuse (Disorder)
Improving Jail Response to the Overdose Crisis: A Hybrid Trial of Jail ECHO to Improve MOUD Implementation and Public Health Outcomes
This project tests a training strategy to help rural jails start or increase their use of medications to treat opioid use disorder (MOUD - methadone, buprenorphine, naltrexone).
- Trial name
- J-ECHO OPS (NCT07637994)
- Testing
- Project ECHO
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Opioid Use Disorder, Mental Health Disorder
Supporting Treatment Access and Recovery in COD
This 4-year study will randomize 1,000 people with co-occurring opioid use and mental health disorders (COD) at medication for opioid use disorder (MOUD) clinics to evaluate the effectiveness of MISSION, a multi-component team…
- Trial name
- STAR-COD (NCT05138614)
- Testing
- Medication for Opioid Use Disorder, MISSION Critical Time Intervention, MISSION Peer Support
- Where
- 5 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- University of Massachusetts, Worcester
COPD (Chronic Obstructive Pulmonary Disease)
Evaluation of the Paramedic Evaluation for Acute COPD Exacerbation
Chronic Obstructive Pulmonary Disease (COPD) is a serious lung condition that affects millions of people in the United States. Each year, it leads to about 150,000 deaths, nearly 900,000 emergency room visits, and 700,000…
- Trial name
- PEACE (NCT07072039)
- Testing
- Paramedic Evaluation for acute COPD Exacerbation, Usual Care
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Massachusetts, Worcester
Suicidal Ideation, Suicide Attempt
Efficacy, Effectiveness, and Implementation of Jaspr Health in Emergency Department- Part B
This Study will evaluate the implementation of a multi-component suicide prevention technology (Jaspr Health) that facilitates delivery of suicided-related evidence-based practices (EBPs) while replacing wasted waiting time with…
- Conditions
- Suicidal Ideation, Suicide Attempt, Self Harm
- Trial name
- Jaspr-PartB (NCT06311591)
- Testing
- Jaspr App
- Where
- 4 sites in United States
- Volunteers
- 27,908 people
- Sponsor
- University of Massachusetts, Worcester
Gestational Diabetes Mellitus (GDM), Metabolic Syndrome
Postpartum Semaglutide to Reduce Cardiometabolic Risk After Gestational Diabetes Mellitus
This is an effectiveness-implementation Hybrid Type 1 study using a randomized clinical trial design to evaluate the effectiveness and potential real-world integration of immediate postpartum semaglutide following a pregnancy…
- Trial name
- NCT07797036
- Testing
- Semaglutide (Wegovy) weekly injection
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- University of Massachusetts, Worcester
Bladder Perforation, Retropubic Midurethral Sling
Retropubic Hydrodissection and Trocar-induced Bladder Perforation During Retropubic Midurethral Slings
Retropubic midurethral slings are a common and effective treatment for stress urine incontinence. The trocar that is attached to the mesh material can hit the bladder which is called a perforation.
- Conditions
- Bladder Perforation, Retropubic Midurethral Sling, Retropubic Hydrodissection
- Trial name
- NCT07208682
- Testing
- retropubic hydrodissection
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Type I Diabetes, Pediatrics
Food is Medicine in Pediatric Patients With Diabetes
The objective of this randomized controlled trial is to evaluate the effect of novel Food is Medicine Programming in the form of medically tailored pre-packaged meals for pediatric patients with Type 1 Diabetes.
- Conditions
- Type I Diabetes, Pediatrics, Food Insecurity
- Trial name
- NCT07535502
- Testing
- Community Servings, PedsQL Survey, Nutrition Counseling
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Massachusetts, Worcester
Sustainability
Sustainability and Precision Prevention Project
This is a five-year hybrid type 3 effectiveness-implementation study evaluating multilevel strategies to sustain a nationwide implementation of an evidence-based HIV prevention curriculum in schools.
- Trial name
- NCT07153042
- Testing
- Biweekly monitoring and feedback (BMF), Site-based assistance and mentorship (SAM), Enhanced site-based assistance and mentorship (Enhanced SAM)
- Where
- The Bahamas
- Volunteers
- 3,705 people
- Sponsor
- University of Massachusetts, Worcester
Completed, with results posted
All 72Pre-Exposure Prophylaxis
Developing mHealth to Promote PrEP Use Among Thai Young Men Who Have Sex With Men
The goal of this study is to develop and pilot test technology-based interventions to promote Pre-exposure Prophylaxis (PrEP) uptake and adherence among Thai young men who have sex with men (YMSM).
- Trial name
- NCT05243030
- Testing
- Motivational Enhancement System for PrEP Uptake and Adherence (MES-PrEP), Motivational Interactive Text Messaging (MTM), Standard PrEP Counseling
- Where
- 3 sites in Thailand
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Diabetes Mellitus
Continuous Glucose Monitoring in the Intensive Care Unit
The aim of the proposed clinical trial is to study the use of the Dexcom G7 continuous glucose monitor (CGM) within the intensive care unit (ICU) environment.
- Trial name
- NCT06190808
- Testing
- Dexcom G7 Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Massachusetts, Worcester
Tuberculosis, Pulmonary Tuberculosis
Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV)
The METHOD study will examine whether adding metformin to standard antibiotic treatment for tuberculosis (TB) in people with HIV is safe and well tolerated.
- Conditions
- Tuberculosis, Pulmonary Tuberculosis, HIV Coinfection
- Trial name
- METHOD (NCT04930744)
- Testing
- Isoniazid, Rifampicin, Ethambutol
- Where
- 2 sites in South Africa
- Volunteers
- 112 people
- Sponsor
- University of Massachusetts, Worcester
Tobacco Smoking
Adapt2Quit - An Adaptive Motivational System for Socio-Economically Disadvantaged Smokers
The goal of this research is to test the Adapt2Quit computer program that uses participant input (message rating on how much the text motivational message might influence one to quit smoking) to select and text motivational…
- Trial name
- A2Q (NCT04720625)
- Testing
- Adapt2Quit, Control
- Where
- 3 sites in United States
- Volunteers
- 757 people
- Sponsor
- University of Massachusetts, Worcester
Osteo Arthritis Knee, Osteoarthritis, Hip
Development of an Osteoarthritis (OA) Care Plan to Improve Process and Quality of OA Treatment Decisions
Knee and hip osteoarthritis (OA) is the most common cause of disability in the U.S. and affects more than 60% of adults over 65 years.
- Trial name
- NCT03102580
- Testing
- OA Care Plan
- Where
- United States
- Volunteers
- 5,713 people
- Sponsor
- University of Massachusetts, Worcester