Research institution
Vastra Gotaland Region Clinical Trials
Studies where Vastra Gotaland Region is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 98Psoriatic Arthritis
Combined High-Intensity Aerobic Training and Resistance Training in Psoriatic Arthritis
The goal of this randomised controlled trial is to evaluate the effects of a 12-week intervention comprising high-intensity interval aerobic training and strength training on cardiovascular function, metabolic health profile and…
- Trial name
- PsA-HIIT (NCT07352696)
- Testing
- Exercise program
- Where
- 2 sites in Sweden
- Volunteers
- 88 people
- Sponsor
- Vastra Gotaland Region
Rheumatoid Arthritis (RA)
Nutrition in Rheumatoid Arthritis
Background: Individuals with Rheumatoid Arthritis (RA) often experience persistent symptoms such as pain and stiffness despite modern pharmacological treatments. They also have an increased risk of cardiovascular disease.
- Trial name
- NUTRA (NCT06831331)
- Testing
- Healthy diet based on NNR2023, Control/waiting-list
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Vastra Gotaland Region
Myocardial Infarct
STunning in Acute Myocardial Infarction - BAS
The objective of this trial is to examine the effect of immediate versus late administration of beta blockers, angiotensin converting enzyme inhibitors (ACEI), and sodium/glucose cotransporter 2 (SGLT2) inhibitors on…
- Trial name
- STAMI-BAS (NCT06562582)
- Testing
- Bisoprolol Oral Tablet, Ramipril Oral Product, Dapagliflozin Oral Product
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Vastra Gotaland Region
Coronary Artery Disease
CABG or PCI in Patients With Ischemic Cardiomyopathy
The STICH-SWEDEHEART trial will compare PCI vs CABG for revascularization of patients with HF and LV systolic dysfunction (LV ejection fraction (LVEF) <40%) and multi-vessel coronary artery disease.
- Trial name
- STICH (NCT05329285)
- Testing
- Percutaneous Coronary Intervention (PCI)
- Where
- Sweden
- Volunteers
- 470 people
- Sponsor
- Vastra Gotaland Region
Critical Illness, Low Peripheral Perfusion
Local Warming to Improve Pulse Oximetry Accuracy in Critically Ill Patients
Pulse oximeters are widely used in intensive care to continuously estimate the oxygen level in the blood. However, pulse oximeter measurements may be less accurate when blood flow to the fingers is poor, which is common in…
- Conditions
- Critical Illness, Low Peripheral Perfusion, Pulse Oximetry Accuracy
- Trial name
- PULSEWARM (NCT07792304)
- Testing
- Protocolized Local Warming
- Where
- 4 sites in Sweden
- Volunteers
- 240 people
- Sponsor
- Vastra Gotaland Region
Breast Cancer Stage IV, Oligometastatic Disease
Stereotactic Ablative Radiotherapy for OligoMetastatic Breast Cancer
TAORMINA is an international, multicentre, randomised phase 3 trial for patients with oligometastatic breast cancer (OMBC) that will be allocated to combined stereotactic ablative radiotherapy (SABR) + systemic therapy…
- Trial name
- TAORMINA (NCT05377047)
- Testing
- SABR
- Where
- 19 sites in Ireland, Israel and 4 more
- Volunteers
- 345 people
- Sponsor
- Vastra Gotaland Region
Graves Disease, Mental Fatigue
Validating Immunological Markers Associated With Mental Fatigue in Graves' Disease
Mental fatigue occurs in many diseases and the reasons are mostly unknown. The investigators hypothesize that remaining mental fatigue after restored euthyroidism in Graves' disease is an autoimmune complication.
- Trial name
- NCT06081439
- Where
- Sweden
- Volunteers
- 430 people
- Sponsor
- Vastra Gotaland Region
Metastatic Uveal Melanoma, Metastatic Cutaneous Melanoma
Locoregional or Systemic Administration of Autologous Tumor Infiltrating Lymphocytes in Patients With Metastatic Melanoma
The purpose of this study is to evaluate the feasibility, safety and tolerability of locoregional or systemic administration of autologous tumor infiltrating lymphocytes in patients with metastatic melanoma
- Trial name
- GoTIL-01 (NCT07183852)
- Testing
- Autologous Tumor Infiltrating Lymphocytes (TIL), Melphalan, Interleukin-2
- Volunteers
- 18 people
- Sponsor
- Vastra Gotaland Region
Uveal Melanoma, Metastatic Cutaneous Melanoma
Locoregional Administration of TIL and Lymphodepletion in Patients With Melanoma and Liver Metastases
Evaluate the safety and tolerability of treatment with autologous tumor infiltrating lymphocytes (TIL) administered via hepatic arterial infusion and preconditioning with percutaneous hepatic perfusion in patients with liver…
- Trial name
- HAITILS-PHP (NCT05903937)
- Testing
- Autologous Tumor Infiltrating Lymphocytes, Melphalan, Interleukin-2
- Volunteers
- 6 people
- Sponsor
- Vastra Gotaland Region
Melanoma (Skin Cancer)
Superparamagnetic Iron Oxide for Sentinel Lymph Node Localization in Patients With Cutaneous Melanoma: MagMen-II
A randomized, international, phase III, multi-center, non- inferiority trial assessing the safety and efficacy of Magtrace® (superparamagnetic iron oxide, SPIO) in identification of lymph nodes in patients with cutaneous melanoma…
- Trial name
- MagMen-II (NCT07552597)
- Testing
- Superparamagnetic Iron Oxide, Technetium (99mTc)
- Volunteers
- 254 people
- Sponsor
- Vastra Gotaland Region
Completed, with results posted
All 3Alcohol Use Disorder, Alcoholism
Varenicline and Bupropion for Alcohol Use Disorder
The COMB study is a randomized double-blind placebo-controlled multicenter trial in Sweden on the efficacy of varenicline and bupropion, in combination and alone, for treatment of alcohol use disorder (AUD).
- Conditions
- Alcohol Use Disorder, Alcoholism, Alcohol Dependence
- Trial name
- NCT04167306
- Testing
- Varenicline Tartrate 1 mg b.i.d, Bupropion Hydrochloride 150 mg b.i.d
- Where
- 4 sites in Sweden
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Osteoarthritis, Knee
A Cost-efficiency Analysis of Primary Assessors for Patients With Knee Pain in Primary Care
Background: Almost half of the Swedish population are overweight or obese. This will probably affect the incidence of osteoarthritis since overweight is a strong risk factor.
- Trial name
- NCT03822533
- Testing
- Physiotherapist as primary assessor, Physician as primary assessor
- Where
- 9 sites in Sweden
- Volunteers
- 363 people
- Sponsor
- Vastra Gotaland Region
Knee Osteoarthritis
Physical Therapist as Primary Assessor for Patients With Knee Pain in Primary Care
In order to manage the future increase in osteoarthritis consultation, patients with osteoarthritis could be assessed by a physical therapist first, so that other patients with more severe conditions could get faster access to a…
- Trial name
- NCT03715764
- Testing
- Physical therapy assessment, Physician assessment
- Volunteers
- 69 people
- Sponsor
- Vastra Gotaland Region