Research institution
West China Hospital Clinical Trials
Studies where West China Hospital is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 197Non-small Cell Lung Cancer (NSCLC)
A Study of Perioperative Adebrelimab Plus Chemotherapy Versus Adjuvant Therapy in Patients With Resectable NSCLC
This is a randomized, multicenter, phase III clinical study to compare the efficacy and safety of perioperative treatment with adebrelimab plus platinum-based chemotherapy versus adebrelimab adjuvant therapy in patients with…
- Trial name
- NCT07895238
- Testing
- Adebrelimab (SHR-1316) + chemotherapy, Adebrelimab
- Volunteers
- 1,088 people
- Sponsor
- West China Hospital
Colorectal Cancer
Fruquintinib Combined With Capecitabine as Adjuvant Extended Therapy After R0 Resection and Perioperative Chemotherapy in Patients With Liver-Only Metastatic Colorectal Cancer
Colorectal cancer (CRC) is among the most common malignancies in China, and approximately half of all patients develop liver metastases.
- Trial name
- NCT07885384
- Testing
- Fruquintinib Combined With Capecitabine, Follow-up observation
- Volunteers
- 140 people
- Sponsor
- West China Hospital
Circumferential Female Urethral Diverticulum
Transvaginal Diverticulum Wall Filling and Coverage Technique for Treating Female Circumferential Urethral Diverticulum
The goal of this clinical study is to learn if a new surgical technique called transvaginal diverticular wall filling and covering is effective and safe for treating circumferential urethral diverticulum (UD) in female patients.
- Trial name
- NCT07006753
- Testing
- Transvaginal Diverticulum Wall Filling and Coverage Technique, Conventional surgery
- Where
- China
- Volunteers
- 100 people
- Sponsor
- West China Hospital
Liver Cancer
PD-1 mRNA LNP Vaccine for Advanced Primary Hepatocellular Carcinoma.
Evaluating the Safety and Efficacy of PD-1 mRNA LNP Vaccine Therapy in Patients with Primary Hepatocellular Carcinoma Who Have Failed Advanced Standard Therapy
- Trial name
- NCT07053072
- Testing
- Low Dose PD-1 mRNA LNP Vaccine, High dose PD-1 mRNA LNP vaccines
- Where
- 2 sites in China
- Volunteers
- 9 people
- Sponsor
- West China Hospital
Hepatocellular Carcinoma
Surgery vs. Watch-and-Wait Strategy in Complete Responders for Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Some people with HCC have no visible active tumor on imaging after receiving anticancer treatment.
- Trial name
- SWITCH-R (NCT07866612)
- Testing
- Curative-Intent Liver Resection, Immunotherapy-Based Systemic Maintenance Therapy
- Where
- 9 sites in China
- Volunteers
- 60 people
- Sponsor
- West China Hospital
Coronary, Coronary Artery Disease
CAPRA-EVO: a Randomized Serial PCCT Trial of Early Evolocumab After ACS
The CAPRA-EVO trial is a single-center, randomized, open-label study with blinded endpoint assessment comparing early evolocumab plus standard lipid-lowering therapy versus standard-of-care lipid-lowering therapy in patients with…
- Trial name
- CAPRA-EVO (NCT07612774)
- Testing
- Evolocumab, Serial photon-counting coronary computed tomography angiography, Standard Lipid-Lowering Therapy
- Where
- 2 sites in China
- Volunteers
- 232 people
- Sponsor
- West China Hospital
Carcinoma, Non-Small-Cell Lung (NSCLC)
Multicenter, Single-Arm, Prospective Phase II Study of Neoadjuvant Cryo-Thermal Ablation Combined With Toripalimab and Chemotherapy for Resectable Stage IB-IIIB Non-Small Cell Lung Cancer
Neoadjuvant chemoimmunotherapy has improved outcomes in patients with resectable non-small cell lung cancer (NSCLC), but a substantial proportion of patients do not achieve a major pathological response.
- Trial name
- NEOCTATC (NCT07855965)
- Testing
- Cryo-Thermal Ablation, Toripalimab, Platinum-based doublet chemotherapy
- Where
- 9 sites in China
- Volunteers
- 40 people
- Sponsor
- West China Hospital
HCC - Hepatocellular Carcinoma, Watch & Wait
Surgery vs. Watch-and-Wait Strategy in Partial & Complete Responders for Hepatocellular Carcinoma
The "Surgery versus Maintenance after Conversion-therapy-achieved Complete/Partial Response in Hepatocellular Carcinoma (SWITCH)" study is a multicenter, open-label, prospective non-randomized cohort study with the protocol…
- Conditions
- HCC - Hepatocellular Carcinoma, Watch & Wait, Surgery
- Trial name
- SWITCH (NCT07410715)
- Testing
- Surgical Resection, Maintenance Therapy Group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- West China Hospital
TNBC - Triple-Negative Breast Cancer
SBRT Combined With PD-1 Inhibitor and Chemotherapy in Early-stage TNBC
Triple-negative breast cancer (TNBC) presents significant challenges due to its limited treatment options and poor efficacy. While neoadjuvant chemotherapy has improved breast-conserving rates and extended survival for TNBC…
- Trial name
- NCT06627712
- Testing
- SBRT+PD-1 Inhibitor + Chemotherapy, PD-1 Inhibitor + Chemotherapy
- Where
- China
- Volunteers
- 318 people
- Sponsor
- West China Hospital
Calcific Aortic Valve Disease, AORTIC VALVE DISEASES
Vericiguat for the Inhibition of Calcific Aortic Valve Stenosis Progression
Calcific aortic valve stenosis (CAVS) is a condition in which the aortic valve progressively narrows and stiffens due to calcium deposition, eventually impairing blood flow from the heart to the body.
- Conditions
- Calcific Aortic Valve Disease, AORTIC VALVE DISEASES, Aortic Valve Stenosis
- Trial name
- VERIFICATION (NCT07715279)
- Testing
- Vericiguat (BAY1021189)
- Where
- China
- Volunteers
- 238 people
- Sponsor
- West China Hospital
Completed, with results posted
All 3Hemangioma
Efficacy and Safety of Propranolol Versus Atenolol on the Proliferative Phase of Infantile Hemangioma
The purpose of this study is to compare the efficacy of orally administered propranolol versus atenolol in the treatment of potentially disfiguring or functionally threatening IHs.
- Trial name
- NCT02342275
- Testing
- Propranolol, Atenolol
- Where
- China
- Volunteers
- 377 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Pain
Dorsal Penile Nerve Block for Rigid Cystoscopy in Men
This study will determine the effectiveness and safety of dorsal penile nerve block (DPNB) in men undergoing rigid cystoscopy.
- Trial name
- NCT02502487
- Testing
- Dorsal Penile Nerve Block, Ropivacaine, Tetracaine
- Where
- China
- Volunteers
- 258 people
- Sponsor
- West China Hospital
Diabetic Nephropathy
Lipo-prostaglandin E1 Improves Renal Hypoxia Evaluated by BOLD-MRI in Patients With Diabetic Nephropathy
The purpose of this study is to evaluate the effect of lipo-prostaglandin E1 （lipo-PGE1) on renal oxygenation in patients with diabetic nephropathy by blood oxygenation level dependent magnetic resonance imaging…
- Trial name
- NCT02628106
- Testing
- Lipo-PGE1
- Where
- China
- Volunteers
- 21 people
- Sponsor
- West China Hospital