Nervous System DiseaseNCT00001367
Diagnosis and History Study of Patients With Different Neurological Conditions
An observational study of Nervous System Disease and Healthy Volunteer, run by National Institute of Neurological Disorders and Stroke (NINDS) at 1 site in United States.
Trial summary
This protocol is a screening and natural history protocol, which allows for evaluation of patients and families where neurological conditions are present for enrollment into other studies and will also be used to screen healthy volunteers to create a pool of potential future HV matches for HMCS protocols. Read more about this study
- Who is it for?
- Ages 2 to 100 years
- Conditions the study is for
- Nervous System Disease, Healthy Volunteer
- How many people
- 3,813 participants
- Where
- 1 siteUnited States
- Study dates
- 30 Sep 1993to not given
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 2 to 100 years
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: The following population groups may participate: - Subjects with neurological disorders who are 2 years old or older, - Family members who are 2 years old or older of people with a neurological disorder, - Healthy volunteers who are 18 years old or older.
Who may be able to join
- Patients with neurological disorders and subjects with a family history of neurological conditions OR
- Healthy volunteers: People age 18 or older who are generally in good health.
Who cannot join
- Patients <2 years old.
- Employees of HMCS in NINDS.
Trial locations and contacts
1 site in 1 country.
United States1 site
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892
About this study
Official title: Diagnosis and Natural History Protocol for Patients With Different Neurological Conditions
This protocol is a screening and natural history protocol, which allows for evaluation of
patients and families where neurological conditions are present for enrollment into other
studies and will also be used to screen healthy volunteers to create a pool of potential future HV matches for HMCS protocols. Through diagnostic evaluations, data will be collected for research use in this study.
...
Read the detailed description
This protocol is a screening and natural history protocol, which allows for evaluation of
patients and families where neurological conditions are present for enrollment into other
studies and will also be used to screen healthy volunteers to create a pool of potential future HV matches for HMCS protocols. Through diagnostic evaluations, data will be collected for research use in this study.
- Conditions
- Nervous System Disease, Healthy Volunteer
- Keywords
- Healthy Volunteer, Nervous System Disease, Natural History
- Medical subject headings
- Nervous System Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| family members | Family Members who are 2 years old or older of people with a neurological disorder | |
| healthy volunteers | healthy volunteers age 18 and older | |
| patients | subjects with neurological disorders who are 2 years old or older |
What is being measured
The primary outcome is the main question the study is designed to answer.
to screen patients with neurological conditions and family members of patients with neurological conditions for enrollment in additional research protocols
The goal is to screen patients with neurological conditions and family members of patients with neurological conditions for enrollment in additional research protocols. No investigational treatments will be administered on this protocol and the NIH physicians will be playing a consultative role to the patient s primary physician.
Measured: ongoing
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Nov 1999 (estimated)
- Study start30 Sep 1993
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Nervous System DiseaseStudies of the same condition, open and under way.
- More trials run by National Institute of Neurological Disorders and Stroke (NINDS)The sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 3,813 participants (actual)
Sponsor and investigators
- Sponsor type
- US National Institutes of Health
- Responsible party
- Sponsor
- Investigators
- Debra J Ehrlich, M.D., Principal investigator, National Institute of Neurological Disorders and Stroke (NINDS)
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00001367
- Sponsor's protocol ID
- 930202
- Other IDs
- 93-N-0202
- Status last verified
- 21 Sep 2026
- First submitted
- 3 Nov 1999
- Last updated
- 5 Nov 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: This protocol was written before creating sharing plans was required. We do share data with other protocols done by our group to avoid having to repeat procedures, but there is no official "research" done in this protocol, so it is unlikely that we will need to share any IPD elsewhere. If there is, we will consider it on a case-by-case basis.
Study at a glance
From the registry record, last updated by the sponsor on 5 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Diagnosis and Natural History Protocol for Patients With Different Neurological Conditions
- ClinicalTrials.gov ID
- NCT00001367
- Acronym / sponsor ID
- 930202
- Conditions
- Nervous System Disease, Healthy Volunteer
- Keywords
- Healthy Volunteer, Nervous System Disease, Natural History
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 3,813 participants (actual)
- Lead sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)US National Institutes of Health
- Study start
- 30 Sep 1993 (actual)
- First posted
- 4 Nov 1999 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This protocol is a screening and natural history protocol, which allows for evaluation of
patients and families where neurological conditions are present for enrollment into other
studies and will also be used to screen healthy volunteers to create a pool of potential future HV matches for HMCS protocols. Through diagnostic evaluations, data will be collected for research use in this study.
...
Detailed description
This protocol is a screening and natural history protocol, which allows for evaluation of
patients and families where neurological conditions are present for enrollment into other
studies and will also be used to screen healthy volunteers to create a pool of potential future HV matches for HMCS protocols. Through diagnostic evaluations, data will be collected for research use in this study.
Study design
- Observational model
- Other
- Time perspective
- Prospective
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| family members | – | –Family Members who are 2 years old or older of people with a neurological disorder |
| healthy volunteers | – | –healthy volunteers age 18 and older |
| patients | – | –subjects with neurological disorders who are 2 years old or older |
Who may qualify
- Ages
- 2 to 100 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- The following population groups may participate: - Subjects with neurological disorders who are 2 years old or older, - Family members who are 2 years old or older of people with a neurological disorder, - Healthy volunteers who are 18 years old or older.
Key inclusion criteria (2 listed)
- Patients with neurological disorders and subjects with a family history of neurological conditions OR
- Healthy volunteers: People age 18 or older who are generally in good health.
Key exclusion criteria (2 listed)
- Patients <2 years old.
- Employees of HMCS in NINDS.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
to screen patients with neurological conditions and family members of patients with neurological conditions for enrollment in additional research protocols
Time frame: ongoing
The goal is to screen patients with neurological conditions and family members of patients with neurological conditions for enrollment in additional research protocols. No investigational treatments will be administered on this protocol and the NIH physicians will be playing a consultative role to the patient s primary physician.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Nov 2026.
- NIH Clinical Center Detailed Web PageLink provided by the sponsor.
- Individual participant dataSharing planned: Undecided. This protocol was written before creating sharing plans was required. We do share data with other protocols done by our group to avoid having to repeat procedures, but there is no official "research" done in this protocol, so it is unlikely that we will need to share any IPD elsewhere. If there is, we will consider it on a case-by-case basis.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Debra J Ehrlich, M.D. principal investigator
National Institute of Neurological Disorders and Stroke (NINDS)
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Nervous System Disease and Healthy Volunteer, run by National Institute of Neurological Disorders and Stroke (NINDS) at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
to screen patients with neurological conditions and family members of patients with neurological conditions for enrollment in additional research protocols (time frame: ongoing). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Nov 2026.