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LymphomaPhase 2NCT00002522

Combination Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Relapsed or Refractory Hodgkin's Lymphoma

A Phase 2 study testing cisplatin, cyclophosphamide and etoposide in people with Lymphoma, run by Temple University at 1 site in United States.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with bone marrow or peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. Read more about this study

Who is it for?
Ages 15 to 70 years
Conditions the study is for
Lymphoma
What is being tested?
cisplatin, cyclophosphamide and etoposide
Type of treatment
Surgery or procedure
How many people
Not given
Where
1 siteUnited States
Study dates
Feb 1993to Feb 2002
Phase
Phase 2
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 15 to 70 years
  • All sexes
  • No healthy volunteers
  • Child, Adult, Older adult

DISEASE CHARACTERISTICS:

  • Histologically proven stage I-IV Hodgkin's lymphoma
  • Must have refractory or relapsed disease, defined by 1 of the following:
  • Failure to achieve a complete remission (CR) after 4 courses of conventional-dose front-line chemotherapy
  • Disease in second or greater remission
  • Patients should be encouraged to undergo transplantation prior to a third salvage regimen
  • Patients previously treated with multiple regimens considered on a case-by-case basis
  • No chemoresistant disease, defined as active progression with tumor growth greater than 25% by volume during first-line chemotherapy
  • Patients who respond to second-line chemotherapy may be eligible
  • Stable residual masses after conventional-dose chemotherapy not considered treatment failures
  • Active (refractory or relapsed) disease must be proven histologically or documented by gallium nitrate uptake
  • Syngeneic marrow transplantation offered to patients with consenting identical twin donor
  • No CNS involvement by lymphoma

PATIENT CHARACTERISTICS:

Age:

  • 15 to 60 (selected patients up to age 70 may be eligible)

Performance status:

  • ECOG 0-2

Life expectancy:

  • Not specified

Hematopoietic:

  • WBC greater than 4,000/mm^3
  • Absolute neutrophil count greater than 2,000/mm^3
  • Platelet count greater than 100,000/mm^3

Hepatic:

  • Bilirubin less than 2.0 mg/dL
  • SGOT and SGPT less than 2 times upper limit of normal
  • Albumin greater than 3.0 g/dL

Renal:

  • Must meet 1 of the following criteria:
  • Creatinine less than 1.8 mg/dL
  • Creatinine clearance greater than 60 mL/min
  • BUN less than 20 mg/dL

Cardiovascular:

  • Left ventricular ejection fraction at least 50%

Pulmonary:

  • DLCO, FEV_1, and FVC greater than 50% of predicted OR
  • Resting pO_2 greater than 70 mm Hg on room air

Other:

  • HIV negative
  • No severe neurologic or emotional disorders
  • No active infection
  • No other disease that would limit life expectancy
  • Not pregnant
  • Fertile patients must use effective contraception
  • Adequate psychosocial support required

PRIOR CONCURRENT THERAPY:

Biologic therapy

  • Not specified

Chemotherapy

  • See Disease Characteristics

Endocrine therapy

  • Not specified

Radiotherapy

  • Not specified

Surgery

  • Not specified

Trial locations and contacts

1 site in 1 country.

United States1 site

  • Fox Chase - Temple Cancer Center

    Philadelphia, Pennsylvania, 19111-2442

Other trials in United States

About this study

Official title: HIGH-DOSE CYCLOPHOSPHAMIDE, ETOPOSIDE, AND CISPLATIN (CEP) WITH RESCUE BY AUTOLOGOUS BONE MARROW OR AUTOLOGOUS PERIPHERAL BLOOD STEM CELLS IN PATIENTS WITH RELAPSED OR REFRACTORY HODGKIN'S DISEASE

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with bone marrow or peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells.

PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy followed by bone marrow or peripheral stem cell transplantation in treating patients with relapsed or refractory Hodgkin's lymphoma.

Read the detailed description

OBJECTIVES:

  • Determine the curative potential of high-dose cyclophosphamide, etoposide, and cisplatin (CEP) followed by syngeneic or autologous bone marrow and/or autologous peripheral blood stem cell (PBSC) rescue in patients with relapsed or refractory stage I-IV Hodgkin's lymphoma.
  • Determine the overall response rate and survival of patients treated with this regimen.
  • Determine the toxicity of this regimen in these patients.
  • Determine the differences in the rate of engraftment, response, and survival of patients treated with bone marrow vs PBSC transplantation.
  • Determine the response rate and survival of patients treated with late consolidative radiotherapy after recovery from transplantation.
  • Determine the toxicity of late consolidative radiotherapy after recovery from transplantation in these patients.

OUTLINE: Syngeneic or autologous bone marrow and/or autologous peripheral blood stem cells (PBSC) are harvested. Syngeneic bone marrow transplantation is preferred for patients with a qualifying identical twin donor. Patients without a syngeneic donor who have a history of lymphomatous involvement of the bone marrow or are profoundly hypocellular undergo harvest of PBSC alone. Patients without a syngeneic donor who have no history of lymphomatous involvement of the bone marrow undergo harvest of autologous bone marrow or PBSC.

Patients receive conditioning comprising cyclophosphamide IV over 1 hour on days -6 to -3 and etoposide IV over 1 hour every 12 hours and cisplatin IV continuously on days -6 to -4. Bone marrow and/or PBSC are infused on day 0. (Patients requiring more than 25 bags of stem cells receive bone marrow transplantation on day 0 and PBSC transplantation on day 1.)

After recovery from transplantation, eligible patients receive consolidative radiotherapy to any site of prior bulk disease (greater than 5 cm) present at any time before transplantation and any site of disease present at the time of transplantation.

Patients are followed at 3, 6, and 12 months and then annually thereafter.

PROJECTED ACCRUAL: A maximum of 30 patients will be accrued for this study.

Conditions
Lymphoma
Being tested
cisplatin, cyclophosphamide, etoposide, autologous bone marrow transplantation, bone marrow ablation with stem cell support
Keywords
stage I adult Hodgkin lymphoma, stage II adult Hodgkin lymphoma, stage III adult Hodgkin lymphoma, stage IV adult Hodgkin lymphoma, recurrent adult Hodgkin lymphoma
Medical subject headings
Lymphoma, Hodgkin Disease

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted27 Jan 2003 (estimated)
  2. Study startFeb 1993
  3. Primary completionFeb 2002
  4. Study completionFeb 2002

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 2
Primary purpose
Treatment
Allocation
Non-randomised
Intervention model
Single group
Masking
None (open label)
IDs, dates and publications
ClinicalTrials.gov ID
NCT00002522
Sponsor's protocol ID
CDR0000078283
Other IDs
TUHSC-2162, NCI-V93-0249
Status last verified
Sep 2010
First submitted
1 Nov 1999
Last updated
1 Oct 2010
Results posted
No

Questions about this trial

What is this clinical trial studying?

A Phase 2 study testing cisplatin, cyclophosphamide and etoposide in people with Lymphoma, run by Temple University at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 1 Oct 2010. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT00002522.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Oct 2010.

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