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Unspecified Adult Solid Tumor, Protocol SpecificPhase 1/2NCT00004063

Cisplatin, Gemcitabine, Interferon Alfa, and Hyperthermia in Treating Patients With Advanced Cancer

A Phase 1/2 study testing recombinant interferon alfa, cisplatin and gemcitabine hydrochloride in people with Unspecified Adult Solid Tumor, Protocol Specific, run by The University of Texas Health Science Center, Houston at 1 site in United States.

Unknown status

Status not confirmed. The sponsor has not verified this record for over two years, so it may be out of date.

Official record
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Trial summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interferon alfa may interfere with the growth of cancer cells. Hyperthermia therapy kills tumor cells by heating them to several degrees above body temperature. Read more about this study

Who is it for?
Ages 18 years and older
What is being tested?
recombinant interferon alfa, cisplatin and gemcitabine hydrochloride
Type of treatment
Surgery or procedure
How many people
30 participants
Where
1 siteUnited States
Study dates
Aug 1999to Nov 2011
Phase
Phase 1/2
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

DISEASE CHARACTERISTICS:

  • Histologically confirmed metastatic, recurrent, or refractory carcinoma
  • Measurable disease by CT, MRI, or physical examination
  • No brain metastases or other CNS disorders

PATIENT CHARACTERISTICS:

Age:

  • 18 and over

Performance status:

  • Karnofsky 60-100%

Life expectancy:

  • At least 12 weeks

Hematopoietic:

  • Absolute granulocyte count at least 1,500/mm^3
  • Platelet count at least 90,000/mm^3
  • Bone marrow cellularity normal on bone marrow biopsy
  • No coagulopathy disorder

Hepatic:

  • Bilirubin no greater than 2.0 mg/dL
  • SGOT no greater than 2 times upper limit of normal
  • PT less than 14 seconds
  • PTT less than 35 seconds
  • No inadequate liver function (no greater than 20% involvement)

Renal:

  • Creatinine no greater than 1.8 mg/dL
  • Creatinine clearance at least 45 mL/min
  • BUN no greater than 25 mg/dL

Cardiovascular:

  • Adequate cardiac function documented by history, physical exam, or stress exercise test (MUGA or ECHO) with resting blood pressure and heart rate increasing appropriately with exercise
  • LVEF at least 45%
  • No prior myocardial infarction
  • No symptomatic coronary artery disease
  • No angina
  • No significant arrhythmia
  • No uncontrolled hypertension
  • No thromboembolic disease

Pulmonary:

  • FEV_1 at least 70% of predicted
  • Arterial PO_2 at least 60 mmHg on room air
  • No massive (greater than 30% involvement) lung disease
  • DLCO greater than 50% of predicted

Other:

  • Not pregnant or nursing
  • Fertile patients must use effective contraception
  • HIV negative
  • No seizure disorders
  • No significant emotional instability
  • No history of malignant hyperthermia following general anesthesia
  • No other concurrent medical illness that would prevent compliance

PRIOR CONCURRENT THERAPY:

Biologic therapy:

  • Not specified

Chemotherapy:

  • Prior chemotherapy allowed

Endocrine therapy:

  • Not specified

Radiotherapy:

  • Not specified

Surgery:

  • At least 6 days since major thoracic or abdominal surgery

Other:

  • No concurrent cardiac glycosides, antiangina drugs, arrhythmia drugs, anticoagulants, thrombolytic agents, adrenal corticosteroids, or aspirin

Trial locations and contacts

1 site in 1 country.

United States1 site, 1 recruiting

  • University of Texas Health Science Center at Houston

    Houston, Texas, 77225

    Joan M.C. Bull, MD, 713-500-6820, joan.m.bull@uth.tmc.edu

    Recruiting

Other trials in United States

About this study

Official title: A Phase I-II Clinical Trial of Cisplatin (Platinol) Followed by Gemcitabine HCl (Gemzar) in Combination With Mild, Fever-Range Whole Body Hyperthermia (LL-WBH) at 40C in Patients With Advanced Malignancies

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interferon alfa may interfere with the growth of cancer cells. Hyperthermia therapy kills tumor cells by heating them to several degrees above body temperature. Combining hyperthermia with chemotherapy and interferon alfa may kill more tumor cells.

PURPOSE: This phase I/II trial is studying the side effects of cisplatin, gemcitabine, interferon alfa, and whole-body hyperthermia and how well they work in treating patients with metastatic, recurrent, or refractory cancer.

Read the detailed description

OBJECTIVES:

  • Determine the toxicity and tumor response in patients with metastatic, recurrent, or refractory malignancies treated with cisplatin, gemcitabine, interferon alfa, and long-duration, low temperature whole body hyperthermia (LL-WBH).

OUTLINE: This is a dose escalation study of cisplatin.

  • Phase I and II: Patients receive gemcitabine IV over 30 minutes on day 1 and 8. Patients receive cisplatin IV over 6 hours on day 15, followed by subcutaneous interferon alfa on days 16 and 17. Patients undergo long-duration, low temperature whole body hyperthermia over 6 hours plus gemcitabine over 30 minutes on day 17. Courses repeat every 5 weeks in the absence of disease progression or unacceptable toxicity.
  • Phase I: Cohorts of 3-6 patients receive escalating doses of cisplatin until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which at least 2 of 3 or 2 of 6 patients experience dose limiting toxicity. The MTD of cisplatin is used for phase II study.

PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.

Being tested
recombinant interferon alfa, cisplatin, gemcitabine hydrochloride, hyperthermia treatment
Keywords
unspecified adult solid tumor, protocol specific

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Response duration

  2. Duration of stable disease

  3. Overall survival

  4. Progression-free survival

  5. Time to response

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted27 Jan 2003 (estimated)
  2. Study startAug 1999
  3. Primary completionNov 2011 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 1/2
Primary purpose
Treatment
Enrolment
30 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT00004063
Sponsor's protocol ID
CDR0000067264
Other IDs
UTHSC-MS-99116, NCI-V99-1561
Status last verified
Dec 2008
First submitted
10 Dec 1999
Last updated
30 Apr 2009
Results posted
No

Questions about this trial

What is this clinical trial studying?

A Phase 1/2 study testing recombinant interferon alfa, cisplatin and gemcitabine hydrochloride in people with Unspecified Adult Solid Tumor, Protocol Specific, run by The University of Texas Health Science Center, Houston at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: status not confirmed, as of the sponsor's last update on 30 Apr 2009. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this combined phase mean?

Phase 1 studies test a treatment in a small group of people for the first time or in a new way, mainly to check safety and find the right dose.

Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

Results are not available in the source record.

How can a doctor refer a patient or contact the research team?

Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Response duration. The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT00004063.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Apr 2009.

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