Cardiovascular DiseasesNCT00005125
NAS-NRC Twin Registry
An observational study of Cardiovascular Diseases and Heart Diseases, run by National Heart, Lung, and Blood Institute (NHLBI).
Trial summary
To continue a registry of World War II veteran twins maintained by the National Academy of Sciences-National Research Council (NAS-NRC). Read more about this study
- Who is it for?
- Any age, men only
- Conditions the study is for
- Cardiovascular Diseases, Heart Diseases, Coronary Disease
- How many people
- Not given
- Where
- No sites listed yet
- Study dates
- Jul 1970to Sep 1988
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- Men only
- No healthy volunteers
- Child, Adult, Older adult
No eligibility criteria
About this study
To continue a registry of World War II veteran twins maintained by the National Academy of Sciences-National Research Council (NAS-NRC).
Read the detailed description
BACKGROUND:
The registry of World War II veteran twins came into existence in the late 1960's through a search and link effort of state vital statistics records and Veterans Administration files through the Medical Follow-up Agency of NAS-NRC. Since that time, the registry has served as a data resource for investigators in a variety of scientific fields who want to study genetic and environmental aspects of various human characteristics. Because of the size and geographic coverage throughout the United States, the registry offers a method of recruiting sizeable numbers of twins for study even under geographic restrictions. Of special value to medical researchers is the built-in medical follow-up for morbidity and mortality through Veterans Administration insurance and benefits records. This allows researchers to gather baseline data which may be related prospectively to morbidity and mortality events.
The NHLBI has made extensive use of the World War II veteran twin registry beginning in 1969, when the NHLBI Twin Study was initiated. At that time, NHLBI used the World War II veteran twin registry to recruit a group of 514 pairs of twins in five geographic areas to participate in a study which included a battery of questionnaires and a physical examination. Since that time, a second examination and third examination of the cohort have been completed and the registry has been used to maintain contact with the twins and provide surveillance for morbidity and mortality events of the participants in the study.
DESIGN NARRATIVE:
Maintenance of the existing registry continued as addresses of all members were updated annually as well as morbidity and mortality data through surveillance of Veterans Administration insurance and death benefit records or through the National Death Index. All morbid events and deaths were coded by ICD codes. Support activities were provided for the NHLBI Twin Study including providing death certificates for events occurring among the 1,028 twins participating in the study and mailed questionnaire follow-up.
Although contract support ended in September, 1988, analyses of the survey and mortality data are continuing.
- Medical subject headings
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Myocardial Ischemia, Obesity
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 May 2000 (estimated)
- Study startJul 1970
- Study completionSep 1988
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (71)Papers the sponsor has linked to this study.
- Other trials for Cardiovascular DiseasesStudies of the same condition, open and under way.
- More trials run by National Heart, Lung, and Blood Institute (NHLBI)The sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
Sponsor and investigators
- Sponsor type
- US National Institutes of Health
- Investigators
- Zdenek HrubecDennis Robinette
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00005125
- Sponsor's protocol ID
- 904
- Status last verified
- Jun 2001
- First submitted
- 25 May 2000
- Last updated
- 3 Jun 2015
- Results posted
- No
Publications
Jablon S, Neel JV, Gershowitz H, Atkinson GF. The NAS-NRC twin panel: methods of construction of the panel, zygosity diagnosis, and proposed use. Am J Hum Genet. 1967 Mar;19(2):133-61. No abstract available.
PubMed 6067093Cederlof R, Friberg L, Hrubec Z. Cardiovascular and respiratory symptoms in relation to tobacco smoking. A study on American twins. Arch Environ Health. 1969 Jun;18(6):934-40. doi: 10.1080/00039896.1969.10665517. No abstract available.
PubMed 5770694Pollin W, Allen MG, Hoffer A, Stabenau JR, Hrubec Z. Psychopathology in 15,909 pairs of veteran twins: evidence for a genetic factor in the pathogenesis of schizophrenia and its relative absence in psychoneurosis. Am J Psychiatry. 1969 Nov;126(5):597-610. doi: 10.1176/ajp.126.5.597. No abstract available.
PubMed 5352613Allen MG, Pollin W. Schizophrenia in twins and the diffuse ego boundary hypothesis. Am J Psychiatry. 1970 Oct;127(4):437-42. doi: 10.1176/ajp.127.4.437. No abstract available.
PubMed 5459506Feinleib M, Havlik RJ, Kwiterovich PO, Tillotson J, Garrison RJ. The National Heart Institute Twin Study. Acta Genet Med Gemellol (Roma). 1970 Jan-Apr;19(1):243-7. doi: 10.1017/s1120962300025592. No abstract available.
PubMed 5533774Hoeffer A, Pollin W. Schizophrenia in the NAS-NRC panel of 15,909 veteran twin pairs. Arch Gen Psychiatry. 1970 Nov;23(5):469-77. doi: 10.1001/archpsyc.1970.01750050085012. No abstract available.
PubMed 5478575Reuling FH, Schwartz JT. Heritability of the effect of corticosteroids on intraocular pressure. Acta Genet Med Gemellol (Roma). 1970 Jan-Apr;19(1):264-7. doi: 10.1017/s1120962300025658. No abstract available.
PubMed 5533775Stabenau JR, Pollin W, Allen MG. Twin studies in schizophrenia and neurosis. Semin Psychiatry. 1970 Feb;2(1):65-74. No abstract available.
PubMed 5535862Cederlof R, Epstein FH, Friberg, et al: Twin Registries in the Study of Chronic Disease. Report of an International Symposium in San Juan, Puerto Rico, 1-4 December 1969, Acta Med Scand Suppl. 523, 1971
Allen MG, Cohen S, Pollin W. Schizophrenia in veteran twins: a diagnostic review. Am J Psychiatry. 1972 Feb;128(8):939-45. doi: 10.1176/ajp.128.8.939. No abstract available.
PubMed 4550731Cohen SM, Allen MG, Pollin W, Hrubec Z. Relationship of schizo-affective psychosis to manic depressive psychosis and shizophrenia. Findings in 15,909 veteran pairs. Arch Gen Psychiatry. 1972 Jun;26(6):539-46. doi: 10.1001/archpsyc.1972.01750240051008. No abstract available.
PubMed 4554807Hrubec Z, Sutton ES. Smoking and health. Lancet. 1972 Oct 28;2(7783):932. doi: 10.1016/s0140-6736(72)92580-9. No abstract available.
PubMed 4116641Schwartz JT, Reuling FH, Feinleib M, Garrison RJ, Collie DJ. Twin heritability study of the effect of corticosteroids on intraocular pressure. J Med Genet. 1972 Jun;9(2):137-43. doi: 10.1136/jmg.9.2.137. No abstract available.
PubMed 5065285Hrubec Z. The effect of diagnostic ascertainment in twins on the assessment of the genetic factor in disease etiology. Am J Hum Genet. 1973 Jan;25(1):15-28. No abstract available.
PubMed 4684503Coffee drinking and ischaemic heart-disease. Lancet. 1973 Mar 10;1(7802):548-9. No abstract available.
PubMed 4119977
Study at a glance
From the registry record, last updated by the sponsor on 3 Jun 2015. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- NAS-NRC Twin Registry
- ClinicalTrials.gov ID
- NCT00005125
- Acronym / sponsor ID
- 904
- Study type
- Observational
- Recruitment status
- Completed
- Lead sponsor
- National Heart, Lung, and Blood Institute (NHLBI)US National Institutes of Health
- Study start
- Jul 1970
- Study completion
- Sep 1988
- First posted
- 26 May 2000 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To continue a registry of World War II veteran twins maintained by the National Academy of Sciences-National Research Council (NAS-NRC).
Detailed description
BACKGROUND:
The registry of World War II veteran twins came into existence in the late 1960's through a search and link effort of state vital statistics records and Veterans Administration files through the Medical Follow-up Agency of NAS-NRC. Since that time, the registry has served as a data resource for investigators in a variety of scientific fields who want to study genetic and environmental aspects of various human characteristics. Because of the size and geographic coverage throughout the United States, the registry offers a method of recruiting sizeable numbers of twins for study even under geographic restrictions. Of special value to medical researchers is the built-in medical follow-up for morbidity and mortality through Veterans Administration insurance and benefits records. This allows researchers to gather baseline data which may be related prospectively to morbidity and mortality events.
The NHLBI has made extensive use of the World War II veteran twin registry beginning in 1969, when the NHLBI Twin Study was initiated. At that time, NHLBI used the World War II veteran twin registry to recruit a group of 514 pairs of twins in five geographic areas to participate in a study which included a battery of questionnaires and a physical examination. Since that time, a second examination and third examination of the cohort have been completed and the registry has been used to maintain contact with the twins and provide surveillance for morbidity and mortality events of the participants in the study.
DESIGN NARRATIVE:
Maintenance of the existing registry continued as addresses of all members were updated annually as well as morbidity and mortality data through surveillance of Veterans Administration insurance and death benefit records or through the National Death Index. All morbid events and deaths were coded by ICD codes. Support activities were provided for the NHLBI Twin Study including providing death certificates for events occurring among the 1,028 twins participating in the study and mailed questionnaire follow-up.
Although contract support ended in September, 1988, analyses of the survey and mortality data are continuing.
Study design
Who may qualify
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Not reported in the source record.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Jun 2015.
- Background: PubMed 6067093Jablon S, Neel JV, Gershowitz H, Atkinson GF. The NAS-NRC twin panel: methods of construction of the panel, zygosity diagnosis, and proposed use. Am J Hum Genet. 1967 Mar;19(2):133-61. No abstract available.
- Background: PubMed 5770694Cederlof R, Friberg L, Hrubec Z. Cardiovascular and respiratory symptoms in relation to tobacco smoking. A study on American twins. Arch Environ Health. 1969 Jun;18(6):934-40. doi: 10.1080/00039896.1969.10665517. No abstract available.
- Background: PubMed 5352613Pollin W, Allen MG, Hoffer A, Stabenau JR, Hrubec Z. Psychopathology in 15,909 pairs of veteran twins: evidence for a genetic factor in the pathogenesis of schizophrenia and its relative absence in psychoneurosis. Am J Psychiatry. 1969 Nov;126(5):597-610. doi: 10.1176/ajp.126.5.597. No abstract available.
- Background: PubMed 5459506Allen MG, Pollin W. Schizophrenia in twins and the diffuse ego boundary hypothesis. Am J Psychiatry. 1970 Oct;127(4):437-42. doi: 10.1176/ajp.127.4.437. No abstract available.
- Background: PubMed 5533774Feinleib M, Havlik RJ, Kwiterovich PO, Tillotson J, Garrison RJ. The National Heart Institute Twin Study. Acta Genet Med Gemellol (Roma). 1970 Jan-Apr;19(1):243-7. doi: 10.1017/s1120962300025592. No abstract available.
- Background: PubMed 5478575Hoeffer A, Pollin W. Schizophrenia in the NAS-NRC panel of 15,909 veteran twin pairs. Arch Gen Psychiatry. 1970 Nov;23(5):469-77. doi: 10.1001/archpsyc.1970.01750050085012. No abstract available.
- Background: PubMed 5533775Reuling FH, Schwartz JT. Heritability of the effect of corticosteroids on intraocular pressure. Acta Genet Med Gemellol (Roma). 1970 Jan-Apr;19(1):264-7. doi: 10.1017/s1120962300025658. No abstract available.
- Background: PubMed 5535862Stabenau JR, Pollin W, Allen MG. Twin studies in schizophrenia and neurosis. Semin Psychiatry. 1970 Feb;2(1):65-74. No abstract available.
- BackgroundCederlof R, Epstein FH, Friberg, et al: Twin Registries in the Study of Chronic Disease. Report of an International Symposium in San Juan, Puerto Rico, 1-4 December 1969, Acta Med Scand Suppl. 523, 1971
- Background: PubMed 4550731Allen MG, Cohen S, Pollin W. Schizophrenia in veteran twins: a diagnostic review. Am J Psychiatry. 1972 Feb;128(8):939-45. doi: 10.1176/ajp.128.8.939. No abstract available.
- Background: PubMed 4554807Cohen SM, Allen MG, Pollin W, Hrubec Z. Relationship of schizo-affective psychosis to manic depressive psychosis and shizophrenia. Findings in 15,909 veteran pairs. Arch Gen Psychiatry. 1972 Jun;26(6):539-46. doi: 10.1001/archpsyc.1972.01750240051008. No abstract available.
- Background: PubMed 4116641Hrubec Z, Sutton ES. Smoking and health. Lancet. 1972 Oct 28;2(7783):932. doi: 10.1016/s0140-6736(72)92580-9. No abstract available.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Zdenek Hrubec
Dennis Robinette
Questions about this trial
What is this clinical trial studying?
An observational study of Cardiovascular Diseases and Heart Diseases, run by National Heart, Lung, and Blood Institute (NHLBI).
The full registered description is in the About this study section and the official record.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Jun 2015. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT00005125, which also lists 71 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Jun 2015; AzTrials last refreshed its copy on 29 Oct 2026.