Cardiovascular DiseasesNCT00005138
High Blood Pressure in the Young
An observational study of Cardiovascular Diseases and Heart Diseases, run by National Heart, Lung, and Blood Institute (NHLBI).
Trial summary
To continue a longitudinal study of blood pressure and blood pressure correlates in a population of 1,140 young adults, first seen in 1973 as adolescents, aged 14-19 years. Read more about this study
- Who is it for?
- Ages Up to 100 years, men only
- Conditions the study is for
- Cardiovascular Diseases, Heart Diseases, Hypertension
- How many people
- Not given
- Where
- No sites listed yet
- Study dates
- Jun 1976to Jun 1989
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Up to 100 years
- Men only
- No healthy volunteers
- Child, Adult, Older adult
No eligibility criteria
About this study
To continue a longitudinal study of blood pressure and blood pressure correlates in a population of 1,140 young adults, first seen in 1973 as adolescents, aged 14-19 years.
Read the detailed description
BACKGROUND:
This study was funded in response to a Request for Application issued in 1975 on High Blood Pressure in the Young. The program on High Blood Pressure in the Young grew out of an awareness that adult hypertension might have its origins in adolescence or even in childhood or infancy. In 1975 NHLBI was supporting little research, except for the Specialized Centers of Research, in identifying the precursors of high blood pressure operating at an early age. Sixteen grants were funded through the program. The program was concluded in 1978 but Dr. Kotchen's grant was renewed as a regular research grant. A second population group was followed in the grant period. From an original population of 409 pregnant, nulliparous adolescents aged 12-18 who had enrolled in the University of Kentucky Young Mothers Program between 1971-1974, 70 were diagnosed as having hypertension during the third trimester of pregnancy. These 70 women plus a control group of 54 normotensive women from the same population were studied as were their children. Blood pressures were measured in young mothers at 3-6 years and at 6-9 years after their first pregnancy. Women with a history of hypertension during pregnancy were heavier, maintained higher blood pressure and had a greater incidence of hypertension in subsequent pregnancies. At the second follow-up, systolic blood pressure and body weight of male children born to hypertensive women were greater than those in males born to normotensive women. Blood pressures of female children of the two groups of mothers did not differ.
DESIGN NARRATIVE:
In 1973 standardized blood pressure, height, and weight were measured in all 14-19 year old students of Bourbon County High School in Kentucky. Additional information collected included age, date of birth, sex, and race. In 1978 a five year follow-up study was undertaken of all adolescents 14-15 years old at the time of the initial survey and of selected 16-19 year olds who were in the high, intermediate, and low ranges of the blood pressure distributions. Follow-up measurements included weight, height, and blood pressure in all subjects, and sodium excretion, serum cholesterol, glucose, triglycerides, exercise, and uric acid concentrations, electrocardiograms, and echocardiograms in the older group. In 1984 the follow-up also included information on socioeconomic variables, medical and family histories, smoking, exercise, life events, coronary-prone behavior, and anxiety. Plasma renin activity and plasma aldosterone were measured before and after treadmill exercise in those young adults with relatively high and relatively low blood pressures to determine if the renin-aldosterone axis is suppressed before the appearance of hypertension. Studies were continued on physiologic, psychosocial, and behavioral risk factors for hypertension, age-related trends in cardiovascular risk factors over time, correlates of elevated blood pressure, and the early cardiac consequences of high blood pressure.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Medical subject headings
- Cardiovascular Diseases, Heart Diseases, Hypertension
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 May 2000 (estimated)
- Study startJun 1976
- Study completionJun 1989
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (20)Papers the sponsor has linked to this study.
- Other trials for Cardiovascular DiseasesStudies of the same condition, open and under way.
- More trials run by National Heart, Lung, and Blood Institute (NHLBI)The sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
Sponsor and investigators
- Sponsor type
- US National Institutes of Health
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00005138
- Sponsor's protocol ID
- 1009
- Other IDs
- R01HL019956
- Status last verified
- May 2000
- First submitted
- 25 May 2000
- Last updated
- 13 May 2016
- Results posted
- No
Publications
Kotchen JM. Effect of relative weight on familial blood pressure aggregations. Am J Epidemiol. 1977 Mar;105(3):214-22. doi: 10.1093/oxfordjournals.aje.a112377.
PubMed 848475Kotchen JM, Kotchen TA. Geographic effect on racial blood pressure differences in adolescents. J Chronic Dis. 1978;31(9-10):581-6. doi: 10.1016/0021-9681(78)90018-8. No abstract available.
PubMed 744788Kotchen JM, Kotchen TA, Cottrill CM, Guthrie GP Jr, Somes G. Blood pressures of young mothers and their first children 3-6 years following hypertension during pregnancy. J Chronic Dis. 1979;32(9-10):653-9. doi: 10.1016/0021-9681(79)90095-x. No abstract available.
PubMed 489705Kotchen TA, Kotchen JM, Guthrie GP Jr, Cottrill CM. Plasma renin activity, reactivity, concentration and substrate following hypertension during pregnancy. Effect of oral contraceptive agents. Hypertension. 1979 Jul-Aug;1(4):355-61. doi: 10.1161/01.hyp.1.4.355.
PubMed 396239Cottrill CM, Kotchen JM, Guthrie G, Kotchen T. Cardiovascular responses to exercise following adolescent hypertensive pregnancy. J Adolesc Health Care. 1980 Dec;1(2):91-5. doi: 10.1016/s0197-0070(80)80031-3.
PubMed 7298484Kotchen TA, Havlik RJ. High blood pressure in the young. Ann Intern Med. 1980 Feb;92(2 Pt 1):254-5. No abstract available.
PubMed 7352733Kotchen TA, Guthrie GP Jr. Renin-angiotensin-aldosterone and hypertension. Endocr Rev. 1980 Winter;1(1):78-99. doi: 10.1210/edrv-1-1-78. No abstract available.
PubMed 6112143Kotchen TA, Havlik RJ. High blood pressure in the young symposium. Hypertension. 1980 Jul-Aug;2(4 Pt 2):I134-5. doi: 10.1161/01.hyp.2.4_pt_2.i134. No abstract available.
PubMed 7399634Kotchen JM, Kotchen TA, Guthrie GP Jr, Cottrill CM, McKean HE. Correlates of adolescent blood pressure at five-year follow-up. Hypertension. 1980 Jul-Aug;2(4 Pt 2):124-9.
PubMed 7399644Kotchen TA, Kotchen JM: Clinical Approaches to High Blood Pressure in the Young. Cardiovasc Rev & Reports, 1:53-57, 1980
Kotchen JM, Kotchen TA: Correlates of High Blood Pressure in Adolescents. In: High Blood Pressure in the Young and Old. Proceedings of the Sixth Hahnemann International Symposium. Onesti G, Kim K (Eds), Grune & Stratton, p 173-182, 1981
Kotchen TA, Guthrie GP Jr, McKean H, Kotchen JM. Adrenergic responsiveness in prehypertensive subjects. Circulation. 1982 Feb;65(2):285-90. doi: 10.1161/01.cir.65.2.285.
PubMed 7032747Kotchen TA, Guthrie GP Jr, Cottrill CM, McKean HE, Kotchen JM. Low renin-aldosterone in "prehypertensive" young adults. J Clin Endocrinol Metab. 1982 Apr;54(4):808-14. doi: 10.1210/jcem-54-4-808.
PubMed 7037816Kotchen JM, McKean HE, Kotchen TA. Blood pressure of young mothers and their children after hypertension in adolescent pregnancy: six- to nine-year follow-up. Am J Epidemiol. 1982 Jun;115(6):861-7. doi: 10.1093/oxfordjournals.aje.a113373.
PubMed 7091144Cottrill CM, Kotchen JM, Guthrie GP Jr, Kotchen TA. Low renin in young mothers and their children following hypertension in pregnancy. Hypertension. 1982 May-Jun;4(3 Pt 2):119-24.
PubMed 7040236
Study at a glance
From the registry record, last updated by the sponsor on 13 May 2016. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- High Blood Pressure in the Young
- ClinicalTrials.gov ID
- NCT00005138
- Acronym / sponsor ID
- 1009
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Study type
- Observational
- Recruitment status
- Completed
- Lead sponsor
- National Heart, Lung, and Blood Institute (NHLBI)US National Institutes of Health
- Study start
- Jun 1976
- Study completion
- Jun 1989 (actual)
- First posted
- 26 May 2000 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To continue a longitudinal study of blood pressure and blood pressure correlates in a population of 1,140 young adults, first seen in 1973 as adolescents, aged 14-19 years.
Detailed description
BACKGROUND:
This study was funded in response to a Request for Application issued in 1975 on High Blood Pressure in the Young. The program on High Blood Pressure in the Young grew out of an awareness that adult hypertension might have its origins in adolescence or even in childhood or infancy. In 1975 NHLBI was supporting little research, except for the Specialized Centers of Research, in identifying the precursors of high blood pressure operating at an early age. Sixteen grants were funded through the program. The program was concluded in 1978 but Dr. Kotchen's grant was renewed as a regular research grant. A second population group was followed in the grant period. From an original population of 409 pregnant, nulliparous adolescents aged 12-18 who had enrolled in the University of Kentucky Young Mothers Program between 1971-1974, 70 were diagnosed as having hypertension during the third trimester of pregnancy. These 70 women plus a control group of 54 normotensive women from the same population were studied as were their children. Blood pressures were measured in young mothers at 3-6 years and at 6-9 years after their first pregnancy. Women with a history of hypertension during pregnancy were heavier, maintained higher blood pressure and had a greater incidence of hypertension in subsequent pregnancies. At the second follow-up, systolic blood pressure and body weight of male children born to hypertensive women were greater than those in males born to normotensive women. Blood pressures of female children of the two groups of mothers did not differ.
DESIGN NARRATIVE:
In 1973 standardized blood pressure, height, and weight were measured in all 14-19 year old students of Bourbon County High School in Kentucky. Additional information collected included age, date of birth, sex, and race. In 1978 a five year follow-up study was undertaken of all adolescents 14-15 years old at the time of the initial survey and of selected 16-19 year olds who were in the high, intermediate, and low ranges of the blood pressure distributions. Follow-up measurements included weight, height, and blood pressure in all subjects, and sodium excretion, serum cholesterol, glucose, triglycerides, exercise, and uric acid concentrations, electrocardiograms, and echocardiograms in the older group. In 1984 the follow-up also included information on socioeconomic variables, medical and family histories, smoking, exercise, life events, coronary-prone behavior, and anxiety. Plasma renin activity and plasma aldosterone were measured before and after treadmill exercise in those young adults with relatively high and relatively low blood pressures to determine if the renin-aldosterone axis is suppressed before the appearance of hypertension. Studies were continued on physiologic, psychosocial, and behavioral risk factors for hypertension, age-related trends in cardiovascular risk factors over time, correlates of elevated blood pressure, and the early cardiac consequences of high blood pressure.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
Study design
Who may qualify
- Ages
- Up to 100 years
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Not reported in the source record.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 May 2016.
- Background: PubMed 848475Kotchen JM. Effect of relative weight on familial blood pressure aggregations. Am J Epidemiol. 1977 Mar;105(3):214-22. doi: 10.1093/oxfordjournals.aje.a112377.
- Background: PubMed 744788Kotchen JM, Kotchen TA. Geographic effect on racial blood pressure differences in adolescents. J Chronic Dis. 1978;31(9-10):581-6. doi: 10.1016/0021-9681(78)90018-8. No abstract available.
- Background: PubMed 489705Kotchen JM, Kotchen TA, Cottrill CM, Guthrie GP Jr, Somes G. Blood pressures of young mothers and their first children 3-6 years following hypertension during pregnancy. J Chronic Dis. 1979;32(9-10):653-9. doi: 10.1016/0021-9681(79)90095-x. No abstract available.
- Background: PubMed 396239Kotchen TA, Kotchen JM, Guthrie GP Jr, Cottrill CM. Plasma renin activity, reactivity, concentration and substrate following hypertension during pregnancy. Effect of oral contraceptive agents. Hypertension. 1979 Jul-Aug;1(4):355-61. doi: 10.1161/01.hyp.1.4.355.
- Background: PubMed 7298484Cottrill CM, Kotchen JM, Guthrie G, Kotchen T. Cardiovascular responses to exercise following adolescent hypertensive pregnancy. J Adolesc Health Care. 1980 Dec;1(2):91-5. doi: 10.1016/s0197-0070(80)80031-3.
- Background: PubMed 7352733Kotchen TA, Havlik RJ. High blood pressure in the young. Ann Intern Med. 1980 Feb;92(2 Pt 1):254-5. No abstract available.
- Background: PubMed 6112143Kotchen TA, Guthrie GP Jr. Renin-angiotensin-aldosterone and hypertension. Endocr Rev. 1980 Winter;1(1):78-99. doi: 10.1210/edrv-1-1-78. No abstract available.
- Background: PubMed 7399634Kotchen TA, Havlik RJ. High blood pressure in the young symposium. Hypertension. 1980 Jul-Aug;2(4 Pt 2):I134-5. doi: 10.1161/01.hyp.2.4_pt_2.i134. No abstract available.
- Background: PubMed 7399644Kotchen JM, Kotchen TA, Guthrie GP Jr, Cottrill CM, McKean HE. Correlates of adolescent blood pressure at five-year follow-up. Hypertension. 1980 Jul-Aug;2(4 Pt 2):124-9.
- BackgroundKotchen TA, Kotchen JM: Clinical Approaches to High Blood Pressure in the Young. Cardiovasc Rev & Reports, 1:53-57, 1980
- BackgroundKotchen JM, Kotchen TA: Correlates of High Blood Pressure in Adolescents. In: High Blood Pressure in the Young and Old. Proceedings of the Sixth Hahnemann International Symposium. Onesti G, Kim K (Eds), Grune & Stratton, p 173-182, 1981
- Background: PubMed 7032747Kotchen TA, Guthrie GP Jr, McKean H, Kotchen JM. Adrenergic responsiveness in prehypertensive subjects. Circulation. 1982 Feb;65(2):285-90. doi: 10.1161/01.cir.65.2.285.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Cardiovascular Diseases and Heart Diseases, run by National Heart, Lung, and Blood Institute (NHLBI).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 May 2016. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT00005138, which also lists 20 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 May 2016; AzTrials last refreshed its copy on 6 Nov 2026.