Blood TransfusionNCT00005319
Epidemiologic Studies of Blood Use in the United States - SCOR in Transfusion Medicine
An observational study of Blood Transfusion, run by National Heart, Lung, and Blood Institute (NHLBI).
Trial summary
To develop and apply quantitative methods by which to measure and characterize blood transfusion practice in specific diagnoses and procedures; to open scientific communication about transfusion practice within and across institutions; and to develop simpler methods for estimating annual national blood collections and… Read more about this study
- Who is it for?
- Ages Up to 100 years, men only
- Conditions the study is for
- Blood Transfusion
- How many people
- Not given
- Where
- No sites listed yet
- Study dates
- Sep 1985to Dec 1996
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Up to 100 years
- Men only
- No healthy volunteers
- Child, Adult, Older adult
No eligibility criteria
About this study
To develop and apply quantitative methods by which to measure and characterize blood transfusion practice in specific diagnoses and procedures; to open scientific communication about transfusion practice within and across institutions; and to develop simpler methods for estimating annual national blood collections and transfusions.
Read the detailed description
DESIGN NARRATIVE:
The study was a subproject within a Specialized Centers of Research (SCOR) in Transfusion Medicine. The experimental design was based on the study and analysis of several unique sets of data. One set consisted of abstracted patient data including ICD-9-CM diagnosis and procedure, DRG and red cell units transfused, from a constant set 100 of United States hospitals for the years 1980,82,84,86, to which a new set of data was added for the year 1989. A similar set of data were gathered from eight cooperating teaching hospitals over the first four years of the grant term; this set included data for transfusions of all blood components, autologous units and factor preparations. A third data base contained the data for four United States surveys conducted in 1982,84,86,87; and was expanded to include 1990 and 92. Using these data, four main tasks were addressed. A Pan-DRG red cell transfusion study was conducted to ascertain red cell use across all DRGs and ICD-9-CM codes. Extensive efforts were devoted to developing new methods to characterize transfusion practice. A series of studies were devoted to characterizing transfusions of all blood components in a selected number of ICD-9-CM classes. The purpose of the fourth task was to develop simpler and more rapid alternative methods for producing national estimates of transfusion activity; as part of this task,new surveys were conducted for 1990 and 92.
Among the questions studied were: Was it possible to identify distinctive attributes of the patients who, though operated, did not require a transfusion or who required a large volume of blood? Were transfusions of non-red cell components related to use of red cells? Could transfusion frequency diagnosis for all blood products be used as a measure of transfusion practice? Did longitudinal comparisons of transfusions over the 9-year interval, 1980-1989, reveal significant trends? Was it possible to discriminate quantitatively between transfusion practices in different hospitals or set of hospitals, or at different times? What was the effect of autologous blood programs in transfusion practice? What was the contribution of comorbid conditions on red cell and component transfusion patterns.?
The dollars for the subproject were approximately 25 percent of total dollars spent each year for the Center.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
- Conditions
- Blood Transfusion
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 May 2000 (estimated)
- Study startSep 1985
- Study completionDec 1996
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (12)Papers the sponsor has linked to this study.
- Other trials for Blood TransfusionStudies of the same condition, open and under way.
- More trials run by National Heart, Lung, and Blood Institute (NHLBI)The sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
Sponsor and investigators
- Sponsor type
- US National Institutes of Health
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00005319
- Sponsor's protocol ID
- 4093
- Other IDs
- P50HL033774
- Status last verified
- May 2002
- First submitted
- 25 May 2000
- Last updated
- 18 Feb 2016
- Results posted
- No
Publications
Wallace EL, Churchill WH, Surgenor DM, Cho GS, McGurk S. Collection and transfusion of blood and blood components in the United States, 1994. Transfusion. 1998 Jul;38(7):625-36. doi: 10.1046/j.1537-2995.1998.38798346630.x.
PubMed 9683100Churchill WH, McGurk S, Chapman RH, Wallace EL, Bertholf MF, Goodnough LT, Kao KJ, Olson JD, Woodson RD, Surgenor DM. The Collaborative Hospital Transfusion Study: variations in use of autologous blood account for hospital differences in red cell use during primary hip and knee surgery. Transfusion. 1998 Jun;38(6):530-9. doi: 10.1046/j.1537-2995.1998.38698326332.x.
PubMed 9661686Surgenor DM, Churchill WH, Wallace EL, Rizzo RJ, McGurk S, Goodnough LT, Kao KJ, Koerner TA, Olson JD, Woodson RD. The specific hospital significantly affects red cell and component transfusion practice in coronary artery bypass graft surgery: a study of five hospitals. Transfusion. 1998 Feb;38(2):122-34. doi: 10.1046/j.1537-2995.1998.38298193094.x.
PubMed 9531943Wallace EL, Churchill WH, Surgenor DM, An J, Cho G, McGurk S, Murphy L. Collection and transfusion of blood and blood components in the United States, 1992. Transfusion. 1995 Oct;35(10):802-12. doi: 10.1046/j.1537-2995.1995.351096026360.x.
PubMed 7570909Churchill WH, Chapman RH, Rutherford CJ, Poss R, Wallace EL, Surgenor DM. Blood product utilization in hip and knee arthroplasty: effect of gender and autologous blood on transfusion practice. Vox Sang. 1994;66(3):182-7. doi: 10.1111/j.1423-0410.1994.tb00307.x.
PubMed 8036787Wallace EL, Surgenor DM, Hao HS, An J, Chapman RH, Churchill WH. Collection and transfusion of blood and blood components in the United States, 1989. Transfusion. 1993 Feb;33(2):139-44. doi: 10.1046/j.1537-2995.1993.33293158046.x.
PubMed 8430453Surgenor DM, Wallace EL, Churchill WH, Hao SH, Chapman RH, Collins JJ Jr. Red cell transfusions in coronary artery bypass surgery (DRGs 106 and 107). Transfusion. 1992 Jun;32(5):458-64. doi: 10.1046/j.1537-2995.1992.32592327721.x.
PubMed 1626350Surgenor DM, Wallace EL, Churchill WH, Hao SH, Chapman RH, Poss R. Red cell transfusions in total knee and total hip replacement surgery. Transfusion. 1991 Jul-Aug;31(6):531-7. doi: 10.1046/j.1537-2995.1991.31691306252.x.
PubMed 1906649Surgenor DM, Wallace EL, Hao SH, Chapman RH. Collection and transfusion of blood in the United States, 1982-1988. N Engl J Med. 1990 Jun 7;322(23):1646-51. doi: 10.1056/NEJM199006073222306.
PubMed 2342524Surgenor DM, Wallace EL, Churchill WH, Hao S, Hale WB, Schnitzer J. Utility of DRG and ICD-9-CM classification codes for the study of transfusion issues. Transfusions in patients with digestive diseases. Transfusion. 1989 Nov-Dec;29(9):761-7. doi: 10.1046/j.1537-2995.1989.29990070178.x.
PubMed 2686107Surgenor DM, Wallace EL, Hale SG, Gilpatrick MW. Changing patterns of blood transfusions in four sets of United States hospitals, 1980 to 1985. Transfusion. 1988 Nov-Dec;28(6):513-8. doi: 10.1046/j.1537-2995.1988.28689059022.x.
PubMed 3194926Surgenor DM, Churchill WH, Wallace EL, Rizzo RJ, Chapman RH, McGurk S, Bertholf MF, Goodnough LT, Kao KJ, Koerner TA, Olson JD, Woodson RD. Determinants of red cell, platelet, plasma, and cryoprecipitate transfusions during coronary artery bypass graft surgery: the Collaborative Hospital Transfusion Study. Transfusion. 1996 Jun;36(6):521-32. doi: 10.1046/j.1537-2995.1996.36696269511.x.
PubMed 8669084
Study at a glance
From the registry record, last updated by the sponsor on 18 Feb 2016. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Epidemiologic Studies of Blood Use in the United States - SCOR in Transfusion Medicine
- ClinicalTrials.gov ID
- NCT00005319
- Acronym / sponsor ID
- 4093
- Conditions
- Blood Transfusion
- Study type
- Observational
- Recruitment status
- Completed
- Lead sponsor
- National Heart, Lung, and Blood Institute (NHLBI)US National Institutes of Health
- Study start
- Sep 1985
- Study completion
- Dec 1996 (actual)
- First posted
- 26 May 2000 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To develop and apply quantitative methods by which to measure and characterize blood transfusion practice in specific diagnoses and procedures; to open scientific communication about transfusion practice within and across institutions; and to develop simpler methods for estimating annual national blood collections and transfusions.
Detailed description
DESIGN NARRATIVE:
The study was a subproject within a Specialized Centers of Research (SCOR) in Transfusion Medicine. The experimental design was based on the study and analysis of several unique sets of data. One set consisted of abstracted patient data including ICD-9-CM diagnosis and procedure, DRG and red cell units transfused, from a constant set 100 of United States hospitals for the years 1980,82,84,86, to which a new set of data was added for the year 1989. A similar set of data were gathered from eight cooperating teaching hospitals over the first four years of the grant term; this set included data for transfusions of all blood components, autologous units and factor preparations. A third data base contained the data for four United States surveys conducted in 1982,84,86,87; and was expanded to include 1990 and 92. Using these data, four main tasks were addressed. A Pan-DRG red cell transfusion study was conducted to ascertain red cell use across all DRGs and ICD-9-CM codes. Extensive efforts were devoted to developing new methods to characterize transfusion practice. A series of studies were devoted to characterizing transfusions of all blood components in a selected number of ICD-9-CM classes. The purpose of the fourth task was to develop simpler and more rapid alternative methods for producing national estimates of transfusion activity; as part of this task,new surveys were conducted for 1990 and 92.
Among the questions studied were: Was it possible to identify distinctive attributes of the patients who, though operated, did not require a transfusion or who required a large volume of blood? Were transfusions of non-red cell components related to use of red cells? Could transfusion frequency diagnosis for all blood products be used as a measure of transfusion practice? Did longitudinal comparisons of transfusions over the 9-year interval, 1980-1989, reveal significant trends? Was it possible to discriminate quantitatively between transfusion practices in different hospitals or set of hospitals, or at different times? What was the effect of autologous blood programs in transfusion practice? What was the contribution of comorbid conditions on red cell and component transfusion patterns.?
The dollars for the subproject were approximately 25 percent of total dollars spent each year for the Center.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
Study design
Who may qualify
- Ages
- Up to 100 years
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Not reported in the source record.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Feb 2016.
- Background: PubMed 9683100Wallace EL, Churchill WH, Surgenor DM, Cho GS, McGurk S. Collection and transfusion of blood and blood components in the United States, 1994. Transfusion. 1998 Jul;38(7):625-36. doi: 10.1046/j.1537-2995.1998.38798346630.x.
- Background: PubMed 9661686Churchill WH, McGurk S, Chapman RH, Wallace EL, Bertholf MF, Goodnough LT, Kao KJ, Olson JD, Woodson RD, Surgenor DM. The Collaborative Hospital Transfusion Study: variations in use of autologous blood account for hospital differences in red cell use during primary hip and knee surgery. Transfusion. 1998 Jun;38(6):530-9. doi: 10.1046/j.1537-2995.1998.38698326332.x.
- Background: PubMed 9531943Surgenor DM, Churchill WH, Wallace EL, Rizzo RJ, McGurk S, Goodnough LT, Kao KJ, Koerner TA, Olson JD, Woodson RD. The specific hospital significantly affects red cell and component transfusion practice in coronary artery bypass graft surgery: a study of five hospitals. Transfusion. 1998 Feb;38(2):122-34. doi: 10.1046/j.1537-2995.1998.38298193094.x.
- Background: PubMed 7570909Wallace EL, Churchill WH, Surgenor DM, An J, Cho G, McGurk S, Murphy L. Collection and transfusion of blood and blood components in the United States, 1992. Transfusion. 1995 Oct;35(10):802-12. doi: 10.1046/j.1537-2995.1995.351096026360.x.
- Background: PubMed 8036787Churchill WH, Chapman RH, Rutherford CJ, Poss R, Wallace EL, Surgenor DM. Blood product utilization in hip and knee arthroplasty: effect of gender and autologous blood on transfusion practice. Vox Sang. 1994;66(3):182-7. doi: 10.1111/j.1423-0410.1994.tb00307.x.
- Background: PubMed 8430453Wallace EL, Surgenor DM, Hao HS, An J, Chapman RH, Churchill WH. Collection and transfusion of blood and blood components in the United States, 1989. Transfusion. 1993 Feb;33(2):139-44. doi: 10.1046/j.1537-2995.1993.33293158046.x.
- Background: PubMed 1626350Surgenor DM, Wallace EL, Churchill WH, Hao SH, Chapman RH, Collins JJ Jr. Red cell transfusions in coronary artery bypass surgery (DRGs 106 and 107). Transfusion. 1992 Jun;32(5):458-64. doi: 10.1046/j.1537-2995.1992.32592327721.x.
- Background: PubMed 1906649Surgenor DM, Wallace EL, Churchill WH, Hao SH, Chapman RH, Poss R. Red cell transfusions in total knee and total hip replacement surgery. Transfusion. 1991 Jul-Aug;31(6):531-7. doi: 10.1046/j.1537-2995.1991.31691306252.x.
- Background: PubMed 2342524Surgenor DM, Wallace EL, Hao SH, Chapman RH. Collection and transfusion of blood in the United States, 1982-1988. N Engl J Med. 1990 Jun 7;322(23):1646-51. doi: 10.1056/NEJM199006073222306.
- Background: PubMed 2686107Surgenor DM, Wallace EL, Churchill WH, Hao S, Hale WB, Schnitzer J. Utility of DRG and ICD-9-CM classification codes for the study of transfusion issues. Transfusions in patients with digestive diseases. Transfusion. 1989 Nov-Dec;29(9):761-7. doi: 10.1046/j.1537-2995.1989.29990070178.x.
- Background: PubMed 3194926Surgenor DM, Wallace EL, Hale SG, Gilpatrick MW. Changing patterns of blood transfusions in four sets of United States hospitals, 1980 to 1985. Transfusion. 1988 Nov-Dec;28(6):513-8. doi: 10.1046/j.1537-2995.1988.28689059022.x.
- Background: PubMed 8669084Surgenor DM, Churchill WH, Wallace EL, Rizzo RJ, Chapman RH, McGurk S, Bertholf MF, Goodnough LT, Kao KJ, Koerner TA, Olson JD, Woodson RD. Determinants of red cell, platelet, plasma, and cryoprecipitate transfusions during coronary artery bypass graft surgery: the Collaborative Hospital Transfusion Study. Transfusion. 1996 Jun;36(6):521-32. doi: 10.1046/j.1537-2995.1996.36696269511.x.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Blood Transfusion, run by National Heart, Lung, and Blood Institute (NHLBI).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 18 Feb 2016. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT00005319, which also lists 12 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Feb 2016.