Monoclonal Antibody and Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma That Has Been Removed During Surgery

DISEASE CHARACTERISTICS:

• Histologically confirmed completely resected stage III or IV melanoma
• Mucosal or ocular subtypes allowed
• HLA-A2 positive
• Positive staining of tumor tissue with antibody HMB-45 for gp100, tyrosinase, and/or MART-1
• Failed (or ineligible for or refusal of) interferon alfa

PATIENT CHARACTERISTICS:

Age:

• Not specified

Performance status:

• Karnofsky 60-100%

Life expectancy:

• At least 12 months

Hematopoietic:

• WBC at least 2,500/mm^3
• Absolute neutrophil count at least 1,500/mm^3
• Platelet count at least 100,000/mm^3
• Hemoglobin at least 10 g/dL
• Hematocrit at least 30%

Hepatic:

• Bilirubin no greater than upper limit of normal (ULN)
• AST no greater than 1.25 times ULN
• Hepatitis B surface antigen negative
• Hepatitis C antibody nonreactive

Renal:

• Creatinine less than 1.25 times ULN

Immunologic:

• Antinuclear antibody (ANA) negative OR
• If ANA positive, must be:
• Antithyroglobulin antibody negative
• Rheumatoid factor negative
• Anti-LKM antibody negative
• Anti-phospholipid antibody negative
• Anti-islet cell antibody negative
• Anti-neutrophil cytoplasmic antibody negative
• HIV negative
• No autoimmune disease (e.g., uveitis or autoimmune inflammatory eye disease)
• No active infection
• No hypersensitivity to tyrosinase:368-376, gp100:209-217, MART-1:26-35, or Montanide ISA-51

Other:

• No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer, superficial bladder cancer, or carcinoma in situ of the cervix
• No underlying medical condition that would preclude study
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• See Disease Characteristics
• No prior anti-cytotoxic T-lymphocyte-associated antigen-4 monoclonal antibody
• No prior tyrosinase, gp100, or MART-1 peptide
• No prior antitumor vaccination
• No prior interleukin-2
• At least 4 weeks since prior immunotherapy for melanoma

Chemotherapy:

• At least 4 weeks since prior chemotherapy for melanoma

Endocrine therapy:

• At least 4 weeks since prior hormonal therapy for melanoma
• At least 4 weeks since prior corticosteroids
• No concurrent systemic or topical corticosteroids

Radiotherapy:

• At least 4 weeks since prior radiotherapy for melanoma

Surgery:

• See Disease Characteristics

Other:

• No prior cytotoxic therapy
• At least 4 weeks since any other prior therapy for melanoma
• Concurrent analgesics allowed if on stable dose for at least 2 weeks before study