Marijuana DependenceMTP-3NCT00107588
Marijuana Treatment Project - 3
A study testing Reinforcement for homework completion, Reinforcement for Abstinence and Case Management in people with Marijuana Dependence, run by UConn Health at 1 site in United States.
Trial summary
The goal of this research is to improve treatment outcome for marijuana-dependent individuals. The current study builds on the findings of our prior NIDA-funded marijuana treatment study in which improved client outcomes were associated with greater treatment attendance, greater client self-efficacy, and greater use… Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Marijuana Dependence
- What is being tested?
- Reinforcement for homework completion, Reinforcement for Abstinence and Case Management
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 215 participants
- Where
- 1 siteUnited States
- Study dates
- Feb 2007to Aug 2012
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Cannabis dependence
- Willing to accept random assignment to interventions
Who cannot join
- Current dependence on alcohol or other drugs
- Problems that require inpatient hospitalization
- Reading ability below fifth grade level
- Lack of reliable transportation to treatment
- Excessive commuting distance
Trial locations and contacts
1 site in 1 country.
United States1 site
University of Connecticut Health Center
Farmington, Connecticut, 06030-3910
About this study
Official title: Contingency Management for Marijuana Dependence
The goal of this research is to improve treatment outcome for marijuana-dependent individuals. The current study builds on the findings of our prior NIDA-funded marijuana treatment study in which improved client outcomes were associated with greater treatment attendance, greater client self-efficacy, and greater use of coping skills. We will use a contingency management paradigm to provide tangible reinforcement for completing homework assignments that are designed to enhance coping skills. It is anticipated that this will result in greater homework compliance, leading to greater self-efficacy regarding one's ability to cope with high-risk situations. Improved self-efficacy will enhance the likelihood of employing coping skills in high-risk situations, thereby increasing the probability of achieving and maintaining abstinence.
Read the detailed description
Participants will receive an intervention combining one session of motivational enhancement therapy with eight sessions of cognitive-behavioral coping skills therapy (MET+CBT). A contingency management procedure will be added to this intervention, providing reinforcement for completion of homework, as verified by call-ins to an Interactive Voice Recording (IVR) system. Outcomes will be compared to an MET+CBT intervention in which reinforcement will be provided for marijuana-free urine specimens, and to a control group that receives Case Management. Recruitment of 234 marijuana-dependent participants will occur over a three-year period. They will be randomly assigned to one of the three 9-session interventions. Treatment will be individual, manualized, and provided on an outpatient basis. Pretreatment assessments will obtain baseline data; follow-up assessments at three-month intervals for one year will evaluate marijuana use outcomes, other drug or alcohol use, and psychosocial functioning. It is anticipated that the intervention in which completion of homework is reinforced will result in the best outcomes. The mechanisms by which the interventions result in behavior change will be the specific focus of attention in this study.
- Conditions
- Marijuana Dependence
- Being tested
- Reinforcement for homework completion, Reinforcement for Abstinence, Case Management
- Keywords
- marijuana dependence, self-efficacy, coping skills, attendance, marijuana abstinence
- Medical subject headings
- Marijuana Abuse
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Reinforcement for homework completionBehavioural
Provides contingent reinforcement for engaging in homework activities designed to enhance coping skills
Reinforcement for AbstinenceBehavioural
Provides contingent reinforcement for submitting marijuana-free urine specimen
Case ManagementBehavioural
Will control for the effect of therapist-client contact by providing supportive case management as an active control condition.
| Study group | Role | What they receive |
|---|---|---|
| Reinforcement for homework completion | Experimental | Not described Receives: Behavioral: Reinforcement for homework completion |
| Reinforcement for Abstinence | Active comparator | Not described Receives: Behavioral: Reinforcement for Abstinence |
| Case Management | Active comparator | Not described Receives: Behavioral: Case Management |
What is being measured
The primary outcome is the main question the study is designed to answer.
Marijuana abstinence
Measured: One-year follow-up period
Self-efficacy, use of coping skills, and treatment attendance
Measured: During 2-month treatment period
Secondary outcomes (1)
Continuous abstinence will be predicted by (a) treatment attendance; (b) posttreatment self-efficacy for coping; and (c) use of coping skills
Measured: One-year follow-up period
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Apr 2005 (estimated)
- Study startFeb 2007
- Primary completionApr 2011
- Study completionAug 2012
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Marijuana DependenceStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 215 participants (actual)
Sponsor and investigators
- Lead sponsor
- UConn Health
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute on Drug Abuse (NIDA)
- Responsible party
- Principal investigator, Mark Litt, UConn Health
- Investigators
- Mark D Litt, Ph.D., Principal investigator, UConn Health
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00107588
- Sponsor's protocol ID
- NIDA-12728-06
- Other IDs
- R01DA012728-06, R01-12728-06
- Acronym
- MTP-3
- Status last verified
- Jul 2017
- First submitted
- 5 Apr 2005
- Last updated
- 28 Jul 2017
- Results posted
- No
- Data monitoring committee
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 28 Jul 2017. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Contingency Management for Marijuana Dependence
- ClinicalTrials.gov ID
- NCT00107588
- Acronym / sponsor ID
- MTP-3 / NIDA-12728-06
- Conditions
- Marijuana Dependence
- Keywords
- marijuana dependence, self-efficacy, coping skills, attendance, marijuana abstinence
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 215 participants (actual)
- Lead sponsor
- UConn HealthUniversity, hospital or other
- Collaborators
- National Institute on Drug Abuse (NIDA)
- Study start
- Feb 2007
- Primary completion
- Apr 2011 (actual)
- Study completion
- Aug 2012 (actual)
- First posted
- 6 Apr 2005 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this research is to improve treatment outcome for marijuana-dependent individuals. The current study builds on the findings of our prior NIDA-funded marijuana treatment study in which improved client outcomes were associated with greater treatment attendance, greater client self-efficacy, and greater use of coping skills. We will use a contingency management paradigm to provide tangible reinforcement for completing homework assignments that are designed to enhance coping skills. It is anticipated that this will result in greater homework compliance, leading to greater self-efficacy regarding one's ability to cope with high-risk situations. Improved self-efficacy will enhance the likelihood of employing coping skills in high-risk situations, thereby increasing the probability of achieving and maintaining abstinence.
Detailed description
Participants will receive an intervention combining one session of motivational enhancement therapy with eight sessions of cognitive-behavioral coping skills therapy (MET+CBT). A contingency management procedure will be added to this intervention, providing reinforcement for completion of homework, as verified by call-ins to an Interactive Voice Recording (IVR) system. Outcomes will be compared to an MET+CBT intervention in which reinforcement will be provided for marijuana-free urine specimens, and to a control group that receives Case Management. Recruitment of 234 marijuana-dependent participants will occur over a three-year period. They will be randomly assigned to one of the three 9-session interventions. Treatment will be individual, manualized, and provided on an outpatient basis. Pretreatment assessments will obtain baseline data; follow-up assessments at three-month intervals for one year will evaluate marijuana use outcomes, other drug or alcohol use, and psychosocial functioning. It is anticipated that the intervention in which completion of homework is reinforced will result in the best outcomes. The mechanisms by which the interventions result in behavior change will be the specific focus of attention in this study.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Reinforcement for homework completion | Experimental | Behavioral: Reinforcement for homework completion |
| Reinforcement for Abstinence | Active comparator | Behavioral: Reinforcement for Abstinence |
| Case Management | Active comparator | Behavioral: Case Management |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Cannabis dependence
- Willing to accept random assignment to interventions
Key exclusion criteria (5 listed)
- Current dependence on alcohol or other drugs
- Problems that require inpatient hospitalization
- Reading ability below fifth grade level
- Lack of reliable transportation to treatment
- Excessive commuting distance
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Reinforcement for homework completionProvides contingent reinforcement for engaging in homework activities designed to enhance coping skills | Behavioural | Reinforcement for homework completion |
| Reinforcement for AbstinenceProvides contingent reinforcement for submitting marijuana-free urine specimen | Behavioural | Reinforcement for Abstinence |
| Case ManagementWill control for the effect of therapist-client contact by providing supportive case management as an active control condition. | Behavioural | Case Management |
Primary outcome
Marijuana abstinence
Time frame: One-year follow-up period
Self-efficacy, use of coping skills, and treatment attendance
Time frame: During 2-month treatment period
1 secondary outcome
Continuous abstinence will be predicted by (a) treatment attendance; (b) posttreatment self-efficacy for coping; and (c) use of coping skills
Time frame: One-year follow-up period
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Jul 2017.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Mark D Litt, Ph.D. principal investigator
UConn Health
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Reinforcement for homework completion, Reinforcement for Abstinence and Case Management in people with Marijuana Dependence, run by UConn Health at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 28 Jul 2017. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Marijuana abstinence (time frame: One-year follow-up period). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Jul 2017; AzTrials last refreshed its copy on 27 Oct 2026.