Parkinson's DiseaseNCT00142363
Cohorts and Collections: Clinical and Genetic Study of Parkinson's Disease and Epilepsies
An observational study of Parkinson's Disease and Epilepsy, run by Institut National de la Santé Et de la Recherche Médicale, France at 15 sites in France.
Trial summary
The DNA and Cell Bank of Instituts Federatifs de Recherche (IFR) of Neurosciences has been running for the last 15 years at the Institut National de la Santé Et de la Recherche Médicale (INSERM) Unit 679 (former unit 289). Read more about this study
- Who is it for?
- Ages 1 year to 90 yearsHealthy volunteers can take part
- Conditions the study is for
- Parkinson's Disease, Epilepsy
- How many people
- 1,700 participants
- Where
- 15 sitesFrance
- Study dates
- May 2004to Dec 2006
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 1 year to 90 years
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- Patients presenting with Parkinson's disease, with a family history or not,
- Minors presenting clinical signs of the disease,
- Controls (without signs of the disease), matched by sex and age with the patients,
- Relatives for the familial cases,
- Patients presenting with an epilepsy episode (myoclonic epilepsy of the newborn, with febrile seizures, of the frontal lobe)
Who cannot join
- Lack of signed informed consent
Trial locations and contacts
15 sites in 1 country.
15 sites in 1 country
France15 sites
Centre Hospitalier du Pays d'Aix
Aix-en-Provence, 13616
Hôpital Gabriel Montpied
Clermont-Ferrand, 63000
CHU de Grenoble
Grenoble, 38000
Hôpital Roger Salengro
Lille, 59000
Hôpital Neurologique Pierre Wertheimer
Lyon, 69003
Hôpital René et Guillaume Laennec
Nantes, 44000
Hôpital Pasteur
Nice, 06000
Hôpital Saint-Antoine
Paris, 75012
Hôpital Pitié-Salpêtrière
Paris, 75013
Pitié-Salpêtrière Hospital - Centre of Clinical Investigations
Paris, 75013
Hôpital Robert Debré
Paris, 75019
Hôpital Haut-Lévêque
Pessac, 33604
Hôpital Pontchaillou
Rennes, 35000
Hôpital Civil
Strasbourg, 67000
Hôpital Purpan
Toulouse, 31000
About this study
Official title: The DNA and Cell Bank of IFR of Neurosciences: Clinical and Genetic Study of Parkinson's Disease and Epilepsies
The DNA and Cell Bank of Instituts Federatifs de Recherche (IFR) of Neurosciences has been running for the last 15 years at the Institut National de la Santé Et de la Recherche Médicale (INSERM) Unit 679 (former unit 289). Since its creation, this structure has been the support of research projects in genetics for neurological and psychiatric disorders. The cohorts established have led to discoveries in monogenic disorders, such as cerebellar ataxias, spastic paraplegias, frontotemporal dementias, epilepsies, Parkinson's and Alzheimer's disease, Charcot-Marie-Tooth disease and related entities. The research projects based on the study of the genetic bases in Parkinson's disease and epilepsies are especially developed for this grant.
Concerning Parkinson's disease, the project is based on the extension of the existing cohort throughout the French Parkinson's Disease Study Group network. Concerning epilepsies, this project is the occasion to build this network with the constitution of a new cohort.
Read more
The specific aims of the scientific projects are the following for Parkinson's disease:
- to evaluate the frequency, the nature and the phenotype associated with parkin mutations in familial or sporadic forms of the disease, according to the age at onset, and
- to identify the genetic susceptibility factors in Parkinson's disease with the study of affected sibpairs and with case/controls association studies.
For epilepsies, the aims are:
- to evaluate the frequency, the nature and the phenotype associated with SCN1A, SCNab and GABR2 gene mutations in familial or sporadic forms of the affection associated with febrile seizures, and
- to search for an intervention SCN1A, SCN1B and GABRG2 as susceptible genes in these forms of epilepsies.
- Conditions
- Parkinson's Disease, Epilepsy
- Keywords
- Parkinson's disease, Parkin, Epilepsy, Phenotype-genotype correlations, Ionic channels
- Medical subject headings
- Parkinson Disease, Epilepsy
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Sep 2005 (estimated)
- Study startMay 2004
- Study completionDec 2006
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (6)Papers the sponsor has linked to this study.
- Other trials for Parkinson's DiseaseStudies of the same condition, open and under way.
- More trials run by Institut National de la Santé Et de la Recherche Médicale, FranceThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 1,700 participants
Sponsor and investigators
- Sponsor type
- Other government
- Collaborators
- Ministry of Health, France
- Investigators
- Alexis Brice, MD, Principal investigator, Assistance Publique - Hôpitaux de Paris, University Paris 6
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00142363
- Sponsor's protocol ID
- 4CH03G
- Status last verified
- Feb 2006
- First submitted
- 1 Sep 2005
- Last updated
- 1 Mar 2006
- Results posted
- No
Publications
Ibanez P, Bonnet AM, Debarges B, Lohmann E, Tison F, Pollak P, Agid Y, Durr A, Brice A. Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease. Lancet. 2004 Sep 25-Oct 1;364(9440):1169-71. doi: 10.1016/S0140-6736(04)17104-3.
PubMed 15451225Lesage S, Leutenegger AL, Ibanez P, Janin S, Lohmann E, Durr A, Brice A; French Parkinson's Disease Genetics Study Group. LRRK2 haplotype analyses in European and North African families with Parkinson disease: a common founder for the G2019S mutation dating from the 13th century. Am J Hum Genet. 2005 Aug;77(2):330-2. doi: 10.1086/432422. No abstract available.
PubMed 16145815Lesage S, Ibanez P, Lohmann E, Pollak P, Tison F, Tazir M, Leutenegger AL, Guimaraes J, Bonnet AM, Agid Y, Durr A, Brice A; French Parkinson's Disease Genetics Study Group. G2019S LRRK2 mutation in French and North African families with Parkinson's disease. Ann Neurol. 2005 Nov;58(5):784-7. doi: 10.1002/ana.20636.
PubMed 16240353Lesage S, Leutenegger AL, Brice A. [LRRK2: a gene belonging to the ROCO family is implicated in the Parkinson's disease]. Med Sci (Paris). 2005 Dec;21(12):1015-7. doi: 10.1051/medsci/200521121015. No abstract available. French.
PubMed 16324633Ibanez P, Lesage S, Lohmann E, Thobois S, De Michele G, Borg M, Agid Y, Durr A, Brice A; French Parkinson's Disease Genetics Study Group. Mutational analysis of the PINK1 gene in early-onset parkinsonism in Europe and North Africa. Brain. 2006 Mar;129(Pt 3):686-94. doi: 10.1093/brain/awl005. Epub 2006 Jan 9.
PubMed 16401616Lesage S, Durr A, Tazir M, Lohmann E, Leutenegger AL, Janin S, Pollak P, Brice A; French Parkinson's Disease Genetics Study Group. LRRK2 G2019S as a cause of Parkinson's disease in North African Arabs. N Engl J Med. 2006 Jan 26;354(4):422-3. doi: 10.1056/NEJMc055540. No abstract available.
PubMed 16436781