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HIV InfectionPhase 1NCT00252148

Safety and Immunogenicity of a Modified Vaccinia Ankara (MVA) HIV Vaccine in HIV Uninfected Adults

A Phase 1 study testing ADMVA in people with HIV Infection, run by International AIDS Vaccine Initiative at 2 sites in United States.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The purpose of this study is to determine the safety of an immune response to an investigational HIV vaccine, ADMVA, at three different dosage levels, in adults who are not infected with HIV Read more about this study

Who is it for?
Ages 18 to 40 yearsHealthy volunteers can take part
Conditions the study is for
HIV Infection
What is being tested?
ADMVA
Type of treatment
Vaccines
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
48 participants
Where
2 sitesUnited States
Study dates
Jan 2005to Aug 2007
Phase
Phase 1
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 40 years
  • All sexes
  • Healthy volunteers accepted
  • Adult

Who may be able to join

  • Healthy adult males and females, as assessed by a medical history, physical exam, and laboratory tests;
  • Age of at least 18 years of age on the day of screening and no greater than 40 years on the day of first vaccination;
  • Willing to comply with the requirements of the protocol and available for follow-up for the planned duration of the study (screening plus 18 months);
  • In the opinion of the principal investigator or designee has understood the information provided. Written informed consent needs to be given before any study-related procedures are performed;
  • Willing to undergo HIV Testing and counseling, and receive HIV test results;
  • If sexually active female, using an effective method of contraception from screening until at least 4 months after last vaccination. All female volunteers must be willing to undergo urine pregnancy tests.
  • If sexually active male, willing to use an effective method of contraception from screening until 4 months after the last vaccination and will be advised not to get his partner pregnant.

Who cannot join

  • Confirmed HIV-1 or HIV-2 infection;
  • Reported high-risk behavior for HIV infection defined as:
  • Within 6 months before vaccination, the volunteer has:
  • Had unprotected vaginal or anal sex with a known HIV infected person or with a casual partner.
  • Engaged in sex work for money or drugs
  • Used injection drugs (illicit), or
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  • Acquired an STD;
  • Any clinically significant abnormality on history or examination including history of immunodeficiency or autoimmune disease; use of systemic corticosteroids, immunosuppressive, antiviral, anticancer, or other medications considered significant by the trial physician within the last 6 months;
  • Any clinically significant acute or chronic medical condition requiring care of a physician (e.g., diabetes, coronary artery disease, rheumatologic illness, malignancy, substance abuse) that in the opinion of the investigator would preclude participation;
  • Any of the following abnormal laboratory parameters listed below:
  • Hemoglobin: <9.0 g/dL
  • Absolute Neutrophil Count (ANL): ≤ 999/mm3
  • Absolute Lymphocyte Count (ALC): ≤ 500/mm3
  • Platelets: ≤ 90,000 ≥ 550,000/mm3
  • Creatinine: > 1.4 x ULN
  • AST: >3.0 x ULN
  • ALT: >3.0 x ULN
  • Urine dipstick: blood = 2+ or more (except in menstruating females); protein = 2+or more
  • Cardiac troponin I: > ULN;
  • Confirmed diagnosis of hepatitis B (surface antigen, HbsAg); hepatitis C (HCV antibodies) or active syphilis;
  • If female, pregnant or planning a pregnancy within 4 months after last vaccination or lactating;
  • Receipt of a live attenuated vaccine (other than influenza) within 30 days or other vaccine within 14 days of vaccination;
  • Receipt of blood transfusion or blood products 6 months prior to vaccination;
  • Participation in another clinical study of an investigational product currently or within past 12 weeks or expected participation during this study;
  • Receipt of another experimental HIV vaccine at any time;
  • History of severe local or systemic reactogenicity to vaccination or history of severe allergic reactions;
  • Major psychiatric illness including any history of schizophrenia or severe psychosis, bipolar disorder requiring therapy, suicidal attempt or ideation in the previous 3 years;
  • In the opinion of the investigator, unlikely to comply with protocol;
  • ECG with clinically significant findings or features that would interfere with the assessment of myo/pericarditis including:
  • conduction disturbance (atrioventricular or intraventricular condition, left or right bundle branch block, AV block of any degree, or QTc prolongation)
  • repolarization (ST segment or T wave) abnormality
  • significant atrial or ventricular arrhythmia
  • frequent atrial or ventricular ectopy (e.g. frequent premature atrial contractions, 2 premature ventricular contractions in a row)
  • ST elevation consistent with ischemia
  • evidence of past or evolving myocardial infarction;
  • History of, or known active cardiac disease including:
  • previous myocardial infarction (heart attack)
  • angina pectoris
  • congestive heart failure
  • valvular heart disease including mitral valve prolapse
  • cardiomyopathy
  • pericarditis
  • stroke or transient ischemic attack
  • chest pain or shortness of breath with activity (such as walking up stairs)
  • other heart conditions under the care of a doctor;
  • Have 3 or more of the following risk factors:
  • high blood pressure diagnosed by a doctor
  • high blood cholesterol diagnosed by a doctor
  • diabetes or high blood sugar diagnosed by a doctor
  • a first degree relative (for example, mother, father, brother, sister) who had a heart condition before the age of 50
  • smoke cigarettes now.
  • History of allergy to aminoglycosides (e.g. gentamycin)
  • History of severe allergy to eggs or egg products e.g., "rash or breathing difficulties"

Trial locations and contacts

2 sites in 1 country.

United States2 sites

  • Rockefeller University Hospital

    New York, New York, 10021

  • University of Rochester Medical Center

    Rochester, New York, 14642

Other trials in United States

About this study

Official title: Randomized, Placebo-Controlled, Dose-Escalating, Double-Blinded Phase 1 Safety and Immunogenicity Study of a Modified Vaccinia Ankara (MVA) Vectored HIV-1 (ADMVA) Vaccine Administered Intramuscularly to HIV-Uninfected, Healthy Volunteers

The purpose of this study is to determine the safety of an immune response to an investigational HIV vaccine, ADMVA, at three different dosage levels, in adults who are not infected with HIV

Read the detailed description

This is a dose escalation trial. Study site staff and volunteers will be blinded. Blinding will not apply to the assignment of dose levels (low, middle or high).

Volunteers will be screened up to 42 days before enrolment and will be followed for 18 months after the first vaccination.

16 volunteers will be randomized in a 3:1 ratio of active vaccine to placebo. Safety and tolerability of the ADMVA vaccine/placebo will be evaluated at least 14 days after the 12th volunteer in the low dose group receives the second injection before proceeding to the middle dose group.

Conditions
HIV Infection
Being tested
ADMVA
Keywords
HIV Preventive Vaccine
Medical subject headings
HIV Infections

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • ADMVABiological

    experimental HIV vaccine, MVA vector expressing HIV clade C env, gag, pol, nef, and tat

Study groups in NCT00252148
Study groupRoleWhat they receive
ADMVAActive comparatorADMVA dosage escalation
Receives: Biological: ADMVA
PlaceboPlacebo comparatorPlacebo is 10mM TRIS HCl, 140mM NaCl, ph 7.7
Receives: Biological: ADMVA

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. safety and tolerability of AMVA

    Measured: 18 months

Secondary outcomes (1)

  1. Immunogenicity of ADMVA

    Measured: 18 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted11 Nov 2005 (estimated)
  2. Study startJan 2005
  3. Primary completionAug 2007
  4. Study completionAug 2007

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 1
Primary purpose
Prevention
Allocation
Randomised
Intervention model
Parallel groups
Masking
Quadruple blind
Who is masked
Participant, Care provider, Investigator, Outcomes assessor
Enrolment
48 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT00252148
Sponsor's protocol ID
IAVI C002
Status last verified
Jun 2010
First submitted
9 Nov 2005
Last updated
11 Feb 2013
Results posted
No
Data monitoring committee
Yes

Publications

  • Vasan S, Schlesinger SJ, Chen Z, Hurley A, Lombardo A, Than S, Adesanya P, Bunce C, Boaz M, Boyle R, Sayeed E, Clark L, Dugin D, Boente-Carrera M, Schmidt C, Fang Q, LeiBa, Huang Y, Zaharatos GJ, Gardiner DF, Caskey M, Seamons L, Ho M, Dally L, Smith C, Cox J, Gill D, Gilmour J, Keefer MC, Fast P, Ho DD. Phase 1 safety and immunogenicity evaluation of ADMVA, a multigenic, modified vaccinia Ankara-HIV-1 B'/C candidate vaccine. PLoS One. 2010 Jan 25;5(1):e8816. doi: 10.1371/journal.pone.0008816.

    PubMed 20111599

  • Elizaga ML, Vasan S, Marovich MA, Sato AH, Lawrence DN, Chaitman BR, Frey SE, Keefer MC; MVA Cardiac Safety Working Group. Prospective surveillance for cardiac adverse events in healthy adults receiving modified vaccinia Ankara vaccines: a systematic review. PLoS One. 2013;8(1):e54407. doi: 10.1371/journal.pone.0054407. Epub 2013 Jan 17.

    PubMed 23349878

Questions about this trial

What is this clinical trial studying?

A Phase 1 study testing ADMVA in people with HIV Infection, run by International AIDS Vaccine Initiative at 2 sites in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 7 inclusion and 53 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 11 Feb 2013. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 1 studies test a treatment in a small group of people for the first time or in a new way, mainly to check safety and find the right dose.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

safety and tolerability of AMVA (time frame: 18 months). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT00252148, which also lists 2 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Feb 2013.

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