DepressionNCT00279526
Depression and Increased Health Services Utilization Among Elderly Primary Care Patients
An observational study of Depression, run by Soroka University Medical Center at 1 site in Israel.
Trial summary
The increase in life expectancy in the 21st century has resulted in a major growth in the prevalence of age-related diseases and conditions. Depression has been found to be the most prevalent among the various mental disorders in later life. Read more about this study
- Who is it for?
- Ages 65 years and older
- Conditions the study is for
- Depression
- How many people
- 450 participants
- Where
- 1 siteIsrael
- Study dates
- Apr 2006to Dec 2006
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 years and older
- All sexes
- No healthy volunteers
- Older adult
Who may be able to join
- Age 65 or older,
- Clalit health organization client
- Outpatient
- Hebrew or English or Russian speaker
- Living in Beer Sheva
Who cannot join
- Known diagnosis of depression, major depression, bipolar disorder, psychosis, dementia or substance abuse
- Current acute illness
Trial locations and contacts
1 site in 1 country.
Israel1 site
Department of Family Medicine, Faculty of Health Sciences, Ben Gurion University of the Negev
Beersheba
About this study
The increase in life expectancy in the 21st century has resulted in a major growth in the prevalence of age-related diseases and conditions. Depression has been found to be the most prevalent among the various mental disorders in later life. It was emphasized that depression in the elderly is a persistent or recurrent disorder resulting from psychosocial stress or physiologic effects of disease and can lead to disability, cognitive impairments, intensified symptoms of other medical conditions and increased utilization of health care services. Due to the rapidly aging population, depression is a serious public health concern that has a great impact on quality of life and may lay a considerable burden on the health care systems. However depression among the elderly may prove to be hard to diagnose since in aged persons depressive symptoms are often masked by somatic complaints or by cognitive impairments. Consequently depression is often under diagnosed and the patients continue to visit constantly the nurse or the physician without getting an adequate answer to their problem. For that reason over utilization of health care services may be an indicator to the presence of undiagnosed depression. The purpose of this study is to examine the relationships between socio-demographic variables, high primary care utilization and depressive symptomatology among aged patients.
Read the detailed description
Introduction The number of Israel's elderly (65 plus) has increased from just 85,200 (4.8% of the population) in 1955 to approximately 670,000 people (about 10%) in 2003 (Brodsky et al., 2005). According to the most conservative of three projections offered by the Israeli Central Bureau of Statistics (CBS), the number of seniors is expected to be approximately 676,500 (9.8% of the population) in 2005, to rise to 722,500 people (10.7% of the population) by 2010 and increase to 1,025,800 (almost 12% of the population) by the year 2020.
The increase in life expectancy in the 20th century has resulted in a major growth in the prevalence of age-related diseases and conditions. Depression has been found to be the most prevalent among various mental disorders in later life and is the third most common reason for consultation in primary care (Shah, 1992). Research shows that 10-15% of the persons over 65 years of age suffer from various levels of depressive symptoms (Jacob\& Palmer, 1998).
Sadock \& Sadock (2003) state that depression among elderly may reach up to 15 percent and among these suffering from dementia from 25- 50 percent. Israeli studies show similar rates of depressive symptomatology as performed in other Western countries. A prevalence of 21.5 percent of depressive symptomatology was found among a random sample of 937 Israeli adults. (Iancu et al., 2003).
Depression represents a heterogeneous set of disorders, usually characterized by sad mood and inability to experience pleasure. Among the elderly it often may present itself atypically, with somatic symptoms dominating the clinical picture (Jacob \& Palmer, 1998). Common physical complaints, start with the most common features as loss of energy or fatigue, unexplained pain, gastrointestinal symptoms, headache, dizziness, palpitations, heartburn, numbness, loss of appetite, insomnia specifically early morning awakening. In general, the more unexplained somatic complaints and physical symptoms a patient have, the higher the likelihood of depression (Glass 2003). Elderly depression impairs significantly the quality of life by leading to disability, cognitive impairments, intensified symptoms from medical conditions and increases utilization of health care services and the direct and indirect medical costs (Luber et al., 2001).
Herrman et al.,( 2002) argue that health care utilization among depressed patients is higher then among those without depression. Elderly with depressive symptoms found to be at least as twice as likely to use emergency department and medical inpatient hospital services compared to patients without depressive symptomatology ( Himelhoch et al., 2002). Simon \& Ormel(1995) as well as Katon et al. (2003) stated that patients with depressive symptoms account for 43-52% higher health care costs than patients without depressive symptoms.
The increase in costs associated with depressive symptoms was noted even after adjusting for the severity of chronic medical illness (Glass, 2003). According to the WHO the significance of illness burden attributable to depression increases with age and thus will grow further by the year 2020 based upon projected demographic shifts towards an older population (Peveler et al., 2002).
This trend was showed in Israel by Brodsky et al.( 2005). They reported an elderly average of 11.5 visits at the FP per year while, in the USA, only 25% of the elderly population visited any physician 10 or more times annually - including visits to the ER and home visits (Health, United States,2003).
Consequently detecting and treating elderly patients with depressive symptoms in Israel, may be cost-effective and produce improvement in health and well-being for the money spent in the care of these older adults.
However depression in the aged patient may be atypical in nature and more difficult to diagnose from that in the general population. Therefore it is often under-diagnosed and under-treated (Jacob \& Palmer, 1998). In contrast to younger depressed patients, elderly patients often avoid reporting or showing that their mood level and tend to hide their state of disease or, worse, they lack the consciousness of the disease and think that enjoying life less than before is an inevitable consequence of aging. Moreover, elderly sometimes attribute their depressive symptoms to general medical conditions. Other factors that may hinder distinguishing depression from other conditions are also concomitant diseases, especially dementia, polypharmacy and drug reactions (Glass, 2003). Furthermore Hybels et al. (2001) compared in their study the demographic and risk factor profiles of elderly individuals with less and more severe depression. The obtained results indicated the need to recognize that elderly adults who do not meet the Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria for depression, and those who fall below the threshold on instruments such as the Center for Epidemiologic Studies-Depression scale (CES-D), may still experience depressive symptomatology that warrant attention.
The current scales used today measure physical deterioration as part of the depressive state, while among the older people these are part of the aging process and may confuse the therapist. The Geriatric Depression Scale (GDS) is a more specific tool for the measurement in this age group. It was developed during the 80's (Brink et al., 1982) proven valid and reliable at 1986 and was translated to many languages including Hebrew. (Zalsman et al., 1998). Today it is one of the most widely used instruments for the screening of depression among the elderly population.
To simplify the screening process a Yale Task Force on Geriatric Assessment has recommended the use of a single question, "Do you often feel sad or depressed?" (Lachs et al., 1990). Mahoney et al.( 1994 ) found this question as a valid and reliable short-form alternative.
In conclusion depression is a prevalent mental disorder in later life and a considerable impending public health problem since it may lay unnecessary cost burden on one hand and is difficult to diagnose on the other. Consequently, there is a need to find the most effective ways for early detection of this condition. This study will examine the question whether high health care services utilization and/ or sociodemographic background may predict the presence of depression among aged patients.
Objectives:
The purposes of this study is to examine the relationships between socio-demographic variables, comorbidity, depressive symptomatology and high primary care utilization.
METHOD:
Participants:
The study will be conducted in 10 primary health care clinics in urban communities of Beersheva, Israel. According to the average health care utilization, 11.5 visits to the FP per year (Brodsky et al., 2005)) among elderly in Israel, we classify two groups: "low care utilizers" with ≤ 6 visits per year and "high care utilizers" with ≥ 16 visits. Primary lists of "high and low care utilizer" will be obtained by query to "Clicks" electronic medical chart system ( Roshtov Soft wear industry ltd.) .
- Conditions
- Depression
- Keywords
- Depression, Health services utilization, Elderly, Primary Care
- Medical subject headings
- Depression, Patient Acceptance of Health Care
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Jan 2006 (estimated)
- Study startApr 2006
- Study completionDec 2006
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for DepressionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Natural history
- Time perspective
- Other
- Enrolment
- 450 participants
Sponsor and investigators
- Lead sponsor
- Soroka University Medical Center
- Sponsor type
- University, hospital or other
- Investigators
- Yan Press, MD, Principal investigator, Ben-Gurion University of the Negev
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00279526
- Sponsor's protocol ID
- sor417105ctil
- Status last verified
- May 2007
- First submitted
- 18 Jan 2006
- Last updated
- 25 May 2007
- Results posted
- No
Study at a glance
From the registry record, last updated by the sponsor on 25 May 2007. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Depression and Increased Health Services Utilization Among Elderly Primary Care Patients
- ClinicalTrials.gov ID
- NCT00279526
- Acronym / sponsor ID
- sor417105ctil
- Conditions
- Depression
- Keywords
- Depression, Health services utilization, Elderly, Primary Care
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 450 participants
- Lead sponsor
- Soroka University Medical CenterUniversity, hospital or other
- Study start
- Apr 2006
- Study completion
- Dec 2006 (actual)
- First posted
- 19 Jan 2006 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The increase in life expectancy in the 21st century has resulted in a major growth in the prevalence of age-related diseases and conditions. Depression has been found to be the most prevalent among the various mental disorders in later life. It was emphasized that depression in the elderly is a persistent or recurrent disorder resulting from psychosocial stress or physiologic effects of disease and can lead to disability, cognitive impairments, intensified symptoms of other medical conditions and increased utilization of health care services. Due to the rapidly aging population, depression is a serious public health concern that has a great impact on quality of life and may lay a considerable burden on the health care systems. However depression among the elderly may prove to be hard to diagnose since in aged persons depressive symptoms are often masked by somatic complaints or by cognitive impairments. Consequently depression is often under diagnosed and the patients continue to visit constantly the nurse or the physician without getting an adequate answer to their problem. For that reason over utilization of health care services may be an indicator to the presence of undiagnosed depression. The purpose of this study is to examine the relationships between socio-demographic variables, high primary care utilization and depressive symptomatology among aged patients.
Detailed description
Introduction The number of Israel's elderly (65 plus) has increased from just 85,200 (4.8% of the population) in 1955 to approximately 670,000 people (about 10%) in 2003 (Brodsky et al., 2005). According to the most conservative of three projections offered by the Israeli Central Bureau of Statistics (CBS), the number of seniors is expected to be approximately 676,500 (9.8% of the population) in 2005, to rise to 722,500 people (10.7% of the population) by 2010 and increase to 1,025,800 (almost 12% of the population) by the year 2020.
The increase in life expectancy in the 20th century has resulted in a major growth in the prevalence of age-related diseases and conditions. Depression has been found to be the most prevalent among various mental disorders in later life and is the third most common reason for consultation in primary care (Shah, 1992). Research shows that 10-15% of the persons over 65 years of age suffer from various levels of depressive symptoms (Jacob\& Palmer, 1998).
Sadock \& Sadock (2003) state that depression among elderly may reach up to 15 percent and among these suffering from dementia from 25- 50 percent. Israeli studies show similar rates of depressive symptomatology as performed in other Western countries. A prevalence of 21.5 percent of depressive symptomatology was found among a random sample of 937 Israeli adults. (Iancu et al., 2003).
Depression represents a heterogeneous set of disorders, usually characterized by sad mood and inability to experience pleasure. Among the elderly it often may present itself atypically, with somatic symptoms dominating the clinical picture (Jacob \& Palmer, 1998). Common physical complaints, start with the most common features as loss of energy or fatigue, unexplained pain, gastrointestinal symptoms, headache, dizziness, palpitations, heartburn, numbness, loss of appetite, insomnia specifically early morning awakening. In general, the more unexplained somatic complaints and physical symptoms a patient have, the higher the likelihood of depression (Glass 2003). Elderly depression impairs significantly the quality of life by leading to disability, cognitive impairments, intensified symptoms from medical conditions and increases utilization of health care services and the direct and indirect medical costs (Luber et al., 2001).
Herrman et al.,( 2002) argue that health care utilization among depressed patients is higher then among those without depression. Elderly with depressive symptoms found to be at least as twice as likely to use emergency department and medical inpatient hospital services compared to patients without depressive symptomatology ( Himelhoch et al., 2002). Simon \& Ormel(1995) as well as Katon et al. (2003) stated that patients with depressive symptoms account for 43-52% higher health care costs than patients without depressive symptoms.
The increase in costs associated with depressive symptoms was noted even after adjusting for the severity of chronic medical illness (Glass, 2003). According to the WHO the significance of illness burden attributable to depression increases with age and thus will grow further by the year 2020 based upon projected demographic shifts towards an older population (Peveler et al., 2002).
This trend was showed in Israel by Brodsky et al.( 2005). They reported an elderly average of 11.5 visits at the FP per year while, in the USA, only 25% of the elderly population visited any physician 10 or more times annually - including visits to the ER and home visits (Health, United States,2003).
Consequently detecting and treating elderly patients with depressive symptoms in Israel, may be cost-effective and produce improvement in health and well-being for the money spent in the care of these older adults.
However depression in the aged patient may be atypical in nature and more difficult to diagnose from that in the general population. Therefore it is often under-diagnosed and under-treated (Jacob \& Palmer, 1998). In contrast to younger depressed patients, elderly patients often avoid reporting or showing that their mood level and tend to hide their state of disease or, worse, they lack the consciousness of the disease and think that enjoying life less than before is an inevitable consequence of aging. Moreover, elderly sometimes attribute their depressive symptoms to general medical conditions. Other factors that may hinder distinguishing depression from other conditions are also concomitant diseases, especially dementia, polypharmacy and drug reactions (Glass, 2003). Furthermore Hybels et al. (2001) compared in their study the demographic and risk factor profiles of elderly individuals with less and more severe depression. The obtained results indicated the need to recognize that elderly adults who do not meet the Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria for depression, and those who fall below the threshold on instruments such as the Center for Epidemiologic Studies-Depression scale (CES-D), may still experience depressive symptomatology that warrant attention.
The current scales used today measure physical deterioration as part of the depressive state, while among the older people these are part of the aging process and may confuse the therapist. The Geriatric Depression Scale (GDS) is a more specific tool for the measurement in this age group. It was developed during the 80's (Brink et al., 1982) proven valid and reliable at 1986 and was translated to many languages including Hebrew. (Zalsman et al., 1998). Today it is one of the most widely used instruments for the screening of depression among the elderly population.
To simplify the screening process a Yale Task Force on Geriatric Assessment has recommended the use of a single question, "Do you often feel sad or depressed?" (Lachs et al., 1990). Mahoney et al.( 1994 ) found this question as a valid and reliable short-form alternative.
In conclusion depression is a prevalent mental disorder in later life and a considerable impending public health problem since it may lay unnecessary cost burden on one hand and is difficult to diagnose on the other. Consequently, there is a need to find the most effective ways for early detection of this condition. This study will examine the question whether high health care services utilization and/ or sociodemographic background may predict the presence of depression among aged patients.
Objectives:
The purposes of this study is to examine the relationships between socio-demographic variables, comorbidity, depressive symptomatology and high primary care utilization.
METHOD:
Participants:
The study will be conducted in 10 primary health care clinics in urban communities of Beersheva, Israel. According to the average health care utilization, 11.5 visits to the FP per year (Brodsky et al., 2005)) among elderly in Israel, we classify two groups: "low care utilizers" with ≤ 6 visits per year and "high care utilizers" with ≥ 16 visits. Primary lists of "high and low care utilizer" will be obtained by query to "Clicks" electronic medical chart system ( Roshtov Soft wear industry ltd.) .
Study design
- Observational model
- Natural history
- Time perspective
- Other
Who may qualify
- Ages
- 65 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Older adult
Key inclusion criteria (5 listed)
- Age 65 or older,
- Clalit health organization client
- Outpatient
- Hebrew or English or Russian speaker
- Living in Beer Sheva
Key exclusion criteria (2 listed)
- Known diagnosis of depression, major depression, bipolar disorder, psychosis, dementia or substance abuse
- Current acute illness
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Not reported in the source record.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 May 2007.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Yan Press, MD principal investigator
Ben-Gurion University of the Negev
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Depression, run by Soroka University Medical Center at 1 site in Israel.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 May 2007. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Israel. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 May 2007.