ConstipationPhase 4NCT00286520
Treatment of Fecal Incontinence and Constipation in Patients With Spinal Cord Injury
A Phase 4 study testing Transanal irrigation with Peristeen Anal Irrigation in people with Constipation and Fecal Incontinence, run by University of Aarhus at 1 site in Denmark.
Trial summary
The study aims to compare a newly developed system for transanal colonic irrigation (Peristeen Anal Irrigation) with a bowel management regime that does not include irrigation in a prospective, randomized trial in spinal cord lesion patients (SCL- patients) with faecal incontinence and/or constipation. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Constipation, Fecal Incontinence, Spinal Cord Injury
- What is being tested?
- Transanal irrigation with Peristeen Anal Irrigation
- Type of treatment
- Surgery or procedure
- How many people
- 80 participants
- Where
- 1 siteDenmark
- Study dates
- Dec 2003to Aug 2005
- Phase
- Phase 4
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Aged 18 or over
- Spinal cord lesion at any level at least 3 months from injury
- At least one or more of the following symptoms:
- Spending ½ hour or more attempting to defecate each day or every second day
- Symptoms of autonomic dysreflexia before or during defecation
- Abdominal discomfort before or during defecation
Show all 10Show fewer
- Episodes of faecal incontinence once or more per month
- The patient is able to understand the treatment and is willing to comply with the prescribed regimen
- The patient is able to perform transanal colonic irrigation seated on a toilet commode with or without assistance
- Signed informed consent has been obtained
Who cannot join
- Co-existing major unsolved physical problems due to the injury
- Perform transanal retrograde irrigation on a regular basis
- Evidence of bowel obstruction
- Evidence of inflammatory bowel disease
- History of cerebral palsy or cerebral apoplexy
- Multiple sclerosis
Show all 13Show fewer
- Diabetic polyneuropathy
- Previous abdominal or perianal surgery (not including minor surgery as appendectomy or haemorrhoidectomy)
- Pregnant or lactating
- Evidence of spinal chock
- Mentally unstable
- Treatment with more than 5 mg prednisolon per day.
- PNS implant (sacral nerve stimulation)
Trial locations and contacts
1 site in 1 country.
Denmark1 site
Surgical Research Unit, Department of Surgery P, Aarhus University Hospital
Aarhus, 8000
About this study
Official title: Treatment of Fecal Incontinence and Constipation in Patients With Spinal Cord Injury - a Prospective, Randomized, Controlled, Multicentre Trial of Transanal Irrigation Vs. Conservative Bowel Management
The study aims to compare a newly developed system for transanal colonic irrigation (Peristeen Anal Irrigation) with a bowel management regime that does not include irrigation in a prospective, randomized trial in spinal cord lesion patients (SCL- patients) with faecal incontinence and/or constipation.
Population; 80 SCL- patients with faecal incontinence and/or constipation from five countries.
Focus on:
Bowel symptom score Neurogenic Bowel Dysfunction score Symptom related quality of life questionnaire Time expenditure for performance of bowel care ans side effects
Read the detailed description
The magnitude of bowel dysfunction in spinal cord injury patients has been documented in several studies. Spinal cord injury affects colorectal motility, transit times, and bowel emptying often leading to constipation, fecal incontinence or a combination of both. Although these symptoms are not life-threatening, they may have a severe impact on quality of life as well as increase levels of anxiety and depression.
Various bowel management programs have been empirical, and individual solutions have been sought on a trial-and-error basis. Transanal irrigation has been used in selected patients with constipation or fecal incontinence. The majority of spinal cord injured patients in a recent study benefited from the treatment. However, there is limited evidence in the literature supporting any bowel management program in spinal cord injury in favor of another and well-designed controlled trials are still lacking. Therefore, the present study aims to compare transanal irrigation with conservative bowel management, defined as best supportive bowel care without irrigation, in a prospective, randomized, controlled, multicentre study among spinal cord injured patients with neurogenic bowel dysfunction.
- Conditions
- Constipation, Fecal Incontinence, Spinal Cord Injury
- Being tested
- Transanal irrigation with Peristeen Anal Irrigation
- Keywords
- Constipation, Fecal incontinence, Spinal cord injury, transanal irrigation, quality of life
- Medical subject headings
- Constipation, Fecal Incontinence, Spinal Cord Injuries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Transanal irrigation with Peristeen Anal IrrigationProcedure or surgery
What is being measured
The primary outcome is the main question the study is designed to answer.
Cleveland Clinic Constipaton Scoring System
St. Mark's Fecal Incontinence Grading System
Secondary outcomes (2)
Neurogenic Bowel Dysfunction Score
American Society of Colorectal Surgeon Fecal Incontinence Score
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Feb 2006 (estimated)
- Study startDec 2003
- Study completionAug 2005
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for ConstipationStudies of the same condition, open and under way.
- More trials run by University of AarhusThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 4
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 80 participants
Sponsor and investigators
- Lead sponsor
- University of Aarhus
- Sponsor type
- University, hospital or other
- Collaborators
- Coloplast A/S, Montecatone Rehabilitation Institute S.p.A., National Spinal Injuries Centre, Stoke Mandeville Hospital, United Kingdom,, University Hospital Heidelberg, Karolinska University Hospital, Central Jutland Regional Hospital
- Investigators
- Soeren Laurberg, professor, D.M.Sci, Study chair, Surgical Research Unit, Department of Surgery P, Aarhus University Hospital, Denmark
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00286520
- Sponsor's protocol ID
- DK021CC
- Status last verified
- Feb 2006
- First submitted
- 30 Jan 2006
- Last updated
- 3 Feb 2006
- Results posted
- No
Publications
Christensen P, Olsen N, Krogh K, Bacher T, Laurberg S. Scintigraphic assessment of retrograde colonic washout in fecal incontinence and constipation. Dis Colon Rectum. 2003 Jan;46(1):68-76. doi: 10.1007/s10350-004-6498-0.
PubMed 12544524Christensen P, Kvitzau B, Krogh K, Buntzen S, Laurberg S. Neurogenic colorectal dysfunction - use of new antegrade and retrograde colonic wash-out methods. Spinal Cord. 2000 Apr;38(4):255-61. doi: 10.1038/sj.sc.3100991.
PubMed 10822397Krogh K, Olsen N, Christensen P, Madsen JL, Laurberg S. Colorectal transport during defecation in patients with lesions of the sacral spinal cord. Neurogastroenterol Motil. 2003 Feb;15(1):25-31. doi: 10.1046/j.1365-2982.2003.00381.x.
PubMed 12588466
Study at a glance
From the registry record, last updated by the sponsor on 3 Feb 2006. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Treatment of Fecal Incontinence and Constipation in Patients With Spinal Cord Injury - a Prospective, Randomized, Controlled, Multicentre Trial of Transanal Irrigation Vs. Conservative Bowel Management
- ClinicalTrials.gov ID
- NCT00286520
- Acronym / sponsor ID
- DK021CC
- Conditions
- Constipation, Fecal Incontinence, Spinal Cord Injury
- Keywords
- Constipation, Fecal incontinence, Spinal cord injury, transanal irrigation, quality of life
- Phase
- Phase 4
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 80 participants
- Lead sponsor
- University of AarhusUniversity, hospital or other
- Collaborators
- Coloplast A/S, Montecatone Rehabilitation Institute S.p.A., National Spinal Injuries Centre, Stoke Mandeville Hospital, United Kingdom,, University Hospital Heidelberg, Karolinska University Hospital, Central Jutland Regional Hospital
- Study start
- Dec 2003
- Study completion
- Aug 2005
- First posted
- 3 Feb 2006 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study aims to compare a newly developed system for transanal colonic irrigation (Peristeen Anal Irrigation) with a bowel management regime that does not include irrigation in a prospective, randomized trial in spinal cord lesion patients (SCL- patients) with faecal incontinence and/or constipation.
Population; 80 SCL- patients with faecal incontinence and/or constipation from five countries.
Focus on:
Bowel symptom score Neurogenic Bowel Dysfunction score Symptom related quality of life questionnaire Time expenditure for performance of bowel care ans side effects
Detailed description
The magnitude of bowel dysfunction in spinal cord injury patients has been documented in several studies. Spinal cord injury affects colorectal motility, transit times, and bowel emptying often leading to constipation, fecal incontinence or a combination of both. Although these symptoms are not life-threatening, they may have a severe impact on quality of life as well as increase levels of anxiety and depression.
Various bowel management programs have been empirical, and individual solutions have been sought on a trial-and-error basis. Transanal irrigation has been used in selected patients with constipation or fecal incontinence. The majority of spinal cord injured patients in a recent study benefited from the treatment. However, there is limited evidence in the literature supporting any bowel management program in spinal cord injury in favor of another and well-designed controlled trials are still lacking. Therefore, the present study aims to compare transanal irrigation with conservative bowel management, defined as best supportive bowel care without irrigation, in a prospective, randomized, controlled, multicentre study among spinal cord injured patients with neurogenic bowel dysfunction.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (10 listed)
- Aged 18 or over
- Spinal cord lesion at any level at least 3 months from injury
- At least one or more of the following symptoms:
- Spending ½ hour or more attempting to defecate each day or every second day
- Symptoms of autonomic dysreflexia before or during defecation
Key exclusion criteria (13 listed)
- Co-existing major unsolved physical problems due to the injury
- Perform transanal retrograde irrigation on a regular basis
- Evidence of bowel obstruction
- Evidence of inflammatory bowel disease
- History of cerebral palsy or cerebral apoplexy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Transanal irrigation with Peristeen Anal Irrigation | Procedure or surgery | – |
Primary outcome
Cleveland Clinic Constipaton Scoring System
St. Mark's Fecal Incontinence Grading System
2 secondary outcomes
Neurogenic Bowel Dysfunction Score
American Society of Colorectal Surgeon Fecal Incontinence Score
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Feb 2006.
- Background: PubMed 12544524Christensen P, Olsen N, Krogh K, Bacher T, Laurberg S. Scintigraphic assessment of retrograde colonic washout in fecal incontinence and constipation. Dis Colon Rectum. 2003 Jan;46(1):68-76. doi: 10.1007/s10350-004-6498-0.
- Background: PubMed 10822397Christensen P, Kvitzau B, Krogh K, Buntzen S, Laurberg S. Neurogenic colorectal dysfunction - use of new antegrade and retrograde colonic wash-out methods. Spinal Cord. 2000 Apr;38(4):255-61. doi: 10.1038/sj.sc.3100991.
- Background: PubMed 12588466Krogh K, Olsen N, Christensen P, Madsen JL, Laurberg S. Colorectal transport during defecation in patients with lesions of the sacral spinal cord. Neurogastroenterol Motil. 2003 Feb;15(1):25-31. doi: 10.1046/j.1365-2982.2003.00381.x.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Soeren Laurberg, professor, D.M.Sci study chair
Surgical Research Unit, Department of Surgery P, Aarhus University Hospital, Denmark
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 4 study testing Transanal irrigation with Peristeen Anal Irrigation in people with Constipation and Fecal Incontinence, run by University of Aarhus at 1 site in Denmark.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 10 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Feb 2006. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Denmark. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 4 studies take place after a treatment is approved, to learn more about its long-term benefits and risks in everyday use.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cleveland Clinic Constipaton Scoring System. The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT00286520, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Feb 2006.