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InsomniaPhase 4NCT00296179

Ambien CR For Treatment Of Insomnia Associated With Depression When Used Concomitantly With Lexapro

A Phase 4 study testing zolpidem tartrate in people with Insomnia, run by Sanofi.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

To demonstrate overall improvement of insomnia in subjects treated with zolpidem tartrate extended-release (Ambien CR) and escitalopram (Lexapro) vs. subjects treated with placebo and escitalopram at 2 months. Read more about this study

Who is it for?
Ages 21 to 64 years
Conditions the study is for
Insomnia
What is being tested?
zolpidem tartrate
How many people
372 participants
Where
No sites listed yet
Study dates
Feb 2006to Jun 2007
Phase
Phase 4
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 21 to 64 years
  • All sexes
  • No healthy volunteers
  • Adult

MAJOR INCLUSION CRITERIA:

  1. Must experience sleep disturbances at least 3 nights/week, based on historical data
  2. Must meet the diagnostic requirements for Major Depressive Disorder
  3. Must have QIDS-SR16 score between 6 and 15
  4. Must be either newly diagnosed or show symptoms of relapse/recurrence of depression while not on medication
  5. Age 21-64, inclusive
  6. Women must use a medically acceptable form of contraception (steroidal contraceptive, double-barrier, or intra-uterine device) during the entire study period, or: be surgically sterilized, post-menopausal, agree to use double-barrier contraception throughout the study period, or must have a negative urine pregnancy test prior to randomization.
  7. Subject must be stabilized on all ongoing long-term medication therapy for at least 28 days prior to screening visit.

MAJOR EXCLUSION CRITERIA:

  1. Severity of depressive episode had been rated as "severe" or "severe with psychotic features."
  2. History of a suicide attempt or suicidal ideation.
  3. History of mania, manic episode or bipolar disease.
  4. Currently using a benzodiazepine or SSRI or more than 2 days of use within the 28 days preceding randomization.
  5. Use of prescription and non-prescription sedative drugs given for the purpose of sleep induction or to relieve jet lag
  6. Any abnormal pre-study laboratory values that require clinical intervention
  7. Prior failure to respond to escitalopram therapy for depression
  8. Current depressive episode requiring inpatient hospitalization.
  9. Shift work or requirement for a regular change in sleep schedule by at least six hours within the previous 28 days.
  10. History of drug addiction, alcoholism, or drug abuse.
  11. A positive urine drug screen for medication that would interfere with the assessment of the study medication.
  12. Known allergy to zolpidem, escitalopram or any of their excipients
  13. History of sleep apnea
  14. History of myasthenia gravis
  15. The presence of any untreated or uncompensated clinically significant renal, endocrine, gastrointestinal, hepatic, respiratory, cardiovascular, other neurologic, hematologic, oncologic, immunologic, cerebrovascular disease or malignancy.
  16. Pregnant or breastfeeding
  17. Subject is participating in another clinical trial, or has completed another clinical trial within 28 days prior to screening.

About this study

Official title: Comparison of Zolpidem Tartrate Extended-Release vs. Placebo in Treatment of Insomnia Associated With Newly Diagnosed Major Depressive Disorder(MDD) or Untreated MDD Relapse, When Used Concomitantly With Escitalopram

To demonstrate overall improvement of insomnia in subjects treated with zolpidem tartrate extended-release (Ambien CR) and escitalopram (Lexapro) vs. subjects treated with placebo and escitalopram at 2 months.

Conditions
Insomnia
Being tested
zolpidem tartrate
Medical subject headings
Sleep Initiation and Maintenance Disorders

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • zolpidem tartrateDrug

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Efficacy: Patient-reported TST

Secondary outcomes (1)

  1. Difference in relapse rates in patients receiving placebo and patients receiving zolpidem MR during 4 month follow-up period

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted24 Feb 2006 (estimated)
  2. Study startFeb 2006
  3. Primary completionJun 2007

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 4
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Enrolment
372 participants
IDs, dates and publications
ClinicalTrials.gov ID
NCT00296179
Sponsor's protocol ID
PM_L_0166
Status last verified
Jul 2008
First submitted
23 Feb 2006
Last updated
28 Jul 2008
Results posted
No

Publications

  • Fava M, Asnis GM, Shrivastava RK, Lydiard B, Bastani B, Sheehan DV, Roth T. Improved insomnia symptoms and sleep-related next-day functioning in patients with comorbid major depressive disorder and insomnia following concomitant zolpidem extended-release 12.5 mg and escitalopram treatment: a randomized controlled trial. J Clin Psychiatry. 2011 Jul;72(7):914-28. doi: 10.4088/JCP.09m05571gry. Epub 2010 Dec 28.

    PubMed 21208597

Questions about this trial

What is this clinical trial studying?

A Phase 4 study testing zolpidem tartrate in people with Insomnia, run by Sanofi.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 28 Jul 2008. Status can change between updates, so confirm with the study contact before making plans.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 4 studies take place after a treatment is approved, to learn more about its long-term benefits and risks in everyday use.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Efficacy: Patient-reported TST. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT00296179, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Jul 2008.

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