ImpotenceNCT00297544

Effect of Sildenafil on Endothelial Function

A study testing Viagra in people with Impotence, run by Rambam Health Care Campus at 1 site in Israel.

Unknown status

Status not confirmed. The sponsor has not verified this record for over two years, so it may be out of date.

Trial summary

We are investigating the chronic effect of daily assumption of Viagra on the blood vessels function in patients with impotence. The study will include 2 groups: 1- patients with multiple risk factors, e.g. hypertension 2- patients with no cardiovascular risk factors Read more about this study

Who is it for?: Ages 40 to 70 years, men only
Conditions the study is for: Impotence
What is being tested?: Viagra
How many people: 60 participants
Where: 1 siteIsrael
Study dates: Oct 2005to not given
Phase: Interventional

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 40 to 70 years
Men only
No healthy volunteers
Adult, Older adult

Who may be able to join

age 40-70
impotence
with and without hypertension, Hypercholesteremia or DM

Who cannot join

CHF: NYHA > II
Stable angina: CCS > II
Nitrate treatment

Trial locations and contacts

1 site in 1 country.

Giris Jacob, Prof., MD, DSc contact

972-4-854-2467

g_jacob@rambam.health.gov.il

Yuram Vardi, Prof., MD contact

972-4-854-2819

y_vardi@rambam.health.gov.il

Israel1 site, 1 recruiting

Rambam Medical Center, Recanati Autonomic Dysfunction CTR
Haifa, 31096
Giris Jacob, MD, DSc, 972-4-854-2594, g_Jacob@rambam.health.gov.il
Yuram Vardi, MD
Recruiting

Other trials in Israel

About this study

Read the detailed description

Conditions: Impotence
Being tested: Viagra
Keywords: impotence, endothelial function, autonomic nervous system
Medical subject headings: Erectile Dysfunction

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

ViagraDrug

What is being measured

The primary outcome is the main question the study is designed to answer.

Improvement of endothelial function following Viagra treatment, according to platismographia.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

Oct 2005?

First posted28 Feb 2006 (estimated)
Study startOct 2005

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Publications (2)Papers the sponsor has linked to this study.
Other trials for ImpotenceStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Early clinical test
Allocation: Randomised
Intervention model: Parallel groups
Masking: Double blind
Enrolment: 60 participants

IDs, dates and publications

ClinicalTrials.gov ID: NCT00297544
Sponsor's protocol ID: 1777-CTIL
Status last verified: Nov 2005
First submitted: 27 Feb 2006
Last updated: 28 Feb 2006
Results posted: No

Publications

Dayan L, Greunwald I, Vardi Y, Jacob G. A new clinical method for the assessment of penile endothelial function using the flow mediated dilation with plethysmography technique. J Urol. 2005 Apr;173(4):1268-72. doi: 10.1097/01.ju.0000152290.71948.bf.
PubMed 15758774
Vardi Y, Appel B, Ofer Y, Greunwald I, Dayan L, Jacob G. Effect of chronic sildenafil treatment on penile endothelial function: a randomized, double-blind, placebo controlled study. J Urol. 2009 Dec;182(6):2850-5. doi: 10.1016/j.juro.2009.08.025. Epub 2009 Oct 17.
PubMed 19837434