HealthyNCT00357695
Role of the Brain in Processing Visually Presented Objects
An observational study of Healthy and Motor Skills, run by National Institute of Neurological Disorders and Stroke (NINDS) at 1 site in United States.
Trial summary
This study will examine the parts of the brain that use visual information to perform movements. Patients with certain brain lesions tend to have difficulty in processing visually presented objects. This study will look at the brain mechanisms underlying the visuo-motor integration. Read more about this study
- Who is it for?
- Ages 20 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy, Motor Skills
- How many people
- 45 participants
- Where
- 1 siteUnited States
- Study dates
- 18 Nov 2003to 28 Oct 2008
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy male or female subjects between the ages of 20 and 60 years old will be eligible within the limits of the exclusion criteria below.
Who cannot join
- A previous history of neurological diseases will be carefully taken by direct interview by the Principal or Associate Investigators. Subjects who had a head injury (severe enough to cause loss of consciousness) or other brain diseases causing mental disturbance, sensory impairment, or motor dysfunction in the past will be excluded. Subjects who have metals either in the mouth, such as dental prostheses, or in the head, such as surgical clips from any previous surgical procedures, are also excluded due to technical limitations in terms of MEG. Furthermore, subjects wearing glasses for visual correction and those with poor vision, even with contact lenses, are excluded also due to technical limitations for MEG. Subjects who have pacemakers or other implanted electrical devices, brain stimulators, dental implants, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, implanted delivery pump, or shrapnel fragments, and welders and metal workers are excluded for MRI for the sake of safety of subjects. Finally, by doing a brief neurological examination of finger movements, the subjects with poor performance of fine finger movements or those who are judged to have mirror movements will be excluded.
Trial locations and contacts
1 site in 1 country.
United States1 site
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, 20892
About this study
Official title: Role of the Parieto-Frontal Network in Automatic Processing of Visually Presented Objects
This study will examine the parts of the brain that use visual information to perform movements. Patients with certain brain lesions tend to have difficulty in processing visually presented objects. This study will look at the brain mechanisms underlying the visuo-motor integration.
Healthy normal volunteers between 20 and 60 years of age are eligible for this study. People who have had a severe head injury with loss of consciousness or any other mental or neurological disorder diagnosed by a doctor may not participate. Candidates will be screened with a medical history, a physical examination focusing on finger movements, and a questionnaire.
Participants' brain activity will be recorded using two techniques - magnetoencephalography(MEG) and magnetic resonance imaging (MRI) - while they watch pictures of various objects flashed on a screen. MEG is a procedure to record magnetic field changes produced by brain activity. During the recording, the subject sits comfortably in an armchair in a dimly lit room and watches pictures presented on a screen. About 50 pictures are shown per session. There are about five sessions, separated by 3-minute breaks. Functional MRI involves taking pictures of the brain using MRI while the subject performs a task. MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues. The MRI scanner is a metal cylinder surrounded by a magnetic field. The subject lies still on a table that can slide in and out of the scanner. During the scan, he or she looks at pictures in six test blocks of 1 minute each, with 30-second breaks between blocks.
Read the detailed description
Objectives: Patients with frontal lobe lesions tend to grasp visually presented objects automatically and forcefully (forced grasping). Grasping of a milder form is seen in infants and the aged population. These facts suggest the presence of an inherent mechanism for suppressing the automatic tendency toward grasping in the healthy adult brain. Previous studies suggest that the parieto-frontal network, especially the lateral premotor cortex, play a role in the cognition of graspable objects and execution of reaching/grasping. Although the task of reaching/grasping in human beings has been studied mainly by neuroimaging techniques, its cognitive and executive aspects have not been clearly distinguished. Therefore, this project aims to elucidate the mechanisms underlying 'automatic grasping' in humans, focusing on the perceptive/cognitive aspect of the reaching/grasping movements.
Study population and design: Pictures of graspable objects and non-graspable objects are visually presented to 45 healthy adult volunteers. Since this study aims to clarify the mechanism of the human brain for automatically recognizing graspable objects, part of this study will require no response task. Additionally, in order to assess how the automatic functions compare to overt mechanisms, an extra testing session will explore making overt judgments of the pictures.
Outcome measures: The brain activations are investigated by event-related magnetic fields, which have high temporal resolution, and by event-related functional magnetic resonance imaging (fMRI), which has relatively high spatial resolution. It is expected that the lateral premotor cortex, in addition to the parietal cortex, is activated by the visual presentation of graspable objects at a shorter latency, and more strongly, as compared with non-graspable objects, even without any actual motor tasks to follow. Additionally, overt grasping of graspable objects will involve similar areas.
- Conditions
- Healthy, Motor Skills
- Keywords
- Praxis, Grasping, Premotor Cortex, Visuo-Motor Integration, Motor Imagination
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Jul 2006 (estimated)
- Study start18 Nov 2003
- Study completion28 Oct 2008
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Enrolment
- 45 participants
Sponsor and investigators
- Lead sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
- Sponsor type
- US National Institutes of Health
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00357695
- Sponsor's protocol ID
- 040047
- Other IDs
- 04-N-0047
- Status last verified
- 28 Oct 2008
- First submitted
- 26 Jul 2006
- Last updated
- 2 Jul 2017
- Results posted
- No
Publications
Jeannerod M, Arbib MA, Rizzolatti G, Sakata H. Grasping objects: the cortical mechanisms of visuomotor transformation. Trends Neurosci. 1995 Jul;18(7):314-20.
PubMed 7571012Chan JL, Ross ED. Alien hand syndrome: influence of neglect on the clinical presentation of frontal and callosal variants. Cortex. 1997 Jun;33(2):287-99. doi: 10.1016/s0010-9452(08)70005-4.
PubMed 9220259Jeannerod M, Decety J, Michel F. Impairment of grasping movements following a bilateral posterior parietal lesion. Neuropsychologia. 1994 Apr;32(4):369-80. doi: 10.1016/0028-3932(94)90084-1.
PubMed 8047246
Study at a glance
From the registry record, last updated by the sponsor on 2 Jul 2017. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Role of the Parieto-Frontal Network in Automatic Processing of Visually Presented Objects
- ClinicalTrials.gov ID
- NCT00357695
- Acronym / sponsor ID
- 040047
- Conditions
- Healthy, Motor Skills
- Keywords
- Praxis, Grasping, Premotor Cortex, Visuo-Motor Integration, Motor Imagination
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 45 participants
- Lead sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)US National Institutes of Health
- Study start
- 18 Nov 2003
- Study completion
- 28 Oct 2008
- First posted
- 27 Jul 2006 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will examine the parts of the brain that use visual information to perform movements. Patients with certain brain lesions tend to have difficulty in processing visually presented objects. This study will look at the brain mechanisms underlying the visuo-motor integration.
Healthy normal volunteers between 20 and 60 years of age are eligible for this study. People who have had a severe head injury with loss of consciousness or any other mental or neurological disorder diagnosed by a doctor may not participate. Candidates will be screened with a medical history, a physical examination focusing on finger movements, and a questionnaire.
Participants' brain activity will be recorded using two techniques - magnetoencephalography(MEG) and magnetic resonance imaging (MRI) - while they watch pictures of various objects flashed on a screen. MEG is a procedure to record magnetic field changes produced by brain activity. During the recording, the subject sits comfortably in an armchair in a dimly lit room and watches pictures presented on a screen. About 50 pictures are shown per session. There are about five sessions, separated by 3-minute breaks. Functional MRI involves taking pictures of the brain using MRI while the subject performs a task. MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues. The MRI scanner is a metal cylinder surrounded by a magnetic field. The subject lies still on a table that can slide in and out of the scanner. During the scan, he or she looks at pictures in six test blocks of 1 minute each, with 30-second breaks between blocks.
Detailed description
Objectives: Patients with frontal lobe lesions tend to grasp visually presented objects automatically and forcefully (forced grasping). Grasping of a milder form is seen in infants and the aged population. These facts suggest the presence of an inherent mechanism for suppressing the automatic tendency toward grasping in the healthy adult brain. Previous studies suggest that the parieto-frontal network, especially the lateral premotor cortex, play a role in the cognition of graspable objects and execution of reaching/grasping. Although the task of reaching/grasping in human beings has been studied mainly by neuroimaging techniques, its cognitive and executive aspects have not been clearly distinguished. Therefore, this project aims to elucidate the mechanisms underlying 'automatic grasping' in humans, focusing on the perceptive/cognitive aspect of the reaching/grasping movements.
Study population and design: Pictures of graspable objects and non-graspable objects are visually presented to 45 healthy adult volunteers. Since this study aims to clarify the mechanism of the human brain for automatically recognizing graspable objects, part of this study will require no response task. Additionally, in order to assess how the automatic functions compare to overt mechanisms, an extra testing session will explore making overt judgments of the pictures.
Outcome measures: The brain activations are investigated by event-related magnetic fields, which have high temporal resolution, and by event-related functional magnetic resonance imaging (fMRI), which has relatively high spatial resolution. It is expected that the lateral premotor cortex, in addition to the parietal cortex, is activated by the visual presentation of graspable objects at a shorter latency, and more strongly, as compared with non-graspable objects, even without any actual motor tasks to follow. Additionally, overt grasping of graspable objects will involve similar areas.
Study design
Who may qualify
- Ages
- 20 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Healthy male or female subjects between the ages of 20 and 60 years old will be eligible within the limits of the exclusion criteria below.
Key exclusion criteria (1 listed)
- A previous history of neurological diseases will be carefully taken by direct interview by the Principal or Associate Investigators. Subjects who had a head injury (severe enough to cause loss of consciousness) or other brain diseases causing mental disturbance, sensory impairment, or motor dysfunction in the past will be excluded. Subjects who have metals either in the mouth, such as dental prostheses, or in the head, such as surgical clips from any previous surgical procedures, are also excluded due to technical limitations in terms of MEG. Furthermore, subjects wearing glasses for visual correction and those with poor vision, even with contact lenses, are excluded also due to technical limitations for MEG. Subjects who have pacemakers or other implanted electrical devices, brain stimulators, dental implants, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, implanted delivery pump, or shrapnel fragments, and welders and metal workers are excluded for MRI for the sake of safety of subjects. Finally, by doing a brief neurological examination of finger movements, the subjects with poor performance of fine finger movements or those who are judged to have mirror movements will be excluded.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Not reported in the source record.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Jul 2017.
- Background: PubMed 7571012Jeannerod M, Arbib MA, Rizzolatti G, Sakata H. Grasping objects: the cortical mechanisms of visuomotor transformation. Trends Neurosci. 1995 Jul;18(7):314-20.
- Background: PubMed 9220259Chan JL, Ross ED. Alien hand syndrome: influence of neglect on the clinical presentation of frontal and callosal variants. Cortex. 1997 Jun;33(2):287-99. doi: 10.1016/s0010-9452(08)70005-4.
- Background: PubMed 8047246Jeannerod M, Decety J, Michel F. Impairment of grasping movements following a bilateral posterior parietal lesion. Neuropsychologia. 1994 Apr;32(4):369-80. doi: 10.1016/0028-3932(94)90084-1.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Healthy and Motor Skills, run by National Institute of Neurological Disorders and Stroke (NINDS) at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Jul 2017. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT00357695, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Jul 2017.