Occipital CortexNCT00376545
Brain Connectivity Between Visual Input and Movement
An observational study of Occipital Cortex and Prefrontal Cortex, run by National Institute of Neurological Disorders and Stroke (NINDS) at 1 site in United States.
Trial summary
This study will explore how the areas in the brain are connected to link what people see to what they do; that is, how they use what they see to help guide their movements. The study uses functional magnetic resonance imaging (fMRI) to look at different areas in the brain while a person performs tasks in which both… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Occipital Cortex, Prefrontal Cortex, Healthy
- How many people
- 25 participants
- Where
- 1 siteUnited States
- Study dates
- 12 Sep 2006to 13 Nov 2008
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Subjects age 18 and older
- Subjects must be right-hand dominant (Edinburgh Handedness Quotient greater than 60)
- Subjects willing to abstain from caffeine or alcohol for 48 hours prior to the fMRI scanning
Who cannot join
- Subjects with any abnormal findings on neurological exam
- Subjects who are pregnant (as determined by a positive urine pregnancy test)
- Subjects with any finding on the MRI safety questionnaire which prevents them from safely undergoing an MRI scan
- Subjects with metallic dental fillings which are likely to cause MRI artifacts
- Subjects with any history of brain tumor, stroke, head trauma or a vascular malformation as obtained by history or from imaging studies
- Subjects with any history of a severe medical condition, such as cardiovascular disease, which would prevent them from lying flat for up to 120 minutes
- Subjects without the capacity to give informed consent
- Subjects with claustrophobia or other restrictions which prevent them from undergoing a scan in a confined space for up to 60 minutes
Trial locations and contacts
1 site in 1 country.
United States1 site
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, 20892
About this study
Official title: Brain Connectivity Between Visual Input and Motor Output
This study will explore how the areas in the brain are connected to link what people see to what they do; that is, how they use what they see to help guide their movements. The study uses functional magnetic resonance imaging (fMRI) to look at different areas in the brain while a person performs tasks in which both what they see (visual input) and what they do (their motor response) are related or unrelated.
Healthy, right-handed normal volunteers who are 18 years of age or older may be eligible for this study. Candidates are screened with a medical history, neurological examination and MRI scan, if one has not been done within a year of entering the study. MRI uses a magnetic field and radio waves to produce images of body tissues and organs. The subject lies on a table that can slide in and out of the scanner (a narrow cylinder), wearing earplugs to muffle loud knocking sounds that occur during scanning. The procedure lasts about 90 minutes, during which the subject is asked to lie still for up to 30 minutes at a time.
Participants undergo fMRI for this 1-day study. fMRI differs from ordinary MRI in that the subject performs tasks during the scanning, allowing researchers to see brain changes that occur during performance of the activity. Before the scan, the subject is trained for the tasks, which include looking at shapes while following them with the fingers and looking at shapes without making finger movements. Following the testing, subjects have a second ordinary MRI scan.
Read the detailed description
OBJECTIVE:
The purpose is to analyze task-related connectivity changes in brain regions, using a block design blood oxygenation level-dependent functional magnetic resonance imaging (BOLD-fMRI), as a function of the linkage between visual input and motor output.
STUDY POPULATION:
- 25 right-hand dominant, healthy adult volunteers
DESIGN:
Connectivity between brain areas can change related to the dependence level between visual input and motor output. The dependence level will be modulated while performed tasks engage visual and motor areas either in a functionally related fashion or not. Subjects will perform a visuomotor task (VM, dependence level = maximal) that consists of tracking a target by exerting force isometrically on a transducer with their right index finger (target signal and exerted force are displayed in the scanner). In the visual plus motor task (V+M), two different tasks will be performed simultaneously. Subjects will perform the same motor task as in VM but without target signal and visual feedback of their force control, while a neutral visual input unrelated to the motor output is dynamically flashed in the screen. In the visual (V), subjects will watch the target signal while relaxed. In the motor task (M), subjects will produce the same motor task as in VM and V+M while staring at a static fixation cross. A rest period will require subjects to fixate on a stationary dot in the middle of the visual field. fMRI scanning will be used to record brain activity during tasks.
The experimental phase will have six sets of 6-minute scanning sessions where the subject will perform the conditions. The conditions will appear pseudo-randomly throughout the scan sessions. V will always precede VM condition to avoid motor system activation secondary to imagination of movement primed by the visual stimulus. The M and VM conditions will be presented in a random order. At the completion of fMRI scanning, a baseline high-resolution MRI T1 scan will be obtained for anatomic localization and co-registration.
OUTCOME MEASURES:
The primary outcome is the connectivity change in brain networks in response to loss of dependence between a sensory input and the motor output. We will be focused on the correlation between the time series of activations in each condition and the connectivity changes over all the conditions. This will allow us to elucidate the task-dependent connectivity between occipital cortex and prefrontal cortex relative to the functional link between visual input and motor output.
- Conditions
- Occipital Cortex, Prefrontal Cortex, Healthy
- Keywords
- Functional Magnetic Resonance Imaging (fMRI), Visuomotor, Occipital Cortex, Prefrontal Cortex, Healthy Volunteer, HV
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Sep 2006 (estimated)
- Study start12 Sep 2006
- Primary completion13 Nov 2008
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Occipital CortexStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Enrolment
- 25 participants
Sponsor and investigators
- Lead sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
- Sponsor type
- US National Institutes of Health
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00376545
- Sponsor's protocol ID
- 060243
- Other IDs
- 06-N-0243
- Status last verified
- 13 Nov 2009
- First submitted
- 14 Sep 2006
- Last updated
- 2 Jul 2017
- Results posted
- No
Publications
Kaiser J, Lutzenberger W. Human gamma-band activity: a window to cognitive processing. Neuroreport. 2005 Feb 28;16(3):207-11. doi: 10.1097/00001756-200502280-00001.
PubMed 15706221Singer W, Gray CM. Visual feature integration and the temporal correlation hypothesis. Annu Rev Neurosci. 1995;18:555-86. doi: 10.1146/annurev.ne.18.030195.003011. No abstract available.
PubMed 7605074von der Malsburg C, Schneider W. A neural cocktail-party processor. Biol Cybern. 1986;54(1):29-40. doi: 10.1007/BF00337113.
PubMed 3719028
Study at a glance
From the registry record, last updated by the sponsor on 2 Jul 2017. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Brain Connectivity Between Visual Input and Motor Output
- ClinicalTrials.gov ID
- NCT00376545
- Acronym / sponsor ID
- 060243
- Conditions
- Occipital Cortex, Prefrontal Cortex, Healthy
- Keywords
- Functional Magnetic Resonance Imaging (fMRI), Visuomotor, Occipital Cortex, Prefrontal Cortex, Healthy Volunteer, HV
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 25 participants
- Lead sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)US National Institutes of Health
- Study start
- 12 Sep 2006
- Primary completion
- 13 Nov 2008 (actual)
- First posted
- 15 Sep 2006 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will explore how the areas in the brain are connected to link what people see to what they do; that is, how they use what they see to help guide their movements. The study uses functional magnetic resonance imaging (fMRI) to look at different areas in the brain while a person performs tasks in which both what they see (visual input) and what they do (their motor response) are related or unrelated.
Healthy, right-handed normal volunteers who are 18 years of age or older may be eligible for this study. Candidates are screened with a medical history, neurological examination and MRI scan, if one has not been done within a year of entering the study. MRI uses a magnetic field and radio waves to produce images of body tissues and organs. The subject lies on a table that can slide in and out of the scanner (a narrow cylinder), wearing earplugs to muffle loud knocking sounds that occur during scanning. The procedure lasts about 90 minutes, during which the subject is asked to lie still for up to 30 minutes at a time.
Participants undergo fMRI for this 1-day study. fMRI differs from ordinary MRI in that the subject performs tasks during the scanning, allowing researchers to see brain changes that occur during performance of the activity. Before the scan, the subject is trained for the tasks, which include looking at shapes while following them with the fingers and looking at shapes without making finger movements. Following the testing, subjects have a second ordinary MRI scan.
Detailed description
OBJECTIVE:
The purpose is to analyze task-related connectivity changes in brain regions, using a block design blood oxygenation level-dependent functional magnetic resonance imaging (BOLD-fMRI), as a function of the linkage between visual input and motor output.
STUDY POPULATION:
- 25 right-hand dominant, healthy adult volunteers
DESIGN:
Connectivity between brain areas can change related to the dependence level between visual input and motor output. The dependence level will be modulated while performed tasks engage visual and motor areas either in a functionally related fashion or not. Subjects will perform a visuomotor task (VM, dependence level = maximal) that consists of tracking a target by exerting force isometrically on a transducer with their right index finger (target signal and exerted force are displayed in the scanner). In the visual plus motor task (V+M), two different tasks will be performed simultaneously. Subjects will perform the same motor task as in VM but without target signal and visual feedback of their force control, while a neutral visual input unrelated to the motor output is dynamically flashed in the screen. In the visual (V), subjects will watch the target signal while relaxed. In the motor task (M), subjects will produce the same motor task as in VM and V+M while staring at a static fixation cross. A rest period will require subjects to fixate on a stationary dot in the middle of the visual field. fMRI scanning will be used to record brain activity during tasks.
The experimental phase will have six sets of 6-minute scanning sessions where the subject will perform the conditions. The conditions will appear pseudo-randomly throughout the scan sessions. V will always precede VM condition to avoid motor system activation secondary to imagination of movement primed by the visual stimulus. The M and VM conditions will be presented in a random order. At the completion of fMRI scanning, a baseline high-resolution MRI T1 scan will be obtained for anatomic localization and co-registration.
OUTCOME MEASURES:
The primary outcome is the connectivity change in brain networks in response to loss of dependence between a sensory input and the motor output. We will be focused on the correlation between the time series of activations in each condition and the connectivity changes over all the conditions. This will allow us to elucidate the task-dependent connectivity between occipital cortex and prefrontal cortex relative to the functional link between visual input and motor output.
Study design
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Subjects age 18 and older
- Subjects must be right-hand dominant (Edinburgh Handedness Quotient greater than 60)
- Subjects willing to abstain from caffeine or alcohol for 48 hours prior to the fMRI scanning
Key exclusion criteria (8 listed)
- Subjects with any abnormal findings on neurological exam
- Subjects who are pregnant (as determined by a positive urine pregnancy test)
- Subjects with any finding on the MRI safety questionnaire which prevents them from safely undergoing an MRI scan
- Subjects with metallic dental fillings which are likely to cause MRI artifacts
- Subjects with any history of brain tumor, stroke, head trauma or a vascular malformation as obtained by history or from imaging studies
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Not reported in the source record.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Jul 2017.
- Background: PubMed 15706221Kaiser J, Lutzenberger W. Human gamma-band activity: a window to cognitive processing. Neuroreport. 2005 Feb 28;16(3):207-11. doi: 10.1097/00001756-200502280-00001.
- Background: PubMed 7605074Singer W, Gray CM. Visual feature integration and the temporal correlation hypothesis. Annu Rev Neurosci. 1995;18:555-86. doi: 10.1146/annurev.ne.18.030195.003011. No abstract available.
- Background: PubMed 3719028von der Malsburg C, Schneider W. A neural cocktail-party processor. Biol Cybern. 1986;54(1):29-40. doi: 10.1007/BF00337113.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Occipital Cortex and Prefrontal Cortex, run by National Institute of Neurological Disorders and Stroke (NINDS) at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Jul 2017. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT00376545, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Jul 2017; AzTrials last refreshed its copy on 1 Nov 2026.