Lipid MetabolismNCT00386854
Metabolic Study of Concentric and Eccentric Muscle Training
A study testing physical training in people with Lipid Metabolism and Insulin Resistance, run by Vorarlberg Institute for Vascular Investigation and Treatment at 1 site in Austria.
Trial summary
The purpose of this study is to evaluate the metabolic and anti-inflammatory effects of eccentric endurance exercise and to compare them with those of concentric exercise in healthy sedentary individuals. Read more about this study
- Who is it for?
- Ages 30 years and olderHealthy volunteers can take part
- Conditions the study is for
- Lipid Metabolism, Insulin Resistance, Inflammation
- What is being tested?
- physical training
- Type of treatment
- Lifestyle or therapy programme
- How many people
- 40 participants
- Where
- 1 siteAustria
- Study dates
- Apr 2003to Aug 2003
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- healthy men and women
- age over 30 years
Who cannot join
- previous systematic endurance training (≥3 times per week ≥30 min)
- body mass index >30 kg/m2
- heavy smoking (>20 cigarettes per day)
- regular alcohol consumption >60g per day
- established musculoskeletal disease
- history of cardiovascular disease
- diabetes mellitus
- unwillingness to stay in the area for the whole study period
Trial locations and contacts
1 site in 1 country.
Austria1 site
Vorarlberg Institute of Vascular Investigation and Treatment
Feldkirch, Vorarlberg, 6807
About this study
The purpose of this study is to evaluate the metabolic and anti-inflammatory effects of eccentric endurance exercise and to compare them with those of concentric exercise in healthy sedentary individuals.
Read the detailed description
Physical exercise decreases the risk of obesity, diabetes mellitus, and cardiovascular disease. Skeletal muscle can be exercised by two ways: Concentric contraction is defined as active shortening of muscles, e.g. by stepping upwards, whereas eccentric muscle contraction is defined as active resistance to stretching, e.g. by stepping downwards. Although the effects of exercise (i.e. the combination of concentric and eccentric muscle contraction) on metabolic parameters have been extensively investigated, there are no data on the specific metabolic effects of concentric versus those of eccentric muscle work in humans.
Comparison(s): Metabolic and anti-inflammatory effects of eccentric endurance exercise (i.e. stepping upwards), compared to metabolic and anti-inflammatory effects of concentric exercise (i.e. stepping downwards).
- Conditions
- Lipid Metabolism, Insulin Resistance, Inflammation
- Being tested
- physical training
- Keywords
- exercise, lipid metabolism, lipoproteins, insulin resistance, inflammation
- Medical subject headings
- Insulin Resistance, Inflammation, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
physical trainingBehavioural
What is being measured
The primary outcome is the main question the study is designed to answer.
Metabolic and anti-inflammatory effects induced by eccentric muscle exercise.
Secondary outcomes (1)
Metabolic and anti-inflammatory effects induced by concentric muscle exercise.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Oct 2006 (estimated)
- Study startApr 2003
- Study completionAug 2003
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Lipid MetabolismStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Early clinical test
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 40 participants
Sponsor and investigators
- Lead sponsor
- Vorarlberg Institute for Vascular Investigation and Treatment
- Sponsor type
- University, hospital or other
- Investigators
- Heinz Drexel, MD, Principal investigator, Vorarlberg Institut of Vascular Investigation and Treatment, Academic Teaching Hospital, Austria
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00386854
- Sponsor's protocol ID
- K01-2003-1
- Status last verified
- Oct 2006
- First submitted
- 10 Oct 2006
- Last updated
- 12 Oct 2006
- Results posted
- No
Publications
Drexel H, Mader A, Saely CH, Tautermann G, Dopheide JF, Vonbank A. Downhill hiking improves low-grade inflammation, triglycerides, body weight and glucose tolerance. Sci Rep. 2021 Jul 15;11(1):14503. doi: 10.1038/s41598-021-93879-1.
PubMed 34267272
Study at a glance
From the registry record, last updated by the sponsor on 12 Oct 2006. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Metabolic Study of Concentric and Eccentric Muscle Training
- ClinicalTrials.gov ID
- NCT00386854
- Acronym / sponsor ID
- K01-2003-1
- Conditions
- Lipid Metabolism, Insulin Resistance, Inflammation
- Keywords
- exercise, lipid metabolism, lipoproteins, insulin resistance, inflammation
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants
- Lead sponsor
- Vorarlberg Institute for Vascular Investigation and TreatmentUniversity, hospital or other
- Study start
- Apr 2003
- Study completion
- Aug 2003
- First posted
- 12 Oct 2006 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to evaluate the metabolic and anti-inflammatory effects of eccentric endurance exercise and to compare them with those of concentric exercise in healthy sedentary individuals.
Detailed description
Physical exercise decreases the risk of obesity, diabetes mellitus, and cardiovascular disease. Skeletal muscle can be exercised by two ways: Concentric contraction is defined as active shortening of muscles, e.g. by stepping upwards, whereas eccentric muscle contraction is defined as active resistance to stretching, e.g. by stepping downwards. Although the effects of exercise (i.e. the combination of concentric and eccentric muscle contraction) on metabolic parameters have been extensively investigated, there are no data on the specific metabolic effects of concentric versus those of eccentric muscle work in humans.
Comparison(s): Metabolic and anti-inflammatory effects of eccentric endurance exercise (i.e. stepping upwards), compared to metabolic and anti-inflammatory effects of concentric exercise (i.e. stepping downwards).
Study design
- Primary purpose
- Early clinical test
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
Who may qualify
- Ages
- 30 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- healthy men and women
- age over 30 years
Key exclusion criteria (8 listed)
- previous systematic endurance training (≥3 times per week ≥30 min)
- body mass index >30 kg/m2
- heavy smoking (>20 cigarettes per day)
- regular alcohol consumption >60g per day
- established musculoskeletal disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| physical training | Behavioural | – |
Primary outcome
Metabolic and anti-inflammatory effects induced by eccentric muscle exercise.
1 secondary outcome
Metabolic and anti-inflammatory effects induced by concentric muscle exercise.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Oct 2006.
- Derived from this study: PubMed 34267272Drexel H, Mader A, Saely CH, Tautermann G, Dopheide JF, Vonbank A. Downhill hiking improves low-grade inflammation, triglycerides, body weight and glucose tolerance. Sci Rep. 2021 Jul 15;11(1):14503. doi: 10.1038/s41598-021-93879-1.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Heinz Drexel, MD principal investigator
Vorarlberg Institut of Vascular Investigation and Treatment, Academic Teaching Hospital, Austria
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing physical training in people with Lipid Metabolism and Insulin Resistance, run by Vorarlberg Institute for Vascular Investigation and Treatment at 1 site in Austria.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Oct 2006. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Austria. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Metabolic and anti-inflammatory effects induced by eccentric muscle exercise.. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT00386854, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Oct 2006.