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Adult Giant Cell GlioblastomaPhase 2NCT00459381

Pazopanib in Treating Patients With Recurrent Glioblastoma

A Phase 2 study testing pazopanib hydrochloride and laboratory biomarker analysis in people with Adult Giant Cell Glioblastoma and Adult Glioblastoma, run by National Cancer Institute (NCI) at 9 sites in United States.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

This phase II trial is studying the side effects and how well pazopanib works in treating patients with recurrent glioblastoma. Pazopanib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor Read more about this study

Who is it for?
Ages 18 years and older
What is being tested?
pazopanib hydrochloride and laboratory biomarker analysis
Type of treatment
Pill or oral medicine
Could I receive a placebo?
No, everyone receives an active treatment
How many people
35 participants
Where
9 sitesUnited States
Study dates
May 2007to Dec 2008
Phase
Phase 2
Are there results?
Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Histologically confirmed glioblastoma multiforme, including gliosarcoma
  • Recurrent disease
  • Must have unequivocal radiographic evidence of tumor progression by MRI, as defined by any of the following:
  • 25% increase in the sum of products of all measurable lesions over smallest sum observed (over baseline if no decrease) using the same techniques as baseline
  • Clear worsening of any evaluable disease
  • Appearance of any new lesions or site
Show all 74Show fewer
  • Clear clinical worsening
  • Must have failed prior radiotherapy that was completed ≥ 42 days ago
  • Patients who received prior therapy that included interstitial brachytherapy or stereotactic radiosurgery must have confirmation of true progressive disease, rather than radiation necrosis, based on positron emission tomography (PET) scan, thallium scanning, magnetic resonance spectroscopy, or surgical documentation of disease
  • Treatment for no more than 2 prior relapses allowed
  • Relapse is defined as progression following initial therapy (i.e., radiotherapy with or without chemotherapy, if that was used as initial therapy; therefore no more than 3 prior therapies [initial therapy and therapy for 2 relapses] allowed)
  • If the patient had a surgical resection for relapsed disease and no anticancer therapy was instituted for up to 12 weeks, and the patient undergoes another surgical resection, this is considered as 1 relapse
  • For patients who had prior therapy for a low-grade glioma, the surgical diagnosis of a glioblastoma multiforme will be considered the first relapse
  • Karnofsky performance status 60-100%
  • Life expectancy > 8 weeks
  • WBC ≥ 3,000/mm^3
  • Absolute neutrophil count ≥ 1,500/mm^3
  • Hemoglobin ≥ 10 g/dL (may be reached by transfusion)
  • Platelet count ≥ 100,000/mm^3
  • PT/INR/PTT ≤ 1.2 times upper limit of normal (ULN)
  • SGOT < 2.5 times ULN
  • Bilirubin < 2.5 times ULN
  • Creatinine < 1.5 mg/dL OR creatinine clearance ≥ 60 mL/min
  • Urine protein:creatinine ratio > 1 OR urine protein < 1,000 mg by 24-hour urine collection OR proteinuria < 1+
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective double-barrier contraception during study therapy OR practice abstinence from sexual intercourse for 14 days prior to, during, and for ≥ 21 days after study therapy
  • Systolic blood pressure (BP) ≤ 140 mm Hg and diastolic BP ≤ 90 mm Hg
  • Prior initiation or adjustment of BP medication allowed provided the average of 3 BP readings is ≤ 140/90 mm Hg
  • No uncontrolled significant medical illnesses that would preclude study therapy
  • No other conditions, including any of the following:
  • Serious or nonhealing wound, ulcer, or bone fracture
  • Abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within the past 28 days
  • Cerebrovascular accident (CVA) within the past 6 months
  • Myocardial infarction, cardiac arrhythmia, admission for unstable angina, cardiac angioplasty, or stenting within the past 84 days
  • Venous thrombosis within the past 84 days
  • New York Heart Association (NYHA) class III or IV heart failure
  • Asymptomatic NYHA class II heart failure while on treatment allowed
  • No other cancer except for nonmelanoma skin cancer or carcinoma in situ of the cervix unless in complete remission and off of all therapy for that disease for ≥ 3 years
  • No disease that would obscure toxicity or dangerously alter drug metabolism
  • No history of allergic reactions attributed to compounds of similar chemical or biological composition to pazopanib hydrochloride or other agents
  • No QTc prolongation (i.e., QTc interval ≥ 500 msecs) or other significant ECG abnormalities
  • No condition that impairs the ability to swallow and retain pazopanib hydrochloride, including any of the following:
  • Gastrointestinal tract disease resulting in an inability to take oral medication
  • Requirement for IV alimentation
  • Prior surgical procedures affecting absorption
  • Active peptic ulcer disease
  • See Disease Characteristics
  • Recovered from prior therapy
  • At least 28 days since prior resection of recurrent or progressive tumor and recovered
  • Residual disease after resection of recurrent glioblastoma is not mandated for eligibility into the study
  • More than 7 days since prior noncytotoxic agents (e.g., interferon, tamoxifen, thalidomide, or isotretinoin)
  • Radiosensitizers allowed
  • More than 14 days since prior investigational agents
  • More than 14 days since prior vincristine
  • More than 21 days since prior procarbazine
  • More than 28 days since prior cytotoxic therapy
  • More than 42 days since prior nitrosoureas
  • No prior bevacizumab
  • No prior sorafenib tosylate or sunitinib malate
  • No prior pazopanib hydrochloride
  • No concurrent CYP2C9 substrates, including any of the following:
  • Anticoagulants (e.g., warfarin [therapeutic doses only])
  • Oral hypoglycemics (e.g., glipizide, glyburide, tolbutamide, glimepiride, or nateglinide)
  • Ergot derivatives (e.g., dihydroergotamine, ergonovine, ergotamine, or methylergonovine)
  • Neuroleptics (e.g., pimozide)
  • Erectile dysfunction agents (e.g., sildenafil, tadalafil, or vardenafil)
  • Antiarrhythmics (e.g., bepridil, flecainide, lidocaine, mexilitine, amiodarone, quinidine, or propafenone)
  • Immune modulators (e.g., cyclosporine, tacrolimus, or sirolimus)
  • Miscellaneous drugs (e.g., theophylline, quetiapine, risperidone, tacrine, clozapine, or atomoxetine)
  • No concurrent combination antiretroviral therapy for HIV-positive patients
  • No other concurrent anticancer therapy (including chemotherapy, radiotherapy, hormonal treatment, or immunotherapy) or investigational drugs
  • No concurrent enzyme-inducing anti-epileptic drugs (EIAEDs)
  • Non-EIAEDs allowed

Who cannot join

None listed.

Trial locations and contacts

9 sites in 1 country.

9 sites in 1 country

United States9 sites

  • National Cancer Institute Neuro-Oncology Branch

    Bethesda, Maryland, 20814

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02115

  • Duke University

    Durham, North Carolina, 27710

  • MD Anderson Cancer Center

    Houston, Texas, 77030

  • University of California Los Angeles

    Los Angeles, California, 90095

  • University of Wisconsin

    Madison, Wisconsin, 53792

  • Memorial Sloan-Kettering Cancer Center

    New York, New York, 10021

  • University of Pittsburgh

    Pittsburgh, Pennsylvania, 15232

  • University of California San Francisco

    San Francisco, California, 94115

Other trials in United States

About this study

Official title: A Phase II Trial of GW786034 (Pazopanib) in Patients With Recurrent Glioblastoma

This phase II trial is studying the side effects and how well pazopanib works in treating patients with recurrent glioblastoma. Pazopanib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor

Read the detailed description

PRIMARY OBJECTIVES:

  1. Determine the therapeutic efficacy of pazopanib hydrochloride, as measured by 6-month progression-free survival (PFS), in patients with recurrent glioblastoma.

II. Determine the safety profile of this drug in these patients.

SECONDARY OBJECTIVES:

  1. Determine the efficacy of this drug, as measured by radiographic response, time to progression, and overall survival, in these patients.

OUTLINE: This is a multicenter study.

Patients receive oral pazopanib hydrochloride daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed periodically for at least 2 years.

Being tested
pazopanib hydrochloride, laboratory biomarker analysis
Medical subject headings
Glioblastoma, Gliosarcoma, Brain Neoplasms

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • pazopanib hydrochlorideDrug

    Also called GW786034B, Votrient

    Given orally

  • laboratory biomarker analysisOther

    Correlative studies

Study groups in NCT00459381
Study groupRoleWhat they receive
Treatment (pazopanib hydrochloride)ExperimentalPatients receive oral pazopanib hydrochloride daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity. Other: laboratory biomarker analysis
Receives: Drug: pazopanib hydrochloride; Other: laboratory biomarker analysis

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. 6 Months Progression-free Survival

    Calculated from study registration till 6month time point. Progression defined by Macdonald criteria Progression imaging features: 25% of more increase in enhancing lesions; any new lesions clinical features: clinical deterioration

    Measured: 6 months

  2. Number of Participants Discontinuing Treatment Due to Toxicity

    Use NCI Common toxicity Criteria Adverse Event Version 3.0 to grade toxicities. Any patient who received at least one dose of pazopanib was evaluable for toxicity. Calculated the number of participants who had an event that was related to pazopanib that caused the patient to stop treatment due to this event.

    Measured: 2 years

Secondary outcomes (5)

  1. Most Common Toxicities Experienced After at Least One Dose of Pazopanib

    NCI Common Toxicity Criteria (CTCAE) version 3.0. All patients that received at least one dose of pazopanib were evaluable. All events recorded that were related to drug were calculated per patient.

    Measured: Up to 2 years

  2. Overall Radiographic Response (ORR) Rate

    The Macdonald criteria, roughly similarly to other systems, divides response into 4 types of response based on imaging (MRI) and clinical features

    1: complete response; 2: partial response; 3:stable disease; 4:progression

    Complete response imaging features: disappearance of all enhancing disease (measurable and non-measurable) sustained for at least 4 weeks; no new lesions clinical features; no corticosteroids; clinically stable or improved

    Partial response imaging features: 50% or more decrease of all measurable enhancing lesions sustained for at least 4 weeks: no new lesions clinical features: stable or reduced corticosteroids; clinically stable or improved

    Stable disease imaging features: does not qualify for complete response, partial response or progression clinical features: clinically stable

    Progression imaging features: 25% of more increase in enhancing lesions; any new lesions clinical features: clinical deterioration

    Measured: 2 years

  3. Best Radiographic Response

    Using the Macdonald criteria, the best MRI image response while the patient was on active treatment.

    1: complete response; 2: partial response; 3:stable disease; 4:progression

    Complete response imaging features: disappearance of all enhancing disease (measurable and non-measurable) sustained for at least 4 weeks; no new lesions clinical features; no corticosteroids; clinically stable or improved

    Partial response imaging features: 50% or more decrease of all measurable enhancing lesions sustained for at least 4 weeks: no new lesions clinical features: stable or reduced corticosteroids; clinically stable or improved

    Stable disease imaging features: does not qualify for complete response, partial response or progression clinical features: clinically stable

    Progression imaging features: 25% of more increase in enhancing lesions; any new lesions clinical features: clinical deterioration

    Measured: 3 years

  4. Overall Survival

    calculated from study registration until date of death or patient censored at the last date known alive

    Measured: From date of registration to date of death due to any cause, assessed up to 2 years

  5. Time to Progression or Progression Free Survival

    PFS for patients who died on treatment or within 30 days of the end of treatment w/out progression date, was date of death. All other pts without documented progression were censored at the date of last follow-up prior to start new treatment.

    All 35 patients were included in an intent to treat analysis for PFS and OS. 3 pts censored for PFS, all less than 2 wks after study registration.

    Measured: 1 year

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted11 Apr 2007 (estimated)
  2. Study startMay 2007
  3. Primary completionDec 2008
  4. Study completionDec 2008

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 2
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrolment
35 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT00459381
Sponsor's protocol ID
NCI-2012-02710
Other IDs
NABTC-0602, U01CA062399, CDR0000538083
Status last verified
Jan 2017
First submitted
9 Apr 2007
Last updated
15 Mar 2017
Data monitoring committee
Yes
Individual data sharing
No

Publications

  • Iwamoto FM, Lamborn KR, Robins HI, Mehta MP, Chang SM, Butowski NA, Deangelis LM, Abrey LE, Zhang WT, Prados MD, Fine HA. Phase II trial of pazopanib (GW786034), an oral multi-targeted angiogenesis inhibitor, for adults with recurrent glioblastoma (North American Brain Tumor Consortium Study 06-02). Neuro Oncol. 2010 Aug;12(8):855-61. doi: 10.1093/neuonc/noq025. Epub 2010 Mar 3.

    PubMed 20200024

Questions about this trial

What is this clinical trial studying?

A Phase 2 study testing pazopanib hydrochloride and laboratory biomarker analysis in people with Adult Giant Cell Glioblastoma and Adult Glioblastoma, run by National Cancer Institute (NCI) at 9 sites in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 74 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 15 Mar 2017. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 9 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

Yes. Results are posted in the registry (first posted 15 Mar 2017). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

6 Months Progression-free Survival (time frame: 6 months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT00459381, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Mar 2017.

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