Open-Angle GlaucomaIOPMGNCT00481208
Diurnal Intraocular Pressure and Peripapillary Retinal Blood Flow in Medically Controlled Open-Angle Glaucoma
An observational study of Open-Angle Glaucoma, run by Yonsei University at 1 site in South Korea.
Trial summary
Diurnal fluctuations of intraocular pressure (IOP) and peripapillary retinal blood flow may have distinctive patterns in medically well-controlled open-angle glaucoma patients. In the results, we found a unique pattern, 'Latent asymmetric IOP', defined as the IOP which differs between the eyes only when placed in the… Read more about this study
- Who is it for?
- Ages 20 to 70 years
- Conditions the study is for
- Open-Angle Glaucoma
- How many people
- 70 participants
- Where
- 1 siteSouth Korea
- Study dates
- Mar 2006to Nov 2006
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Open-angle glaucoma
- Topical anti-glaucoma medications
Who cannot join
- Ocular surgery history
- Other ocular disease history
- Oral glaucoma medications
Trial locations and contacts
1 site in 1 country.
South Korea1 site
Severance Hospital, Yonsei University College of Medicine
Seoul, 120-752
About this study
Diurnal fluctuations of intraocular pressure (IOP) and peripapillary retinal blood flow may have distinctive patterns in medically well-controlled open-angle glaucoma patients. In the results, we found a unique pattern, 'Latent asymmetric IOP', defined as the IOP which differs between the eyes only when placed in the supine position. Unique effects of this latent asymmetric IOP on Visual field and diurnal IOP fluctuations were studied.
Read the detailed description
Diurnal fluctuations of intraocular pressure (IOP) and peripapillary retinal blood flow have been implicated to be one of the important factors to affect visual field progression. However, there was no study to investigate them in medically well-controlled open-angle glaucoma patients. So we want to find the unique patterns.
Study 1. Subjects : Patients with medically well controlled open angle glaucoma Method : IOP and peripapillary retinal blood flow were measured for 24 hours. The relationship between the two were studied.
Study 2. Of the patients enrolled in study 1 , those on the same medical regimen for both eyes were analyzed for the presence of a latent asymmetric IOP and it's influence and association with visual field and diurnal IOP fluctuation.
- Conditions
- Open-Angle Glaucoma
- Keywords
- open-angle glaucoma, diurnal fluctuation, intraocular pressure, peripapillary retinal blood flow, latent asymmetric intraocular pressure
- Medical subject headings
- Glaucoma, Open-Angle
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Jun 2007 (estimated)
- Study startMar 2006
- Study completionNov 2006
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Open-Angle GlaucomaStudies of the same condition, open and under way.
- More trials run by Yonsei UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Natural history
- Time perspective
- Other
- Enrolment
- 70 participants (actual)
Sponsor and investigators
- Lead sponsor
- Yonsei University
- Sponsor type
- University, hospital or other
- Investigators
- Chan Yun Kim, MD, PhD, Study chair, Department of Ophthalmology, Yonsei University College of Medicine
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00481208
- Sponsor's protocol ID
- 4-2006-0146
- Acronym
- IOPMG
- Status last verified
- May 2007
- First submitted
- 31 May 2007
- Last updated
- 1 Jun 2007
- Results posted
- No
- Data monitoring committee
- No