Type 2 Diabetes MellitusPhase 1NCT00501397
A Study of the Effects of Ketoconazole Taken Orally Has on the PK Profiles of a Dose of GSK189075 in Healthy Volunteers
A Phase 1 study testing ketoconazole and GSK189075 in people with Type 2 Diabetes Mellitus and Diabetes Mellitus, Type 2, run by GlaxoSmithKline at 1 site in United States.
Trial summary
The purpose of this research study is to evaluate the effect of several daily doses of ketoconazole (a medication used to treat fungal infections like athlete's foot) on a single dose of GSK189075 (an experimental diabetes drug), and also to evaluate the safety and tolerability of GSK189075 in healthy volunteers. Read more about this study
- Who is it for?
- Ages 18 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2
- What is being tested?
- ketoconazole and GSK189075
- How many people
- 22 participants
- Where
- 1 siteUnited States
- Study dates
- Feb 2007to not given
- Phase
- Phase 1
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Are a healthy, non-smoking male or female.
- Are 18 to 55 years old, inclusive.
- Have a body weight of > or equal to 110 pounds.
- Are a female who is unable to have any more children and have a negative pregnancy test.
- Are willing and able to provide written informed consent before the start of any study-related procedures.
- Are able to understand and comply with protocol requirements, instructions, and protocol-stated restrictions.
Who cannot join
- Smoke or use any tobacco products.
- Have a known allergic reaction to ketoconazole or study drug.
- Have a history of regular alcohol consumption greater than 7 drinks per week for females or greater than 14 drinks per week for males.
- Have a positive drug or alcohol or smoking test at screening or check-in to the clinic.
- Have participated in another clinical trial within 30 days prior to screening in which you have received an investigational drug.
- Have donated a pint of blood within 56 days before the first dose of study drug.
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- Have any known or suspected stomach condition (or stomach surgery within the 6 months prior to dosing).
- Have abnormal liver test results.
- Have a documented history or diagnosis of cirrhosis.
- Have positive results for hepatitis C or B, or HIV at screening.
- Have blood pressure outside of the normal range.
- Are a male subject who is unwilling to either abstain from sexual activity or unwilling to use birth control during the course of the study.
- Are using non-prescription drugs, vitamins, herbal or dietary supplements (including St John's Wort) within 7 days before the first dose of study medication,
- Have any abnormality identified on the screening physical or laboratory examination that the study physician feels would make it inappropriate for you to participate in the study.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: An Open Label Study in Healthy Volunteers to Investigate the Effect of Ketoconazole on the Pharmacokinetics of GSK189075
The purpose of this research study is to evaluate the effect of several daily doses of ketoconazole (a medication used to treat fungal infections like athlete's foot) on a single dose of GSK189075 (an experimental diabetes drug), and also to evaluate the safety and tolerability of GSK189075 in healthy volunteers. The study will see whether ketoconazole causes GSK189075 to stay in your bloodstream for a longer period of time. It will also examine whether GSK189075 causes any changes in the amount of glucose you have in your urine.
- Being tested
- ketoconazole, GSK189075
- Keywords
- ketoconazole,, drug interaction,, pharmacokinetics, T2DM,
- Medical subject headings
- Diabetes Mellitus, Type 2
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ketoconazoleDrug
GSK189075Drug
Also called ketoconazole
What is being measured
The primary outcome is the main question the study is designed to answer.
Plasma blood samples for GSK189075 at Day 1 Session 1, Days 5 & 6 Session 3
Measured: at Day 1 Session 1, Days 5 & 6 Session 3 urine collections for volume
urine collections for volume, glucose, & creatinine at Day 1 Session 1, Days 5 & 6 Session 3.
Measured: at Day 1 Session 1, Days 5 & 6 Session 3.
Secondary outcomes (5)
Adverse events: all visits
Measured: all visits
ECG,labs: Screening,Days -1 & 1 Session 1,Day 4 Session 2,Days 5-6 Session 3
Measured: Screening,Days -1 & 1 Session 1,Day 4 Session 2,Days 5-6 Session 3
Labs:followup
Measured: followup
Urine: Day 1 Session 1,Days 5-6 Session 3
Measured: Day 1 Session 1,Days 5-6 Session 3
Vitals: Screening,Days -1 & 1 Session 1,Days 1-4 Session 2,Days 5-6 Session 3,followup
Measured: Screening,Days -1 & 1 Session 1,Days 1-4 Session 2,Days 5-6 Session 3,followup
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Jul 2007 (estimated)
- Study startFeb 2007
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Type 2 Diabetes MellitusStudies of the same condition, open and under way.
- More trials run by GlaxoSmithKlineThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 1
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 22 participants (actual)
Sponsor and investigators
- Lead sponsor
- GlaxoSmithKline
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- GSK Clinical Trials, Study director, GlaxoSmithKline
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00501397
- Sponsor's protocol ID
- KG2108197
- Status last verified
- Feb 2011
- First submitted
- 13 Jul 2007
- Last updated
- 4 Jun 2012
- Results posted
- No
- Data monitoring committee
- No
Study at a glance
From the registry record, last updated by the sponsor on 4 Jun 2012. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- An Open Label Study in Healthy Volunteers to Investigate the Effect of Ketoconazole on the Pharmacokinetics of GSK189075
- ClinicalTrials.gov ID
- NCT00501397
- Acronym / sponsor ID
- KG2108197
- Keywords
- ketoconazole,, drug interaction,, pharmacokinetics, T2DM,
- Phase
- Phase 1
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 22 participants (actual)
- Lead sponsor
- GlaxoSmithKlineIndustry (pharma, biotech, devices)
- Study start
- Feb 2007
- First posted
- 16 Jul 2007 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this research study is to evaluate the effect of several daily doses of ketoconazole (a medication used to treat fungal infections like athlete's foot) on a single dose of GSK189075 (an experimental diabetes drug), and also to evaluate the safety and tolerability of GSK189075 in healthy volunteers. The study will see whether ketoconazole causes GSK189075 to stay in your bloodstream for a longer period of time. It will also examine whether GSK189075 causes any changes in the amount of glucose you have in your urine.
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Single group
- Masking
- None (open label)
Who may qualify
- Ages
- 18 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Are a healthy, non-smoking male or female.
- Are 18 to 55 years old, inclusive.
- Have a body weight of > or equal to 110 pounds.
- Are a female who is unable to have any more children and have a negative pregnancy test.
- Are willing and able to provide written informed consent before the start of any study-related procedures.
Key exclusion criteria (14 listed)
- Smoke or use any tobacco products.
- Have a known allergic reaction to ketoconazole or study drug.
- Have a history of regular alcohol consumption greater than 7 drinks per week for females or greater than 14 drinks per week for males.
- Have a positive drug or alcohol or smoking test at screening or check-in to the clinic.
- Have participated in another clinical trial within 30 days prior to screening in which you have received an investigational drug.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ketoconazole | Drug | – |
| GSK189075Also: ketoconazole | Drug | – |
Primary outcome
Plasma blood samples for GSK189075 at Day 1 Session 1, Days 5 & 6 Session 3
Time frame: at Day 1 Session 1, Days 5 & 6 Session 3 urine collections for volume
urine collections for volume, glucose, & creatinine at Day 1 Session 1, Days 5 & 6 Session 3.
Time frame: at Day 1 Session 1, Days 5 & 6 Session 3.
5 secondary outcomes
Adverse events: all visits
Time frame: all visits
ECG,labs: Screening,Days -1 & 1 Session 1,Day 4 Session 2,Days 5-6 Session 3
Time frame: Screening,Days -1 & 1 Session 1,Day 4 Session 2,Days 5-6 Session 3
Labs:followup
Time frame: followup
Urine: Day 1 Session 1,Days 5-6 Session 3
Time frame: Day 1 Session 1,Days 5-6 Session 3
Vitals: Screening,Days -1 & 1 Session 1,Days 1-4 Session 2,Days 5-6 Session 3,followup
Time frame: Screening,Days -1 & 1 Session 1,Days 1-4 Session 2,Days 5-6 Session 3,followup
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Jun 2012.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
GSK Clinical Trials study director
GlaxoSmithKline
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 1 study testing ketoconazole and GSK189075 in people with Type 2 Diabetes Mellitus and Diabetes Mellitus, Type 2, run by GlaxoSmithKline at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 14 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Jun 2012. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 1 studies test a treatment in a small group of people for the first time or in a new way, mainly to check safety and find the right dose.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Plasma blood samples for GSK189075 at Day 1 Session 1, Days 5 & 6 Session 3 (time frame: at Day 1 Session 1, Days 5 & 6 Session 3 urine collections for volume). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Jun 2012.