HealthyNCT00611156
Examination of the Effects of Four Different Spices on Energy Metabolism
A study testing ginger, black pepper and horseradish in people with Healthy, run by University of Copenhagen at 1 site in Denmark.
Trial summary
The objective of this study is to examine whether four different spices (ginger, black pepper, horseradish and mustard) are able to increase energy metabolism. Since chili and other spices have been shown to increase energy expenditure compared to placebo, we expect that some or all of the four spices may actually… Read more about this study
- Who is it for?
- Ages 18 to 50 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- ginger, black pepper and horseradish
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 22 participants
- Where
- 1 siteDenmark
- Study dates
- Oct 2006to Jun 2007
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- male
- healthy and not use medication (regularly)
- normal weight
- non smoker
- tolerate and like spicy food
- stable body weight last two months
Who cannot join
- increased blood pressure
- abnormal EKG
- mental, metabolic and chronic diseases
Trial locations and contacts
1 site in 1 country.
Denmark1 site
Department of Human Nutrition, The Royal Veterinary and Agricultural University
Frederiksberg, DK-1958
About this study
Official title: Bioactive Food Ingredients and Energy Metabolism: The Effects of Ginger, Black Pepper, Horseradish and Mustard on Meal-Induced Thermogenesis and Fat Oxidation
The objective of this study is to examine whether four different spices (ginger, black pepper, horseradish and mustard) are able to increase energy metabolism.
Since chili and other spices have been shown to increase energy expenditure compared to placebo, we expect that some or all of the four spices may actually increase energy expenditure - although not to a large degree.
Read the detailed description
Several pungent food ingredients, such as chili,and also other bioactive food ingredients, e.g. green tea, have been shown to be able to increase energy expenditure and fat oxidation during the hours following a meal containing the bioactive ingredient. Furthermore, we will also look at the subjects own feelings of appetite and thereby examine whether the appetite is affected by the spicy food. We expect to see some small effects on these parameters.
- Conditions
- Healthy
- Being tested
- ginger, black pepper, horseradish, mustard, placebo
- Keywords
- Thermogenesis, Meal-induced thermogenesis, energy expenditure, fat oxidation, bioactive ingredients, spices, ginger, horseradish, black pepper, mustard
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
gingerDietary supplement
added to a brunch meal
black pepperDietary supplement
Added to a brunch meal
horseradishDietary supplement
Added to a brunch meal
mustardDietary supplement
Added to a brunch meal
placeboDietary supplement
Added to a bruch meal
| Study group | Role | What they receive |
|---|---|---|
| A | Experimental | Spice Receives: Dietary Supplement: ginger |
| B | Experimental | Spice Receives: Dietary Supplement: black pepper |
| C | Experimental | Spice Receives: Dietary Supplement: horseradish |
| D | Experimental | Spice Receives: Dietary Supplement: mustard |
| E | Placebo comparator | Placebo Receives: Dietary Supplement: placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
energy expenditure
Measured: November 2007
Secondary outcomes (6)
blood pressure
Measured: December 2007
heart rate
Measured: December 2007
VAS-scores for appetite, hunger, fullness, etc. - and palatability
Measured: November 2007
tolerance
Measured: November 2007
Fat and carbohydrate oxidation
Measured: November 2007
Meal-induced thermogenesis
Measured: November 2007
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Feb 2008 (estimated)
- Study startOct 2006
- Study completionJun 2007
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for HealthyStudies of the same condition, open and under way.
- More trials run by University of CopenhagenThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 22 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Copenhagen
- Sponsor type
- University, hospital or other
- Collaborators
- University of Aarhus
- Investigators
- Arne Astrup, Professor MD, Study chair, Department of Human Nutrition, RVAU
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00611156
- Sponsor's protocol ID
- B228-IHE-2006-NTG
- Status last verified
- Aug 2007
- First submitted
- 28 Jan 2008
- Last updated
- 8 Feb 2008
- Results posted
- No
- Data monitoring committee
- No
Publications
Gregersen NT, Belza A, Jensen MG, Ritz C, Bitz C, Hels O, Frandsen E, Mela DJ, Astrup A. Acute effects of mustard, horseradish, black pepper and ginger on energy expenditure, appetite, ad libitum energy intake and energy balance in human subjects. Br J Nutr. 2013 Feb 14;109(3):556-63. doi: 10.1017/S0007114512001201. Epub 2012 Jul 5.
PubMed 23021155
Study at a glance
From the registry record, last updated by the sponsor on 8 Feb 2008. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Bioactive Food Ingredients and Energy Metabolism: The Effects of Ginger, Black Pepper, Horseradish and Mustard on Meal-Induced Thermogenesis and Fat Oxidation
- ClinicalTrials.gov ID
- NCT00611156
- Acronym / sponsor ID
- B228-IHE-2006-NTG
- Conditions
- Healthy
- Keywords
- Thermogenesis, Meal-induced thermogenesis, energy expenditure, fat oxidation, bioactive ingredients, spices, ginger, horseradish
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 22 participants (actual)
- Lead sponsor
- University of CopenhagenUniversity, hospital or other
- Collaborators
- University of Aarhus
- Study start
- Oct 2006
- Study completion
- Jun 2007 (actual)
- First posted
- 8 Feb 2008 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The objective of this study is to examine whether four different spices (ginger, black pepper, horseradish and mustard) are able to increase energy metabolism.
Since chili and other spices have been shown to increase energy expenditure compared to placebo, we expect that some or all of the four spices may actually increase energy expenditure - although not to a large degree.
Detailed description
Several pungent food ingredients, such as chili,and also other bioactive food ingredients, e.g. green tea, have been shown to be able to increase energy expenditure and fat oxidation during the hours following a meal containing the bioactive ingredient. Furthermore, we will also look at the subjects own feelings of appetite and thereby examine whether the appetite is affected by the spicy food. We expect to see some small effects on these parameters.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (investigator)
- Number of arms
- 5
| Arm | Type | Receives |
|---|---|---|
| A | Experimental | Dietary Supplement: gingerSpice |
| B | Experimental | Dietary Supplement: black pepperSpice |
| C | Experimental | Dietary Supplement: horseradishSpice |
| D | Experimental | Dietary Supplement: mustardSpice |
| E | Placebo comparator | Dietary Supplement: placeboPlacebo |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- male
- healthy and not use medication (regularly)
- normal weight
- non smoker
- tolerate and like spicy food
Key exclusion criteria (3 listed)
- increased blood pressure
- abnormal EKG
- mental, metabolic and chronic diseases
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| gingeradded to a brunch meal | Dietary supplement | A |
| black pepperAdded to a brunch meal | Dietary supplement | B |
| horseradishAdded to a brunch meal | Dietary supplement | C |
| mustardAdded to a brunch meal | Dietary supplement | D |
| placeboAdded to a bruch meal | Dietary supplement | E |
Primary outcome
energy expenditure
Time frame: November 2007
6 secondary outcomes
blood pressure
Time frame: December 2007
heart rate
Time frame: December 2007
VAS-scores for appetite, hunger, fullness, etc. - and palatability
Time frame: November 2007
tolerance
Time frame: November 2007
Fat and carbohydrate oxidation
Time frame: November 2007
Meal-induced thermogenesis
Time frame: November 2007
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Feb 2008.
- Derived from this study: PubMed 23021155Gregersen NT, Belza A, Jensen MG, Ritz C, Bitz C, Hels O, Frandsen E, Mela DJ, Astrup A. Acute effects of mustard, horseradish, black pepper and ginger on energy expenditure, appetite, ad libitum energy intake and energy balance in human subjects. Br J Nutr. 2013 Feb 14;109(3):556-63. doi: 10.1017/S0007114512001201. Epub 2012 Jul 5.
Related trials for Healthy
Recruiting
THE EFFECTS OF GAME-BASED EXERCISE PROGRAMS
Physical Activity, Body Image
Not yet recruitingPhase 1
A Phase I Study of GLR2053 Tablets in Chinese Healthy Adult Participants
Atopic Dermatitis
Recruiting
Colon-delivered Riboflavin and Gut Microbiota Composition
Microbiome Dysbiosis, Gut Health
Not yet recruiting
Neuroergonomic Analysis of a Brain-Computer Interface Device (BCI)
Healthy Volunteers - Male and Female
RecruitingPhase 1
First-in-Human Trial to Assess REGN20423 in Healthy Adult Participants and Adult Participants With Atopic Dermatitis
Healthy Volunteer, Atopic Dermatitis
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Arne Astrup, Professor MD study chair
Department of Human Nutrition, RVAU
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing ginger, black pepper and horseradish in people with Healthy, run by University of Copenhagen at 1 site in Denmark.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Feb 2008. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Denmark. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
energy expenditure (time frame: November 2007). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT00611156, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Feb 2008.