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Amnestic Mild Cognitive ImpairmentNCT00643266

Recollection Training in Healthy Older Adults and Older Adults With Amnestic Mild Cognitive Impairment

A study testing Recollection Training in people with Amnestic Mild Cognitive Impairment and Aging, run by Baycrest at 1 site in Canada.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

We have developed a training intervention that successfully improves older adults' memory. We have also shown that older adults whose memory is as good as younger adults' memory (Hi-Old) use an altered pattern of memory-related brain activity compared to younger adults, whereas healthy older adults with poorer memory… Read more about this study

Who is it for?
Ages 65 to 90 yearsHealthy volunteers can take part
Conditions the study is for
Amnestic Mild Cognitive Impairment, Aging
What is being tested?
Recollection Training
Could I receive a placebo?
No, everyone receives an active treatment
How many people
91 participants
Where
1 siteCanada
Study dates
Feb 2008to Aug 2013
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 65 to 90 years
  • All sexes
  • Healthy volunteers accepted
  • Older adult

Who may be able to join

  • 65-90 years old
  • English as a first language or learned before kindergarten
  • Right handed

Who cannot join

  • Neurologic disorder
  • Major medical disorder affecting cognition
  • Psychiatric disorder
  • Metal in the body that poses a hazard in the MRI scanner

Trial locations and contacts

1 site in 1 country.

Canada1 site

  • Baycrest

    Toronto, Ontario, M6A 2E1

Other trials in Canada

About this study

Official title: Memory Interventions for Older Adults

We have developed a training intervention that successfully improves older adults' memory. We have also shown that older adults whose memory is as good as younger adults' memory (Hi-Old) use an altered pattern of memory-related brain activity compared to younger adults, whereas healthy older adults with poorer memory (Lo-Old) do not. We have also shown that individuals with amnestic Mild Cognitive Impairment (aMCI) have impairments of conscious, effortful, Recollection-based memory processes, whereas their automatic, Familiarity-based memory processes are intact. Our primary current goal is to investigate whether our successful memory intervention will improve Recollection and produce induce altered patterns of brain activity in the Lo-Old and aMCI.

Young, Lo-Old, Hi-Old, and aMCI will be scanned using functional magnetic resonance imaging while performing two memory tasks. Half of the Lo-Old and half of the aMCI will then receive the memory intervention, while the other half in each group will receive a control program consisting of information and games about aging. The Lo-Old and aMCI will then be rescanned while performing the two memory tasks. We predict that the memory intervention will improve performance on a number of memory tasks, and will induce altered patterns of brain activity. In the Lo-Old, their brain activity after the memory intervention will look more like the Hi-Old, while brain activity will become more focal in the aMCI.

Being tested
Recollection Training, Control
Keywords
recollection training, aging, amnestic mild cognitive impairment, fMRI

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Recollection TrainingBehavioural

    Also called Memory training

    Participants are exposed to long lists of words. Each word is presented either visually or auditorily, and each word is repeated after a variable number of intervening words (the lag), in each the same modality, or the other modality. Participants are instructed to respond "yes" only to words repeated in the same modality. If a performance criterion is met, the lag is increased for the next session; if the performance criterion is not met, the same lag is repeated in the next session.

  • ControlBehavioural

    Also called Educational Control

    Participants view PowerPoint presentations on various topics related to memory and aging (e.g., structural brain changes, diet, stress, depression) and how each of these topics affect memory, and after each presentation, play a Jeopardy-like game to test their knowledge gain

Study groups in NCT00643266
Study groupRoleWhat they receive
1ExperimentalRecollection training via graduated increases in task difficulty, carried out over 36 sessions over 9 training days
Receives: Behavioral: Recollection Training
2Active comparatorComputer-delivered information sessions about memory and aging with Jeopardy-like games to engage participants
Receives: Behavioral: Control

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Recollection estimates

    Recollection, defined as Correct "yes" responses to "Same" repetitions minus Incorrect "yes" responses to "Different" repetitions, as a function of condition (trained versus control), lag (3, 16) and time (pre-, post-, and 3 month follow-up)

    Measured: Immediately post-training and three months post-training

Secondary outcomes (2)

  1. Brain activation as assessed by functional magnetic resonance imaging

    Prefrontal (inferior, middle, and superior frontal gyri) activation for Different Repetitions minus Same Repetitions, as a function of group (trained versus control), lag (3, 16), and time (pre, post). Additional analyses will compare trained versus control older adults with younger adults on these measures at baseline (pre). Analyses will include an exploration of prefrontal laterality of the effects (left minus right), to see whether training induces greater bilaterality of activation.

    Measured: Immediately post-training

  2. Transfer to other recollection-dependent task and to subjective memory measures

    Source memory, self-ordered pointing, n-back, a Sternberg task, CVLT, an AB-AC test of proactive interference, the Memory Controllability Inventory, Multifactorial Memory Questionnaire (Ability and Contentment subscales), Meta-Memory in Adulthood questionnaire (locus of control, anxiety, and capability subscales), and an in-house measure of the efficacy of the control program

    Measured: Immediately post-training and three months post-training

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted26 Mar 2008 (estimated)
  2. Study startFeb 2008
  3. Primary completionAug 2013
  4. Study completionAug 2013

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Basic science
Allocation
Non-randomised
Intervention model
Parallel groups
Masking
Single blind
Who is masked
Investigator
Enrolment
91 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT00643266
Sponsor's protocol ID
RecollectionTraining
Other IDs
CIHR MOP 67015, ASC 08 95
Status last verified
Nov 2018
First submitted
26 Feb 2008
Last updated
16 Nov 2018
Results posted
No
Data monitoring committee
No

Publications

  • Anderson ND, Ebert PL, Jennings JM, Grady CL, Cabeza R, Graham SJ. Recollection- and familiarity-based memory in healthy aging and amnestic mild cognitive impairment. Neuropsychology. 2008 Mar;22(2):177-87. doi: 10.1037/0894-4105.22.2.177.

    PubMed 18331160

  • Guild EB, Vasquez BP, Maione AM, Mah L, Ween J, Anderson ND. Dynamic working memory performance in individuals with single-domain amnestic mild cognitive impairment. J Clin Exp Neuropsychol. 2014;36(7):751-60. doi: 10.1080/13803395.2014.941790. Epub 2014 Aug 30.

    PubMed 25175752

  • Ebert PL, Anderson ND. Proactive and retroactive interference in young adults, healthy older adults, and older adults with amnestic mild cognitive impairment. J Int Neuropsychol Soc. 2009 Jan;15(1):83-93. doi: 10.1017/S1355617708090115.

    PubMed 19128531

  • Anderson ND, Ebert PL, Grady CL, Jennings JM. Repetition lag training eliminates age-related recollection deficits (and gains are maintained after three months) but does not transfer: Implications for the fractionation of recollection. Psychol Aging. 2018 Feb;33(1):93-108. doi: 10.1037/pag0000214.

    PubMed 29494181

  • Meusel LA, Grady CL, Ebert PE, Anderson ND. Brain-behavior relationships in source memory: Effects of age and memory ability. Cortex. 2017 Jun;91:221-233. doi: 10.1016/j.cortex.2016.12.023. Epub 2017 Jan 12.

    PubMed 28161030

Questions about this trial

What is this clinical trial studying?

A study testing Recollection Training in people with Amnestic Mild Cognitive Impairment and Aging, run by Baycrest at 1 site in Canada.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 16 Nov 2018. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Recollection estimates (time frame: Immediately post-training and three months post-training). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT00643266, which also lists 5 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Nov 2018.

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