Healthy SubjectsNCT00733941
Interval Training in Young Healthy Individuals
A study testing High frequency training and normal frequence training in people with Healthy Subjects and Exercise Test, run by Norwegian University of Science and Technology at 2 sites in Norway.
Trial summary
Individuals who participate in regular physical exercise possess a lower prevalence of cardiovascular risk factors such as hypertension, type 2 diabetes, obesity and hypercholesterolemia, and aerobic exercise is therefore considered an important adjuvant therapy in risk factor modification and to promote health. Read more about this study
- Who is it for?
- Ages 18 to 27 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy Subjects, Exercise Test
- What is being tested?
- High frequency training and normal frequence training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 24 participants
- Where
- 2 sitesNorway
- Study dates
- Sep 2008to Dec 2009
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 27 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- BMI<27, non-smokers, train less that 1-2 times per week, VO2max <60 for male and <50 for female.
Who cannot join
- Hypertension, diabetes and cardiovascular disease.
Trial locations and contacts
2 sites in 1 country.
Norway2 sites
Norwegian University of Science and Technology
Trondheim, 7020
NTNU
Trondheim, 7489
About this study
Official title: Interval Training: Training, Detraining and Retraining; an Interventional Study
Individuals who participate in regular physical exercise possess a lower prevalence of cardiovascular risk factors such as hypertension, type 2 diabetes, obesity and hypercholesterolemia, and aerobic exercise is therefore considered an important adjuvant therapy in risk factor modification and to promote health.
The main focus of the present study is therefore to detect how rapid it is possible to increase aerobic capacity with interval running exercise.
The hypothesis is that it is possible to improve maximal oxygen uptake faster when increasing training frequency. The total gain in maximal oxygen uptake will however be the same between the two groups when they have performed the same amount of training
Read the detailed description
We will perform aerobic interval training at an intensity of 90-95% of maximum heart rate in healthy individuals. The subjects will be randomly assigned to carry out a total of 24 exercise-sessions, either at 3 times per week or 8 times per week.
The two groups will carry out 24 training sessions before 8 weeks of detraining will provide how rapidly aerobic capacity is lost due to inactivity. After the detraining period a retraining phase is introduced to detect if improvements in aerobic capacity occur more rapidly compared to before the first training period
The subjects will be tested for oxygen uptake, pumping capacity of the heart, blood volume, skeletal muscle enzyme activity, endothelial function.
- Conditions
- Healthy Subjects, Exercise Test
- Being tested
- High frequency training, normal frequence training
- Keywords
- Exercise test, Running, Arterial diameter, Monitoring, physiologic, Oxygen Consumption
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High frequency trainingBehavioural
24 training sessions, 8x weekly, followed by detraining phase 8 weeks, and retraining
normal frequence trainingBehavioural
24 training sessions, 3x weekly, followed by detraining phase 8 weeks, and retraining
| Study group | Role | What they receive |
|---|---|---|
| High frequency training | Experimental | 24 interval exercises performed 8 times per week Receives: Behavioral: High frequency training |
| Normal frequency training | Experimental | 24 interval exercises performed 3 times per week Receives: Behavioral: normal frequence training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Oxygen uptake
Measured: Before and after the training-, detraining- and retraining-phase
Secondary outcomes (1)
Cardiac function and skeletal muscle enzyme activity
Measured: After training, detraining and retraining
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Aug 2008 (estimated)
- Study startSep 2008
- Primary completionJun 2009
- Study completionDec 2009
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Healthy SubjectsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 24 participants (actual)
Sponsor and investigators
- Lead sponsor
- Norwegian University of Science and Technology
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Øivind Rognmo, PhD, Principal investigator, Norwegian University of Science and TechnologyUlrik Wisløff, Professor, Principal investigator, National Taiwan Normal University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00733941
- Sponsor's protocol ID
- 4.2008.1755
- Status last verified
- May 2015
- First submitted
- 12 Aug 2008
- Last updated
- 27 May 2015
- Results posted
- No
- Data monitoring committee
- No
Publications
Hatle H, Stobakk PK, Molmen HE, Bronstad E, Tjonna AE, Steinshamn S, Skogvoll E, Wisloff U, Ingul CB, Rognmo O. Effect of 24 sessions of high-intensity aerobic interval training carried out at either high or moderate frequency, a randomized trial. PLoS One. 2014 Feb 7;9(2):e88375. doi: 10.1371/journal.pone.0088375. eCollection 2014.
PubMed 24516645
Study at a glance
From the registry record, last updated by the sponsor on 27 May 2015. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Interval Training: Training, Detraining and Retraining; an Interventional Study
- ClinicalTrials.gov ID
- NCT00733941
- Acronym / sponsor ID
- 4.2008.1755
- Conditions
- Healthy Subjects, Exercise Test
- Keywords
- Exercise test, Running, Arterial diameter, Monitoring, physiologic, Oxygen Consumption
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 24 participants (actual)
- Lead sponsor
- Norwegian University of Science and TechnologyUniversity, hospital or other
- Study start
- Sep 2008
- Primary completion
- Jun 2009 (actual)
- Study completion
- Dec 2009 (actual)
- First posted
- 13 Aug 2008 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Individuals who participate in regular physical exercise possess a lower prevalence of cardiovascular risk factors such as hypertension, type 2 diabetes, obesity and hypercholesterolemia, and aerobic exercise is therefore considered an important adjuvant therapy in risk factor modification and to promote health.
The main focus of the present study is therefore to detect how rapid it is possible to increase aerobic capacity with interval running exercise.
The hypothesis is that it is possible to improve maximal oxygen uptake faster when increasing training frequency. The total gain in maximal oxygen uptake will however be the same between the two groups when they have performed the same amount of training
Detailed description
We will perform aerobic interval training at an intensity of 90-95% of maximum heart rate in healthy individuals. The subjects will be randomly assigned to carry out a total of 24 exercise-sessions, either at 3 times per week or 8 times per week.
The two groups will carry out 24 training sessions before 8 weeks of detraining will provide how rapidly aerobic capacity is lost due to inactivity. After the detraining period a retraining phase is introduced to detect if improvements in aerobic capacity occur more rapidly compared to before the first training period
The subjects will be tested for oxygen uptake, pumping capacity of the heart, blood volume, skeletal muscle enzyme activity, endothelial function.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| High frequency training | Experimental | Behavioral: High frequency training24 interval exercises performed 8 times per week |
| Normal frequency training | Experimental | Behavioral: normal frequence training24 interval exercises performed 3 times per week |
Who may qualify
- Ages
- 18 to 27 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- BMI<27, non-smokers, train less that 1-2 times per week, VO2max <60 for male and <50 for female.
Key exclusion criteria (1 listed)
- Hypertension, diabetes and cardiovascular disease.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High frequency training24 training sessions, 8x weekly, followed by detraining phase 8 weeks, and retraining | Behavioural | High frequency training |
| normal frequence training24 training sessions, 3x weekly, followed by detraining phase 8 weeks, and retraining | Behavioural | Normal frequency training |
Primary outcome
Oxygen uptake
Time frame: Before and after the training-, detraining- and retraining-phase
1 secondary outcome
Cardiac function and skeletal muscle enzyme activity
Time frame: After training, detraining and retraining
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 May 2015.
- Results publication: PubMed 24516645Hatle H, Stobakk PK, Molmen HE, Bronstad E, Tjonna AE, Steinshamn S, Skogvoll E, Wisloff U, Ingul CB, Rognmo O. Effect of 24 sessions of high-intensity aerobic interval training carried out at either high or moderate frequency, a randomized trial. PLoS One. 2014 Feb 7;9(2):e88375. doi: 10.1371/journal.pone.0088375. eCollection 2014.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Øivind Rognmo, PhD principal investigator
Norwegian University of Science and Technology
Ulrik Wisløff, Professor principal investigator
National Taiwan Normal University
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing High frequency training and normal frequence training in people with Healthy Subjects and Exercise Test, run by Norwegian University of Science and Technology at 2 sites in Norway.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 May 2015. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Norway. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Oxygen uptake (time frame: Before and after the training-, detraining- and retraining-phase). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT00733941, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 May 2015.