Chronic SinusitisNCT00880516
Genetic Factors in Chronic Sinusitis
An observational study of Chronic Sinusitis, run by University of Chicago at 1 site in United States.
Trial summary
The purpose of this study is to learn more about the genetics of chronic sinusitis and identify genes involved in chronic sinusitis. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Chronic Sinusitis
- How many people
- 1,200 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Apr 2009to Dec 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Adults with and without chronic sinusitis
Who may be able to join
- Age> 18 years
- Diagnosis of chronic sinusitis or normal sinuses (with verification by imaging.) You must have a recent CT scan showing either normal sinuses or the presence of sinus disease.
Who cannot join
- Genetic or acquired immunodeficiency
- Ciliary dyskinesia
- Cystic fibrosis
- Autoimmune disease
- Cancer of the sinuses
Trial locations and contacts
1 site in 1 country.
About this study
The purpose of this study is to learn more about the genetics of chronic sinusitis and identify genes involved in chronic sinusitis.
- Conditions
- Chronic Sinusitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| control | Adults with normal sinuses | |
| case | Adults with chronic sinusitis and positive findings on imaging. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Association of genetic variation with CRS disease status
Measured: Adult age
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Apr 2009 (estimated)
- Study start1 Apr 2009
- Primary completionDec 2027 (estimated)
- Study completionDec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Chronic SinusitisStudies of the same condition, open and under way.
- More trials run by University of ChicagoThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 1,200 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Chicago
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Jayant Pinto, MD, Principal investigator, University of Chicago
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00880516
- Sponsor's protocol ID
- 16749A
- Status last verified
- Jan 2026
- First submitted
- 9 Apr 2009
- Last updated
- 2 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
Study at a glance
From the registry record, last updated by the sponsor on 2 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Genetic Factors in Chronic Sinusitis
- ClinicalTrials.gov ID
- NCT00880516
- Acronym / sponsor ID
- 16749A
- Conditions
- Chronic Sinusitis
- Study type
- Observational
- Recruitment status
- Active, not recruiting
- Enrolment
- 1,200 participants (estimated)
- Lead sponsor
- University of ChicagoUniversity, hospital or other
- Study start
- 1 Apr 2009 (actual)
- Primary completion
- Dec 2027 (estimated)
- Study completion
- Dec 2027 (estimated)
- First posted
- 13 Apr 2009 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to learn more about the genetics of chronic sinusitis and identify genes involved in chronic sinusitis.
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| control | – | –Adults with normal sinuses |
| case | – | –Adults with chronic sinusitis and positive findings on imaging. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Adults with and without chronic sinusitis
Key inclusion criteria (2 listed)
- Age> 18 years
- Diagnosis of chronic sinusitis or normal sinuses (with verification by imaging.) You must have a recent CT scan showing either normal sinuses or the presence of sinus disease.
Key exclusion criteria (5 listed)
- Genetic or acquired immunodeficiency
- Ciliary dyskinesia
- Cystic fibrosis
- Autoimmune disease
- Cancer of the sinuses
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Association of genetic variation with CRS disease status
Time frame: Adult age
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Feb 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jayant Pinto, MD principal investigator
University of Chicago
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Chronic Sinusitis, run by University of Chicago at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 2 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Association of genetic variation with CRS disease status (time frame: Adult age). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Feb 2026.