AzTrials
AzTrials

ObesityInSightNCT00945633

Dietary, Physiological, Genetic, and Behavioral Predictors of Health in a Young, Ethnically-Mixed Population

An observational study of Obesity, run by Pennington Biomedical Research Center at 1 site in United States.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
Search all trials

Trial summary

Dietary intervention and other strategies to prevent unhealthy weight gain and the development of obesity should be based on knowledge of dietary, physiological, genetic and behavioral determinants and their contributing interactions. Read more about this study

Who is it for?
Ages 20 to 35 yearsHealthy volunteers can take part
Conditions the study is for
Obesity
How many people
90 participants
Where
1 siteUnited States
Study dates
Jun 2008to Aug 2030
Phase
Observational
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 20 to 35 years
  • All sexes
  • Healthy volunteers accepted
  • Adult

Study population: The sample includes 90 free-living participants aged 20-35 years.

Who may be able to join

  • Inclusion criteria will be healthy men and women between the ages of 20-35, with BMI < 27.5 kg/m2, and fasting blood glucose < 126 mg/dl.

Who cannot join

  • History of diabetes, history of obesity (BMI > 30).
  • History of known inherited medical conditions that might influence future health status.
  • Current or planned medication usage that might influence future health status.
  • Prior serious injuries/surgeries that might influence future health status.
  • Women who are pregnant or breastfeeding (once enrolled, pregnancy will not cause subjects to be terminated from the study).
  • Women who are < 6 months postpartal, or women who have discontinued breastfeeding < 3 months prior to screening.
Show all 13Show fewer
  • History of cancer (including skin cancer) within 5 years.
  • History or organ transplant.
  • Previous diagnosis with HIV, Hepatitis B or C, or tuberculosis.
  • Abuse of alcohol or illegal drugs.
  • Abnormal EKG.
  • Presence of pacemaker, defibrillator, or implanted metal.
  • History of eating disorders and abnormal psychological scores for the screening measures described under Psychological Assessment Measures in the Appendix. This psychological screening will be conducted approximately two weeks prior to outpatient testing.

Trial locations and contacts

1 site in 1 country.

United States1 site

  • Pennington Biomedical Research Center

    Baton Rouge, Louisiana, 70808

Other trials in United States

About this study

Dietary intervention and other strategies to prevent unhealthy weight gain and the development of obesity should be based on knowledge of dietary, physiological, genetic and behavioral determinants and their contributing interactions. Identifying these determinants is difficult because physiological susceptibility to specific dietary and behavioral factors implicated in unhealthy weight gain differs between populations and individuals within the populations. The research challenge is identifying specific determinants in a free-living, adult population.

Understanding the interaction between diet and the underlying susceptibility factors such as physiologic, genetic and epigenetic, and behavioral factors mandate an integrated approach.

Read more

This integrated approach should include understanding the interplay of physiological factors (genetics, epigenetics, taste preferences, susceptibility to energy excess, etc.) and behavioral factors (food cravings, restraint, disinhibition, physical activity) as each of these domains is a potential driving force in energy expenditure, food preference, dietary choices, and food intake.

Which of these factor(s) is most important? The investigators propose that by examining dietary, physiological, genetic, and behavioral factors in an integrated fashion we will gain insight into the obesity epidemic and identify the most important determinants of weight gain. As a secondary aim, the investigators will identify a single parsimonious collection of factors and develop strategies to mitigate the risks of developing obesity.

Read the detailed description

This is a prospective, longitudinal, clinical study using an epidemiological approach. The sample consists of 90 free-living participants aged 20-35 years. The participants will undergo a series of assessments in the domains of diet, physiological factors, and behavioral factors at baseline and every 12 months for 2 years.

OBJECTIVES

  1. Identify dietary, physiological, genetic and behavioral determinants of unhealthy weight gain in healthy, young, ethnically-mixed men and women.
  2. Identify relationships between genetic measures of taste perception and the determinants of unhealthy weight gain in the said population.
  3. Identify relationships among the determinants of unhealthy weight gain that contribute to an individual's susceptibility to obesity.
Conditions
Obesity
Keywords
Obesity, unhealthy weight gain
Medical subject headings
Obesity

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Changes in body weight

    Changes in body weight (kg) from baseline

    Measured: Annually over 2 years

Secondary outcomes (1)

  1. Changes in fat mass

    Changes in fat mass (kg) from baseline

    Measured: Annually over 2 years

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted24 Jul 2009 (estimated)
  2. Study startJun 2008
  3. Primary completionAug 2030 (estimated)
  4. Study completionAug 2030 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
90 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT00945633
Sponsor's protocol ID
PBRC 27036
Acronym
InSight
Status last verified
Sep 2026
First submitted
22 Jul 2009
Last updated
24 Sep 2026
Results posted
No
Data monitoring committee
No
Individual data sharing
No

Publications

  • Harrington DM, Martin CK, Ravussin E, Katzmarzyk PT. Activity related energy expenditure, appetite and energy intake: potential implications for weight management. Appetite. 2013 Aug;67:1-7. doi: 10.1016/j.appet.2013.03.005. Epub 2013 Mar 22.

    PubMed 23523668

  • Tudor-Locke C, Martin CK, Brashear MM, Rood JC, Katzmarzyk PT, Johnson WD. Predicting doubly labeled water energy expenditure from ambulatory activity. Appl Physiol Nutr Metab. 2012 Dec;37(6):1091-100. doi: 10.1139/h2012-097. Epub 2012 Sep 11.

    PubMed 22963352

  • Edwards LM, Kemp GJ, Dwyer RM, Walls JT, Fuller H, Smith SR, Earnest CP. Integrating muscle cell biochemistry and whole-body physiology in humans:(31)P-MRS data from the InSight trial. Sci Rep. 2013;3:1182. doi: 10.1038/srep01182. Epub 2013 Jan 31.

    PubMed 23378914

  • Staiano AE, Marker AM, Martin CK, Katzmarzyk PT. Physical activity, mental health, and weight gain in a longitudinal observational cohort of nonobese young adults. Obesity (Silver Spring). 2016 Sep;24(9):1969-75. doi: 10.1002/oby.21567. Epub 2016 Jul 28.

    PubMed 27465398

  • Raja GK, Sarzynski MA, Katzmarzyk PT, Johnson WD, Tchoukalova Y, Smith SR, Bouchard C. Commonality versus specificity among adiposity traits in normal-weight and moderately overweight adults. Int J Obes (Lond). 2014 May;38(5):719-23. doi: 10.1038/ijo.2013.153. Epub 2013 Aug 16.

    PubMed 23949614

  • Staiano AE, Martin CK, Champagne CM, Rood JC, Katzmarzyk PT. Sedentary time, physical activity, and adiposity in a longitudinal cohort of nonobese young adults. Am J Clin Nutr. 2018 Nov 1;108(5):946-952. doi: 10.1093/ajcn/nqy191.

    PubMed 30475973

  • Katzmarzyk PT, Most J, Redman LM, Rood J, Ravussin E. Energy expenditure and substrate oxidation in White and African American young adults without obesity. Eur J Clin Nutr. 2018 Jun;72(6):920-922. doi: 10.1038/s41430-018-0202-2. Epub 2018 May 30.

    PubMed 29849180

  • Fazzino TL, Dorling JL, Apolzan JW, Martin CK. Meal composition during an ad libitum buffet meal and longitudinal predictions of weight and percent body fat change: The role of hyper-palatable, energy dense, and ultra-processed foods. Appetite. 2021 Dec 1;167:105592. doi: 10.1016/j.appet.2021.105592. Epub 2021 Jul 8.

    PubMed 34245802

  • Lam YY, Redman LM, Smith SR, Bray GA, Greenway FL, Johannsen D, Ravussin E. Determinants of sedentary 24-h energy expenditure: equations for energy prescription and adjustment in a respiratory chamber. Am J Clin Nutr. 2014 Apr;99(4):834-42. doi: 10.3945/ajcn.113.079566. Epub 2014 Feb 5.

    PubMed 24500151

Questions about this trial

What is this clinical trial studying?

An observational study of Obesity, run by Pennington Biomedical Research Center at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 24 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Changes in body weight (time frame: Annually over 2 years). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT00945633, which also lists 9 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Sep 2026.

AzTrials uses cookies for analytics and advertising. You can accept or reject them; the site works either way. Privacy Policy.

Free account

Log in to keep searching

You’ve used your 3 free searches. AzTrials is free: log in or create a free account to keep searching clinical trials and save the ones you want to follow.

Create a free accountLog in