AgingSWEETNCT01031394
Frequency of Aerobic/Resistance Training in Older Women
A study testing Frequency of Aerobic/Resistance Training - 3 to 3 in people with Aging, run by University of Alabama at Birmingham at 1 site in United States.
Trial summary
The objective of this study is to provide insight into the effects combined training frequency has on improving fitness, ease of physical activity, and maintenance of a high total energy expenditure. Read more about this study
- Who is it for?
- Ages 60 years and older, women onlyHealthy volunteers can take part
- Conditions the study is for
- Aging
- What is being tested?
- Frequency of Aerobic/Resistance Training - 3 to 3
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 105 participants
- Where
- 1 siteUnited States
- Study dates
- Jan 2004to Mar 2011
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 years and older
- Women only
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- healthy women over 60 years of age,
- Caucasian or African-American.
Who cannot join
- smoking,
- diabetes,
- osteoporosis,
- inability to coperform weight bearing exercises, currently performing to much exercise.
Trial locations and contacts
1 site in 1 country.
About this study
The objective of this study is to provide insight into the effects combined training frequency has on improving fitness, ease of physical activity, and maintenance of a high total energy expenditure. Such information is critical to our understanding of ways to improve well-being, quality of life, and independence of an aging population. 105 participants will be enrolled in this study. The length of time for your involvement in the study will be 32 weeks. You will undergo the procedures listed in this consent form on 3 separate occasions-initially at your entry, at 16 weeks and again at 32 weeks.
Read the detailed description
Frequency of aerobic/resistance training in older women
Abstract Combined aerobic and resistance training have unique benefits for maintaining a physical activity (PA). However, the optimal training program for combining these two modes of training in older adults is unknown. This study builds on current and past studies showing that training induced gains in aerobic fitness, muscle strength, and ease of PA are important for maintaining an active lifestyle, a favorable body composition, and high bone density. Traditionally 3 d/wk combined training has been felt to be optimal while recent studies suggest 1 d/wk combined training may create similar adaptations as more frequent training. However, our previous and ongoing studies suggest that 1 d/wk combined aerobic and resistance training (C1) may be insufficient stimulus to induce optimal adaptations and that 3 d/wk combined training (C3) may be too frequent a stimulus for older adults. This study will enable us to compare the effects of C1, 2 d/wk combined training (C2), and C3 on fitness, body composition, ease of PA, PA, and total free-living energy expenditure (TEE). We hypothesize that C2 will result in a larger increase in muscle size, bone density, strength, aerobic capacity, power, ease of PA, PA, and TEE than either C1 or C3. Circulating cytokines and psychological mood states linked to chronic overstress will also be examined. Objectives: We will examine changes in circulating cytokines, mood states, muscle size, bone density, aerobic capacity, strength, power, ease of PA, PA, and TEE following 16 and 32 wks training. Design: We will to evaluate 78 (>60 yrs) Black and White women matched for age, race, and BMI into C1, C2, or C3 groups prior to, after 16, and after 32 wks training. Women will undergo evaluation of metabolic parameters in a General Clinical Research Center. Significance: This study should provide insight into the effects combined training frequency has on improving fitness, ease of PA, and maintenance of a high TEE. Such information is critical to our understanding of ways to improve well being, quality of life, and independence of an aging population.
- Conditions
- Aging
- Being tested
- Frequency of Aerobic/Resistance Training - 3 to 3
- Keywords
- exercise, resistance training
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Frequency of Aerobic/Resistance Training - 3 to 3Other
Also called freqency of aerobic and resistance training
comparing group results based upon frequency of exercise
| Study group | Role | What they receive |
|---|---|---|
| Group 1 | Active comparator | 1 aerobic and 1 resistance training per week Receives: Other: Frequency of Aerobic/Resistance Training - 3 to 3 |
| Group 2 | Active comparator | 2 aerobic and 2 resistance training each per week Receives: Other: Frequency of Aerobic/Resistance Training - 3 to 3 |
| Group 3 | Active comparator | 3 aerobic and 3 resistance training per week Receives: Other: Frequency of Aerobic/Resistance Training - 3 to 3 |
What is being measured
The primary outcome is the main question the study is designed to answer.
Use a repeated measures analysis to compare differences in TEE and other parameters among the 3 intervention groups across time
Measured: over 32 weeks of training
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Dec 2009 (estimated)
- Study startJan 2004
- Primary completionMar 2011
- Study completionMar 2011
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for AgingStudies of the same condition, open and under way.
- More trials run by University of Alabama at BirminghamThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 105 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Alabama at Birmingham
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute on Aging (NIA)
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01031394
- Sponsor's protocol ID
- F050820002
- Other IDs
- R01AG027084
- Acronym
- SWEET
- Status last verified
- Oct 2015
- First submitted
- 10 Dec 2009
- Last updated
- 27 Oct 2015
- Results posted
- No
- Data monitoring committee
- No
Publications
Martins C, Gower B, Hunter GR. Metabolic adaptation after combined resistance and aerobic exercise training in older women. Obesity (Silver Spring). 2022 Jul;30(7):1453-1461. doi: 10.1002/oby.23450. Epub 2022 Jun 21.
PubMed 35729736Carter SJ, Baranauskas MN, Singh H, Martins C, Hunter GR. ARTE index revisited: linking biomarkers of cardiometabolic health with free-living physical activity in postmenopausal women. Am J Physiol Regul Integr Comp Physiol. 2022 Apr 1;322(4):R292-R298. doi: 10.1152/ajpregu.00075.2021. Epub 2022 Jan 26.
PubMed 35081314
Study at a glance
From the registry record, last updated by the sponsor on 27 Oct 2015. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Frequency of Aerobic/Resistance Training in Older Women
- ClinicalTrials.gov ID
- NCT01031394
- Acronym / sponsor ID
- SWEET / F050820002
- Conditions
- Aging
- Keywords
- exercise, resistance training
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 105 participants (actual)
- Lead sponsor
- University of Alabama at BirminghamUniversity, hospital or other
- Collaborators
- National Institute on Aging (NIA)
- Study start
- Jan 2004
- Primary completion
- Mar 2011 (actual)
- Study completion
- Mar 2011 (actual)
- First posted
- 14 Dec 2009 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The objective of this study is to provide insight into the effects combined training frequency has on improving fitness, ease of physical activity, and maintenance of a high total energy expenditure. Such information is critical to our understanding of ways to improve well-being, quality of life, and independence of an aging population. 105 participants will be enrolled in this study. The length of time for your involvement in the study will be 32 weeks. You will undergo the procedures listed in this consent form on 3 separate occasions-initially at your entry, at 16 weeks and again at 32 weeks.
Detailed description
Frequency of aerobic/resistance training in older women
Abstract Combined aerobic and resistance training have unique benefits for maintaining a physical activity (PA). However, the optimal training program for combining these two modes of training in older adults is unknown. This study builds on current and past studies showing that training induced gains in aerobic fitness, muscle strength, and ease of PA are important for maintaining an active lifestyle, a favorable body composition, and high bone density. Traditionally 3 d/wk combined training has been felt to be optimal while recent studies suggest 1 d/wk combined training may create similar adaptations as more frequent training. However, our previous and ongoing studies suggest that 1 d/wk combined aerobic and resistance training (C1) may be insufficient stimulus to induce optimal adaptations and that 3 d/wk combined training (C3) may be too frequent a stimulus for older adults. This study will enable us to compare the effects of C1, 2 d/wk combined training (C2), and C3 on fitness, body composition, ease of PA, PA, and total free-living energy expenditure (TEE). We hypothesize that C2 will result in a larger increase in muscle size, bone density, strength, aerobic capacity, power, ease of PA, PA, and TEE than either C1 or C3. Circulating cytokines and psychological mood states linked to chronic overstress will also be examined. Objectives: We will examine changes in circulating cytokines, mood states, muscle size, bone density, aerobic capacity, strength, power, ease of PA, PA, and TEE following 16 and 32 wks training. Design: We will to evaluate 78 (>60 yrs) Black and White women matched for age, race, and BMI into C1, C2, or C3 groups prior to, after 16, and after 32 wks training. Women will undergo evaluation of metabolic parameters in a General Clinical Research Center. Significance: This study should provide insight into the effects combined training frequency has on improving fitness, ease of PA, and maintenance of a high TEE. Such information is critical to our understanding of ways to improve well being, quality of life, and independence of an aging population.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Group 1 | Active comparator | Other: Frequency of Aerobic/Resistance Training - 3 to 31 aerobic and 1 resistance training per week |
| Group 2 | Active comparator | Other: Frequency of Aerobic/Resistance Training - 3 to 32 aerobic and 2 resistance training each per week |
| Group 3 | Active comparator | Other: Frequency of Aerobic/Resistance Training - 3 to 33 aerobic and 3 resistance training per week |
Who may qualify
- Ages
- 60 years and older
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- healthy women over 60 years of age,
- Caucasian or African-American.
Key exclusion criteria (4 listed)
- smoking,
- diabetes,
- osteoporosis,
- inability to coperform weight bearing exercises, currently performing to much exercise.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Frequency of Aerobic/Resistance Training - 3 to 3Also: freqency of aerobic and resistance trainingcomparing group results based upon frequency of exercise | Other | Group 1, Group 2, Group 3 |
Primary outcome
Use a repeated measures analysis to compare differences in TEE and other parameters among the 3 intervention groups across time
Time frame: over 32 weeks of training
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Oct 2015.
- Derived from this study: PubMed 35729736Martins C, Gower B, Hunter GR. Metabolic adaptation after combined resistance and aerobic exercise training in older women. Obesity (Silver Spring). 2022 Jul;30(7):1453-1461. doi: 10.1002/oby.23450. Epub 2022 Jun 21.
- Derived from this study: PubMed 35081314Carter SJ, Baranauskas MN, Singh H, Martins C, Hunter GR. ARTE index revisited: linking biomarkers of cardiometabolic health with free-living physical activity in postmenopausal women. Am J Physiol Regul Integr Comp Physiol. 2022 Apr 1;322(4):R292-R298. doi: 10.1152/ajpregu.00075.2021. Epub 2022 Jan 26.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Frequency of Aerobic/Resistance Training - 3 to 3 in people with Aging, run by University of Alabama at Birmingham at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Oct 2015. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Use a repeated measures analysis to compare differences in TEE and other parameters among the 3 intervention groups across time (time frame: over 32 weeks of training). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT01031394, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Oct 2015.