AzTrials
AzTrials

Multiple MyelomaNCT01081028

Connect® MM- The Multiple Myeloma Disease Registry

An observational study of Multiple Myeloma, run by Celgene at 253 sites in 2 countries.

Terminated

Stopped early. The study ended before it was planned to and will not resume.

Official record
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Trial summary

The purpose of the Connect® MM Registry is to explore the natural history and real world management of patients with newly diagnosed symptomatic multiple myeloma (MM) and provide unique insights into the management of MM and the impact of this hematologic disorder on patients. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Multiple Myeloma
What is being tested?
First-line therapy and Second-line Multiple Myeloma treatments
How many people
3,011 participants
Where
253 sitesin 2 countries
Study dates
1 Sep 2009to 31 Dec 2024
How long will I take part?
16 Years
Phase
Observational
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Study population: Patients with newly diagnosed multiple myeloma and being treated in community or academic settings in the United States

Who may be able to join

  • Cohort 1 and 2
  • Newly diagnosed with symptomatic MM within 2 months of enrollment in Connect® MM registry
  • Age ≥18 years
  • Willing and able to provide signed informed consent
  • Agrees to complete patient assessment questionnaires either alone or with minimal assistance from caregivers and/or trained site personnel
  • Cohort 3
Show all 9Show fewer
  • Received 1L therapy for symptomatic active MM and subsequently has evidence of disease progression. Prior 1L MM treatment received, including anti-myeloma therapy, transplant, chemotherapy, radiation, and surgery, must be known.
  • Initiated or intends to initiate 2L systemic therapy for MM after the first documented relapsed/refractory date (i.e. 1L PD).
  • Enrollment date must be within 90 days of start date (or intended start date) of 2L systemic therapy.

Who cannot join

  • Cohort 1 and 2
  • None
  • Cohort 3
  • Patient's 1L MM treatment was for smoldering MM or MGUS, and not for symptomatic MM
  • Currently active in any MM Registry, including but not limited to, the Connect® MM registry or another Celgene/BMS-Sponsored registry.
  • Patients who have discontinued from Connect® MM or another Celgene/BMS-Sponsored registry could be considered for enrollment in Cohort 3, if inclusion and exclusion criteria are met.
  • Currently enrolled or intending to enroll within 90 days in any interventional clinical trial in which any treatment is an investigational product that cannot be identified

Trial locations and contacts

253 sites in 2 countries.

253 sites in 2 countries

United States252 sites

  • US Oncology - Texas Cancer Center - Abilene (South)

    Abilene, Texas, 79606

  • Summa Health System - Cancer Research Office

    Akron, Ohio, 44304

  • Phoebe Putney Memorial Hospital

    Albany, Georgia, 31701

  • US Oncology - New York Oncology Hematology, PC-Albany

    Albany, New York, 12206

  • US Oncology - Albany Medical Cancer Center

    Albany, New York, 12208

  • US Oncology - Texas Oncology, PA - Amarillo

    Amarillo, Texas, 79106

  • Central Utah Clinic

    American Fork, Utah, 84003

  • McFarland Clinic

    Ames, Iowa, 50010

  • US Oncology - Amsterdam Community Cancer Program

    Amsterdam, New York, 12010

  • Pacific Cancer Medical Center, Inc

    Anaheim, California, 92801

  • Fox Valley Hematology & Oncology

    Appleton, Wisconsin, 54915

  • US Oncology - Texas Oncology - Arlington South

    Arlington, Texas, 76014

  • US Oncology - Arlington Fairfax Hematology Oncology

    Arlington, Virginia, 22205

  • Cancer Care & Hematology Specialists of Chicagoland, PC

    Arlington Heights, Illinois, 60005

  • Peachtree Hematology-Oncology Consultants

    Atlanta, Georgia, 30318

  • Georgia Cancer Specialists

    Atlanta, Georgia, 30331

  • US Oncology- Rocky Mountain Cancer Center-Aurora

    Aurora, Colorado, 80012

  • US Oncology - Texas Oncology - Midtown

    Austin, Texas, 78705

  • US Oncology - Texas Oncology Cancer Center

    Austin, Texas, 78731

  • US Oncology - South Austin Cancer Center

    Austin, Texas, 78745

  • US Oncology - Texas Oncology North Austin

    Austin, Texas, 78758

  • Austin Cancer Centers

    Austin, Texas, 78759

  • US Oncology - Southwest Regional Cancer Center - North

    Austin, Texas, 78759

  • Mary Bird Perkins Cancer Center

    Baton Rouge, Louisiana, 70809

  • Michigan State University/Bay Regional Medical Center

    Bay City, Michigan, 48706

  • US Oncology - Texas Oncology, PA - Bedford

    Bedford, Texas, 76022

  • Indiana Blood and Marrow Transplant, LLC

    Beech Grove, Indiana, 46107

  • St. Francis Cancer Research

    Beech Grove, Indiana, 46107

  • Essex Oncology of North Jersey, PA

    Belleville, New Jersey, 07109

  • Peace Health Medical Group

    Bellingham, Washington, 98226

  • Alta Bates Summit Comprehensive Cancer Center

    Berkeley, California, 94704

  • Oncology Hematology of Lehigh Valley

    Bethlehem, Pennsylvania, 18015

  • Hematology Oncology Associates of the Quad Cities

    Bettendorf, Iowa, 52722

  • Legacy Pharma Research

    Bismarck, North Dakota, 58501

  • Med Center One

    Bismarck, North Dakota, 58501

  • US Oncology - Rocky Mountain Cancer Center-Boulder

    Boulder, Colorado, 80303

  • Hematology Oncology Associates

    Boynton Beach, Florida, 33426

  • University Cancer Institute

    Boynton Beach, Florida, 33426

  • Collaborative Research Group

    Boynton Beach, Florida, 33435

  • St. Joseph Regional Cancer Center

    Bryan, Texas, 77802

  • Jonah Cancer Care Center & ECMC

    Buffalo, New York, 14215

  • Southbay Oncology Hematology Partners

    Campbell, California, 95008

  • Gabrail Cancer Center Research

    Canton, Ohio, 44718

  • US Oncology - Cancer Centers of North Carolina - Cary

    Cary, North Carolina, 27518

  • US Oncology - Texas Oncology Cedar Park

    Cedar Park, Texas, 78613

  • Iowa Blood and Cancer Care of PCI

    Cedar Rapids, Iowa, 52402

  • Charleston Hematology Oncology Associates, PA

    Charleston, South Carolina, 29403

  • The Center for Cancer and Hematologic Disease

    Cherry Hill, New Jersey, 08003

  • St. Louis Cancer Care, LLP

    Chesterfield, Missouri, 63017

  • John H. Stroger, Jr. Hospital of Cook County

    Chicago, Illinois, 60612

  • Rush University Medical Center

    Chicago, Illinois, 60612

  • Univeristy of Chicago Medical Center, Section of Hematology/Oncology

    Chicago, Illinois, 60637

  • Cleveland VA Medical Center

    Cleveland, Ohio, 44106

  • Scott & White Clinic

    College Station, Texas, 77802

  • Family Cancer Center, PLLC

    Collierville, Tennessee, 38017

  • US Oncology- Rocky Mountain Cancer Center at the Pavillion

    Colorado Springs, Colorado, 80907

  • US Oncology - Rocky Mountain Cancer Center-Colorado Springs

    Colorado Springs, Colorado, 80909

  • Mid Ohio Oncology/Hematology, Inc

    Columbus, Ohio, 43219

  • Flora Research Associates

    Coral Springs, Florida, 33065

  • Compassionate Cancer Care Medical Group (Corona)

    Corona, California, 92879

  • South Texas Institute of Cancer

    Corpus Christi, Texas, 78405

  • Coastal Bend Cancer Center

    Corpus Christi, Texas, 78463

  • Hematology & Oncology Associates of Rhode Island

    Cranston, Rhode Island, 02920

  • US Oncology - Texas Cancer Center at Medical City

    Dallas, Texas, 75230

  • US Oncology -Texas Oncology, PA - Dallas

    Dallas, Texas, 75231

  • Geisinger Medical Center

    Danville, Pennsylvania, 17822

  • Archbold Cancer Center

    Deerfield Beach, Florida, 33441

  • Flora Research Associates

    Deerfield Beach, Florida, 33441

  • US Oncology - Rocky Mountain Cancer Center-Midtown

    Denver, Colorado, 80218

  • US Oncology - Rocky Mountain Cancer Center-Rose

    Denver, Colorado, 80220

  • Consultants in Medical Oncology and Hematology, PC

    Drexel Hill, Pennsylvania, 19026

  • Duluth Clinic Cancer Center

    Duluth, Minnesota, 55805

  • DUMC Division of Cellular Therapy/ABMT

    Durham, North Carolina, 27705

  • US Oncology - Cancer Centers of the Carolinas - Easley

    Easley, South Carolina, 29640

  • US Oncology - Puget Sound Cancer Center-Edmonds

    Edmonds, Washington, 98133

  • US Oncology - El Paso Cancer Treatment Ctr

    El Paso, Texas, 79902

  • Elmhurst Memorial Hospital

    Elmhurst, Illinois, 60126

  • Hematology Oncology Center, Inc

    Elyria, Ohio, 44035

  • Drs. Forte, Schleider, Attas & Condemi, PA

    Englewood, New Jersey, 07432

  • Southwest Cancer Care

    Escondido, California, 92025

  • US Oncology - Willamette Valley Cancer Institute - Eugene

    Eugene, Oregon, 97401-8122

  • Northshore University Health System

    Evanston, Illinois, 60201

  • Providence Everett Medical Center

    Everett, Washington, 98201

  • US Oncology - Fairfax-Northern VA Hem-Onc PC

    Fairfax, Virginia, 22031

  • Medical Specialists of Fairfield

    Fairfield, Connecticut, 06824

  • Roger Maris Cancer Center

    Fargo, North Dakota, 58122

  • Genesys Hurley Cancer Institute

    Flint, Michigan, 48503

  • Michigan State University/McLaren Regional Medical Center

    Flint, Michigan, 48532

  • Broward Oncology Associates, PA

    Fort Lauderdale, Florida, 33308

  • St. Edward Mercy Medical Center

    Fort Smith, Arkansas, 72903

  • US Oncology - Texas Oncology, PA - Forth Worth

    Fort Worth, Texas, 76104

  • US Oncology - Southwest Forth Worth Cancer Center

    Fort Worth, Texas, 76132

  • Compassionate Cancer Care Medical Group (Fountain Valley)

    Fountain Valley, California, 92708

  • Virginia K. Crosson Cancer Center

    Fullerton, California, 92835

  • Florida Cancer Specialists & Research Institute

    Gainesville, Florida, 32605

  • US Oncology - Fairfax Northern Virginia Hematology-Oncology, PC-Gainesville

    Gainesville, Virginia, 20155

  • US Oncology - Texas Oncology, PA - Garland

    Garland, Texas, 75042

  • Center for Cancer Care @ Goshen Health Systems

    Goshen, Indiana, 46526

  • TORI - St. Mary's Advanced Medical Pavilion

    Grand Junction, Colorado, 80501

  • US Oncology - Texas Oncology - Grapevine

    Grapevine, Texas, 76051

  • St. Vincent Hospital/Green Bay Oncology

    Green Bay, Wisconsin, 54301

  • US Oncology - Cancer Centers of the Carolinas - Butternut

    Greenville, South Carolina, 29605

  • US Oncology - Cancer Centers of the Carolinas - West Faris

    Greenville, South Carolina, 29605

  • US Oncology - Cancer Centers of the Carolinas - Eastside

    Greenville, South Carolina, 29615

  • Andrews and Patel Associates

    Harrisburg, Pennsylvania, 17111

  • Ingalls Cancer Research Center

    Harvey, Illinois, 60426

  • TORI - Comprehensive Cancer Centers of NV

    Henderson, Nevada, 89052

  • Carolina Oncology Specialists, PA

    Hickory, North Carolina, 28602

  • Emerywood Hematology/Oncology

    High Point, North Carolina, 27262

  • SC Cancer Specialists, PA

    Hilton Head Island, South Carolina, 29926

  • Memorial Cancer Institute

    Hollywood, Florida, 33021

  • Straub Clinic and Hospital

    Honolulu, Hawaii, 96813

  • Genesis Cancer Center

    Hot Springs, Arkansas, 71913

  • MD Anderson Cancer Center

    Houston, Texas, 77030

  • The Methodist Hospital Research Institute-AOCT

    Houston, Texas, 77030

  • US Oncology - Florida Cancer Institute - New Hope-Hudson

    Hudson, Florida, 34667

  • US Oncology - Cavell Cancer Treatment Program

    Hudson, New York, 12534

  • The Cancer Center of Huntsville

    Huntsville, Alabama, 35801

  • Capecod Hospital/Davenport Mugar Cancer Center

    Hyannis, Massachusetts, 02601

  • Indiana University Cancer Center Clinical Research Office

    Indianapolis, Indiana, 46202

  • Southlake Oncology dba Las Colinas Hematology Oncology

    Irving, Texas, 75063

  • Jackson Oncology Associates

    Jackson, Mississippi, 39202

  • Integrated Community Oncology Network, LLC

    Jacksonville, Florida, 32256

  • Capitol Comprehensive Cancer Care Clinic

    Jefferson City, Missouri, 65109

  • Broome Oncology

    Johnson City, New York, 13790

  • Joliet Oncology

    Joliet, Illinois, 60435

  • Clopton Clinic Hematology/Oncology

    Jonesboro, Arkansas, 72401

  • West Michigan Cancer Center

    Kalamazoo, Michigan, 49007

  • Columbia Basin Hematology and Oncology

    Kennewick, Washington, 99337

  • US Oncology - San Antonio Tumor & Blood Clinic - Kerrville

    Kerrville, Texas, 78028

  • US Oncology - Medical Oncology Associates (Nahar)

    Kingston, Pennsylvania, 18704

  • US Oncology - Texas Oncology - Kyle

    Kyle, Texas, 78640

  • Arena Oncology Associates, PC

    Lake Success, New York, 11042

  • Watson Clinic

    Lakeland, Florida, 33805

  • US Oncology - Rocky Mountain Cancer Center-Lakewood

    Lakewood, Colorado, 80228

  • TORI - Antelope Valley Cancer Center

    Lancaster, California, 93534

  • Lancaster Cancer Center

    Lancaster, Pennsylvania, 17605

  • Michigan State University/Breslin Cancer Center

    Lansing, Michigan, 48910

  • Michigan State University/Lapeer Regional Medical Center

    Lapeer, Michigan, 48446

  • Southern Nevada Cancer Research Foundation

    Las Vegas, Nevada, 89106

  • US Oncology - New York Oncology Hematology, PC-Latham

    Latham, New York, 12110-0610

  • Cancer & Blood Disease Center

    Lecanto, Florida, 34461

  • US Oncology - Fairfax-Northern Virgina Hem-Onc, PC-Leesburg

    Leesburg, Virginia, 20176

  • Nebraska Hematology Oncology, PC

    Lincoln, Nebraska, 68506

  • Southeast Nebraska Hematology & Oncology Consultants, PC

    Lincoln, Nebraska, 68510

  • Little Rock Hematology Oncology Associates, PA

    Little Rock, Arkansas, 72205

  • US Oncology - Rocky Mountain Cancer Center-Littleton

    Littleton, Colorado, 80120-4413

  • US Oncology - Rocky Mountain Cancer Center-Sky Ridge

    Lone Tree, Colorado, 80124

  • US Oncology - Rocky Mountain Cancer Center-Longmont

    Longmont, Colorado, 80501

  • US Oncology - Longview Cancer Center

    Longview, Texas, 75601

  • Baptist Hospital East

    Louisville, Kentucky, 40207

  • Joe Arrington Cancer Research and Treatment Center

    Lubbock, Texas, 79410

  • Medical Oncology and Blood Disorders, LLP

    Manchester, Connecticut, 06040

  • US Oncology - Allison Cancer Center

    Midland, Texas, 79701

  • CMS Water Tower Medical Commons Medical Oncology #100

    Milwaukee, Wisconsin, 53211

  • Montana Cancer Institute Foundation

    Missoula, Montana, 59802

  • Medical Arts Associates, Ltd

    Moline, Illinois, 61265

  • Monterey Bay Oncology

    Monterey, California, 94930

  • West Virginia University - Clinical Trials Research Unit

    Morgantown, West Virginia, 26506

  • Hematology-Oncology Associates of Northern NJ dba Carol G. Simon

    Morristown, New Jersey, 07962

  • Michigan State University/Mount Clemens Regional Medical Center

    Mount Clemens, Michigan, 48043

  • Cancer Research-Munster

    Munster, Indiana, 46321

  • SCRI

    Nashville, Tennessee, 37203

  • Cancer Care Center Inc.

    New Albany, Indiana, 47150

  • Hospital of Central Connecticut

    New Britain, Connecticut, 06050

  • Pasco Hernando Oncology Associates (Kumar)

    New Port Richey, Florida, 34652

  • US Oncology - Florida Cancer Institute - New Hope-New Port Richey

    New Port Richey, Florida, 34655

  • Delaware Clinical & Laboratory Physicians, PA

    Newark, Delaware, 19713

  • Oncology Hematology Associates of SW IN

    Newburgh, Indiana, 47630

  • Oncology Specialists, S.C.

    Niles, Illinois, 60714

  • TORI - North Valley Hematology/Oncology

    Northridge, California, 91328

  • Newland Medical Associates

    Novi, Michigan, 48375

  • Hematology Oncology Associates

    Oakland, California, 94609

  • US Oncology - Texas Oncology - Odessa

    Odessa, Texas, 79761

  • Northern Utah Associates

    Ogden, Utah, 84403

  • Michigan State University/Memorial Cancer Center

    Owosso, Michigan, 48867

  • Comprehensive Cancer Center

    Palm Springs, California, 92262

  • US Oncology - Rocky Mountain Cancer Center-Parker

    Parker, Colorado, 80138

  • Sacred Heart Medical Oncology Group

    Pensacola, Florida, 32504

  • Illinois Cancer Care

    Peoria, Illinois, 61615

  • The Western Pennsylvania Hospital

    Pittsburgh, Pennsylvania, 15224

  • UPCI Hillman Cancer Center

    Pittsburgh, Pennsylvania, 15232

  • US Oncology - North Texas Regional Cancer Center

    Plano, Texas, 75075

  • US Oncology - Texas Oncology Plano West Cancer Center

    Plano, Texas, 75093

  • Bay Area Cancer Research Group, LLC

    Pleasant Hill, California, 94523

  • New Hope Cancer & Research Institute

    Pomona, California, 91767

  • US Oncology - Cancer Centers of North Carolina - Falls

    Raleigh, North Carolina, 27614

  • Berks Hematology Oncology Associates

    Reading, Pennsylvania, 19612

  • VA Sierra Nevada Healthcare System

    Reno, Nevada, 89502

  • US Oncology - New York Oncology Hematology, PC-Rexford

    Rexford, New York, 12148

  • Campassionate Cancer Care Medical Group (Riverside)

    Riverside, California, 92501

  • Cancer Care Centers of Brevard

    Rockledge, Florida, 32955

  • Capitol Hematology Oncology Medical Group - Sutter Roseville

    Roseville, California, 95661

  • US Oncology - Texas Oncology Seton Williamson

    Round Rock, Texas, 78665

  • US Oncology - Texas Oncology - Round Rock Cancer Center

    Round Rock, Texas, 78681

  • St. Joseph Oncology

    Saint Joseph, Missouri, 64507

  • Park Nicollet Institute - Louisiana Ave.

    Saint Louis Park, Minnesota, 55426

  • University of Utah - Huntsman Cancer Institute

    Salt Lake City, Utah, 84112

  • US Oncology - Cancer Care Centers of South Texas

    San Antonio, Texas, 78217

  • US Oncology - HOAST - Medical Dr.

    San Antonio, Texas, 78229

  • US Oncology - San Antonio Tumor & Blood Clinic - M. Oak

    San Antonio, Texas, 78258-3912

  • US Oncology - Texas Oncology - San Marcos

    San Marcos, Texas, 78666

  • TORI - Central Coast Medical Oncology

    Santa Maria, California, 93454

  • Redwood Regional Medical Group, Inc.

    Santa Rosa, California, 95403

  • Summit Cancer Care

    Savannah, Georgia, 31404

  • US Oncology - Puget Sound Cancer Center-Seattle

    Seattle, Washington, 98133

  • US Oncology - Cancer Center of the Carolinas - Seneca

    Seneca, South Carolina, 29672

  • Siouxland Hematology-Oncology Associates, LLP

    Sioux City, Iowa, 51101

  • Sanford Clinic

    Sioux Falls, South Dakota, 57104

  • Avera Cancer Institute

    Sioux Falls, South Dakota, 57105

  • Orchard Research

    Skokie, Illinois, 60076

  • Steeplechase Cancer Center

    Somerville, New Jersey, 08876

  • Northern Indiana Cancer Research Consortium

    South Bend, Indiana, 46601

  • Newland Medical Associates

    Southfield, Michigan, 48075

  • US Oncology - Cancer Centers of the Carolinas - Spartanburg

    Spartanburg, South Carolina, 29307

  • US Oncology - Cancer Care Northwest - Sherman

    Spokane, Washington, 99202

  • Medical Oncology Associates PS

    Spokane, Washington, 99208

  • St. John's Medical Research Institute

    Springfield, Missouri, 65807

  • US Oncology - Willamette Valley Cancer Institute - Springfield

    Springfield, Oregon, 97477

  • University Hematology Oncology, Inc.

    St Louis, Missouri, 63110

  • Washington University in St. Louis, Division of Oncology, Section of Bone Marrow Transplantation & Leukemia

    St Louis, Missouri, 63110

  • Hematology Oncology Consultants, Inc

    St Louis, Missouri, 63136

  • St. John's Mercy Medical Center

    St Louis, Missouri, 63141

  • Hematology Oncology, PC

    Stamford, Connecticut, 06902-3628

  • Stockton Hematology Oncology Medical Group, Inc.

    Stockton, California, 95204

  • SUNY Upstate Medical University - Adult Program

    Syracuse, New York, 14222

  • Scott & White Healthcare Department of Research

    Temple, Texas, 76508

  • Bronx River Medical Associates

    The Bronx, New York, 10467

  • Eastchester Center for Cancer Care

    The Bronx, New York, 10469

  • Florida Hospital Waterman-Lake County Oncology & Hematology

    The Villages, Florida, 32159

  • US Oncology - Rocky Mountain Cancer Center-Thornton

    Thornton, Colorado, 80260

  • US Oncology - Troy Cancer Treatment Program

    Troy, New York, 12180

  • US Oncology - Arizona Oncology Associates - Rudasill

    Tucson, Arizona, 85704

  • DCH Health System

    Tuscaloosa, Alabama, 35401

  • ETMC dba Blood and Cancer Center - East Texas

    Tyler, Texas, 75701

  • ETMC dba Tyler Hematology Oncology

    Tyler, Texas, 75701

  • Carle Cancer Center

    Urbana, Illinois, 61801

  • US Oncology - Texas Oncology Cancer Care and Research Center

    Waco, Texas, 76712

  • Providence St. Mary Regional Cancer Center

    Walla Walla, Washington, 99362

  • Cedar Valley Medical Specialists

    Waterloo, Iowa, 50701

  • Covenant Clinic

    Waterloo, Iowa, 50702

  • Waukesha Memorial Hospital

    Waukesha, Wisconsin, 53188

  • Institute for Myeloma and Bone Cancer Research

    West Hollywood, California, 90069

  • Alliance Hematology Oncology, PA

    Westminster, Maryland, 21157

  • Cleveland Clinic Florida

    Weston, Florida, 33331

  • Cancer Center of Kansas, PA

    Wichita, Kansas, 67214

  • US Oncology - Texoma Cancer Center

    Wichita Falls, Texas, 76310

  • US Oncology - Shenandoah Oncology - Winchester

    Winchester, Virginia, 22601

  • US Oncology - Fairfax-Northern Virginia Hem-Onc, PC-Woodbridge

    Woodbridge, Virginia, 22191

  • Lawrence M. Stallings MD LTD dba Trilogy Cancer Care

    Wooster, Ohio, 44691

  • Fallon Clinic

    Worcester, Massachusetts, 01608

  • US Oncology - Yakima Valley Memorial Hospital/North Star Lodge

    Yakima, Washington, 98902

Other trials in United States

Puerto Rico1 site

  • Auxilio Cancer Center

    San Juan, 00918

Other trials in Puerto Rico

About this study

The purpose of the Connect® MM Registry is to explore the natural history and real world management of patients with newly diagnosed symptomatic multiple myeloma (MM) and provide unique insights into the management of MM and the impact of this hematologic disorder on patients.

Being tested
First-line therapy, Second-line Multiple Myeloma treatments
Keywords
Multiple Myeloma, MM, disease registry, Connect®
Medical subject headings
Multiple Myeloma

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • First-line therapyOther

    As prescribed by treating physician

  • Second-line Multiple Myeloma treatmentsDrug

    As prescribed by the treating physician

Study groups in NCT01081028
Study groupRoleWhat they receive
Cohort 1: Patients enrolled between Sep 2009 and Nov 2011Newly diagnosed multiple myeloma patients enrolled between Sep 2009 and Nov 2011.
Receives: Other: First-line therapy
Cohort 2: Patients enrolled between December 2012 and mid-2016Newly diagnosed multiple myeloma patients enrolled between Dec 2012 and mid-2016
Receives: Other: First-line therapy
Cohort 3: Patients enrolled from 2023Relapsed/Refractory multiple myeloma patients receiving second-line therapy
Receives: Drug: Second-line Multiple Myeloma treatments

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Participant baseline demographics

    Measured: Baseline

  2. Participant medical history

    Measured: Baseline

  3. Participant Multiple Myeloma diagnosis information

    Measured: Baseline

  4. Participant Multiple Myeloma treatment history

    Measured: Baseline

  5. Multiple Myeloma-related supportive concomitant medications and procedures

    Measured: Baseline, every 3-months up to 5 years (Cohort 3), or up to 16 years (Cohort 1 & 2), or date of early discontinuation

  6. Occurance of second primary malignancy

    Measured: Baseline, every 3-months up to 5 years (Cohort 3), or up to 16 years (Cohort 1 & 2), or date of early discontinuation

  7. Number of participants enrolled in a clinical trial

    Cohort 1 and 2 only

    Measured: Baseline, every 3-months up to 16 years or date of early discontinuation

  8. Lines of therapy prescribed

    Measured: Baseline, every 3-months up to 5 years (Cohort 3), or up to 16 years (Cohort 1 & 2), or date of early discontinuation

  9. Participant disease response assessment results

    Measured: Baseline, every 3-months up to 5 years (Cohort 3), or up to 16 years (Cohort 1 & 2), or date of early discontinuation

Secondary outcomes (16)

  1. Participant socioeconomic status

    Cohort 3 only

    Measured: Baseline

  2. Participant EuroQol-5 Dimensions (EQ-5D) questionnaire results

    Measured: Baseline, every 3-months up to 5 years (Cohort 3) or up to 16 years (Cohort 1 and 2), or date of early discontinuation

  3. Participant Functional Assessment of Cancer Therapy - Multiple Myeloma (FACT-MM) questionnaire results

    Measured: Baseline, every 3-months up to 5 years (Cohort 3) or up to 16 years (Cohort 1 and 2), or date of early discontinuation

  4. Participant Visual Analogue Score (VAS) questionnaire results

    Measured: Baseline, every 3-months up to 5 years (Cohort 3) or up to 16 years (Cohort 1 and 2), or date of early discontinuation

  5. Participant participant survival status

    Measured: Every 3-months up to 5 years (Cohort 3) or up to 16 years (Cohort 1 and 2), or date of early discontinuation

  6. Participant participant Adverse Events (AEs)

    Measured: Every 3-months up to 5 years (Cohort 3) or up to 16 years (Cohort 1 and 2) or date of early discontinuation

  7. Reason for registry discontinuation

    Measured: Date of early discontinuation assessed up to 5 years (Cohort 3) or up to 16 years (Cohort 1 and 2)

  8. Reason for treatment initiation or discontinuation

    Cohort 3 only

    Measured: Baseline, and every 3-months up to 5 years or date of early discontinuation

  9. Participant COVID-19 infection and vaccination status

    Cohort 3 only

    Measured: Baseline, and every 3-months up to 5 years or date of early discontinuation

  10. Treating clinician response to frailty questionnaire

    Cohort 3 only

    Measured: Baseline, and every 3-months up to 5 years or date of early discontinuation

  11. Participant Brief Pain Inventory (BPI) questionnaire results

    Cohort 3 only

    Measured: Baseline, and every 3-months up to 5 years or date of early discontinuation

  12. Participant response to social support questionnaire

    Cohort 3 only

    Measured: Baseline, and every 3-months up to 5 years or date of early discontinuation

  13. Treating clinician response to social support questionnaire

    Cohort 3 only

    Measured: Baseline, and every 3-months up to 5 years or date of early discontinuation

  14. Number of participants that have received stem cell transplant

    Cohort 3 only

    Measured: Baseline, and every 3-months up to 5 years or date of early discontinuation

  15. Number of hospitalization or emergency room visits

    Measured: Every 3-months up to 5 years (Cohort 3) or up to 16 years (Cohort 1 and 2) or date of early discontinuation

  16. Cause of death

    Measured: Every 3-months up to 5 years (Cohort 3) or up to 16 years (Cohort 1 and 2) or date of early discontinuation

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted5 Mar 2010 (estimated)
  2. Study start1 Sep 2009
  3. Primary completion31 Dec 2024
  4. Study completion31 Dec 2024

Why it stopped: Business objectives have changed

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
3,011 participants (actual)
Target duration
16 Years
IDs, dates and publications
ClinicalTrials.gov ID
NCT01081028
Sponsor's protocol ID
Connect ® MM
Other IDs
CC-5013-MM-036, CA078-1009
Status last verified
Apr 2026
First submitted
4 Mar 2010
Last updated
13 Apr 2026
Results posted
No
Data monitoring committee
No

Publications

  • Rifkin RM, Jagannath S, Durie BGM, Narang M, Terebelo HR, Gasparetto CJ, Toomey K, Hardin JW, Wagner L, Parikh K, Abouzaid S, Srinivasan S, Kitali A, Zafar F, Abonour R. Treatment Outcomes and Health Care Resource Utilization in Patients With Newly Diagnosed Multiple Myeloma Receiving Lenalidomide-only Maintenance, Any Maintenance, or No Maintenance: Results from the Connect MM Registry. Clin Ther. 2018 Jul;40(7):1193-1202.e1. doi: 10.1016/j.clinthera.2018.05.017. Epub 2018 Jul 23.

    PubMed 30007443

  • Shah JJ, Abonour R, Gasparetto C, Hardin JW, Toomey K, Narang M, Srinivasan S, Kitali A, Zafar F, Flick ED, Rifkin RM. Analysis of Common Eligibility Criteria of Randomized Controlled Trials in Newly Diagnosed Multiple Myeloma Patients and Extrapolating Outcomes. Clin Lymphoma Myeloma Leuk. 2017 Sep;17(9):575-583.e2. doi: 10.1016/j.clml.2017.06.013. Epub 2017 Jun 17.

    PubMed 28886839

  • Terebelo HR, Abonour R, Gasparetto CJ, Toomey K, Durie BGM, Hardin JW, Jagannath S, Wagner L, Narang M, Flick ED, Srinivasan S, Yue L, Kitali A, Agarwal A, Rifkin RM; CONNECT MM Registry Investigators. Development of a prognostic model for overall survival in multiple myeloma using the Connect(R) MM Patient Registry. Br J Haematol. 2019 Dec;187(5):602-614. doi: 10.1111/bjh.16139. Epub 2019 Aug 5.

    PubMed 31382320

  • Rifkin RM, Abonour R, Terebelo H, Shah JJ, Gasparetto C, Hardin J, Srinivasan S, Ricafort R, Nagarwala Y, Durie BG. Connect MM Registry: The Importance of Establishing Baseline Disease Characteristics. Clin Lymphoma Myeloma Leuk. 2015 Jun;15(6):368-76. doi: 10.1016/j.clml.2014.12.002. Epub 2014 Dec 11.

    PubMed 25617035

  • Rifkin RM, Abonour R, Shah JJ, Mehta J, Narang M, Terebelo H, Gasparetto C, Toomey K, Hardin JW, Lu JJ, Kenvin L, Srinivasan S, Knight R, Nagarwala Y, Durie BG. Connect MM(R) - the Multiple Myeloma Disease Registry: incidence of second primary malignancies in patients treated with lenalidomide. Leuk Lymphoma. 2016 Sep;57(9):2228-31. doi: 10.3109/10428194.2015.1132419. Epub 2016 Jan 13. No abstract available.

    PubMed 26766599

  • Terebelo H, Srinivasan S, Narang M, Abonour R, Gasparetto C, Toomey K, Hardin JW, Larkins G, Kitali A, Rifkin RM, Shah JJ. Recognition of early mortality in multiple myeloma by a prediction matrix. Am J Hematol. 2017 Sep;92(9):915-923. doi: 10.1002/ajh.24796. Epub 2017 Jul 19.

    PubMed 28543165

  • Jagannath S, Abonour R, Durie BGM, Gasparetto C, Hardin JW, Narang M, Terebelo HR, Toomey K, Wagner L, Srinivasan S, Kitali A, Yue L, Flick ED, Agarwal A, Rifkin RM. Heterogeneity of Second-Line Treatment for Patients With Multiple Myeloma in the Connect MM Registry (2010-2016). Clin Lymphoma Myeloma Leuk. 2018 Jul;18(7):480-485.e3. doi: 10.1016/j.clml.2018.04.007. Epub 2018 May 4.

    PubMed 29844008

  • Jagannath S, Abonour R, Durie BGM, Narang M, Terebelo HR, Gasparetto CJ, Toomey K, Hardin JW, Wagner L, Agarwal A, Srinivasan S, Kitali A, Flick ED, Sturniolo M, Rifkin RM. Impact of post-ASCT maintenance therapy on outcomes in patients with newly diagnosed multiple myeloma in Connect MM. Blood Adv. 2018 Jul 10;2(13):1608-1615. doi: 10.1182/bloodadvances.2018017186.

    PubMed 29986853

  • Abonour R, Wagner L, Durie BGM, Jagannath S, Narang M, Terebelo HR, Gasparetto CJ, Toomey K, Hardin JW, Kitali A, Gibson CJ, Srinivasan S, Swern AS, Rifkin RM. Impact of post-transplantation maintenance therapy on health-related quality of life in patients with multiple myeloma: data from the Connect(R) MM Registry. Ann Hematol. 2018 Dec;97(12):2425-2436. doi: 10.1007/s00277-018-3446-y. Epub 2018 Jul 29.

    PubMed 30056582

  • Jagannath S, Rifkin RM, Gasparetto CJ, Toomey K, Durie BGM, Hardin JW, Terebelo HR, Wagner L, Narang M, Ailawadhi S, Omel JL, Srinivasan S, He M, Ung B, Kitali A, Flick ED, Agarwal A, Abonour R; CONNECT MM Registry Investigators. Treatment Journeys of Patients With Newly Diagnosed Multiple Myeloma (NDMM): Results From The Connect MM Registry. Clin Lymphoma Myeloma Leuk. 2020 May;20(5):272-276. doi: 10.1016/j.clml.2019.10.002. Epub 2019 Oct 14. No abstract available.

    PubMed 32144027

  • Ailawadhi S, Jagannath S, Lee HC, Narang M, Rifkin RM, Terebelo HR, Durie BGM, Toomey K, Hardin JW, Gasparetto CJ, Wagner L, Omel JL, He M, Yue L, Flick ED, Agarwal A, Abonour R; Connect MM Registry Investigators. Association between race and treatment patterns and survival outcomes in multiple myeloma: A Connect MM Registry analysis. Cancer. 2020 Oct 1;126(19):4332-4340. doi: 10.1002/cncr.33089. Epub 2020 Jul 24.

    PubMed 32706404

  • Abonour R, Rifkin RM, Gasparetto C, Toomey K, Durie BGM, Hardin JW, Terebelo HR, Jagannath S, Narang M, Ailawadhi S, Omel JL, Lee HC, Srinivasan S, Kitali A, Agarwal A, Wagner L; CONNECT MM Registry Investigators. Effect of initial treatment on health-related quality of life in patients with newly diagnosed multiple myeloma without immediate stem cell transplant intent: results from the Connect(R) MM Registry. Br J Haematol. 2021 Apr;193(1):93-100. doi: 10.1111/bjh.17131. Epub 2020 Oct 29.

    PubMed 33118614

  • Ailawadhi S, Lee HC, Omel J, Toomey K, Hardin JW, Gasparetto CJ, Jagannath S, Rifkin RM, Durie BGM, Narang M, Terebelo HR, Joshi P, Jou YM, Mouro J, Yu E, Abonour R. Impact of lenalidomide-bortezomib-dexamethasone induction on patients with newly diagnosed multiple myeloma and renal impairment: Results from the Connect(R) MM Registry. Blood Cancer J. 2024 Nov 11;14(1):198. doi: 10.1038/s41408-024-01177-6.

    PubMed 39528478

  • Lee HC, Ramasamy K, Weisel K, Abonour R, Hardin JW, Rifkin RM, Ailawadhi S, Terebelo HR, Durie BGM, Tang D, Joshi P, Liu L, Jou YM, Che M, Hernandez G, Narang M, Toomey K, Gasparetto C, Wagner LI, Jagannath S. Treatment Patterns, Survival, Quality of Life, and Healthcare Resource Use Among Patients With Triple-Class Refractory Multiple Myeloma in US Clinical Practice: Findings From the Connect MM Disease Registry. Clin Lymphoma Myeloma Leuk. 2023 Feb;23(2):112-122. doi: 10.1016/j.clml.2022.11.008. Epub 2022 Nov 23.

    PubMed 36567211

  • Engelhardt M, Ihorst G, Singh M, Rieth A, Saba G, Pellan M, Lebioda A. Real-World Evaluation of Health-Related Quality of Life in Patients With Multiple Myeloma From Germany. Clin Lymphoma Myeloma Leuk. 2021 Feb;21(2):e160-e175. doi: 10.1016/j.clml.2020.10.002. Epub 2020 Oct 24.

    PubMed 33218965

Questions about this trial

What is this clinical trial studying?

An observational study of Multiple Myeloma, run by Celgene at 253 sites in 2 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 9 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: stopped early, as of the sponsor's last update on 13 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 253 sites in United States, Puerto Rico. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study was stopped early (reason given: Business objectives have changed). Results are not available in the source record.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Participant baseline demographics (time frame: Baseline). The study lists 9 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT01081028, which also lists 16 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Apr 2026.

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