Central Venous PressureNCT01099241
Central Venous Pressure (CVP) Assessment by Ultrasound and Physical Examination
An observational study of Central Venous Pressure, run by University of Iowa at 1 site in United States.
Trial summary
Ultrasound may be useful for noninvasively determining the central venous pressure. We intend to compare the clinical examination of the neck veins; ultrasound delineation of the internal jugular vein; and the central venous pressure measured with an intravascular catheter. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Central Venous Pressure
- How many people
- 38 participants
- Where
- 1 siteUnited States
- Study dates
- Aug 2007to Mar 2010
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients admitted to Intensive care unit.
Who may be able to join
- adult medical or surgical ICU patients who have preexisting central venous (jugular/subclavian only) catheters.
Who cannot join
- subjects with only a femoral venous catheter.
- subjects whose CVP measurement by the indwelling catheter exceeds 20cm of water.
- subjects younger than 18 years old.
- inability to obtain informed consent from the subject or the subjects authorized representative.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Use of Ultrasound to Determine Central Venous Pressure in Critically Ill Patients
Ultrasound may be useful for noninvasively determining the central venous pressure. We intend to compare the clinical examination of the neck veins; ultrasound delineation of the internal jugular vein; and the central venous pressure measured with an intravascular catheter.
- Conditions
- Central Venous Pressure
- Keywords
- CVP, US, Ultrasonography
What is being measured
The primary outcome is the main question the study is designed to answer.
Correlation of CVP measurement via ultrasound and central venous catheter
CVP as determined non-invasively with the transcutaneous ultrasound probe will correlate with a high degree of accuracy to the measurement obtained invasively by the catheter and pressure transducer.
Measured: At data collection: this is a physiologic study
Secondary outcomes (1)
Correlation of CVP measurement via physical examination of IJV and EJV.
Despite its more tortuous course and smaller caliber, the external jugular vein will be as reliable (compared to the catheter) as the internal jugular to estimate CVP
Measured: At data collection: physiologic study
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Apr 2010 (estimated)
- Study startAug 2007
- Primary completionMar 2010
- Study completionMar 2010
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (9)Papers the sponsor has linked to this study.
- Other trials for Central Venous PressureStudies of the same condition, open and under way.
- More trials run by University of IowaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Time perspective
- Prospective
- Enrolment
- 38 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Iowa
- Sponsor type
- University, hospital or other
- Investigators
- Gregory A Schmidt, Principal investigator, Roy J. & Lucille A. Carver College of Medicine, University of Iowa
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01099241
- Sponsor's protocol ID
- 20076777
- Status last verified
- Mar 2010
- First submitted
- 26 Mar 2010
- Last updated
- 6 Apr 2010
- Results posted
- No
- Data monitoring committee
- No
Publications
Baumann UA, Marquis C, Stoupis C, Willenberg TA, Takala J, Jakob SM. Estimation of central venous pressure by ultrasound. Resuscitation. 2005 Feb;64(2):193-9. doi: 10.1016/j.resuscitation.2004.08.015.
PubMed 15680529Bazaral M, Harlan S. Ultrasonographic anatomy of the internal jugular vein relevant to percutaneous cannulation. Crit Care Med. 1981 Apr;9(4):307-10. doi: 10.1097/00003246-198104000-00004.
PubMed 7214938Cook DJ. Clinical assessment of central venous pressure in the critically ill. Am J Med Sci. 1990 Mar;299(3):175-8. doi: 10.1097/00000441-199003000-00006.
PubMed 2316561Davison R, Cannon R. Estimation of central venous pressure by examination of jugular veins. Am Heart J. 1974 Mar;87(3):279-82. doi: 10.1016/0002-8703(74)90064-7. No abstract available.
PubMed 4812363Lipton B. Estimation of central venous pressure by ultrasound of the internal jugular vein. Am J Emerg Med. 2000 Jul;18(4):432-4. doi: 10.1053/ajem.2000.7335.
PubMed 10919533Lipton BM. Determination of elevated jugular venous pressure by real-time ultrasound. Ann Emerg Med. 1999 Jul;34(1):115. doi: 10.1016/s0196-0644(99)70287-8. No abstract available.
PubMed 10409088Rizvi K, Deboisblanc BP, Truwit JD, Dhillon G, Arroliga A, Fuchs BD, Guntupalli KK, Hite D, Hayden D; NIH/NHLBI ARDS Clinical Trials Network. Effect of airway pressure display on interobserver agreement in the assessment of vascular pressures in patients with acute lung injury and acute respiratory distress syndrome. Crit Care Med. 2005 Jan;33(1):98-103; discussion 243-4. doi: 10.1097/01.ccm.0000150650.70142.e9.
PubMed 15644654Vinayak AG, Levitt J, Gehlbach B, Pohlman AS, Hall JB, Kress JP. Usefulness of the external jugular vein examination in detecting abnormal central venous pressure in critically ill patients. Arch Intern Med. 2006 Oct 23;166(19):2132-7. doi: 10.1001/archinte.166.19.2132.
PubMed 17060544Deol GR, Collett N, Ashby A, Schmidt GA. Ultrasound accurately reflects the jugular venous examination but underestimates central venous pressure. Chest. 2011 Jan;139(1):95-100. doi: 10.1378/chest.10-1301. Epub 2010 Aug 26.
PubMed 20798190
Study at a glance
From the registry record, last updated by the sponsor on 6 Apr 2010. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Use of Ultrasound to Determine Central Venous Pressure in Critically Ill Patients
- ClinicalTrials.gov ID
- NCT01099241
- Acronym / sponsor ID
- 20076777
- Conditions
- Central Venous Pressure
- Keywords
- CVP, US, Ultrasonography
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 38 participants (actual)
- Lead sponsor
- University of IowaUniversity, hospital or other
- Study start
- Aug 2007
- Primary completion
- Mar 2010 (actual)
- Study completion
- Mar 2010 (actual)
- First posted
- 6 Apr 2010 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Ultrasound may be useful for noninvasively determining the central venous pressure. We intend to compare the clinical examination of the neck veins; ultrasound delineation of the internal jugular vein; and the central venous pressure measured with an intravascular catheter.
Study design
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients admitted to Intensive care unit.
Key inclusion criteria (1 listed)
- adult medical or surgical ICU patients who have preexisting central venous (jugular/subclavian only) catheters.
Key exclusion criteria (4 listed)
- subjects with only a femoral venous catheter.
- subjects whose CVP measurement by the indwelling catheter exceeds 20cm of water.
- subjects younger than 18 years old.
- inability to obtain informed consent from the subject or the subjects authorized representative.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Correlation of CVP measurement via ultrasound and central venous catheter
Time frame: At data collection: this is a physiologic study
CVP as determined non-invasively with the transcutaneous ultrasound probe will correlate with a high degree of accuracy to the measurement obtained invasively by the catheter and pressure transducer.
1 secondary outcome
Correlation of CVP measurement via physical examination of IJV and EJV.
Time frame: At data collection: physiologic study
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Apr 2010.
- Background: PubMed 15680529Baumann UA, Marquis C, Stoupis C, Willenberg TA, Takala J, Jakob SM. Estimation of central venous pressure by ultrasound. Resuscitation. 2005 Feb;64(2):193-9. doi: 10.1016/j.resuscitation.2004.08.015.
- Background: PubMed 7214938Bazaral M, Harlan S. Ultrasonographic anatomy of the internal jugular vein relevant to percutaneous cannulation. Crit Care Med. 1981 Apr;9(4):307-10. doi: 10.1097/00003246-198104000-00004.
- Background: PubMed 2316561Cook DJ. Clinical assessment of central venous pressure in the critically ill. Am J Med Sci. 1990 Mar;299(3):175-8. doi: 10.1097/00000441-199003000-00006.
- Background: PubMed 4812363Davison R, Cannon R. Estimation of central venous pressure by examination of jugular veins. Am Heart J. 1974 Mar;87(3):279-82. doi: 10.1016/0002-8703(74)90064-7. No abstract available.
- Background: PubMed 10919533Lipton B. Estimation of central venous pressure by ultrasound of the internal jugular vein. Am J Emerg Med. 2000 Jul;18(4):432-4. doi: 10.1053/ajem.2000.7335.
- Background: PubMed 10409088Lipton BM. Determination of elevated jugular venous pressure by real-time ultrasound. Ann Emerg Med. 1999 Jul;34(1):115. doi: 10.1016/s0196-0644(99)70287-8. No abstract available.
- Background: PubMed 15644654Rizvi K, Deboisblanc BP, Truwit JD, Dhillon G, Arroliga A, Fuchs BD, Guntupalli KK, Hite D, Hayden D; NIH/NHLBI ARDS Clinical Trials Network. Effect of airway pressure display on interobserver agreement in the assessment of vascular pressures in patients with acute lung injury and acute respiratory distress syndrome. Crit Care Med. 2005 Jan;33(1):98-103; discussion 243-4. doi: 10.1097/01.ccm.0000150650.70142.e9.
- Background: PubMed 17060544Vinayak AG, Levitt J, Gehlbach B, Pohlman AS, Hall JB, Kress JP. Usefulness of the external jugular vein examination in detecting abnormal central venous pressure in critically ill patients. Arch Intern Med. 2006 Oct 23;166(19):2132-7. doi: 10.1001/archinte.166.19.2132.
- Derived from this study: PubMed 20798190Deol GR, Collett N, Ashby A, Schmidt GA. Ultrasound accurately reflects the jugular venous examination but underestimates central venous pressure. Chest. 2011 Jan;139(1):95-100. doi: 10.1378/chest.10-1301. Epub 2010 Aug 26.
Related trials for Central Venous Pressure
Not yet recruitingObservational study
Duke Virtual IntEgrated Workflow
Falls Injury, Readmission Rates
Not yet recruitingObservational study
Central Venous Pressure Versus Inferior Vena Cava Distensibility Index in Assessing Fluid Responsiveness in Septic Shocked Patients
Central Venous Pressure and Inferior Vena Cava Distensibility Index in Assessing Fluid Responsiveness in Septic Shocked Patients
Recruiting
Non-invasive Central Venous Pressure Estimation in Pediatric Patients
Central Venous Pressure
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Gregory A Schmidt principal investigator
Roy J. & Lucille A. Carver College of Medicine, University of Iowa
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Central Venous Pressure, run by University of Iowa at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Apr 2010. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Correlation of CVP measurement via ultrasound and central venous catheter (time frame: At data collection: this is a physiologic study). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT01099241, which also lists 9 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Apr 2010; AzTrials last refreshed its copy on 8 Nov 2026.