ObesityNCT01143363
Effect of High-intensity Intermittent Sprinting on Appetite Control on Obese Volunteers
A study testing Moderate intensity exercise, High intensity intermittent training and Short sprint in people with Obesity, run by Norwegian University of Science and Technology at 1 site in Norway.
Trial summary
Several studies have shown that high intensity intermittent sprints (HIIS) are more effective than moderate intensity continuous cycling (MICC) in reducing fat mass and improving insulin resistance in normal weight individuals. Read more about this study
- Who is it for?
- Ages 18 to 50 yearsHealthy volunteers can take part
- Conditions the study is for
- Obesity
- What is being tested?
- Moderate intensity exercise, High intensity intermittent training and Short sprint
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 12 participants
- Where
- 1 siteNorway
- Study dates
- May 2010to Jun 2014
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- an inactive lifestyle,
- weight stable on the previous 3 months,
- not currently dieting to loose weight
- restraint score derived from the Three Factor Eating Behaviour Questionnaire ≤12
Who cannot join
- history of coronary heart disease,
- type 1 or type 2 diabetes,
- anaemia,
- gout,
- depression or other psychological disorders,
- eating disorders,
- drug or alcohol abuse within the last two years,
- current medication known to affect appetite or induce weight loss and hypertension.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Acute Effects of High-intensity Intermittent Sprinting vs. Moderate Intensity Continuous Cycling on Appetite Control on Obese Volunteers
Several studies have shown that high intensity intermittent sprints (HIIS) are more effective than moderate intensity continuous cycling (MICC) in reducing fat mass and improving insulin resistance in normal weight individuals. Changes in the appetite-regulatory system in response to exercise are likely to explain, at least partially, the better outcome observed after HIIS. Unfortunately, there are no studies comparing the impact of different types of acute aerobic exercise on the release of appetite-regulating hormones, subjective feelings of appetite and subsequent energy intake (EI).
The primary objective of this study is to investigate the effects of acute isocaloric bouts of HIIT and MICC or a short duration sprint, in comparison with a resting control condition, on the postprandial release of appetite-regulating hormones, subjective feelings of appetite and subsequent EI in obese individuals. The investigators hypothesize that an isocaloric session of HIIS will result in a better short-term appetite control compared with MICC, by reducing hunger feelings and subsequent food intake more than MICC and by inducing a larger increase in the release of satiety gut peptides compared with the MICC.
Read the detailed description
This will be a randomised cross-over study with four legs. Participants will act as their own controls and will be assigned to the four experimental conditions (resting, HIIS, MICC and SDS), 1 week apart, in a counter-balanced order.
Participants will be asked to come to the Unit five times: one preliminary session and four experimental conditions (resting, HIIS and MICC isocaloric sessions and SDS). In the preliminary session, anthropometric data (weight and height) will be collected and a maximal fitness test performed, using a cycle ergometer.
For the four experimental conditions, participants will be asked to arrive at approximately 8.00, having fasted for at least 10 hours, and a cannula will be inserted into an antecubital vein. Two fasting blood samples will be taken and a standard breakfast offered. After that, serial blood samples will be taken at regular intervals for a period of 3h.
Participants will be asked to rate their subjective feelings of hunger and fullness using visual analogue scales (VAS) throughout each study morning at different time points. Three hours after breakfast, participants will be placed in individual rooms, presented with a standardized lunch and instructed to rate the taste and palatability of the food presented.
- Conditions
- Obesity
- Being tested
- resting - control, Moderate intensity exercise, High intensity intermittent training, Short sprint
- Keywords
- Obesity, exercise, appetite, hunger, satiety, food intake
- Medical subject headings
- Obesity, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
resting - controlBehavioural
Moderate intensity exerciseBehavioural
High intensity intermittent trainingBehavioural
Short sprintBehavioural
| Study group | Role | What they receive |
|---|---|---|
| Resting - control | Placebo comparator | No exercise Receives: Behavioral: resting - control |
| Moderate intensity exercise | Experimental | Moderate intensity exercise (continuous) 1h after breakfast Receives: Behavioral: Moderate intensity exercise |
| High intensity intermittent training | Experimental | High intensity intermittent training 1h after breakfast Receives: Behavioral: High intensity intermittent training |
| Short sprint | Experimental | Short sprint 1h after breakfast Receives: Behavioral: Short sprint |
What is being measured
The primary outcome is the main question the study is designed to answer.
Changes in gut peptides
Measured: Blood samples taken in fasting and postprandially for 3h
Secondary outcomes (1)
Food intake at test meal
Food intake at a test meal will be assessed 3h after breakfast (at 180 minutes)
Measured: 3h after breakfast
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Jun 2010 (estimated)
- Study startMay 2010
- Primary completionDec 2012
- Study completionJun 2014
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for ObesityStudies of the same condition, open and under way.
- More trials run by Norwegian University of Science and TechnologyThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 12 participants (actual)
Sponsor and investigators
- Lead sponsor
- Norwegian University of Science and Technology
- Sponsor type
- University, hospital or other
- Collaborators
- Helse Midt-Norge
- Responsible party
- Sponsor
- Investigators
- Catia Martins, PhD, Principal investigator, Norwegian University of Science and Technology
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01143363
- Sponsor's protocol ID
- 2010/444-7
- Status last verified
- Feb 2015
- First submitted
- 2 Jun 2010
- Last updated
- 6 Feb 2015
- Results posted
- No
- Data monitoring committee
- No
Publications
Martins C, Stensvold D, Finlayson G, Holst J, Wisloff U, Kulseng B, Morgan L, King NA. Effect of moderate- and high-intensity acute exercise on appetite in obese individuals. Med Sci Sports Exerc. 2015 Jan;47(1):40-8. doi: 10.1249/MSS.0000000000000372.
PubMed 24824772
Study at a glance
From the registry record, last updated by the sponsor on 6 Feb 2015. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acute Effects of High-intensity Intermittent Sprinting vs. Moderate Intensity Continuous Cycling on Appetite Control on Obese Volunteers
- ClinicalTrials.gov ID
- NCT01143363
- Acronym / sponsor ID
- 2010/444-7
- Conditions
- Obesity
- Keywords
- Obesity, exercise, appetite, hunger, satiety, food intake
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 12 participants (actual)
- Lead sponsor
- Norwegian University of Science and TechnologyUniversity, hospital or other
- Collaborators
- Helse Midt-Norge
- Study start
- May 2010
- Primary completion
- Dec 2012 (actual)
- Study completion
- Jun 2014 (actual)
- First posted
- 14 Jun 2010 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Several studies have shown that high intensity intermittent sprints (HIIS) are more effective than moderate intensity continuous cycling (MICC) in reducing fat mass and improving insulin resistance in normal weight individuals. Changes in the appetite-regulatory system in response to exercise are likely to explain, at least partially, the better outcome observed after HIIS. Unfortunately, there are no studies comparing the impact of different types of acute aerobic exercise on the release of appetite-regulating hormones, subjective feelings of appetite and subsequent energy intake (EI).
The primary objective of this study is to investigate the effects of acute isocaloric bouts of HIIT and MICC or a short duration sprint, in comparison with a resting control condition, on the postprandial release of appetite-regulating hormones, subjective feelings of appetite and subsequent EI in obese individuals. The investigators hypothesize that an isocaloric session of HIIS will result in a better short-term appetite control compared with MICC, by reducing hunger feelings and subsequent food intake more than MICC and by inducing a larger increase in the release of satiety gut peptides compared with the MICC.
Detailed description
This will be a randomised cross-over study with four legs. Participants will act as their own controls and will be assigned to the four experimental conditions (resting, HIIS, MICC and SDS), 1 week apart, in a counter-balanced order.
Participants will be asked to come to the Unit five times: one preliminary session and four experimental conditions (resting, HIIS and MICC isocaloric sessions and SDS). In the preliminary session, anthropometric data (weight and height) will be collected and a maximal fitness test performed, using a cycle ergometer.
For the four experimental conditions, participants will be asked to arrive at approximately 8.00, having fasted for at least 10 hours, and a cannula will be inserted into an antecubital vein. Two fasting blood samples will be taken and a standard breakfast offered. After that, serial blood samples will be taken at regular intervals for a period of 3h.
Participants will be asked to rate their subjective feelings of hunger and fullness using visual analogue scales (VAS) throughout each study morning at different time points. Three hours after breakfast, participants will be placed in individual rooms, presented with a standardized lunch and instructed to rate the taste and palatability of the food presented.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Resting - control | Placebo comparator | Behavioral: resting - controlNo exercise |
| Moderate intensity exercise | Experimental | Behavioral: Moderate intensity exerciseModerate intensity exercise (continuous) 1h after breakfast |
| High intensity intermittent training | Experimental | Behavioral: High intensity intermittent trainingHigh intensity intermittent training 1h after breakfast |
| Short sprint | Experimental | Behavioral: Short sprintShort sprint 1h after breakfast |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- an inactive lifestyle,
- weight stable on the previous 3 months,
- not currently dieting to loose weight
- restraint score derived from the Three Factor Eating Behaviour Questionnaire ≤12
Key exclusion criteria (8 listed)
- history of coronary heart disease,
- type 1 or type 2 diabetes,
- anaemia,
- gout,
- depression or other psychological disorders,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| resting - control | Behavioural | Resting - control |
| Moderate intensity exercise | Behavioural | Moderate intensity exercise |
| High intensity intermittent training | Behavioural | High intensity intermittent training |
| Short sprint | Behavioural | Short sprint |
Primary outcome
Changes in gut peptides
Time frame: Blood samples taken in fasting and postprandially for 3h
1 secondary outcome
Food intake at test meal
Time frame: 3h after breakfast
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Feb 2015.
- Results publication: PubMed 24824772Martins C, Stensvold D, Finlayson G, Holst J, Wisloff U, Kulseng B, Morgan L, King NA. Effect of moderate- and high-intensity acute exercise on appetite in obese individuals. Med Sci Sports Exerc. 2015 Jan;47(1):40-8. doi: 10.1249/MSS.0000000000000372.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Catia Martins, PhD principal investigator
Norwegian University of Science and Technology
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Moderate intensity exercise, High intensity intermittent training and Short sprint in people with Obesity, run by Norwegian University of Science and Technology at 1 site in Norway.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Feb 2015. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Norway. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Changes in gut peptides (time frame: Blood samples taken in fasting and postprandially for 3h). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT01143363, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Feb 2015.