Renal Replacement TherapyHA-AKINCT01151514
Referral Patterns for Hospital Acquired Acute Kidney Injury and Relevance to Renal Outcomes
An observational study of Renal Replacement Therapy and Mortality, run by Centre Hospitalier Universitaire Vaudois at 1 site in Switzerland.
Trial summary
Few studies analyzed the referral time to nephrologists and its impact on the patient outcome in a large cohort. The investigators described the incidence and determined the outcome with respect to renal function recovery, renal replacement therapy (RRT) requirement and in-hospital mortality of Hospital Acquired Acute… Read more about this study
- Who is it for?
- Ages 18 to 90 years
- Conditions the study is for
- Renal Replacement Therapy, Mortality
- What is being tested?
- Nephrologist referral
- How many people
- Not given
- Where
- 1 siteSwitzerland
- Study dates
- Start not givento not given
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 90 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: This study population consisted of patients who were hospitalized in the medical and surgical departments as well as in the intensive care untis (ICU) of the University Hospital of Lausanne (Centre Hospitalier Universitaire Vaudois [CHUV]) that is a tertiary care academic medical center. Patients with AKI coming from ICU in the medicine or surgery wards, and patients from medicine or surgery wards, who required a transfer to ICU during the hospital stay, were also included whatever the cause of the transfer.
Who may be able to join
- Adult patients.
- Hospitalization in the medicine and surgery wards and in the intensive care unit.
- Hospitalized patients with acquired acute kidney injury according to the
- Acute Kidney Injury Network (AKIN)criteria.
- HA-AKI patients with no referral to the nephrologist (nrHA-AKI).
- HA-AKI patients referred late (more than five days [> 5 days]) to the nephrologist (lrHA-AKI).
- HA-AKI patients early referred (within five days after sCr increase) to the nephrologist (erHA-AKI).
Who cannot join
- Patients with AKI at the time of the hospital admission and during the first
- 48 hours after admission.
- Patients hospitalized in other wards.
- Children under 18.
Trial locations and contacts
1 site in 1 country.
About this study
Few studies analyzed the referral time to nephrologists and its impact on the patient outcome in a large cohort. The investigators described the incidence and determined the outcome with respect to renal function recovery, renal replacement therapy (RRT) requirement and in-hospital mortality of Hospital Acquired Acute Kidney Injury (HA-AKI) without nephrology referral (nrHA-AKI) and late referred HA-AKI patients to nephrologists (lrHA-AKI) compared with early referral patients (erHA-AKI). The patients included were admitted to the tertiary care academic center of Lausanne (Switzerland) between 2004 and 2008, in the medical and surgical services and in the intensive care unit (ICU).
- Conditions
- Renal Replacement Therapy, Mortality
- Being tested
- Nephrologist referral
- Keywords
- No referral, Late referral, Acute kidney injury, Intensive care unit, In-hospital mortality, Renal outcome, Requirement for renal replacement therapy, Length of hospital stay, Impact, Incidence
- Medical subject headings
- Acute Kidney Injury, Tooth, Impacted
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Nephrologist referralOther
Also called Control group: early-referred patients with HA-AKI.
Nephrologist specialty, renal replacement therapy
| Study group | Role | What they receive |
|---|---|---|
| nrHA-AKI patients | Patients with hospital-acquired acute kidney injury not referred to the nephrologists Receives: Other: Nephrologist referral | |
| lrHA-AKI patients | Patients with hospital-acquired acute kidney injury whao are late referred to the nephrologists Receives: Other: Nephrologist referral |
What is being measured
The primary outcome is the main question the study is designed to answer.
Referral patterns for hospital acquired acute kidney injury and relevance to renal outcomes
Recovery of renal function during hospital stay. Requirement for renal replacement therapy.
Secondary outcomes (1)
Referral patterns for hospital acquired acute kidney injury and relevance to renal outcomes
Length of hospital stay. In-hospital mortality.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Jun 2010 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Renal Replacement TherapyStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire VaudoisThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire Vaudois
- Sponsor type
- University, hospital or other
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01151514
- Sponsor's protocol ID
- HA-AKI referral
- Acronym
- HA-AKI
- Status last verified
- Aug 2010
- First submitted
- 23 Jun 2010
- Last updated
- 28 Jun 2010
- Results posted
- No
- Data monitoring committee
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 28 Jun 2010. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Referral Patterns for Hospital Acquired Acute Kidney Injury and Relevance to Renal Outcomes
- ClinicalTrials.gov ID
- NCT01151514
- Acronym / sponsor ID
- HA-AKI / HA-AKI referral
- Conditions
- Renal Replacement Therapy, Mortality
- Keywords
- No referral, Late referral, Acute kidney injury, Intensive care unit, In-hospital mortality, Renal outcome, Requirement for renal replacement therapy, Length of hospital stay
- Study type
- Observational
- Recruitment status
- Completed
- Lead sponsor
- Centre Hospitalier Universitaire VaudoisUniversity, hospital or other
- First posted
- 28 Jun 2010 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Few studies analyzed the referral time to nephrologists and its impact on the patient outcome in a large cohort. The investigators described the incidence and determined the outcome with respect to renal function recovery, renal replacement therapy (RRT) requirement and in-hospital mortality of Hospital Acquired Acute Kidney Injury (HA-AKI) without nephrology referral (nrHA-AKI) and late referred HA-AKI patients to nephrologists (lrHA-AKI) compared with early referral patients (erHA-AKI). The patients included were admitted to the tertiary care academic center of Lausanne (Switzerland) between 2004 and 2008, in the medical and surgical services and in the intensive care unit (ICU).
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| nrHA-AKI patients | – | Other: Nephrologist referralPatients with hospital-acquired acute kidney injury not referred to the nephrologists |
| lrHA-AKI patients | – | Other: Nephrologist referralPatients with hospital-acquired acute kidney injury whao are late referred to the nephrologists |
Who may qualify
- Ages
- 18 to 90 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- This study population consisted of patients who were hospitalized in the medical and surgical departments as well as in the intensive care untis (ICU) of the University Hospital of Lausanne (Centre Hospitalier Universitaire Vaudois [CHUV]) that is a tertiary care academic medical center. Patients with AKI coming from ICU in the medicine or surgery wards, and patients from medicine or surgery wards, who required a transfer to ICU during the hospital stay, were also included whatever the cause of the transfer.
Key inclusion criteria (7 listed)
- Adult patients.
- Hospitalization in the medicine and surgery wards and in the intensive care unit.
- Hospitalized patients with acquired acute kidney injury according to the
- Acute Kidney Injury Network (AKIN)criteria.
- HA-AKI patients with no referral to the nephrologist (nrHA-AKI).
Key exclusion criteria (4 listed)
- Patients with AKI at the time of the hospital admission and during the first
- 48 hours after admission.
- Patients hospitalized in other wards.
- Children under 18.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Nephrologist referralAlso: Control group: early-referred patients with HA-AKI.Nephrologist specialty, renal replacement therapy | Other | lrHA-AKI patients, nrHA-AKI patients |
Primary outcome
Referral patterns for hospital acquired acute kidney injury and relevance to renal outcomes
Recovery of renal function during hospital stay. Requirement for renal replacement therapy.
1 secondary outcome
Referral patterns for hospital acquired acute kidney injury and relevance to renal outcomes
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Jun 2010.
- Related InfoLink provided by the sponsor.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Renal Replacement Therapy and Mortality, run by Centre Hospitalier Universitaire Vaudois at 1 site in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 28 Jun 2010. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Referral patterns for hospital acquired acute kidney injury and relevance to renal outcomes. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Jun 2010.