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Acute Decompensated Heart FailureKorAHFNCT01389843

Registry (Prospective Cohort) for Heart Failure in Korea (KorAHF)

An observational study of Acute Decompensated Heart Failure, run by Byung-Hee Oh at 1 site in South Korea.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

KorAHF is a multi-center registry (prospective cohort) for acute decompensated heart failure patients in Korea. The aim of this registry is to analyze several causes affecting prognosis and survival and to develop new strategies for managing acute decompensated heart failure. Read more about this study

Who is it for?
Any age
Conditions the study is for
Acute Decompensated Heart Failure
How many people
5,625 participants
Where
1 siteSouth Korea
Study dates
Mar 2011to Dec 2018
Phase
Observational
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages Any age
  • All sexes
  • No healthy volunteers
  • Child, Adult, Older adult

Study population: acute decompensated heart failure

Who may be able to join

  • All consecutive hospitalized adult patients who have 1 and (2 and/or 3)
  • Symptom and/or sign of heart failure
  • Lung congestion
  • Objective finding of LV systolic dysfunction (LVEF), or structural heart disease

Who cannot join

  • N.C.

Trial locations and contacts

1 site in 1 country.

South Korea1 site

  • Seoul National University Hospital

    Seoul, 03080

Other trials in South Korea

About this study

KorAHF is a multi-center registry (prospective cohort) for acute decompensated heart failure patients in Korea.

The aim of this registry is to analyze several causes affecting prognosis and survival and to develop new strategies for managing acute decompensated heart failure.

Keywords
Heart failure, Registry, Cohort, Heart Disease, Cardiovascular Diseases
Medical subject headings
Heart Failure, Heart Diseases, Cardiovascular Diseases

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Study groups in NCT01389843
Study groupRoleWhat they receive
All consecutive hospitalized adult patientsAll consecutive hospitalized adult patients who have 1 and (2 and/or 3) 1. Symptom and/or sign of heart failure 2. Lung congestion 3. Objective finding of LV systolic dysfunction (LVEF), or structural heart disease.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Mortality and Re-hospitalization of acute decompensated heart failure

    1. In-hospital mortality
    2. Annual mortality
    3. Re-hospitalization

    Measured: 5 years (tentative)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted8 Jul 2011 (estimated)
  2. Study startMar 2011
  3. Primary completionDec 2018
  4. Study completionDec 2018

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
5,625 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT01389843
Sponsor's protocol ID
H-1102-072-352
Acronym
KorAHF
Status last verified
Sep 2019
First submitted
6 Jul 2011
Last updated
20 Sep 2019
Results posted
No
Data monitoring committee
Yes
Individual data sharing
Yes: Data be shared with participating institution and NNIH

Publications

  • Kwon O, Yoon M, Park JJ. Obesity paradox in heart failure with and without diabetes mellitus: a retrospective cohort study : Obesity paradox and DM in HF. Clin Res Cardiol. 2026 Sep 8. doi: 10.1007/s00392-026-03007-0. Online ahead of print.

    PubMed 42709147

  • Yoon M, Park JJ, Youn JC, Lee SE, Lee HY, Choi JO, Kim KH, Yang DH, Cho MC, Kang SM, Yoo BS. Comparison of Natriuretic Peptide Levels in Sinus Rhythm and Atrial Fibrillation in Acute Heart Failure. Int J Heart Fail. 2025 Apr 24;7(2):85-95. doi: 10.36628/ijhf.2025.0007. eCollection 2025 Apr.

    PubMed 40519716

  • Cho Y, Yoon M, Kim J, Lee JH, Oh IY, Lee CJ, Kang SM, Choi DJ. Artificial Intelligence-Based Electrocardiographic Biomarker for Outcome Prediction in Patients With Acute Heart Failure: Prospective Cohort Study. J Med Internet Res. 2024 Jul 3;26:e52139. doi: 10.2196/52139.

    PubMed 38959500

  • Kim ES, Park SK, Youn JC, Lee HS, Lee HY, Cho HJ, Choi JO, Jeon ES, Lee SE, Kim MS, Kim JJ, Hwang KK, Cho MC, Chae SC, Kang SM, Park JJ, Choi DJ, Yoo BS, Cho JY, Kim KH, Oh BH, Greenberg B, Baek SH. Real-World Eligibility and Cost-Effectiveness Analysis of Empagliflozin for Heart Failure in Korea. J Korean Med Sci. 2024 Jan 8;39(1):e8. doi: 10.3346/jkms.2024.39.e8.

    PubMed 38193327

  • Hong JA, Kim MS, Park H, Lee SE, Lee HY, Cho HJ, Choi JO, Jeon ES, Hwang KK, Chae SC, Baek SH, Kang SM, Choi DJ, Yoo BS, Kim KH, Cho MC, Kim JJ, Oh BH. Prognostic Value of QRS Duration among Patients with Cardiogenic Shock Complicating Acute Heart Failure: Data from the Korean Acute Heart Failure (KorAHF) Registry. Int J Heart Fail. 2020 Mar 16;2(2):121-130. doi: 10.36628/ijhf.2019.0016. eCollection 2020 Apr.

    PubMed 36263287

  • Park J, Mebazaa A, Park JJ, Rhee TM, Park HA, Lee GY, Choi JO, Jeon ES, Lee SE, Cho HJ, Lee HY, Oh BH, Choi DJ; Korean Acute Heart Failure (KorAHF) Investigators. Incidence, Risk Factors and Prognosis of Contrast-Induced Acute Kidney Injury in Acute Heart Failure Patients Undergoing Coronary Angiography. Int J Heart Fail. 2019 Oct 24;1(1):72-85. doi: 10.36628/ijhf.2019.0006. eCollection 2019 Oct.

    PubMed 36262741

  • Kim W, Park JJ, Lee HY, Kim KH, Yoo BS, Kang SM, Baek SH, Jeon ES, Kim JJ, Cho MC, Chae SC, Oh BH, Kook W, Choi DJ. Predicting survival in heart failure: a risk score based on machine-learning and change point algorithm. Clin Res Cardiol. 2021 Aug;110(8):1321-1333. doi: 10.1007/s00392-021-01870-7. Epub 2021 Jul 14.

    PubMed 34259921

  • Park JJ, Lee HY, Kim KH, Yoo BS, Kang SM, Baek SH, Jeon ES, Kim JJ, Cho MC, Chae SC, Oh BH, Choi DJ. Heart failure and atrial fibrillation: tachycardia-mediated acute decompensation. ESC Heart Fail. 2021 Aug;8(4):2816-2825. doi: 10.1002/ehf2.13354. Epub 2021 May 6.

    PubMed 33960144

  • Cho Y, Cho SY, Oh IY, Lee JH, Park JJ, Lee HY, Kim KH, Yoo BS, Kang SM, Baek SH, Jeon ES, Kim JJ, Cho MC, Chae SC, Oh BH, Choi DJ. Implantable Cardioverter-defibrillator Utilization and Its Outcomes in Korea: Data from Korean Acute Heart Failure Registry. J Korean Med Sci. 2020 Nov 30;35(46):e397. doi: 10.3346/jkms.2020.35.e397.

    PubMed 33258331

  • Park CS, Park JJ, Mebazaa A, Lee HY, Kim KH, Yoo BS, Kang SM, Baek SH, Jeon ES, Kim JJ, Cho MC, Chae SC, Oh BH, Choi DJ. Response to beta-blockers and natriuretic peptide level in acute heart failure: analysis of data from the Korean acute heart failure registry. Clin Res Cardiol. 2021 Sep;110(9):1392-1403. doi: 10.1007/s00392-020-01689-8. Epub 2020 Jun 25.

    PubMed 32588127

  • Kong MG, Jang SY, Jang J, Cho HJ, Lee S, Lee SE, Kim KH, Yoo BS, Kang SM, Baek SH, Choi DJ, Jeon ES, Kim JJ, Cho MC, Chae SC, Oh BH, Lim S, Park SK, Lee HY. Impact of diabetes mellitus on mortality in patients with acute heart failure: a prospective cohort study. Cardiovasc Diabetol. 2020 May 2;19(1):49. doi: 10.1186/s12933-020-01026-3.

    PubMed 32359358

  • Son MK, Park JJ, Lim NK, Kim WH, Choi DJ. Impact of atrial fibrillation in patients with heart failure and reduced, mid-range or preserved ejection fraction. Heart. 2020 Aug;106(15):1160-1168. doi: 10.1136/heartjnl-2019-316219. Epub 2020 Apr 27.

    PubMed 32341140

  • Seo WW, Park JJ, Park HA, Cho HJ, Lee HY, Kim KH, Yoo BS, Kang SM, Baek SH, Jeon ES, Kim JJ, Cho MC, Chae SC, Oh BH, Choi DJ. Guideline-directed medical therapy in elderly patients with heart failure with reduced ejection fraction: a cohort study. BMJ Open. 2020 Feb 6;10(2):e030514. doi: 10.1136/bmjopen-2019-030514.

    PubMed 32034017

  • Park JJ, Park CS, Mebazaa A, Oh IY, Park HA, Cho HJ, Lee HY, Kim KH, Yoo BS, Kang SM, Baek SH, Jeon ES, Kim JJ, Cho MC, Chae SC, Oh BH, Choi DJ. Characteristics and outcomes of HFpEF with declining ejection fraction. Clin Res Cardiol. 2020 Feb;109(2):225-234. doi: 10.1007/s00392-019-01505-y. Epub 2019 Jul 2.

    PubMed 31267239

  • Lee JH, Park JJ, Cho Y, Oh IY, Yoo BS, Kim JJ, Kim KH, Kang SM, Baek SH, Jeon ES, Cho MC, Chae SC, Oh BH, Choi DJ. Prognostic Implication of Ventricular Conduction Disturbance Pattern in Hospitalized Patients with Acute Heart Failure Syndrome. Korean Circ J. 2019 Jul;49(7):602-611. doi: 10.4070/kcj.2018.0290. Epub 2019 Feb 26.

    PubMed 30891964

Questions about this trial

What is this clinical trial studying?

An observational study of Acute Decompensated Heart Failure, run by Byung-Hee Oh at 1 site in South Korea.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 20 Sep 2019. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in South Korea. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Mortality and Re-hospitalization of acute decompensated heart failure (time frame: 5 years (tentative)). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT01389843, which also lists 23 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Sep 2019.

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